CN110974860A - Preparation method of pseudo-ginseng wall-broken decoction pieces - Google Patents

Preparation method of pseudo-ginseng wall-broken decoction pieces Download PDF

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CN110974860A
CN110974860A CN201911424597.1A CN201911424597A CN110974860A CN 110974860 A CN110974860 A CN 110974860A CN 201911424597 A CN201911424597 A CN 201911424597A CN 110974860 A CN110974860 A CN 110974860A
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wall
pseudo
ginseng
decoction pieces
drying
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刘宝
周正凤
李祥
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Puer Songmao Diancao Liuwei Pharmaceutical Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting

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  • Preparation Of Fruits And Vegetables (AREA)

Abstract

The application discloses a preparation method of panax notoginseng wall-broken decoction pieces, which comprises the following steps: the preparation method of the pseudo-ginseng wall-broken decoction pieces comprises the following steps: slicing fresh pseudo-ginseng, sterilizing, carrying out primary freeze drying, breaking the wall, granulating, carrying out secondary freeze drying, and finishing granules to obtain the pseudo-ginseng wall-broken decoction pieces. In order to exert the 'raw beating' effect of the pseudo-ginseng to the maximum extent, namely the effect of promoting blood circulation and removing blood stasis, the application performs freeze drying on the raw pseudo-ginseng to finish drying at the bottom crossing temperature, avoids curing the pseudo-ginseng after heating, and then adopts wall breaking and crushing to prepare powder.

