CN111035723A - Traditional Chinese medicine pill for treating recurrent genital herpes, preparation method and application - Google Patents

Traditional Chinese medicine pill for treating recurrent genital herpes, preparation method and application Download PDF

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Publication number
CN111035723A
CN111035723A CN202010010617.7A CN202010010617A CN111035723A CN 111035723 A CN111035723 A CN 111035723A CN 202010010617 A CN202010010617 A CN 202010010617A CN 111035723 A CN111035723 A CN 111035723A
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genital herpes
recurrent genital
traditional chinese
chinese medicine
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Inventor
曾武城
袁丞达
杨敏
应航宇
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Hangzhou Hospital of Traditional Chinese Medicine
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Hangzhou Hospital of Traditional Chinese Medicine
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Priority to CN202010010617.7A priority Critical patent/CN111035723A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/85Verbenaceae (Verbena family)
    • A61K36/855Clerodendrum, e.g. glorybower
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • A61K35/644Beeswax; Propolis; Royal jelly; Honey
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/648Myriapods, e.g. centipedes or millipedes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/19Acanthaceae (Acanthus family)
    • A61K36/195Strobilanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315Isatis, e.g. Dyer's woad
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/483Gleditsia (locust)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/68Plantaginaceae (Plantain Family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/748Oldenlandia or Hedyotis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994Coix (Job's tears)
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/90Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses

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Abstract

The invention provides a traditional Chinese medicine pill for treating recurrent genital herpes, a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine treatment diseases. The traditional Chinese medicine pill solves the problems of frequent recurrence of the existing genital herpes and the like, and the traditional Chinese medicine pill for treating the recurrent genital herpes comprises the following raw materials in parts by weight: 6-15 parts of folium isatidis, 6-15 parts of honeysuckle, 3-12 parts of nidus vespae, 6-12 parts of rhizoma smilacis glabrae, 15-30 parts of oldenlandia diffusa, 30-50 parts of semen coicis, 5-15 parts of salvia miltiorrhiza, 1-3 parts of centipede, 30-50 parts of astragalus mongholicus, 3-15 parts of monkshood, 5-15 parts of plantain herb, 3-15 parts of spina gleditsiae and 70-150 parts of honey. The invention has the advantages of reducing the recurrence rate and the like.

