CN103948799A - Preparation method of Bulbophyllurn radiatum Lindl. submicron powder - Google Patents
Preparation method of Bulbophyllurn radiatum Lindl. submicron powder Download PDFInfo
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Abstract
The invention discloses a preparation method of Bulbophyllurn radiatum Lindl. submicron powder. The preparation method comprises the following steps of 1, pretreatment: taking a fresh or dried Bulbophyllurn radiatum Lindl. medicinal material, removing impurities, cleaning the Bulbophyllurn radiatum Lindl. medicinal material by water and cutting the cleaned Bulbophyllurn radiatum Lindl. medicinal material into slices, sections or shredded Bulbophyllurn radiatum Lindl., 2, low-temperature refrigeration, 3, low-temperature crushing for preparation of coarse powder of 40-100 meshes, 4, low-temperature vacuum microwave drying, 5, low-temperature air-flow crushing until granularity is less than 200 meshes, and 6, low-temperature resonance ultramicro-pulverization until granularity is less than 300 meshes, and split charging and packaging so that the Bulbophyllurn radiatum Lindl. submicron powder finished product is obtained. The preparation method is economic and environmentally friendly, effectively utilizes the Bulbophyllurn radiatum Lindl. medicinal material and improves medicinal effects.
Description
Technical field
The invention belongs to Study on Supermicro-pulverization of Traditional Chinese Drugs processing technique field, relate to a kind of preparation method of Chinese medicine Bulbophyllum superfine powder.
Background technology
It is genus maximum in the orchid family that Bulbophyllum belongs to (Bulbophyllum), and approximately there is kind more than 1000 in the whole world, is mainly distributed in Asia, Africa and american torrid zone area.There is 98 kind of 3 mutation in China, wherein often make the kind more than ten that has of Medicinal, comprise fragrant Bulbophyllum (B.ambrosium), Herba Bulbophylli inconspicui (B.inconspicuum), Herba Bulbophylli kwangtungensis (B.kwangtungense), Bulbophyllum odoratissimum Lindl. (B.odoratissimum) tooth lobe Bulbophyllum (B.levinei) etc.Although Bulbophyllum platymiscium is not yet incorporated into Chinese Pharmacopoeia, some local regulations, as Zhejiang Province's Chinese medicine processing standard, are recorded.Bulbophyllum has heat-clearing and toxic substances removing, hard masses softening and resolving, and the effect of relieving cough and resolving phlegm, is mainly used in treating fever caused by exogenous pathogens, wind heat pharyngalgia, yin asthenia generating intrinsic heat, rheumatic arthralgia, furuncle and swells and ache etc.Bulbophyllum main component has luxuriant and rich with fragrance class, bibenzyl, Phenylpropanoid Glycosides, flavone, steroidal etc., comprises hair orchid phenanthrene, 24, the compounds such as 24-dimethyl cycloartane-3-alcohol, two hydrogen 4-hydroxy-3-methoxycinnamic alcohol, cupreol.Pharmacologically active also shows, Bulbophyllum has good antitumor, anti-Pyricularia oryzae, suppresses the effects such as macrophage NO release.Luxuriant and rich with fragrance class and bibenzyl are the compositions with important biomolecule activity of finding in Dendrobium Sw in recent years, and specific examples of such components content is also very abundant in Bulbophyllum, therefore Bulbophyllum is carried out to deep R and D, be conducive to expand medicinal plants category, find new active component, the exploitation of new product, new pharmaceutical formulation is also had to benifit very much.
Superfine communication technique is to develop in the world in recent years a very fast new technique, and it has some special physicochemical properties that general granule does not have, as good dissolubility, dispersibility, adsorptivity, chemical reactivity etc.Although the application of superfine communication technique in herbal pharmaceutical industry started late, distinctive advantage and wide application prospect have been manifested.Chinese medicine ultra-fine powder cell wall breaking rate is high, is conducive to the emission and absorption of medicine; Increase drug absorption rate, improve its bioavailability; Reduce dosage, conservation, raises the efficiency, and reduces costs.In addition, Chinese medicine ultra-fine powder also helps the new dosage form of preparation, not only can be used for powder formale, also can be used for dosage form for oral administration and the multiple exterior-applied formulations such as capsule, tablet, oral liquid.