Description

Preparation method of pseudo-ginseng wall-broken decoction pieces
Technical Field
The application relates to a preparation method of panax notoginseng wall-broken decoction pieces, and belongs to the field of wall-broken decoction pieces.
Background
The processing of Chinese herbs is an important part of the heritage of Chinese medicine, and in order to adapt to the state of illness and constitution of patients, some herbs need to be processed to change or alleviate their properties, and the herbs are burned, refined, processed and roasted to be cooked and determined to achieve the purpose of treatment.
The raw and cooked pseudo-ginseng powder has different preparation processes and different efficacies. The effects of stopping bleeding and resisting inflammation of cooked Notoginseng radix are reduced, while the effects of replenishing blood and nourishing blood, strengthening body resistance and consolidating constitution are enhanced. The raw notoginseng is mainly used for treating traumatic injury, traumatic hemorrhage and other diseases, and can prevent and treat cardiovascular and cerebrovascular diseases such as coronary heart disease, angina pectoris, hyperlipemia, hypertension, cerebral apoplexy and the like, namely 'raw beating, ripe tonifying'.
With the continuous development of the panax notoginseng industry, the demand of the market for panax notoginseng is continuously increased, and the panax notoginseng cultivation shows that the panax notoginseng is transferred from a genuine producing area to a non-genuine producing area, so that the pharmaceutical ingredients of the panax notoginseng sold in the market at present are lower than those of the genuine producing area and even lower than the regulation of pharmacopoeia of the people's republic of China.
The underground effective component of the existing powder preparation process of panax notoginseng is mainly panaxatriol saponin, and is easy to decompose and inactivate at the temperature of over 100 ℃ due to alcohol bonds in the panaxatriol saponin.
The raw radix Notoginseng needs to be dried, stored and transported for a long distance, and after being dried, the raw radix Notoginseng has high hardness and can not be directly eaten, and can be eaten only after being smashed into powder. However, in the existing grinding process, the properties of active ingredients in raw pseudo-ginseng are changed and are mostly changed into cooked pseudo-ginseng, and the efficacy of the raw pseudo-ginseng cannot be well maintained and exerted.
Particularly, the problem of protecting the active ingredients of the raw pseudo-ginseng when the pseudo-ginseng needs to be prepared into wall-broken decoction pieces is not solved well all the time. The existing pseudo-ginseng sterilization methods all need heating, the effective active ingredients of pseudo-ginseng are easy to lose after heating, and the activity of the product is reduced.
Disclosure of Invention
The application provides a preparation method of panax notoginseng wall-broken decoction pieces for solving the technical problems.
The application provides a preparation method of panax notoginseng wall-broken decoction pieces, which comprises the following steps: the preparation method of the pseudo-ginseng wall-broken decoction pieces is characterized by comprising the following steps: slicing fresh pseudo-ginseng, sterilizing, carrying out primary freeze drying, wall breaking, granulating, carrying out secondary freeze drying, and finishing granules to obtain the pseudo-ginseng wall-broken decoction pieces;
the sterilization process comprises the steps of: soaking the pseudo-ginseng slices in ozone water with the ozone concentration of 20-30 mg/L and the water temperature of 6-13 ℃ for 0.5-1.0 h for sterilization, and then cleaning the pseudo-ginseng slices in the ozone water.
The ozone water with the concentration is adopted to soak the pseudo-ginseng slices, so that the brittleness of cell walls in the slices can be enhanced, the pseudo-ginseng slices are subjected to integral sterilization, the wall breaking efficiency of the slices is favorably improved, secondary sterilization is not needed in subsequent operation, and the product quality is improved.
Preferably, the slicing step further comprises a sorting step before the slicing step, wherein the sorting step is used for sorting the fresh pseudo-ginseng to remove non-medicinal parts and impurities in the fresh pseudo-ginseng.
Preferably, the primary freeze-drying step comprises: and (3) putting the cut pseudo-ginseng into a freeze dryer, drying for 24-60 hours at the temperature of-50-0 ℃, and drying until the water content is less than or equal to 5% to obtain the dried pseudo-ginseng slices. And by carrying out freeze drying once under the condition, the brittleness of cell walls can be improved on the premise of wall breaking, the subsequent wall breaking treatment efficiency is further accelerated, the activity of effective components is kept while the water content of the product is reduced, and high-temperature inactivation or denaturation is avoided. After the ozone water is adopted for soaking, the overflow efficiency of the ozone water in freeze drying is higher, and the quantity and the size of holes formed on cell walls during overflow are higher than the effect of cleaning and soaking by pure water.
Preferably, the step of breaking the walls comprises: placing the dried Notoginseng radix tablet into WFM-100 type micronizing vibration mill for breaking cell wall and pulverizing until diameter of Notoginseng radix powder satisfies D90Stopping when the particle size is less than or equal to 45 mu m, and controlling the temperature to be less than or equal to 10 ℃ in the wall breaking process of the superfine grinding vibration mill. The wall breaking is carried out at low temperature, the change of the performance of the pseudo-ginseng caused by temperature rise in the wall breaking process can be avoided, meanwhile, residual ozone water in slices can break cell walls in a swelling way when being heated and evaporated, the wall breaking efficiency is improved, and the cell wall breaking proportion is higher in the same breaking time.
Preferably, the granulating step is to mix the panax notoginseng wall-broken powder with a solvent to prepare a soft material and granulate, wherein the solvent is water or an ethanol solution. The method does not need to add any organic solvent and does not need the subsequent step of removing the solvent. The volume concentration of the ethanol solution is 20-90%.
Preferably, the secondary freeze-drying comprises: drying for 24-48 h at the drying temperature of-50-0 ℃, performing secondary freeze drying on the granulated medicinal material, and drying until the water content is less than or equal to 8% to obtain the freeze-dried wall-broken decoction pieces. And the secondary freeze drying can further reduce the water content of the product and ensure that the product reaches the standard.
Preferably, the method comprises the following steps: and (3) granulating the freeze-dried wall-broken decoction pieces by using a swing type granulator, wherein a screen mesh in the swing type granulator is 10-20 meshes.
Preferably, the process operates within a class D denuded zone. Is beneficial to inhibiting the total amount of microorganisms in the product.
Specifically, the method comprises the following steps:
(1) and (3) sterilization treatment: selecting fresh pseudo-ginseng medicinal materials (removing non-medicinal parts and impurities), slicing, soaking in ozone water with the ozone concentration of 20-30 mg/L and the water temperature of 6-13 ℃ for 0.5-1.0 h for sterilization, and then cleaning slices in the ozone water;
(2) and (3) freeze drying: and (3) putting the cut pseudo-ginseng into a freeze dryer, drying for 24-60 hours at the drying temperature of-50-0 ℃, and drying until the water content is less than or equal to 5% to obtain the dried pseudo-ginseng slices.