Description

Traditional Chinese medicine pill for treating recurrent genital herpes, preparation method and application
Technical Field
The invention belongs to the technical field of traditional Chinese medicine treatment of sexual diseases, and particularly relates to a traditional Chinese medicine pill for treating recurrent genital herpes, a preparation method and application thereof.
Background
With the development of economic society, the sexual openness degree of people is improved, various diseases are more and more, particularly, the incidence rate of genital herpes is higher, once the virus is infected, the virus is carried throughout the life and repeatedly attacks, a series of physiological, psychological and social problems are brought to patients and families, and therefore, the reduction and the control of relapse are the key for treating the disease. The western medicine treatment mainly aims at resisting viruses at present, has definite recent curative effect, can play roles in relieving attack symptoms and shortening the course of disease, but still cannot reduce frequent relapse, and cannot improve local and general accompanying symptoms of patients caused by the disease.
Disclosure of Invention
The first object of the present invention is to solve the above problems of the prior art, and to provide a Chinese medicinal pill for treating recurrent genital herpes; the second purpose of the invention is to provide a preparation method of the traditional Chinese medicine pill for treating recurrent genital herpes.
The first object of the present invention can be achieved by the following technical solutions: the traditional Chinese medicine pill for treating recurrent genital herpes is characterized by comprising the following raw materials in parts by weight:
6-15 parts of folium isatidis, 6-15 parts of honeysuckle, 3-12 parts of nidus vespae, 6-12 parts of rhizoma smilacis glabrae, 15-30 parts of oldenlandia diffusa, 30-50 parts of semen coicis, 5-15 parts of salvia miltiorrhiza, 1-3 parts of centipede, 30-50 parts of astragalus mongholicus, 3-15 parts of monkshood, 5-15 parts of plantain herb, 3-15 parts of spina gleditsiae and 70-150 parts of honey.
The second object of the present invention can be achieved by the following technical solutions: the preparation method of the traditional Chinese medicine pill for treating recurrent genital herpes is characterized by comprising the following steps:
s01: pulverizing folium Isatidis, flos Lonicerae, nidus Vespae, rhizoma Smilacis Glabrae, herba Hedyotidis Diffusae, Coicis semen, Saviae Miltiorrhizae radix, Scolopendra, radix astragali, radix Aconiti lateralis Preparata, herba plantaginis, and spina Gleditsiae;
s02: putting the pulverized components into a mixing granulator according to a certain proportion, adding honey, stirring, and introducing hot steam until the mixture is viscous;
s03: and (4) extruding and granulating the viscous mixture obtained in the step (S02), and making the extruded medicine granules into pills to obtain the pills.
Preferably, in step S01, the particle size of the pulverized Chinese medicinal components is 120 meshes.
Preferably, in step S02, the temperature of the viscous mixture is 64-85 deg.C, and the humidity is 14-16%.
Preferably, in step S03, the pill has a diameter of 2.5-5 mm.
Preferably, in step S02, honey is added in multiple portions.
Preferably, the method further comprises steps S04 and S04, wherein the pills prepared in the step S03 are packaged and stored.
The third object of the present invention can be achieved by the following technical solutions: application of traditional Chinese medicine pills for treating recurrent genital herpes in treatment of recurrent genital herpes
Compared with the prior art, the invention has the following advantages:
1. the traditional Chinese medicine pills prepared according to the formula are convenient to take, can reduce or even eliminate virus latency, reduce the recurrence rate, prolong the recurrence period, improve systemic and local symptoms and improve the quality of life.
Detailed Description
The following are specific examples of the present invention and further describe the technical solutions of the present invention, but the present invention is not limited to these examples.
Example 1
The formula is as follows:
6 parts of folium isatidis, 6 parts of honeysuckle, 3 parts of nidus vespae, 6 parts of rhizoma smilacis glabrae, 15 parts of oldenlandia diffusa, 30 parts of semen coicis, 5 parts of salvia miltiorrhiza, 1 part of centipede, 30 parts of astragalus membranaceus, 3 parts of monkshood, 5 parts of plantain herb, 3 parts of spina gleditsiae and 70 parts of honey.
Example 2
The formula is as follows:
15 parts of folium isatidis, 15 parts of honeysuckle, 12 parts of nidus vespae, 12 parts of rhizoma smilacis glabrae, 30 parts of oldenlandia diffusa, 50 parts of semen coicis, 15 parts of salvia miltiorrhiza, 3 parts of centipede, 50 parts of astragalus membranaceus, 15 parts of monkshood, 15 parts of plantain herb, 15 parts of spina gleditsiae and 150 parts of honey.
Example 3
The formula is as follows:
10 parts of folium isatidis, 11 parts of honeysuckle, 8 parts of nidus vespae, 9 parts of rhizoma smilacis glabrae, 18 parts of oldenlandia diffusa, 40 parts of semen coicis, 10 parts of salvia miltiorrhiza, 2 parts of centipede, 40 parts of astragalus mongholicus, 9 parts of monkshood, 10 parts of plantain herb, 9 parts of spina gleditsiae and 110 parts of honey.
Preparation method
Pulverizing folium Isatidis, flos Lonicerae, nidus Vespae, rhizoma Smilacis Glabrae, herba Hedyotidis Diffusae, Coicis semen, Saviae Miltiorrhizae radix, Scolopendra, radix astragali, radix Aconiti lateralis Preparata, herba plantaginis, and spina Gleditsiae into 120 mesh fine powder with a traditional Chinese medicine pulverizer;
putting the fine powder into a mixing granulator according to a certain proportion, adding a small amount of honey for many times, stirring and mixing uniformly, and introducing hot steam until the mixture is viscous, wherein the temperature of the viscous mixture is 64-85 ℃, and the humidity is 14-16%.
Extruding the viscous mixture to granulate, and making the extruded medicine particles into pills with the diameter of 2.5-5 mm. Packaging the pills according to specifications, and storing the pills in a dark and cool place.
Pellets were prepared according to the formulations of example 1, example 2 and example 3 using the methods described above.
The pellets prepared according to example 1 were experimental group 1; the pill prepared according to example 2 was experimental group 2 and the pill prepared according to example 3 was experimental group 3.
The using method comprises the following steps: the composition is administered 2 times per day, 6-8 pills each time, and is administered for 2-4 weeks; clinical experiments show that after the pill is used, the disease condition of a patient is effectively controlled, the recurrence rate is only 5%, and in the 5% recurrence rate, the recurrence period is prolonged to half a year (recurrence happens in 1 month regularly), and the symptoms of herpes on the whole body or part of the body are relieved.
The specific embodiments described herein are merely illustrative of the spirit of the invention. Various modifications or additions may be made to the described embodiments or alternatives may be employed by those skilled in the art without departing from the spirit or ambit of the invention as defined in the appended claims.