Bulbophyllum clinical practice is at present substantially all to mash external application with decocting mode for oral administration or fresh goods, utilization rate is very low, a lot of effective ingredient are failed stripping, cause the significant wastage of Bulbophyllum resource, and the extraction ratio of the composition that the mode that decocting boils is little to most of polarity (as luxuriant and rich with fragrance class, bibenzyl) is very low, may make due drug effect reduce.The utilization that superfine communication technique is Bulbophyllum provides a feasible approach, as develops suitable breaking method, not only can improve therapeutic effect, has also effectively utilized Chinese crude drug, and protection natural resources of Chinese medicinal materials, has improved economic benefit.
Summary of the invention
The object of this invention is to provide the preparation method of the Bulbophyllum superfine powder of a kind of economy, environmental protection, effectively utilize Bulbophyllum medical material, improve its drug effect.
The technical solution adopted for the present invention to solve the technical problems is:
A preparation method for Bulbophyllum superfine powder, comprises the steps:
(1) pretreatment: get fresh or dry Bulbophyllum medical material, remove impurity, wash, cut into slices or section or silk;
(2) freezing: the Bulbophyllum that step (1) is obtained is spread out and carried out freezingly, and cryogenic temperature is-5～-80 ℃;
(3) pulverize at low temperature: the Bulbophyllum that step (2) is obtained is pulverized under the cryogenic conditions of 0～-80 ℃, sieves, and obtains 40～100 object coarse powder;
(4) low-temperature vacuum microwave is dry: it is dry that the Bulbophyllum coarse powder that step (3) is obtained carries out low-temperature vacuum microwave, microwave power: 1～80kw, and temperature :-5～-50 ℃, vacuum: 0.04～0.09Pa, microwave drying total time, 0.1～2h;
(5) low-temperature airflow is pulverized: the Bulbophyllum xeraphium that step (4) is obtained carries out superfine grinding under the cryogenic conditions of 0～-40 ℃, to 200 orders;
(6) low temperature resonance micronizing: control temperature below 20 ℃, the Bulbophyllum micropowder that step (5) the is obtained micronizing that resonates, makes its particle diameter reach 300 orders following (detection of its particle diameter can detect by methods such as scanning electron microscope, laser particle analyzers);
(7) subpackage and packing: get the superfine powder that step (6) makes, after microwave sterilizating, in aseptic subpackaged chamber, carry out subpackage, according to the specification of 1～5 gram of every bag, carry out subpackage and outer package, make Bulbophyllum superfine powder finished product.
As preferably, in step (2), cryogenic temperature is at-10～-25 ℃.
As preferably, in step (3), pulverize temperature at-5～-25 ℃.
As preferably, in step (4), in microwave drying process, can take interval 30～90s, the microwave treatment mode of heating 30～60s (is that every heating 30～60s just stops heating 30～90s and then continuation heating 30～60s stops heating 30～90s again, circulation successively), also can laser heating, but should observe at any time temperature variations, as long as temperature is no more than-5 ℃.Bulbophyllum powder is heated too fast and destroys effective ingredient and coking rather, and the total time that low-temperature microwave is processed is preferably at 0.5～2 hour.
As preferably, in step (5), low-temperature airflow is pulverized temperature at 0～-5 ℃.
As preferably, in step (6), low temperature resonance micronizing temperature can not be over 20 ℃.
As preferably, in step (7), aseptic subpackaged room temperature is at 18～26 ℃, and relative humidity is below 65%.The object of processing is like this to avoid powder moisture absorption and microbiological contamination.
As preferably, the microwave sterilizating described in step (7) is at power 1～3kw, sterilizing 2～10min under the microwave condition of frequency 2450～3000MHZ.
The Bulbophyllum superfine powder making through the present invention is because its particle diameter is little, dissolubility is good, be easy to extract, can be by extracting the separated various effective ingredient of mode enrichment or obtaining the different active components that active constituent content is high, for further preparation or product development provide basis.In addition, the Bulbophyllum powder that makes through the present invention is pollution-free, purity is high, therefore can also directly take as oral Chinese medicine decoction pieces, and the effective ingredient in Bulbophyllum can be absorbed fast and efficiently, increases substantially Effects.
The present invention can make the water insoluble active ingredients such as luxuriant and rich with fragrance class contained in Bulbophyllum, bibenzyl, Phenylpropanoid Glycosides, flavone, steroidal become stable nano-particle, is more convenient for taking, absorbs and brings into play curative effect.