(3) Wall breaking: placing dried Notoginseng radix tablet into WFM-100 type or other machine with ultramicro pulverizing function for breaking cell wall and pulverizing at temperature of less than 10 deg.C until Notoginseng radix particle diameter satisfies D90Less than or equal to 45 μm to obtain wall-broken powder of Notoginseng radix.
(4) And (3) granulating: mixing the wall-broken powder of radix Notoginseng with water or ethanol solution to obtain soft material and granulating.
(5) And (3) carrying out secondary freeze drying on the granulated medicinal materials at the drying temperature of-50-0 ℃ for 24-48 h until the drying moisture is not higher than 8%, thus obtaining the freeze-dried wall-broken decoction pieces.
(6) And (3) finishing the freeze-dried wall-broken decoction pieces by using a swing granulator, wherein a screen mesh is 10-20 meshes.
The whole processes of (1) to (6) are operated in a D-level clean area, and the pollution of product microorganisms is controlled.
The beneficial effects that this application can produce include:
1) the preparation method of the pseudo-ginseng wall-broken decoction pieces provided by the application has the advantages that the pseudo-ginseng is freeze-dried at the bottom-crossing temperature to complete drying, the pseudo-ginseng is prevented from being cured after heating, and then wall-breaking crushing is adopted to prepare powder, so that the pseudo-ginseng wall-broken decoction pieces can effectively retain the pseudo-ginseng blood circulation-promoting and blood stasis-removing effects, the dissolution proportion of effective components can be increased, the taking convenience of the powder decoction pieces is retained, and the technical problems that the effective components of the traditional raw pseudo-ginseng powder are damaged in the powder preparation process and the dissolution rate of the effective components of the raw pseudo-ginseng is low are solved.
2) The preparation method of the panax notoginseng wall-broken decoction pieces provided by the application comprises the steps of sorting, purifying and washing (the number of microorganisms is controlled by cleaning), slicing and other pretreatment processes, and freeze drying, wall-breaking ultramicro, granulating, secondary freeze drying, granulating and other steps are carried out on the processed medicinal materials to prepare the panax notoginseng wall-broken decoction pieces.
3) According to the preparation method of the pseudo-ginseng wall-broken decoction pieces, sterilization is realized by soaking pseudo-ginseng with ozone water, the concentration of ozone in the ozone water is 20-30 mg/L, the water temperature is 6-13 ℃, the ozone sterilization treatment time is 0.5-1.0 h, treatment is carried out according to the condition, impurities on the surface of the pseudo-ginseng in the subsequent cleaning step are easier to remove, meanwhile, the toughness of cell walls is reduced, the breaking of the cell walls after the subsequent wall-breaking treatment is facilitated, and the release of effective components is promoted. Through subsequent steps of freeze drying and the like, the water content in the pseudo-ginseng is reduced, a sterilization step is not required to be added independently, sterilization and cleaning are combined, and adverse effects of the independent sterilization step on products are avoided.
Detailed Description
The present application will be described in detail with reference to examples, but the present application is not limited to these examples.
Examples
Unless otherwise specified, the raw materials and reagents in the examples of the present application were purchased commercially and were not processed.
Examples 1-3 preparation of samples of freeze-dried wall-broken decoction pieces of Panax notoginseng 1-3
(1) And (3) sterilization treatment: selecting fresh pseudo-ginseng medicinal materials (removing non-medicinal parts and impurities), slicing, soaking in ozone water with the ozone concentration of 20-30 mg/L and the water temperature of 6-13 ℃ for 0.5-1.0 h for sterilization, and then cleaning slices in the ozone water;
(2) and (3) freeze drying: and (3) putting the cut pseudo-ginseng into a freeze dryer, drying for 24-60 hours at the drying temperature of-50-0 ℃, and drying until the water content is less than or equal to 5% to obtain the dried pseudo-ginseng slices.
(3) Wall breaking: placing dried Notoginseng radix tablet into WFM-100 type ultrafine grinding vibration mill at temperature of less than or equal to 10 deg.C for breaking cell wall and pulverizing to diameter of Notoginseng radix powderSatisfies D90Less than or equal to 45 μm to obtain wall-broken powder of Notoginseng radix.
(4) And (3) granulating: mixing the wall-broken powder of Notoginseng radix with the solution to make soft mass and granulating.
(5) And (3) carrying out secondary freeze drying on the granulated medicinal materials at the drying temperature of-50-0 ℃ for 24-48 h until the drying moisture is not higher than 8%, thus obtaining the freeze-dried wall-broken decoction pieces.
(6) And (3) finishing the freeze-dried wall-broken decoction pieces by using a swing type granulator, wherein a screen mesh in the swing type granulator is 10-20 meshes.
The whole processes of (1) to (6) are operated in a D-level clean area, and the pollution of product microorganisms is controlled.
The operating parameters for each of samples 1-3 in examples 1-3 are shown in Table 1.
TABLE 1
Figure BDA0002353228440000051
Comparative example 1 preparation of panax notoginseng wall-broken decoction piece sample D1
All of the same as in example 1 was that primary freeze-drying and secondary freeze-drying were not performed.
According to the existing method, the wall-breaking efficiency, the wall-breaking solubility and the ginsenoside Rg of samples 1-3 and D11(C42H72O14) Ginsenoside Rb1(C54H92O23) And notoginsenoside R1(C47H80O18) The levels, microbial limits were measured and the results were similar to those in table 2, and are typically as listed in table 2.
TABLE 2 comparative table of test results for sample 1 and sample D1
Figure BDA0002353228440000061
As can be seen from table 2, the method provided by the present application can maintain a low microbial limit by performing ozone water immersion on the slices, and can also effectively reduce the wall breaking time, and improve the effective component precipitation efficiency and the effective component total amount.
The effective components measured in D1 are the main effective components of cooked pseudo-ginseng, so that the method provided by the application can better retain the effective components in the fresh pseudo-ginseng relatively.
Reference throughout this specification to "one embodiment," "another embodiment," "an embodiment," "a preferred embodiment," or the like, means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment described generally in this application. The appearances of the same phrase in various places in the specification are not necessarily all referring to the same embodiment. Further, when a particular feature, structure, or characteristic is described in connection with any embodiment, it is submitted that it is within the scope of the disclosure to effect such feature, structure, or characteristic in connection with other embodiments.
Although the present application has been described herein with reference to a number of illustrative embodiments thereof, it should be understood that numerous other modifications and embodiments can be devised by those skilled in the art that will fall within the spirit and scope of the principles of this disclosure. More specifically, various variations and modifications are possible in the component parts and/or arrangements of the subject combination arrangement within the scope of the disclosure and claims of this application. In addition to variations and modifications in the component parts and/or arrangements, other uses will also be apparent to those skilled in the art.

