CN104523430A - Freezing low-temperature superfine grinding method for traditional Chinese medicine - Google Patents
Freezing low-temperature superfine grinding method for traditional Chinese medicine Download PDFInfo
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- CN104523430A CN104523430A CN201410775735.1A CN201410775735A CN104523430A CN 104523430 A CN104523430 A CN 104523430A CN 201410775735 A CN201410775735 A CN 201410775735A CN 104523430 A CN104523430 A CN 104523430A
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Abstract
The invention discloses a freezing low-temperature superfine grinding method for traditional Chinese medicine. The method includes the following steps of providing the clean, dry and segmented traditional Chinese medicine, adding water to the traditional Chinese medicine so that the traditional Chinese medicine can be fully soaked, completely removing moisture through settling, keeping the surfaces of the traditional Chinese medicine dry, conducting freezing at the temperature of -24 DEG C to -28 DEG C for 3 hours to 4 hours, and conducting superfine grinding on the frozen traditional Chinese medicine in the environment with the temperature lower than -10 DEG C. According to the method, due to the fact that the traditional Chinese medicine is frozen and can be easily smashed, the fineness degree of the dried traditional Chinese medicine powder where superfine grinding is conducted can reach 0.006 micron to 0.5 micron, effective constituents of the traditional Chinese medicine are fully released, the absorption rate and the utilization rate of the traditional Chinese medicine are increased, the obtained traditional Chinese medicine powder can be directly used for making medicine and health care food through extracting and processing, and the medicinal value of the traditional Chinese medicine is better utilized.
Description
Technical field
The present invention relates to plant medicine material manufacture field, refer to a kind of Freezing superfine grinding method of Chinese crude drug especially.
Background technology
Study on Supermicro-pulverization of Traditional Chinese Drugs technology is that recent domestic develops a very fast new technique, is one of important directions of modernization of Chinese medicine development.The micronizing of Chinese crude drug makes full use of valuable source fully to extract Effective Component of Chinese Medicine, the better advanced means playing drug effect.But existing micronizing all being that raw material carries out with drying traditional Chinese medicinal materials, is difficult to reach the object of micronizing: 1, medical material contains a large amount of sugars because there is following problem, be difficult to finish-drying, water content is up to the granularity less than pulverizing.2, medical material contains a large amount of cellulose pliability and well not easily pulverizes.3, be transformed into frictional force heating by mechanical forces such as extruding impactings in micronizing process, break and changed a lot of effective ingredient, volatile ingredient runs off large.
Summary of the invention
The object of the invention is the Freezing superfine grinding method that a kind of Chinese crude drug is provided to overcome prior art, Effective Component of Chinese Medicine is fully discharged, improve absorbance and the utilization rate of Chinese medicine.
In order to achieve the above object, provided technical scheme is:
A Freezing superfine grinding method for Chinese crude drug, comprises the following steps:
A, provide clean, the Chinese crude drug of dry, cutting process;
B, to be added water by a Chinese crude drug and fully soak, then clear solid carbon dioxide divides, and keeps Chinese crude drug dry tack free;
C, the Chinese crude drug of b carried out-24 DEG C ~-28 DEG C freezing, freezing 3 hours ~ 4 hours, particularly preferably Chinese crude drug carry out-25 DEG C freezing, freezing 4 hours;
D, by Chinese crude drug freezing in c lower than-10 DEG C, carry out micronizing particularly preferably in-15 DEG C of environment.
