CN111053942A - 一种甲壳素百里香精油凝胶及其制备方法 - Google Patents

一种甲壳素百里香精油凝胶及其制备方法 Download PDF

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CN111053942A
CN111053942A CN201911363122.6A CN201911363122A CN111053942A CN 111053942 A CN111053942 A CN 111053942A CN 201911363122 A CN201911363122 A CN 201911363122A CN 111053942 A CN111053942 A CN 111053942A
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chitin
suspension
complex
essential oil
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隋晓锋
蒋阳
周行云
王碧佳
冯雪凌
毛志平
徐红
钟毅
张琳萍
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National Dong Hwa University
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Abstract

本发明涉及一种甲壳素百里香精油凝胶及其制备方法，使用甲壳素悬浮液和/或甲壳素复配物悬浮液以及百里香精油来制备Pickering乳液，冷冻，干燥，从而形成油凝胶。本发明使用甲壳素悬浮液和/或甲壳素复配物悬浮液制备的Pickering乳液稳定性高，制备的油凝胶具有黏附性、抗菌、止血及伤口愈合等优良性能，可用于伤口敷料领域。

Description

一种甲壳素百里香精油凝胶及其制备方法
技术领域
本发明属于凝胶及其制备领域，特别涉及一种甲壳素百里香精油凝胶及其制备方法。
背景技术
细菌感染构成严重的全球挑战,威胁公共健康并造成沉重的经济负担。细菌感染后导致毒素急剧增加,会显著延长或扰乱伤口愈合过程。由于抗生素的过量使用,使细菌产生耐药性,进一步加剧了该问题。因此,为了解决细菌耐药性问题,开发替代抗生素的制剂已成为迫切需要。
精油是疏水性，芳香性，挥发性液体，可通过最常用的蒸馏，精制或溶剂萃取从植物的花，种子，叶，果实和根中获得。近几十年来，人们对在食品，香料，芳香疗法和药物中使用精油的兴趣不断上升(Burt,Sara."Essential oils:their antibacterial propertiesand potential applications in foods—a review."International journal of foodmicrobiology 94.3(2004):223-253.)。由于精油具有生物活性化合物，例如香芹酚，丁香酚和百里酚，已被证明具有抗菌，抗真菌，抗病毒，杀虫和抗氧化特性(Pranoto,Yudi,VilasM.Salokhe,and Sudip K.Rakshit."Physical and antibacte rial properties ofalginate-based edible film incorporated with garlic oil."Food researchinternational 38.3(2005):267-272.)。肉桂，丁香，罗勒，薰衣草和迷迭香油已显示出抗菌和抗真菌活性，而柠檬和迷迭香油也具有抗氧化性能(Prabuseenivasan,Seenivasan,Manickkam Jayakumar,and Savarimuthu Ignacimuthu."In vitro antibacterialactivity of some plant essential oils."BMC complementary and alternativemedicine 6.1(2006):39.)。百里香精油富含百里酚和香芹酚，可产生显着的抗氧化和抗菌作用(Marino,Marilena,Carla Bersani,and Giuseppe Comi."Antimicrobial activityof the essential oils of Thymus vulgaris L.measured using a bioimpedometricmethod."Journal of food protection 62.9(1999):1017-1023.)。布拉加等指出百里酚可以有效控制许多感染中的炎症过程，这对于适当的伤口愈合是必不可少的(Braga,PierCarlo,et al."Anti-inflammatory activity of thymol:inhibitory effect on therelease of human neutrophil elastase."Pharmacology 77.3(2006):130-136.)。由于炎症会引起许多并发症，包括伤口开裂，感染和胶原蛋白合成受损，因此当使用百里香必不可少的伤口愈合材料时，百里酚具有抗发炎的作用(Busti,Anthony J.,et al."Effectsof perioperative antiinflammatory and immunomodulating therapy on surgicalwound healing."Pharmacotherapy:The Journal of Human Pharmacology and DrugTherapy 25.11(2005):1566-1591.)。