Claims (8)

1. The preparation method of the panax notoginseng wall-broken decoction pieces is characterized by comprising the following steps: slicing fresh pseudo-ginseng, sterilizing, carrying out primary freeze drying, wall breaking, granulating, carrying out secondary freeze drying, and finishing granules to obtain the pseudo-ginseng wall-broken decoction pieces;
the sterilization process comprises the steps of: soaking the pseudo-ginseng slices in ozone water with the ozone concentration of 20-30 mg/L and the water temperature of 6-13 ℃ for 0.5-1.0 h for sterilization, and then cleaning the pseudo-ginseng slices in the ozone water.
2. The method for preparing panax notoginseng wall-broken decoction pieces as claimed in claim 1, further comprising a sorting step before the slicing step, wherein the sorting step is used for sorting the fresh panax notoginseng to remove non-medicinal parts and impurities in the fresh panax notoginseng.
3. The method for preparing panax notoginseng wall-broken decoction pieces according to claim 1, wherein the primary freeze-drying step comprises: and (3) putting the cut pseudo-ginseng into a freeze dryer, drying for 24-60 hours at the temperature of-50-0 ℃, and drying until the water content is less than or equal to 5% to obtain the dried pseudo-ginseng slices.
4. The method for preparing panax notoginseng wall-broken decoction pieces as claimed in claim 3, wherein the wall-breaking step comprises: placing the dried Notoginseng radix tablet into WFM-100 type micronizing vibration mill for breaking cell wall and pulverizing until diameter of Notoginseng radix powder satisfies D90Stopping when the particle size is less than or equal to 45 mu m, and controlling the temperature to be less than or equal to 10 ℃ in the wall breaking process of the superfine grinding vibration mill.
5. The method for preparing panax notoginseng wall-broken decoction pieces according to claim 1, wherein the granulating step is to mix panax notoginseng wall-broken powder with a solvent to prepare a soft material, and then granulate, wherein the solvent is water or ethanol solution.
6. The method for preparing panax notoginseng wall-broken decoction pieces according to claim 5, wherein the secondary freeze drying comprises: drying for 24-48 h at the drying temperature of-50-0 ℃, performing secondary freeze drying on the granulated medicinal material, and drying until the water content is less than or equal to 8% to obtain the freeze-dried wall-broken decoction pieces.
7. The method for preparing panax notoginseng wall-broken decoction pieces as claimed in claim 1, which comprises the following steps: and (3) granulating the freeze-dried wall-broken decoction pieces by using a swing type granulator, wherein a screen mesh in the swing type granulator is 10-20 meshes.
8. The method for preparing panax notoginseng wall-broken decoction pieces according to claim 1, wherein the method is operated in a class D clean zone.
CN201911424597.1A 2019-12-31 2019-12-31 Preparation method of pseudo-ginseng wall-broken decoction pieces Pending CN110974860A (en)

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Application publication date: 20200410