CN111053886A - 一种治疗家禽肠道疾病的中药添加剂、含该中药添加剂的药物组合物及其制备方法和应用 - Google Patents
一种治疗家禽肠道疾病的中药添加剂、含该中药添加剂的药物组合物及其制备方法和应用 Download PDFInfo
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Abstract
本发明公开了一种治疗家禽肠道疾病的中药添加剂，包括以下重量份原料，鱼腥草粗提取3‑9份、VB1 2‑10份、牛磺酸1‑5份、鞣酸蛋白0.5‑30份、黄芩3‑10份、白术3‑9份、盐酸小檗碱1‑10份、硫酸小檗碱1‑10份、植物精油1‑10份。还公开了一种包含上述中药添加剂和药学上可接受载体的药物组合物。本发明的中药添加剂和药物组合物能降低肠炎腹泻的不利影响，减少因疾病带来的经济损失。
Description
技术领域
本发明属于中药技术领域，涉及一种治疗家禽肠道疾病的中药添加剂、含该中药添加剂的药物组合物及其制备方法和应用。
背景技术
肠炎腹泻一般由大肠杆菌、沙门氏菌类以及一些病毒引起的一种常见多发性胃肠道传染病。该病传染性强，发病率高，易引起流行。在现代养殖业中，肠炎腹泻是最常见的一种疾病，尤其初生幼畜禽极易多发，并具有发病率高，死亡率高的特点。由于该阶段的畜禽存在抵抗力差，消化系统发育不完全等特征，极易引起细菌、病毒和寄生虫等感染而出现腹泻，另天气突变、转栏、运输等应激反应和消化不良也是引起腹泻的原因。如果不给予及时合理的治疗，病情会进一步转为慢性腹泻，影响幼畜禽的生长速度，严重时会因呕吐、绝食、电解质紊乱导致脱水，甚致死亡。现阶段对肠炎腹泻的治疗主要以化学药物为主，但长期使用抗生素，细菌容易产生耐药性，一旦耐药菌株产生后，抗生素治疗就达不到效果。
因此，亟需提供一种无抗药性、无残留、能较好防治畜禽肠炎腹泻的药物，减少此病造成的经济损失，也间接增加了养殖的经济效益的绿色药品。
发明内容
针对现有技术中存在的上述技术问题，本发明提供了一种防治肠炎、菌痢、痢疾、顽固性腹泻的中药添加剂，通过选用清热杀菌、健脾燥湿的中药，提供一种无抗药性无残留的绿色药品，将肠炎腹泻的不利影响降到最低点，减少因疾病带来的经济损失，也间接增加了养殖的经济效益。
一方面，本发明提供了一种治疗家禽肠道疾病的中药添加剂，包括以下重量份原料，鱼腥草粗提取3-9份、VB1 2-10份、牛磺酸1-5份、鞣酸蛋白0.5-30份、黄芩3-10份、白术3-9份、盐酸小檗碱1-10份、硫酸小檗碱1-10份、植物精油1-10份。
进一步地，包括以下重量份原料，鱼腥草粗提取5份、VB1 5份、牛磺酸2份、鞣酸蛋白10份、黄芩5份、白术5份、盐酸小檗碱4份、硫酸小檗碱4份、植物精油4份。
另一方面，本发明提供一种药物组合物，包括上述的治疗家禽肠道疾病的中药添加剂和药学上可接受的载体。
进一步地，所述药物组合物为口服制剂或注射用制剂。
进一步地，所述的口服制剂包括丸剂、胶囊剂、片剂、散剂、颗粒剂或口服液。
另一方面，本发明提供一种药物组合物的制备方法，将上述的治疗家禽肠道疾病的中药添加剂混合后粉碎，经溶媒提取后，提取物与药学上可接受的载体混合制备制备成药物组合物。
进一步地，所述溶媒包括水、乙醇溶液或者乙醚。
另一方面，本发明还提供了上述的治疗家禽肠道疾病的中药添加剂或含该中药添加剂的药物组合物在制备防治肠炎、菌痢、痢疾或顽固性腹泻药物中的应用。
本发明药物组合物基于中医“辨证论治”的治疗理论而来。
原则：燥湿健脾，标本兼治，虚实并治，筛选出清热解毒、化湿开胃、健脾燥湿的天然药物，根据中医理论，按照一定的重量配比制备而成。
鱼腥草：具有清热解毒、消痈排脓、利尿通淋的功效，临床用于肺痈吐脓、痰热喘咳、热痢、热淋、痈肿疮毒等症。
白术：性温，味甘、苦，归脾经、胃经，具有健脾、益气、燥湿利水、止汗的功效，用治脾胃气弱、不思饮食、倦怠少气、虚胀、泄泻、痰饮、水肿、黄疸、湿痹、小便不利、头晕、自汗、胎气不安等，有明显且持久的抗利尿作用，对胃肠系统有双向调节作用，还有解痉、保肝、抗菌等药理作用，还能够促进肠胃蠕动、利胆、抗氧化、降血糖、抗凝血、抗菌、扩张血管、抑制心脏、镇静等作用。
鞣酸蛋白：止泻药，适用于急性胃肠炎及各种非细菌性腹泻，小肠处分解出鞣酸，使肠黏膜表层蛋白凝固，形成一层保护膜，减少渗出，减轻刺激及肠蠕动，有收敛、止泻作用。