甲壳素已被证明是无毒的，可生物降解的，生物功能的，生物相容的，并具有抗菌特性(Pranoto,Y.,S.K.Rakshit,and V.M.Salokhe."Enhancing antimicrobial activityof chitosan films by incorporating garlic oil,potassium sorbate and nisin."LWT-Food Science and Technology 38.8(2005):859-865.)。甲壳素的独特的性质和相当缓慢的生物降解作用而在组织工程和药物输送，包装中发现了许多应用。一些载有药物的壳聚糖正作为新型药物传递系统出现，并且这些材料似乎具有局部持续传递癌症化学治疗剂的潜力。壳聚糖还具有促进皮肤愈合的特性，因为它具有快速的皮肤再生能力，除了具有抑菌作用外，还具有加速的伤口愈合性能。
发明内容
本发明所要解决的技术问题是提供一种甲壳素百里香精油凝胶及其制备方法，克服现有技术无法使用亲水性材料固化疏水性液体油的缺陷，本发明中采用甲壳素悬浮液和/或甲壳素复配物悬浮液以及百里香精油来制备Pickering乳液，冷冻，干燥，从而形成百里香精油凝胶。本发明的一种百里香精油皮克林乳液，包括：油相：百里香精油；水相：甲壳素悬浮液和/或甲壳素复配物悬浮液；其中油相和水相体积比例为5:95-50:50。
进一步，优选地油相和水相比例为7:93-15:85。
所述甲壳素的分子量大小为为50万-300万。
所述油相为百里香精油。
所述甲壳素复配物悬浮液为甲壳素悬浮液与羧甲基纤维素的复配物、甲壳素悬浮液与黄原胶的复配物、甲壳素悬浮液素与甲基纤维素的复配物、甲壳素悬浮液与羟丙基纤维素的复配物、甲壳素悬浮液与单宁酸的复配物、甲壳素悬浮液与蛋白质的复配物、甲壳素悬浮液与乙基纤维素复配物、甲壳素悬浮液与壳聚糖的复配物、甲壳素悬浮液与脂肪醇的复配物、甲壳素悬浮液与脂肪酸的复配物、甲壳素悬浮液与天然蜡的复配物、甲壳素悬浮液与硬脂酸的复配物、甲壳素悬浮液与谷甾醇的复配物、甲壳素悬浮液与卵磷脂的复配物、甲壳素悬浮液与去水山梨糖醇三硬脂酸酯的复配物中的一种或几种。
所述甲壳素悬浮液和/或甲壳素复配物悬浮液的甲壳素和甲壳素复配物占悬浮液的质量分数0.1％-5％。
本发明的一种所述皮克林乳液组合物的制备方法，包括：将百里香精油加入甲壳素悬浮液和/或甲壳素复配物悬浮液中，均质，得到百里香精油皮克林Pickering乳液。
所述均质为：均质时间1-30min，均质转速8000-15000rpm，温度为10-30℃。
本发明的一种基于皮克林乳液的百里香精油凝胶。
本发明的一种所述百里香精油凝胶的制备方法，将权利要求1所述百里香精油皮克林乳液，冷冻干燥，即得固体或半固体状百里香精油凝胶；其中冷冻、干燥为：冷冻温度为-197℃～-5℃，冷冻时间为10-20h；干燥压力为10Pa-200 Pa，干燥时间为5h-48h。
本发明的一种所述百里香精油凝胶应用于伤口敷料领域。
本发明使用甲壳素为稳定剂，甲壳素作为固体粒子为稳定剂，制备具有抗菌的油凝胶。
有益效果：
(1)本发明使用甲壳素悬浮液和/或甲壳素复配物悬浮液制备的Pickering制备的百里香油凝胶实现了液体油的固化，可用于伤口敷料；
(2)本发明制备的固体或半固体油凝胶具有良好的抗菌性。
附图说明
图1为本发明的制备工艺流程图；
图2为实施例1制备的Pickering乳液；
图3为实施例1制备的百里香精油凝胶；
图4为实施例2制备的Pickering乳液；
图5为实施例2制备的百里香精油凝胶；
图6为实施例1、2制备的油凝胶的抗菌性能；其中a为实施例1不加油凝胶的对比实验，实验表明不加油凝胶有大量的细菌生长，b为实施例1使用油凝胶的对比实验，使用油凝胶，细菌得到抑制；c为实施例2不加油凝胶的对比实验，实验表明不加油凝胶有大量的细菌生长，d为实施例2使用油凝胶的对比实验，使用油凝胶，细菌得到抑制。
具体实施方式
下面结合具体实施例，进一步阐述本发明。应理解，这些实施例仅用于说明本发明而不用于限制本发明的范围。此外应理解，在阅读了本发明讲授的内容之后，本领域技术人员可以对本发明作各种改动或修改，这些等价形式同样落于本申请所附权利要求书所限定的范围。百里香精油为商品化精油。
实施例1
百里香精油Pickering乳液的制备：
将10ml质量分数为2％的甲壳素(分子量大小为100万)悬浮液加入到25mL的烧杯中，加入10ml百里香精油，在均质机中以10000rpm的转速均质分散1min，即得到稳定的百里香精油Pickering乳液，如图2所示。
百里香精油凝胶的制备方法，具体步骤为：
(1)制备Pickering乳液：将10ml质量分数为2％的甲壳素(分子量大小为100万)悬浮液加入到25mL的烧杯中，加入10ml百里香精油，在均质机中以10000rpm的转速均质分散1min，即得到稳定的百里香精油Pickering乳液。
(2)将百里香精油Pickering乳液放在-20℃冰箱中冷冻12h，使用冷冻干燥机干燥48h，得到百里香精油凝胶，如图3所示。
实施例2
百里香精油Pickering乳液的制备：
将10ml质量分数为2％的甲壳素复配物悬浮液(甲壳素和羧甲基纤维素复配物的重量比为1：1)悬浮液加入到25mL的烧杯中，加入10ml百里香精油，在均质机中以10000rpm的转速均质分散1min，即得到稳定的百里香精油Pickering乳液，如图4所示。
百里香精油凝胶的制备方法，具体步骤为：
(1)制备Pickering乳液：将10ml质量分数为2％的甲壳素复配物悬浮液(甲壳素和羧甲基纤维素复配物的重量比为1：1)加入到25mL的烧杯中，加入10ml百里香精油，在均质机中以10000rpm的转速均质分散1min，即得到稳定的百里香精油Pickering乳液。
(2)将百里香Pickering乳液放在-20℃冰箱中冷冻12h，使用冷冻干燥机干燥48h，得到百里香精油凝胶，如图5所示。
抗菌测试：
对不使用甲壳素油凝胶的样品和使用甲壳素油凝胶的样品进行抗菌测试，发现使用油凝胶的样品具有良好的抗菌效果，如图6所示。

