CN111012884A - Medicine penetration method for treating cervical vertebra and lumbar intervertebral disc protrusion - Google Patents

Medicine penetration method for treating cervical vertebra and lumbar intervertebral disc protrusion Download PDF

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Publication number
CN111012884A
CN111012884A CN201911303827.9A CN201911303827A CN111012884A CN 111012884 A CN111012884 A CN 111012884A CN 201911303827 A CN201911303827 A CN 201911303827A CN 111012884 A CN111012884 A CN 111012884A
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chinese herbal
herbal medicine
medicine
raw materials
intervertebral disc
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王国江
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Jiangsu Baoyitang Traditional Chinese Medicine Museum Co Ltd
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Jiangsu Baoyitang Traditional Chinese Medicine Museum Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A61K36/12—Filicopsida or Pteridopsida
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/254—Acanthopanax or Eleutherococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8884—Arisaema, e.g. Jack in the pulpit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A61K36/8988—Gastrodia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Abstract

The invention discloses a medicine permeation method for treating cervical vertebra and lumbar intervertebral disc protrusion, which specifically comprises the following steps: s1, preparing traditional Chinese medicine preparations: the method comprises the steps of selecting Chinese herbal medicine raw materials, removing impurities and mildewed parts on the Chinese herbal medicine, cleaning the Chinese herbal medicine raw materials by an ultrasonic cleaning machine after the impurities are removed, crushing the cleaned Chinese herbal medicine raw materials in a crushing machine, filtering the crushed Chinese herbal medicine raw materials by a 80-mesh sieve, and then putting the filtered Chinese herbal medicine raw materials in a reaction kettle. According to the medicine permeation method for treating the cervical vertebra and lumbar disc herniation, the adopted traditional Chinese medicine preparation can be directly coated on the surface layer of the skin, the medicine property is mild, no side effect is caused to a human body, meanwhile, the medicine can be rapidly introduced into the bottom layer of the skin through the penetration enhancer made of isopropyl myristate through ultrasonic waves and is absorbed by a patient to the inside of the human body to reach an affected part directly, the medicine permeability is improved, the medicine permeation method is beneficial to the recovery of the patient, and the medicine permeation method has a wide application prospect.