Compared with prior art, the present invention has following advantage: 1, in the course of processing, do not add other adjuvant, use pure physical method processing, superfine powder is pollution-free, pure, take safety; 2, the Bulbophyllum medical material that the present invention utilizes is all herbal medicine, comprises its root, false phosphorus stem, leaf, and Bulbophyllum Herb all can utilize, and has both taken full advantage of each position of Bulbophyllum, can save Bulbophyllum resource again, reduces production costs, and increases economic efficiency; 3, the inventive method can make the cell wall structure of Bulbophyllum be pulverized completely, is conducive to the abundant release of active ingredient in cell, and dissolution is greatly improved, and effective ingredient absorption in vivo is significantly increased, and is beneficial to bring into play drug effect; 4, the Bulbophyllum superfine powder that the present invention makes stores convenient, steady quality.
The specific embodiment
Below by specific embodiment, technical scheme of the present invention is described in further detail.
In the present invention, if not refer in particular to, the raw material adopting and equipment etc. all can be buied from market or this area is conventional.Method in following embodiment, is the conventional method of this area if no special instructions.
According to following embodiment, the present invention may be better understood.Yet, those skilled in the art will readily understand, embodiment described concrete feed liquid proportioning, process conditions and result thereof be only for the present invention is described, and should also can not limit the present invention described in detail in claims.
The Bulbophyllum medical material that the embodiment of the present invention is used is fresh Bulbophyllum herb.
Embodiment 1:
(1) pretreatment: get Bulbophyllum medical material, remove impurity, wash, be cut into 2～4mm decoction pieces;
(2) freezing: the Bulbophyllum decoction pieces that step (1) is obtained is spread out and carried out freezingly, and cryogenic temperature is-5 ℃.
(3) pulverize at low temperature: the Bulbophyllum decoction pieces that step (2) is obtained is pulverized under the cryogenic conditions of-5 ℃, sieves, and obtains 40～100 object coarse powder.
(4) low-temperature vacuum microwave is dry: the Bulbophyllum coarse powder that step (3) is obtained is put into vacuum microwave drying case, and power-on is carried out low-temperature vacuum microwave and is dried, and adjusts microwave power: 1kw, microwave drying total time, 2h, baking temperature :-20 ℃; Vacuum: 0.04Pa.In microwave drying process, can take interval 30s, the microwave treatment mode of heating 30s (being that every heating 30s just stops heating 30s and then continuation heating 30s stops heating 30s again, circulation successively),
(5) low-temperature airflow is pulverized: the Bulbophyllum xeraphium that step (4) is obtained carries out superfine grinding under the cryogenic conditions below 0 ℃, to 200 orders.
(6) low temperature dither is pulverized: the Bulbophyllum micropowder that step (5) is obtained is carried out micronizing in low temperature dither pulverizer, control temperature-5 ℃ of left and right, make its particle diameter reach between 0.2mm～1nm (detection of its particle diameter can by scanning electron microscope, detect).
(7) subpackage and packing: get the superfine powder that step (6) makes, through microwave power 1kw frequency 2450MHZ microwave sterilizating 2 minutes, put to room temperature, 18～26 ℃ of temperature, subpackage is carried out in the aseptic subpackaged chamber of humidity below 65%, specification according to 1～5 gram of every bag is carried out subpackage and outer package, makes finished product.The Bulbophyllum superfine powder making is yellowish green superfine powder, and hands is twisted with the fingers without granular sensation, has no complete cell under microscope.Under Electronic Speculum, recording mean diameter is 22.6um.
Embodiment 2:
(1) pretreatment: get Bulbophyllum medical material, remove impurity, wash, be cut into 2～4mm decoction pieces;
(2) freezing: the Bulbophyllum decoction pieces that step (1) is obtained is spread out and carried out freezingly, and cryogenic temperature is-80 ℃.
(3) pulverize at low temperature: the Bulbophyllum decoction pieces that step (2) is obtained is pulverized under the cryogenic conditions of-80 ℃, sieves, and obtains 40～100 object coarse powder.
(4) low-temperature vacuum microwave is dry: it is dry that the Bulbophyllum coarse powder that step (3) is obtained carries out low-temperature vacuum microwave, microwave power: 80kw, microwave drying total time, 0.1h, temperature :-50 ℃; Vacuum: 0.09Pa.In microwave drying process, can take interval 60s, the microwave treatment mode of heating 60s (being that every heating 60s just stops heating 60s and then continuation heating 60s stops heating 60s again, circulation successively),
(5) low-temperature airflow is pulverized: the Bulbophyllum xeraphium that step (4) is obtained is pulverized under the cryogenic conditions of-50 ℃, to 200 orders.