盐酸小檗碱，是从黄连、黄柏中提炼出来的一种抗菌性生物碱，有清热解毒、杀菌消炎作用。
硫酸小檗碱，用于细菌性肠炎、各种化脓性感染症。
与现有的技术相比，本发明具有以下特点与有益效果：
本发明选用清热解毒、燥湿止痢、健脾和胃的中药，而发明的一种无抗药性无残留的绿色药品，将肠炎腹泻的不利影响降到最低点，减少因疾病带来的经济损失。
1、唯一高效安全的(类氧化锌)植物源性饲用肠道收敛剂。
2、肠道收敛，快速解决肠炎、水便和过料问题；(24小时粪便成型，过料解决)。
3、中和细菌肠毒素，抗肠道细菌及病毒。
4、驱除蛔虫等肠道线虫。
5、除臭——降低粪及肉中粪臭素水平。
6、高剂量应用治疗效果显著，低剂量应用提高饲料利用率，提高生产性能，促生长。
具体实施方式
下面结合具体实施例，进一步阐述本发明，但不作为技术限制。应理解这些实施例仅用于说明本发明而不用于限制本发明的范围。
实施例1
本实施例提供一种治疗家禽肠道疾病的中药添加剂，包括以下重量份原料，鱼腥草粗提取3份、VB1 2份、牛磺酸1份、鞣酸蛋白0.5份、黄芩3份、白术3份、盐酸小檗碱1份、硫酸小檗碱1份、植物精油1份。
将上述的中药添加剂混合后粉碎，经水或其他溶媒(例如，乙醇溶液、乙醚)提取后，提取物与药学上可接受的载体混合制备成药物组合物。药物组合物可以制成丸剂、胶囊剂、片剂、散剂、颗粒剂或口服液等口服制剂，或者制成注射用制剂。
实施例2
本实施例提供一种治疗家禽肠道疾病的中药添加剂，包括以下重量份原料，鱼腥草粗提取5份、VB1 5份、牛磺酸2份、鞣酸蛋白10份、黄芩5份、白术5份、盐酸小檗碱4份、硫酸小檗碱4份、植物精油4份。
将上述的中药添加剂混合后粉碎，经水或其他溶媒(例如，乙醇溶液、乙醚)提取后，提取物与药学上可接受的载体混合制备成药物组合物。药物组合物可以制成丸剂、胶囊剂、片剂、散剂、颗粒剂或口服液等口服制剂，或者制成注射用制剂。
实施例3
本实施例提供一种治疗家禽肠道疾病的中药添加剂，包括以下重量份原料，鱼腥草粗提取7份、VB1 7份、牛磺酸4份、鞣酸蛋白20份、黄芩8份、白术7份、盐酸小檗碱7份、硫酸小檗碱7份、植物精油7份。
将上述的中药添加剂混合后粉碎，经水或其他溶媒(例如，乙醇溶液、乙醚)提取后，提取物与药学上可接受的载体混合制备成药物组合物。药物组合物可以制成丸剂、胶囊剂、片剂、散剂、颗粒剂或口服液等口服制剂，或者制成注射用制剂。
实施例4
本实施例提供一种治疗家禽肠道疾病的中药添加剂，包括以下重量份原料，鱼腥草粗提取9份、VB1 10份、牛磺酸5份、鞣酸蛋白30份、黄芩10份、白术9份、盐酸小檗碱10份、硫酸小檗碱10份、植物精油10份。
将上述的中药添加剂混合后粉碎，经水或其他溶媒(例如，乙醇溶液、乙醚)提取后，提取物与药学上可接受的载体混合制备成药物组合物。药物组合物可以制成丸剂、胶囊剂、片剂、散剂、颗粒剂或口服液等口服制剂，或者制成注射用制剂。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等，均应包含在本发明的保护范围之内。
Claims (9)
1.一种治疗家禽肠道疾病的中药添加剂，其特征在于，包括以下重量份原料，鱼腥草粗提取3-9份、VB1 2-10份、牛磺酸1-5份、鞣酸蛋白0.5-30份、黄芩3-10份、白术3-9份、盐酸小檗碱1-10份、硫酸小檗碱1-10份、植物精油1-10份。
2.根据权利要求1所述的一种治疗家禽肠道疾病的中药添加剂，其特征在于，鱼腥草粗提取5份、VB1 5份、牛磺酸2份、鞣酸蛋白10份、黄芩5份、白术5份、盐酸小檗碱4份、硫酸小檗碱4份、植物精油4份。
3.一种药物组合物，其特征在于，包括权利要求1或2中所述的中药添加剂和药学上可接受的载体。
4.根据权利要求3所述的一种药物组合物，其特征在于，所述药物组合物为口服制剂或注射用制剂。
5.根据权利要求4所述的一种药物组合物，其特征在于，所述的口服制剂包括丸剂、胶囊剂、片剂、散剂、颗粒剂或口服液。
6.一种药物组合物的制备方法，其特征在于，将权利要求1所述的中药添加剂混合后粉碎，经溶媒提取后，提取物与药学上可接受的载体混合制备制备成药物组合物。
7.根据权利要求6所述的一种药物组合物的制备方法，其特征在于，所述溶媒包括水、乙醇溶液或者乙醚。
8.权利要求1或2中所述的中药添加剂在制备防治肠炎、菌痢、痢疾或顽固性腹泻药物中的应用。