Description

Medicine penetration method for treating cervical vertebra and lumbar intervertebral disc protrusion
Technical Field
The invention relates to the technical field of drug therapy, in particular to a drug permeation method for treating cervical vertebra and lumbar intervertebral disc protrusion.
Background
The cervical disc herniation is a pathological process of disc degeneration, indicates that the stability of the segment is weakened at the beginning of the degeneration, the degeneration does not necessarily lead to the disc herniation, the disc herniation does not represent clinical morbidity, only indicates that the pathological basis of the compression of spinal cord or nerve root appears clinically, therefore, the cervical disc herniation and the cervical spondylosis are not suitable to be classified as the same disease, the disc herniation refers to the protrusion of the protruded nucleus pulposus and the corresponding fiber ring into the vertebral canal, and the subchondral bone hyperplasia of the segment vertebral body is not accompanied or slightly accompanied, and osteophyte is formed; under certain conditions, intervertebral disc degeneration occurs and osteophyte formation of adjacent segments occurs, but does not cause clinical morbidity, once the annulus fibrosus of the intervertebral disc is ruptured, and the degenerative nucleus pulposus is extruded to cause the spinal cord or spinal nerve roots to be pressed, and the intervertebral disc is only a pure intervertebral disc tissue as a pressing object and is called as cervical intervertebral disc protrusion.
The lumbar intervertebral disc protrusion is one of the more common diseases, mainly because each part of the lumbar intervertebral disc (nucleus pulposus, annulus fibrosus and cartilage plates), especially the nucleus pulposus, has degenerative changes of different degrees, under the action of external force factors, the annulus fibrosus of the intervertebral disc is ruptured, and nucleus pulposus tissues protrude (or are separated) from the ruptured part to the back or the vertebral canal, so that adjacent spinal nerve roots are stimulated or pressed, and a series of clinical symptoms such as lumbar pain, numbness and pain of one lower limb or two lower limbs are generated.
For patients suffering from cervical vertebra and lumbar intervertebral disc protrusion, the problems of inappetence, nausea, constipation and the like caused by gastrointestinal dysfunction brought to patients by oral administration can be solved by a transdermal administration mode, and the method is a novel treatment method.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides a medicine permeation method for treating cervical vertebra and lumbar intervertebral disc protrusion, and solves the problems that most medicines are low in transdermal absorption efficiency, the treatment effect is difficult to achieve through skin absorption, the medicine permeation is reduced, and the liver and kidney functions are damaged due to large side effects of western medicines used for a long time.
(II) technical scheme
In order to achieve the purpose, the invention is realized by the following technical scheme: a medicine permeation method for treating cervical vertebra lumbar intervertebral disc protrusion specifically comprises the following steps:
s1, preparing traditional Chinese medicine preparations: selecting Chinese herbal medicine raw materials, removing impurities and mildewed parts on the Chinese herbal medicine, cleaning the Chinese herbal medicine raw materials by an ultrasonic cleaning machine after removal, crushing the cleaned Chinese herbal medicine raw materials in a crushing machine, filtering the crushed Chinese herbal medicine raw materials by a 80-mesh sieve, then putting the filtered Chinese herbal medicine raw materials in a reaction kettle, adding ethanol at the temperature of 90-100 ℃, leaching for 120min, finally obtaining a Chinese herbal medicine preparation by centrifugation and concentration distillation, removing the impurities in the Chinese herbal medicine preparation by a filter, and finally obtaining the Chinese herbal medicine preparation for later use;
s2, preparing a penetration enhancer: dissolving isopropyl myristate in water, adding N-hydroxysuccinimide, mixing in a mixer to obtain penetration enhancer, and waiting for use;
s3, setting parameters of ultrasonic waves: modulating respective duration time of a high-frequency component, a medium-frequency component and a low-frequency component of the ultrasonic wave, wherein the respective duration time range of the three components is 2-98% of the period of the modulated ultrasonic wave, and the radiation time range of the modulated ultrasonic wave;
s4, ultrasonic infiltration method: cleaning and disinfecting the skin of a patient needing to be coated in a certain area, firstly coating the penetration enhancer prepared in the S2 on the skin of the patient after cleaning, then applying the traditional Chinese medicine medicament obtained in the S1 on the surface of the skin coated with the penetration enhancer through low-frequency ultrasonic waves, and quickly penetrating the traditional Chinese medicine medicament into the skin.
Preferably, the Chinese herbal medicine materials in the S1 are prepared from garden balsam stem, medicinal cyathula root, arisaema tuber, cassia bark, achyranthes root, common clubmoss herb, slenderstyle acanthopanax bark, rhizoma wenyujin concinnatae, east Asian tree fern rhizome and eucommia bark and tall gastrodia tuber.
Preferably, the ultrasonic infiltration method in S4 is performed for 6-30min each time, 1 time every day or every other day, and 1 treatment course is 10-15 times.
Preferably, the irradiation time in S3 is in the range of 0.5min to 24 h.
Preferably, the isopropyl myristate in S2 is prepared by esterification of isopropyl myristate with isopropanol.
(III) advantageous effects
The invention provides a medicine permeation method for treating cervical vertebra and lumbar intervertebral disc protrusion. The method has the following beneficial effects: the medicine penetration method for treating the cervical vertebra and lumbar disc herniation comprises the following steps of S1: selecting Chinese herbal medicine raw materials, removing impurities and mildewed parts on the Chinese herbal medicine, cleaning the Chinese herbal medicine raw materials by an ultrasonic cleaning machine after removal, crushing the cleaned Chinese herbal medicine raw materials in a crushing machine, filtering the crushed Chinese herbal medicine raw materials by a 80-mesh sieve, then putting the filtered Chinese herbal medicine raw materials in a reaction kettle, adding ethanol at the temperature of 90-100 ℃, leaching for 120min, finally obtaining a Chinese herbal medicine preparation by centrifugation and concentration distillation, removing the impurities in the Chinese herbal medicine preparation by a filter, and finally obtaining the Chinese herbal medicine preparation for later use; s2, preparing a penetration enhancer: dissolving isopropyl myristate in water, adding N-hydroxysuccinimide, mixing in a mixer to obtain penetration enhancer, and waiting for use; s3, setting parameters of ultrasonic waves: modulating respective duration time of a high-frequency component, a medium-frequency component and a low-frequency component of the ultrasonic wave, wherein the respective duration time range of the three components