Claims (8)

1. The traditional Chinese medicine pill for treating recurrent genital herpes is characterized by comprising the following raw materials in parts by weight:
6-15 parts of folium isatidis, 6-15 parts of honeysuckle, 3-12 parts of nidus vespae, 6-12 parts of rhizoma smilacis glabrae, 15-30 parts of oldenlandia diffusa, 30-50 parts of semen coicis, 5-15 parts of salvia miltiorrhiza, 1-3 parts of centipede, 30-50 parts of astragalus mongholicus, 3-15 parts of monkshood, 5-15 parts of plantain herb, 3-15 parts of spina gleditsiae and 70-150 parts of honey.
2. A method for preparing a Chinese medicinal pill for treating recurrent genital herpes as claimed in claim 1, comprising the steps of:
s01: pulverizing folium Isatidis, flos Lonicerae, nidus Vespae, rhizoma Smilacis Glabrae, herba Hedyotidis Diffusae, Coicis semen, Saviae Miltiorrhizae radix, Scolopendra, radix astragali, radix Aconiti lateralis Preparata, herba plantaginis, and spina Gleditsiae;
s02: putting the pulverized components into a mixing granulator according to a certain proportion, adding honey, stirring, and introducing hot steam until the mixture is viscous;
s03: and (4) extruding and granulating the viscous mixture obtained in the step (S02), and making the extruded medicine granules into pills to obtain the pills.
3. The preparation method of the traditional Chinese medicine pill for treating recurrent genital herpes according to claim 2, wherein in step S01, the particle size of the crushed traditional Chinese medicine components is 120 meshes.
4. The method for preparing a Chinese medicinal pill for treating recurrent genital herpes as claimed in claim 2, wherein the temperature of the viscous mixture is 64-85 ℃ and the humidity is 14-16% in step S02.
5. The method for preparing a Chinese medicinal pill for treating recurrent genital herpes as claimed in claim 2, wherein the diameter of the pill in step S03 is 2.5-5 mm.
6. The method for preparing a Chinese medicinal pill for treating recurrent genital herpes as claimed in claim 2, wherein in step S02, honey is added in multiple portions.
7. The method for preparing a Chinese medicinal pill for treating recurrent genital herpes according to claim 2, further comprising the steps of S04, S04: the pills made in step S03 are packaged and stored.
8. Use of a Chinese medicinal pill according to claim 1 for treating recurrent genital herpes.
CN202010010617.7A 2020-01-06 2020-01-06 Traditional Chinese medicine pill for treating recurrent genital herpes, preparation method and application Pending CN111035723A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101336976A (en) * 2008-08-19 2009-01-07 牛德兴 Oral traditional Chinese medicine formulation for treating genital herpes and preparation method thereof
CN103623299A (en) * 2013-11-25 2014-03-12 青岛大学医学院附属医院 Compound traditional Chinese medicine for treating herpes progenitalis
CN110478395A (en) * 2019-09-02 2019-11-22 成都前路通生物科技有限公司 A kind of pharmaceutical composition and preparation method thereof for treating recurrent genital herpes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101336976A (en) * 2008-08-19 2009-01-07 牛德兴 Oral traditional Chinese medicine formulation for treating genital herpes and preparation method thereof
CN103623299A (en) * 2013-11-25 2014-03-12 青岛大学医学院附属医院 Compound traditional Chinese medicine for treating herpes progenitalis
CN110478395A (en) * 2019-09-02 2019-11-22 成都前路通生物科技有限公司 A kind of pharmaceutical composition and preparation method thereof for treating recurrent genital herpes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
罗建凯: "中西医结合治疗复发性生殖器疱疹42例", 《实用中医药杂志》 *
陈晋广 等: "黄白液治疗复发性生殖器疱疹54例", 《中医杂志》 *

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Application publication date: 20200421