(6) low temperature dither is pulverized: the Bulbophyllum micropowder that step (5) is obtained is carried out micronizing in high-frequency resonance grinding machine or other micronizing machinery, makes its particle diameter reach (detection of its particle diameter can detect by methods such as scanning electron microscope, laser particle analyzers) between 0.2mm～1nm.
(7) subpackage and packing: get the superfine powder that step (6) makes, through microwave power 1kw frequency 2450MHZ microwave sterilizating 2 minutes, put to room temperature, 18～26 ℃ of temperature, subpackage is carried out in the aseptic subpackaged chamber of humidity below 65%, specification according to 1～5 gram of every bag is carried out subpackage and outer package, makes finished product.The Bulbophyllum superfine powder making is yellowish green superfine powder, and hands is twisted with the fingers without granular sensation, has no complete cell under microscope.Under Electronic Speculum, recording mean diameter is 28.3um.
Embodiment 3:
(1) pretreatment: get Bulbophyllum medical material, remove impurity, wash, be cut into 2～4mm decoction pieces;
(2) freezing: the Bulbophyllum decoction pieces that step (1) is obtained is spread out and carried out freezingly, and cryogenic temperature is-40 ℃.
(3) pulverize at low temperature: the Bulbophyllum decoction pieces that step (2) is obtained is pulverized under the cryogenic conditions of-40 ℃, sieves, and obtains 40～100 object coarse powder.
(4) low-temperature vacuum microwave is dry: it is dry that the Bulbophyllum coarse powder that step (3) is obtained carries out low-temperature vacuum microwave, microwave power: 40kw, microwave drying total time, 0.6h, temperature :-35 ℃; Vacuum: 0.07Pa.In microwave drying process, can take interval 90s, the microwave treatment mode of heating 900s (being that every heating 90s just stops heating 90s and then continuation heating 90s stops heating 90s again, circulation successively),
(5) low-temperature airflow is pulverized: the Bulbophyllum xeraphium that step (4) is obtained carries out superfine grinding under the cryogenic conditions of-20 ℃, to 200 orders.
(6) low temperature dither is pulverized: the Bulbophyllum micropowder that step (5) is obtained is carried out micronizing in high-frequency resonance grinding machine or other micronizing machinery, makes its particle diameter reach (detection of its particle diameter can detect by scanning electron microscope method) between 0.2mm～1nm.
(7) subpackage and packing: get the superfine powder that step (6) makes, through microwave power 1kw frequency 2450MHZ microwave sterilizating 2 minutes, put to room temperature, 18～26 ℃ of temperature, subpackage is carried out in the aseptic subpackaged chamber of humidity below 65%, specification according to 1～5 gram of every bag is carried out subpackage and outer package, makes finished product.The Bulbophyllum superfine powder making is yellowish green superfine powder, and hands is twisted with the fingers without granular sensation, has no complete cell under microscope.Under Electronic Speculum, recording mean diameter is 26.9um.
Embodiment 4:
(1) pretreatment: get Bulbophyllum medical material, remove impurity, wash, be cut into 2～4mm decoction pieces;
(2) freezing: the Bulbophyllum decoction pieces that step (1) is obtained is spread out and carried out freezingly, and cryogenic temperature is-5 ℃.
(3) pulverize at low temperature: the Bulbophyllum decoction pieces that step (2) is obtained is pulverized under the cryogenic conditions of-5 ℃, sieves, and obtains 40～100 object coarse powder.
(4) low-temperature vacuum microwave is dry: it is dry that the Bulbophyllum coarse powder that step (3) is obtained carries out low-temperature vacuum microwave, microwave power: 1kw, microwave drying total time, 2h, temperature :-20 ℃; Vacuum: 0.04Pa.In microwave drying process, can take interval 30s, the microwave treatment mode of heating 30s (being that every heating 30s just stops heating 30s and then continuation heating 30s stops heating 30s again, circulation successively),
(5) low-temperature airflow is pulverized: the Bulbophyllum xeraphium that step (4) is obtained carries out superfine grinding under the cryogenic conditions below 0 ℃, to 300 orders.