is 2-98% of the period of the modulated ultrasonic wave, and the radiation time range of the modulated ultrasonic wave; s4, ultrasonic infiltration method: the skin to be coated on a patient is cleaned and disinfected in a certain area, after cleaning, the penetration enhancer prepared in S2 is coated on the skin of the patient, the traditional Chinese medicine preparation obtained in S1 is applied to the surface of the skin coated with the penetration enhancer through low-frequency ultrasonic waves, the traditional Chinese medicine preparation is quickly penetrated into the skin, the adopted traditional Chinese medicine preparation can be directly coated on the surface layer of the skin, the medicine property is mild, no side effect is caused on a human body, meanwhile, the penetration enhancer prepared from isopropyl myristate can quickly guide the medicine into the bottom layer of the skin through the ultrasonic waves, and the medicine can be absorbed by the patient to reach an affected part in the human body directly, so that the permeability of the medicine is improved, and the application prospect is wide.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The embodiment of the invention provides a technical scheme that: a medicine penetration method for treating protrusion of lumbar and cervical intervertebral discs adopts traditional Chinese medicine agents which can be directly coated on the surface layer of skin, has mild medicine property and no side effect on human body, and simultaneously adopts penetration enhancer made of isopropyl myristate to quickly introduce the medicine into the bottom layer of the skin through ultrasonic waves, so that the medicine can be absorbed by patients to reach the affected part inside the human body, thereby improving the permeability of the medicine, having wide application prospect and specifically comprising the following steps:
s1, preparing traditional Chinese medicine preparations: selecting Chinese herbal medicine raw materials, removing impurities and mildewed parts on the Chinese herbal medicine, cleaning the Chinese herbal medicine raw materials by an ultrasonic cleaning machine after removal, crushing the Chinese herbal medicine raw materials in a crusher after cleaning, filtering the crushed Chinese herbal medicine raw materials by a 80-mesh sieve, then putting the filtered raw materials in a reaction kettle, adding ethanol at the temperature of 90-100 ℃, leaching for 120min, finally obtaining a Chinese herbal medicine medicament by centrifugation and concentration distillation, removing the impurities in the Chinese herbal medicine medicament by the filter to finally obtain the Chinese herbal medicine medicament for standby, converting a high-frequency oscillation signal sent by an ultrasonic generator by the principle of the ultrasonic cleaning machine into high-frequency mechanical oscillation by a transducer, transmitting the high-frequency mechanical oscillation signal into a medium cleaning solvent, radiating the ultrasonic waves forwards in a cleaning solution at intervals to enable the liquid to flow to generate tens of thousands of micro bubbles with the diameter of 50-500 mu m, micro bubbles existing in liquid vibrate under the action of a sound field, the bubbles form and grow in a negative pressure area where ultrasonic waves longitudinally propagate, when sound pressure reaches a certain value in a positive pressure area, the bubbles rapidly increase and then are suddenly closed, shock waves are generated when the bubbles are closed, thousands of atmospheric pressures are generated around the bubbles, insoluble dirt is damaged, and the insoluble dirt is dispersed in cleaning liquid, when group particles are wrapped by the oil dirt and adhered to the surface of a cleaning piece, the oil is emulsified, and solid particles are separated, so that the aim of cleaning the cleaning piece is fulfilled;
s2, preparing a penetration enhancer: the isopropyl myristate can be widely applied to cosmetics and can play a role in moisturizing and moistening skin, the skin has good absorbability to the product, the isopropyl myristate can effectively contact hair follicles in the cortex and permeate into the deep cortex, and active ingredients in the cosmetics are brought in to fully play the role of the active ingredients, and the isopropyl myristate is used as a cosmetic solvent, a skin moisturizer and a penetrant;
s3, setting parameters of ultrasonic waves: modulating respective duration time of a high-frequency component, a medium-frequency component and a low-frequency component of the ultrasonic wave, wherein the respective duration time range of the three components is 2-98% of the period of the modulated ultrasonic wave, and the radiation time range of the modulated ultrasonic wave;
s4, ultrasonic infiltration method: cleaning and disinfecting the skin of a patient needing to be coated in a certain area, firstly coating the penetration enhancer prepared in the S2 on the skin of the patient after cleaning, then applying the traditional Chinese medicine medicament obtained in the S1 on the surface of the skin coated with the penetration enhancer through low-frequency ultrasonic waves, and quickly penetrating the traditional Chinese medicine medicament into the skin.
In the invention, the Chinese herbal medicine raw materials in S1 are prepared from garden balsam stem, medicinal cyathula root, arisaema tuber, cinnamon, achyranthes root, common clubmoss herb, cortex acanthopanacis, rhizoma wenyujin concinnatae, east Asian tree fern rhizome and gastrodia elata, the medicinal cyathula root is the dried root of medicinal cyathula root of amaranthaceae, dug in autumn and winter, reed heads, fibrous roots and silt are removed, the medicinal cyathula root is dried or aired to be semi-dry, stacked and moistened, then dried or aired, the garden balsam stem is also called medicinal herbs, coumaphos and the like, the perennial herb is high (10-)30-80(-100) cm, the stem is upright, the stem is 4 prismatic, no branch is formed, the branch with inflorescence is formed at the upper part, the branch is split, green or light purple, short and soft hair is spread all over or developed at the upper part of; the leaves are oval-shaped, oval-shaped like needles, oval-shaped like ellipse to oval-shaped like triangle or wide oval, the grass is slightly soft or short and soft at the tip of the stalk and the tip of the lateral branch of the panicle inflorescence; the corolla is funnel-shaped and cylindrical, 6.5-7.5 mm long, bluish purple, light red to white, the outer surface has no hair, the inner surface is short and soft on the far axial surface of the cylindrical part, the thin fruit is narrow and elliptical, the thin fruit is stored in a rod-shaped calyx which is stored in a rod-shaped manner, the thin fruit is reversely folded and close to the inflorescence axis, the thin and soft corolla is combined with fruit peel, the flowering phase is 6-10 months, and the fruiting phase is 8-12 months.
In the invention, the ultrasonic penetration method in S4 is used for 6-30min per treatment, 1 time every day or every other day, and 1 treatment course is 10-15 times.
In the present invention, the irradiation time in S3 is in the range of 0.5min to 24 hours.
In the present invention, isopropyl myristate in S2 is obtained by esterification of isopropyl myristate with isopropyl alcohol.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (5)