The present invention before pulverizing first by the Chinese medicine of clean, dry, simple cutting process, add water fully to soak saturated rear clear solid carbon dioxide and divide, now crude drug cell is swollen by blister, volume increases 10-12 doubly, more be conducive to pulverizing, freezing 4 hours at-25 DEG C afterwards, now cell volume expands further, because water volume in freezing process increases by 1/10th, some cell wall can be split up, what now medical material entirety embodied is the characteristic of water--hard and crisp and frangible, and now add and pulverize lower than utilizing in super micron mill in-10 DEG C of environment.Granularity broken after pulverizing is the same with conventional micronizing, but its true volume only has original 1/10th after twice expansion, therefore by Du Keda 0.006 ~ 0.5 μm fine after the Chinese drugs powder drying of micronizing, far below conventional superfine grinding method.Advantage of the present invention: 1, the large 10-13 of the medical material of volume ratio drying doubly, is more conducive to pulverizing.2, freezing medical material take ice as main component, hard and crisp, is easy to broken.3, the heat release in crushing process is absorbed by the ice of-25 DEG C, and the local temperature of medical material, lower than 0 DEG C, is conducive to the active component keeping medical material.4, granularity is little, and surface area increases, and is more conducive to the extraction of effective ingredient.By breaking method of the present invention, Effective Component of Chinese Medicine is fully discharged, Chinese medicine is made to have good dissolubility, dispersibility, adsorptivity and chemical reactivity, improve absorbance and the utilization rate of Chinese medicine, be particularly suitable for the industrialization continuous seepage of thermal sensitivity biomaterial as the micronizing of Chinese crude drug, by Du Keda 0.006 ~ 0.5 μm fine after the Chinese drugs powder drying of micronizing, the Chinese drugs powder of gained can be directly used in extraction and be processed into medicine, health food, and its medical value is better utilized.
Detailed description of the invention
A Freezing superfine grinding method for Chinese crude drug, comprises the following steps:
A, pre-treatment is carried out to Chinese crude drug, provides clean, dry, the Chinese crude drug of cutting or slicing treatment;
B, at room temperature a Chinese crude drug is added pure water water and fully soak full, then clear solid carbon dioxide divides, and keep Chinese crude drug dry tack free, now crude drug cell is swollen by blister, and volume increases 10-12 doubly;
C, the Chinese crude drug of b carried out-24 DEG C ~-28 DEG C freezing, freezing 3 hours ~ 4 hours, particularly preferably Chinese crude drug carry out-25 DEG C freezing, freezing 4 hours, now cell volume expands further, because water volume in freezing process increases by 1/10th, some cell wall can be split up, and what now medical material entirety embodied is the characteristic of water--and hard and crisp and frangible;
D, by Chinese crude drug freezing in c lower than-10 DEG C, particularly preferably-15 DEG C of environment utilize super micron mill to carry out micronizing, notice that charging rate wants slow.Superfine powder after pulverizing directly enter next step extract or lyophilization as high-end health product or pharmaceutical raw material, its medical value is better utilized.
The detailed description of the above-mentioned explanation embodiment of the present invention, but the invention is not restricted to above-mentioned institute implementation method, in scope in right described in interpellation book technical scheme, different implementation methods can be implemented by some amendments, and this amendment should belong to scope of the present invention.
Claims (3)
1. a Freezing superfine grinding method for Chinese crude drug, is characterized in that comprising the following steps:
A, provide clean, the Chinese crude drug of dry, cutting process;
B, to be added water by a Chinese crude drug and fully soak, then clear solid carbon dioxide divides, and keeps Chinese crude drug dry tack free;
C, the Chinese crude drug of b carried out-24 DEG C ~-28 DEG C freezing, freezing 3 hours ~ 4 hours;
D, Chinese crude drug freezing in c is carried out micronizing in lower than-10 DEG C of environment.
2. the superfine comminution at low temperature method of a kind of Chinese crude drug according to claim 1, is characterized in that in described c step, Chinese crude drug carry out-25 DEG C freezing, freezing 4 hours.