(6) subpackage and packing: get the superfine powder that step (6) makes, through microwave power 1kw frequency 2450MHZ microwave sterilizating 2 minutes, put to room temperature, 18～26 ℃ of temperature, subpackage is carried out in the aseptic subpackaged chamber of humidity below 65%, specification according to 1～5 gram of every bag is carried out subpackage and outer package, makes finished product.The Bulbophyllum superfine powder making is yellowish green superfine powder, and hands is twisted with the fingers without granular sensation, has no complete cell under microscope.Under Electronic Speculum, recording mean diameter is 26.2um.
Embodiment 5:
(1) pretreatment: get Bulbophyllum medical material, remove impurity, wash, be cut into 2～4mm decoction pieces;
(2) freezing: the Bulbophyllum decoction pieces that step (1) is obtained is spread out and carried out freezingly, and cryogenic temperature is-40 ℃.
(3) pulverize at low temperature: the Bulbophyllum decoction pieces that step (2) is obtained is pulverized under the cryogenic conditions of-40 ℃, sieves, and obtains 40～100 object coarse powder.
(4) low-temperature vacuum microwave is dry: it is dry that the Bulbophyllum coarse powder that step (3) is obtained carries out low-temperature vacuum microwave, microwave power: 40kw, microwave drying total time, 0.6h, temperature :-35 ℃; Vacuum: 0.07Pa.In microwave drying process, can take interval 60s, the microwave treatment mode of heating 60s (being that every heating 60s just stops heating 60s and then continuation heating 60s stops heating 60s again, circulation successively),
(5) low temperature dither is pulverized: the Bulbophyllum micropowder that step (4) is obtained is carried out micronizing in high-frequency resonance grinding machine, makes its particle diameter reach (detection of its particle diameter can detect by methods such as scanning electron microscope, laser particle analyzers) between 0.2mm～1nm.
(6) subpackage and packing: get the superfine powder that step (6) makes, through microwave power 1kw frequency 2450MHZ microwave sterilizating 2 minutes, put to room temperature, 18～26 ℃ of temperature, subpackage is carried out in the aseptic subpackaged chamber of humidity below 65%, specification according to 1～5 gram of every bag is carried out subpackage and outer package, makes finished product.The Bulbophyllum superfine powder making is yellowish green superfine powder, and hands is twisted with the fingers without granular sensation, has no complete cell under microscope.Under Electronic Speculum, recording mean diameter is 28.1um.
Embodiment 6:
(1) pretreatment: get Bulbophyllum medical material, remove impurity, wash, be cut into 2～4mm decoction pieces;
(2) freezing: the Bulbophyllum decoction pieces that step (1) is obtained is spread out and carried out freezingly, and cryogenic temperature is-40 ℃.
(3) pulverize at low temperature: the Bulbophyllum decoction pieces that step (2) is obtained is pulverized under the cryogenic conditions of-40 ℃, sieves, and obtains 40～100 object coarse powder.
(4) low-temperature vacuum microwave is dry: it is dry that the Bulbophyllum coarse powder that step (3) is obtained carries out low-temperature vacuum microwave, microwave power: 40kw, microwave drying total time, 0.6h, temperature :-35 ℃; Vacuum: 0.07Pa.In microwave drying process, can take interval 90s, the microwave treatment mode of heating 90s (being that every heating 90s just stops heating 90s and then continuation heating 90s stops heating 90s again, circulation successively),
(5) low temperature dither is pulverized: the dry coarse powder of Bulbophyllum that step (4) is obtained carries out micronizing in high-frequency resonance grinding machine, and its particle diameter is reached below 200 orders
(6) low-temperature airflow is pulverized: the Bulbophyllum xeraphium that step (5) is obtained carries out superfine grinding under the cryogenic conditions of-20 ℃, between 0.2mm～1nm.(detection of its particle diameter can detect by methods such as scanning electron microscope, laser particle analyzers).
(7) subpackage and packing: get the superfine powder that step (6) makes, through microwave power 1kw frequency 2450MHZ microwave sterilizating 2 minutes, put to room temperature, 18～26 ℃ of temperature, subpackage is carried out in the aseptic subpackaged chamber of humidity below 65%, specification according to 1～5 gram of every bag is carried out subpackage and outer package, makes finished product.The Bulbophyllum superfine powder making is yellowish green superfine powder, and hands is twisted with the fingers without granular sensation, has no complete cell under microscope.Under Electronic Speculum, recording mean diameter is 26.7um.