1. A medicine penetration method for treating cervical vertebra and lumbar intervertebral disc protrusion is characterized in that: the method specifically comprises the following steps:
s1, preparing traditional Chinese medicine preparations: selecting Chinese herbal medicine raw materials, removing impurities and mildewed parts on the Chinese herbal medicine, cleaning the Chinese herbal medicine raw materials by an ultrasonic cleaning machine after removal, crushing the cleaned Chinese herbal medicine raw materials in a crushing machine, filtering the crushed Chinese herbal medicine raw materials by a 80-mesh sieve, then putting the filtered Chinese herbal medicine raw materials in a reaction kettle, adding ethanol at the temperature of 90-100 ℃, leaching for 120min, finally obtaining a Chinese herbal medicine preparation by centrifugation and concentration distillation, removing the impurities in the Chinese herbal medicine preparation by a filter, and finally obtaining the Chinese herbal medicine preparation for later use;
s2, preparing a penetration enhancer: dissolving isopropyl myristate in water, adding N-hydroxysuccinimide, mixing in a mixer to obtain penetration enhancer, and waiting for use;
s3, setting parameters of ultrasonic waves: modulating respective duration time of a high-frequency component, a medium-frequency component and a low-frequency component of the ultrasonic wave, wherein the respective duration time range of the three components is 2-98% of the period of the modulated ultrasonic wave, and the radiation time range of the modulated ultrasonic wave;
s4, ultrasonic infiltration method: cleaning and disinfecting the skin of a patient needing to be coated in a certain area, firstly coating the penetration enhancer prepared in the S2 on the skin of the patient after cleaning, then applying the traditional Chinese medicine medicament obtained in the S1 on the surface of the skin coated with the penetration enhancer through low-frequency ultrasonic waves, and quickly penetrating the traditional Chinese medicine medicament into the skin.
2. The drug-through method for treating protrusion of cervical or lumbar intervertebral disc according to claim 1, wherein: the Chinese herbal medicine raw materials in the S1 are prepared from garden balsam stem, medicinal cyathula root, arisaema tuber, cinnamon, achyranthes root, buck grass, slenderstyle acanthopanax bark, rhizoma wenyujin concinnatae, east Asian tree fern rhizome and eucommia bark and tall gastrodia tuber.
3. The drug-through method for treating protrusion of cervical or lumbar intervertebral disc according to claim 1, wherein: the ultrasonic penetration method in S4 is used for 6-30min per treatment, 1 time every day or every other day, and 1 treatment course is 10-15 times.
4. The drug-through method for treating protrusion of cervical or lumbar intervertebral disc according to claim 1, wherein: the irradiation time range in the S3 is 0.5min-24 h.
5. The drug-through method for treating protrusion of cervical or lumbar intervertebral disc according to claim 1, wherein: the isopropyl myristate in S2 is prepared by esterification reaction of isopropyl myristate and isopropanol.
CN201911303827.9A 2019-12-17 2019-12-17 Medicine penetration method for treating cervical vertebra and lumbar intervertebral disc protrusion Pending CN111012884A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113975617A (en) * 2021-11-05 2022-01-28 深圳市福妍堂中医药创新发展有限公司 Medical instrument method and system for regulating female menstrual disorder