3. the superfine comminution at low temperature method of a kind of Chinese crude drug according to claim 1, is characterized in that in described Step d, Chinese crude drug carries out micronizing in-15 DEG C of environment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410775735.1A CN104523430A (en) | 2014-12-17 | 2014-12-17 | Freezing low-temperature superfine grinding method for traditional Chinese medicine |
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| CN201410775735.1A CN104523430A (en) | 2014-12-17 | 2014-12-17 | Freezing low-temperature superfine grinding method for traditional Chinese medicine |
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Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105476851A (en) * | 2015-11-20 | 2016-04-13 | 贵州贵龙中药材科技有限公司 | Crushing method of traditional Chinese medicine materials |
| CN106853148A (en) * | 2016-01-05 | 2017-06-16 | 云南大唐汉方制药股份有限公司 | Compound longxuejie preparation and preparation method thereof |
| CN106890209A (en) * | 2016-01-05 | 2017-06-27 | 云南大唐汉方制药股份有限公司 | A kind of cough-relieving compound preparation and preparation method thereof |
| CN108371676A (en) * | 2018-05-18 | 2018-08-07 | 广州暨南生物医药研究开发基地有限公司 | A kind of preparation method of the loyal gout Ultramicro-powder of tiger |
| CN109512856A (en) * | 2018-12-20 | 2019-03-26 | 江西赣隆药业有限公司 | It is a kind of to have effects that clearing heat and detoxicating and invigorating spleen to remove dampness clover broken wall medicine materical crude slice and preparation method thereof |
| CN109528858A (en) * | 2018-12-25 | 2019-03-29 | 江西赣隆药业有限公司 | It is a kind of for treating the Veronicastrum Herb broken wall medicine materical crude slice and preparation method thereof of cirrhotic ascites and nephritic dropsy |
| CN109549962A (en) * | 2018-12-20 | 2019-04-02 | 江西赣隆药业有限公司 | The preparation method of Siberian cocklebur grass broken wall medicine materical crude slice with antispastic and analgesic efficacy and Siberian cocklebur grass broken wall medicine materical crude slice prepared therefrom |
| CN109568355A (en) * | 2018-12-18 | 2019-04-05 | 江西赣隆药业有限公司 | It is a kind of with Yin nourishing and lung moistening, cooling blood and hemostasis, the lichen broken wall medicine materical crude slice of heat-clearing toxin-expelling functions and preparation method thereof |
| CN109602833A (en) * | 2018-12-11 | 2019-04-12 | 江西赣隆药业有限公司 | One seed ginseng potato broken wall medicine materical crude slice and preparation method thereof |
| CN109602801A (en) * | 2018-12-17 | 2019-04-12 | 江西赣隆药业有限公司 | Have effects that the preparation method of the five fingers mandarin orange broken wall medicine materical crude slice of liver-smoothing, qi-regulating protecting the stomach and relieve the pain and the five fingers mandarin orange broken wall medicine materical crude slice prepared therefrom |
| CN109602792A (en) * | 2018-12-11 | 2019-04-12 | 江西赣隆药业有限公司 | A kind of trollflower broken wall medicine materical crude slice and preparation method thereof |
| CN109646473A (en) * | 2018-12-17 | 2019-04-19 | 江西赣隆药业有限公司 | For treating abundant expectoration, panting, not well, overstrain cough hemoptysis hempleaf groundsel herb broken wall medicine materical crude slice and preparation method thereof of coughing up phlegm |
| CN109846832A (en) * | 2018-12-17 | 2019-06-07 | 江西赣隆药业有限公司 | For treat the lance asiabell root broken wall medicine materical crude slice of spiritlessness and weakness and dizziness headache preparation method and lance asiabell root broken wall medicine materical crude slice prepared therefrom |
| CN109846835A (en) * | 2018-12-19 | 2019-06-07 | 江西赣隆药业有限公司 | A kind of Bai Yun Shen broken wall medicine materical crude slice and preparation method thereof with strengthening the spleen and stomach, tonifying lung gas, expelling phlegm and arresting coughing |
| CN109868181A (en) * | 2019-03-01 | 2019-06-11 | 临泉县清华地产中药材有限责任公司 | A kind of garlic oil and its process for separation and purification |
| CN110974860A (en) * | 2019-12-31 | 2020-04-10 | 普洱淞茂滇草六味制药股份有限公司 | Preparation method of pseudo-ginseng wall-broken decoction pieces |