9.权利要求3至5任一权利要求所述的药物组合物在制备防治肠炎、菌痢、痢疾或顽固性腹泻药物中的应用。
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01172340A (ja) * | 1987-12-26 | 1989-07-07 | Nisshin Flour Milling Co Ltd | 鶏のブドウ球菌症の予防及び治療剤 |
| CN1781548A (zh) * | 2005-09-06 | 2006-06-07 | 贵州泛德制药有限公司 | 治疗胃、肠疾病的药物制剂及其制备方法 |
| CN102450430A (zh) * | 2010-10-22 | 2012-05-16 | 张城 | 蛋鸡饲料添加剂的配方 |
| CN105815570A (zh) * | 2016-03-25 | 2016-08-03 | 广州英赛特生物技术有限公司 | 鞣酸蛋白在制备动物用饲料添加剂中的应用 |
| CN106924404A (zh) * | 2015-12-31 | 2017-07-07 | 天津中敖生物科技有限公司 | 治疗鸡胃肠炎的中药组合物及其制备方法 |
| CN107125461A (zh) * | 2016-02-29 | 2017-09-05 | 湖南晶天科技实业有限公司 | 一种饲料添加剂肠溶包衣单宁酸衍生物以及一种饲料 |
| CN107125438A (zh) * | 2016-02-29 | 2017-09-05 | 湖南晶天科技实业有限公司 | 一种饲料添加剂鞣酸生物碱及其制备方法以及一种复合添加剂和一种饲料 |
| CN109999117A (zh) * | 2019-05-24 | 2019-07-12 | 湖南泰谷生物兽药有限公司 | 防治肠炎、菌痢、痢疾、顽固性腹泻的中药组合物 |
-
2020
- 2020-01-10 CN CN202010027436.5A patent/CN111053886A/zh active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01172340A (ja) * | 1987-12-26 | 1989-07-07 | Nisshin Flour Milling Co Ltd | 鶏のブドウ球菌症の予防及び治療剤 |
| CN1781548A (zh) * | 2005-09-06 | 2006-06-07 | 贵州泛德制药有限公司 | 治疗胃、肠疾病的药物制剂及其制备方法 |
| CN102450430A (zh) * | 2010-10-22 | 2012-05-16 | 张城 | 蛋鸡饲料添加剂的配方 |
| CN106924404A (zh) * | 2015-12-31 | 2017-07-07 | 天津中敖生物科技有限公司 | 治疗鸡胃肠炎的中药组合物及其制备方法 |
| CN107125461A (zh) * | 2016-02-29 | 2017-09-05 | 湖南晶天科技实业有限公司 | 一种饲料添加剂肠溶包衣单宁酸衍生物以及一种饲料 |
| CN107125438A (zh) * | 2016-02-29 | 2017-09-05 | 湖南晶天科技实业有限公司 | 一种饲料添加剂鞣酸生物碱及其制备方法以及一种复合添加剂和一种饲料 |
| CN105815570A (zh) * | 2016-03-25 | 2016-08-03 | 广州英赛特生物技术有限公司 | 鞣酸蛋白在制备动物用饲料添加剂中的应用 |
| CN109999117A (zh) * | 2019-05-24 | 2019-07-12 | 湖南泰谷生物兽药有限公司 | 防治肠炎、菌痢、痢疾、顽固性腹泻的中药组合物 |
Non-Patent Citations (3)
| Title |
|---|
| 夏道伦: "中药防治禽病疗效好", 《农村新技术》 * |
| 张俭等: "鱼腥草在畜禽疾病防治中的应用", 《江苏农业科学》 * |
| 舒刚等: "初产蛋鸡非病原性腹泻的防治", 《中国家禽》 * |
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