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CN1981823A (en) * 2005-12-18 2007-06-20 徐福云 Compound preparation for treating extruded lumbar vertebrae disk
CN101721483A (en) * 2008-10-30 2010-06-09 王秀兰 Traditional Chinese medicine for treating prolapse of lumbar intervertebral disc
CN104771701A (en) * 2015-04-22 2015-07-15 张根勇 Traditional Chinese medicine composition for treating lumbar cervical diseases and powder of composition and preparation method of powder
CN107596286A (en) * 2016-07-12 2018-01-19 李振祥 A kind of Washout traditional Chinese medicine powder for controlling the protrasion of the lumbar intervertebral disci
CN107596287A (en) * 2016-07-12 2018-01-19 李振祥 A kind of the smoked of the protrasion of the lumbar intervertebral disci of controlling washes Chinese medicine

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Publication number Priority date Publication date Assignee Title
CN1981823A (en) * 2005-12-18 2007-06-20 徐福云 Compound preparation for treating extruded lumbar vertebrae disk
CN101721483A (en) * 2008-10-30 2010-06-09 王秀兰 Traditional Chinese medicine for treating prolapse of lumbar intervertebral disc
CN104771701A (en) * 2015-04-22 2015-07-15 张根勇 Traditional Chinese medicine composition for treating lumbar cervical diseases and powder of composition and preparation method of powder
CN107596286A (en) * 2016-07-12 2018-01-19 李振祥 A kind of Washout traditional Chinese medicine powder for controlling the protrasion of the lumbar intervertebral disci
CN107596287A (en) * 2016-07-12 2018-01-19 李振祥 A kind of the smoked of the protrasion of the lumbar intervertebral disci of controlling washes Chinese medicine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113975617A (en) * 2021-11-05 2022-01-28 深圳市福妍堂中医药创新发展有限公司 Medical instrument method and system for regulating female menstrual disorder

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