| CN113956115A (en) * | 2018-07-04 | 2022-01-21 | 黑龙江省农业科学院土壤肥料与环境资源研究所 | Method for preparing beet organic fertilizer from edible fungus residues and application of beet organic fertilizer in beet cultivation |
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Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105476851A (en) * | 2015-11-20 | 2016-04-13 | 贵州贵龙中药材科技有限公司 | Crushing method of traditional Chinese medicine materials |
| CN106853148A (en) * | 2016-01-05 | 2017-06-16 | 云南大唐汉方制药股份有限公司 | Compound longxuejie preparation and preparation method thereof |
| CN106890209A (en) * | 2016-01-05 | 2017-06-27 | 云南大唐汉方制药股份有限公司 | A kind of cough-relieving compound preparation and preparation method thereof |
| CN108371676A (en) * | 2018-05-18 | 2018-08-07 | 广州暨南生物医药研究开发基地有限公司 | A kind of preparation method of the loyal gout Ultramicro-powder of tiger |
| CN108371676B (en) * | 2018-05-18 | 2021-06-29 | 广州暨南生物医药研究开发基地有限公司 | Preparation method of Ligustrum japonicum Thunb super-fine powder for gout |
| CN113956115A (en) * | 2018-07-04 | 2022-01-21 | 黑龙江省农业科学院土壤肥料与环境资源研究所 | Method for preparing beet organic fertilizer from edible fungus residues and application of beet organic fertilizer in beet cultivation |
| CN109602833A (en) * | 2018-12-11 | 2019-04-12 | 江西赣隆药业有限公司 | One seed ginseng potato broken wall medicine materical crude slice and preparation method thereof |
| CN109602792A (en) * | 2018-12-11 | 2019-04-12 | 江西赣隆药业有限公司 | A kind of trollflower broken wall medicine materical crude slice and preparation method thereof |
| CN109846832A (en) * | 2018-12-17 | 2019-06-07 | 江西赣隆药业有限公司 | For treat the lance asiabell root broken wall medicine materical crude slice of spiritlessness and weakness and dizziness headache preparation method and lance asiabell root broken wall medicine materical crude slice prepared therefrom |
| CN109602801A (en) * | 2018-12-17 | 2019-04-12 | 江西赣隆药业有限公司 | Have effects that the preparation method of the five fingers mandarin orange broken wall medicine materical crude slice of liver-smoothing, qi-regulating protecting the stomach and relieve the pain and the five fingers mandarin orange broken wall medicine materical crude slice prepared therefrom |
| CN109646473A (en) * | 2018-12-17 | 2019-04-19 | 江西赣隆药业有限公司 | For treating abundant expectoration, panting, not well, overstrain cough hemoptysis hempleaf groundsel herb broken wall medicine materical crude slice and preparation method thereof of coughing up phlegm |
| CN109568355A (en) * | 2018-12-18 | 2019-04-05 | 江西赣隆药业有限公司 | It is a kind of with Yin nourishing and lung moistening, cooling blood and hemostasis, the lichen broken wall medicine materical crude slice of heat-clearing toxin-expelling functions and preparation method thereof |
| CN109846835A (en) * | 2018-12-19 | 2019-06-07 | 江西赣隆药业有限公司 | A kind of Bai Yun Shen broken wall medicine materical crude slice and preparation method thereof with strengthening the spleen and stomach, tonifying lung gas, expelling phlegm and arresting coughing |
| CN109549962A (en) * | 2018-12-20 | 2019-04-02 | 江西赣隆药业有限公司 | The preparation method of Siberian cocklebur grass broken wall medicine materical crude slice with antispastic and analgesic efficacy and Siberian cocklebur grass broken wall medicine materical crude slice prepared therefrom |
| CN109512856A (en) * | 2018-12-20 | 2019-03-26 | 江西赣隆药业有限公司 | It is a kind of to have effects that clearing heat and detoxicating and invigorating spleen to remove dampness clover broken wall medicine materical crude slice and preparation method thereof |
| CN109528858A (en) * | 2018-12-25 | 2019-03-29 | 江西赣隆药业有限公司 | It is a kind of for treating the Veronicastrum Herb broken wall medicine materical crude slice and preparation method thereof of cirrhotic ascites and nephritic dropsy |
| CN109868181A (en) * | 2019-03-01 | 2019-06-11 | 临泉县清华地产中药材有限责任公司 | A kind of garlic oil and its process for separation and purification |
| CN110974860A (en) * | 2019-12-31 | 2020-04-10 | 普洱淞茂滇草六味制药股份有限公司 | Preparation method of pseudo-ginseng wall-broken decoction pieces |
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