Claims (10)

1.一种百里香精油皮克林乳液，组分包括：以百里香精油为油相；以甲壳素悬浮液和/或甲壳素复配物悬浮液为水相；其中，油相和水相体积比例为5:95-50:50。
2.根据权利要求1所述皮克林乳液，其特征在于，所述甲壳素的分子量大小为50万-300万。
3.根据权利要求1所述皮克林乳液，其特征在于，所述油相为百里香精油。
4.根据权利要求1所述皮克林乳液，其特征在于，所述甲壳素复配物悬浮液为甲壳素悬浮液与羧甲基纤维素的复配物、甲壳素悬浮液与黄原胶的复配物、甲壳素悬浮液素与甲基纤维素的复配物、甲壳素悬浮液与羟丙基纤维素的复配物、甲壳素悬浮液与单宁酸的复配物、甲壳素悬浮液与蛋白质的复配物、甲壳素悬浮液与乙基纤维素复配物、甲壳素悬浮液与壳聚糖的复配物、甲壳素悬浮液与脂肪醇的复配物、甲壳素悬浮液与脂肪酸的复配物、甲壳素悬浮液与天然蜡的复配物、甲壳素悬浮液与硬脂酸的复配物、甲壳素悬浮液与谷甾醇的复配物、甲壳素悬浮液与卵磷脂的复配物、甲壳素悬浮液与去水山梨糖醇三硬脂酸酯的复配物中的一种或几种。
5.根据权利要求1所述皮克林乳液，其特征在于，所述甲壳素悬浮液和/或甲壳素复配物悬浮液的甲壳素和甲壳素复配物占悬浮液的质量分数0.1％-5％。
6.一种权利要求1所述皮克林乳液组合物的制备方法，包括：将百里香精油加入甲壳素悬浮液和/或甲壳素复配物悬浮液中，均质，得到百里香精油皮克林Pickering乳液。
7.根据权利要求1所述制备方法，其特征在于，所述均质为：均质时间1-30min，均质转速8000-15000rpm，温度为10-30℃。
8.一种基于权利要求1皮克林乳液的百里香精油凝胶。
9.一种权利要求8所述百里香精油凝胶的制备方法，其特征在于，将权利要求1所述百里香精油皮克林乳液，冷冻干燥，即得；其中冷冻、干燥为：冷冻温度为-197℃～-5℃，冷冻时间为10-20h；干燥压力为10Pa-200 Pa，干燥时间为5h-48h。
10.一种权利要求8所述百里香精油凝胶应用于伤口敷料领域。
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111588654A (zh) * 2020-06-08 2020-08-28 大连工业大学 一种可食用型抗菌油凝胶及其制备方法
CN111759889A (zh) * 2020-07-29 2020-10-13 山东广玉源环保科技有限公司 一种含甲壳素的止血组合物及其气雾剂
CN112336685A (zh) * 2020-10-29 2021-02-09 西南交通大学 一种抗菌微乳凝胶及其制备方法
CN112641031A (zh) * 2020-12-14 2021-04-13 中国农业科学院农业质量标准与检测技术研究所 一种同时利用天然植物精油和多糖有效降低大肠杆菌耐压性的方法
CN113647608A (zh) * 2021-09-08 2021-11-16 河北农业大学 一种水包油凝胶Pickering乳液及其制备方法和用途
CN115253936A (zh) * 2022-06-30 2022-11-01 季华实验室 一种纳米纤维油凝胶剂的制备方法
CN115678041A (zh) * 2022-11-21 2023-02-03 东北林业大学 一种纳米级甲壳素基耐环境变化的HIPPEs制备方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004062600A2 (en) * 2003-01-08 2004-07-29 Lectec Corporation Antiviral patch
CN101024094A (zh) * 2007-01-11 2007-08-29 南京零一新材料工程研究中心 可生物降解的壳聚糖多孔止血材料及其制备方法
CN102727930A (zh) * 2011-04-01 2012-10-17 广州奥托沙医药科技有限公司 一种医用可吸收骨创面止血材料及其制备方法
CN105994697A (zh) * 2016-05-25 2016-10-12 东华大学 一种食用油凝胶及其制备方法
CN107106720A (zh) * 2014-06-05 2017-08-29 约翰内斯堡威特沃特斯兰德大学 一种伤口敷料
CN107620132A (zh) * 2016-07-13 2018-01-23 天津市职业大学 乳液静电纺丝核壳结构抗菌纳米纤维膜及其制备方法
CN109529093A (zh) * 2018-10-29 2019-03-29 上海工程技术大学 一种用于创口灭菌止血的海藻酸纤维及其制备方法
CN109898358A (zh) * 2019-03-07 2019-06-18 天津科技大学 一种植物源缓释抗菌气凝胶的制备方法

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004062600A2 (en) * 2003-01-08 2004-07-29 Lectec Corporation Antiviral patch
CN101024094A (zh) * 2007-01-11 2007-08-29 南京零一新材料工程研究中心 可生物降解的壳聚糖多孔止血材料及其制备方法
CN102727930A (zh) * 2011-04-01 2012-10-17 广州奥托沙医药科技有限公司 一种医用可吸收骨创面止血材料及其制备方法
CN107106720A (zh) * 2014-06-05 2017-08-29 约翰内斯堡威特沃特斯兰德大学 一种伤口敷料
CN105994697A (zh) * 2016-05-25 2016-10-12 东华大学 一种食用油凝胶及其制备方法
CN107620132A (zh) * 2016-07-13 2018-01-23 天津市职业大学 乳液静电纺丝核壳结构抗菌纳米纤维膜及其制备方法
CN109529093A (zh) * 2018-10-29 2019-03-29 上海工程技术大学 一种用于创口灭菌止血的海藻酸纤维及其制备方法
CN109898358A (zh) * 2019-03-07 2019-06-18 天津科技大学 一种植物源缓释抗菌气凝胶的制备方法

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111588654A (zh) * 2020-06-08 2020-08-28 大连工业大学 一种可食用型抗菌油凝胶及其制备方法
CN111759889A (zh) * 2020-07-29 2020-10-13 山东广玉源环保科技有限公司 一种含甲壳素的止血组合物及其气雾剂
CN112336685A (zh) * 2020-10-29 2021-02-09 西南交通大学 一种抗菌微乳凝胶及其制备方法
CN112641031A (zh) * 2020-12-14 2021-04-13 中国农业科学院农业质量标准与检测技术研究所 一种同时利用天然植物精油和多糖有效降低大肠杆菌耐压性的方法
CN112641031B (zh) * 2020-12-14 2021-08-03 中国农业科学院农业质量标准与检测技术研究所 一种同时利用天然植物精油和多糖有效降低大肠杆菌耐压性的方法
CN113647608A (zh) * 2021-09-08 2021-11-16 河北农业大学 一种水包油凝胶Pickering乳液及其制备方法和用途
CN115253936A (zh) * 2022-06-30 2022-11-01 季华实验室 一种纳米纤维油凝胶剂的制备方法
CN115678041A (zh) * 2022-11-21 2023-02-03 东北林业大学 一种纳米级甲壳素基耐环境变化的HIPPEs制备方法

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