Above embodiment is only explanation technical conceive of the present invention and feature; its object is to allow person skilled in the art understand content of the present invention and implemented; can not limit the scope of the invention with this; all equivalences that spirit is done according to the present invention change or modify, and all should be encompassed in protection scope of the present invention.
Claims (8)
1. a preparation method for Bulbophyllum superfine powder, comprises the steps:
(1) pretreatment: get fresh or dry Bulbophyllum medical material, remove impurity, wash, cut into slices or section or silk;
(2) freezing: the Bulbophyllum that step (1) is obtained is spread out and carried out freezingly, and cryogenic temperature is-5～-80 ℃;
(3) pulverize at low temperature: the Bulbophyllum that step (2) is obtained is pulverized under the cryogenic conditions of 0～-80 ℃, sieves, and obtains 40～100 object coarse powder;
(4) low-temperature vacuum microwave is dry: it is dry that the Bulbophyllum coarse powder that step (3) is obtained carries out low-temperature vacuum microwave, microwave power: 1～80kw, and temperature :-5～-50 ℃, vacuum: 0.04～0.09Pa, microwave drying total time, 0.1～2h;
(5) low-temperature airflow is pulverized: the Bulbophyllum xeraphium that step (4) is obtained carries out superfine grinding under the cryogenic conditions of 0～-40 ℃, to 200 orders;
(6) low temperature resonance micronizing: control temperature below 20 ℃, the Bulbophyllum micropowder that step (5) the is obtained micronizing that resonates, reaches below 300 orders its particle diameter;
(7) subpackage and packing: get the superfine powder that step (6) makes, after microwave sterilizating, in aseptic subpackaged chamber, carry out subpackage, according to the specification of 1～5 gram of every bag, carry out subpackage and outer package, make Bulbophyllum superfine powder finished product.
2. the preparation method of Bulbophyllum superfine powder as claimed in claim 1, is characterized in that: in step (2), cryogenic temperature is at-10～-25 ℃.
3. the preparation method of Bulbophyllum superfine powder as claimed in claim 1, is characterized in that: in step (3), pulverize temperature at-5～-25 ℃.
4. the preparation method of Bulbophyllum superfine powder as claimed in claim 1, is characterized in that: in step (4), in microwave drying process, take to heat 30～60s, the microwave treatment mode of interval 30～90s.
5. the preparation method of Bulbophyllum superfine powder as claimed in claim 4, is characterized in that: in step (4), the total time that low-temperature microwave is processed was at 0.5～2 hour.
6. the preparation method of Bulbophyllum superfine powder as claimed in claim 1, is characterized in that: in step (5), pulverize at low temperature temperature is at 0～-5 ℃.
7. the preparation method of Bulbophyllum superfine powder as claimed in claim 1, is characterized in that: in step (7), aseptic subpackaged room temperature is at 18～26 ℃, and relative humidity is below 65%.
8. the preparation method of Bulbophyllum superfine powder as claimed in claim 1, is characterized in that: the microwave sterilizating described in step (7) is sterilizing 2～10min under the microwave condition of power 1～3kw, frequency 2450～3000MHZ.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106074450A (en) * | 2016-06-27 | 2016-11-09 | 嘉兴杰顺工业设计有限公司 | The bioactivity protective technique prepared for medical material superfine powder |
| CN110961231A (en) * | 2019-12-23 | 2020-04-07 | 金晓飞 | Preparation method and application of macleaya cordata traditional Chinese medicinal material ultramicro wall-breaking powder |
| CN112076256A (en) * | 2020-09-24 | 2020-12-15 | 北京金崇光药业有限公司 | Low-temperature ultrafine grinding process |
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| CN103463438A (en) * | 2013-08-23 | 2013-12-25 | 浙江磐谷药源有限公司 | Preparing method and application of Goodyera schlechtendaliana broken wall freeze-dried powder |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102846698A (en) * | 2012-08-20 | 2013-01-02 | 浙江中医药大学中药饮片有限公司 | Wall-broken radix tetrastigme oral decoction pieces |
| CN103463438A (en) * | 2013-08-23 | 2013-12-25 | 浙江磐谷药源有限公司 | Preparing method and application of Goodyera schlechtendaliana broken wall freeze-dried powder |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074450A (en) * | 2016-06-27 | 2016-11-09 | 嘉兴杰顺工业设计有限公司 | The bioactivity protective technique prepared for medical material superfine powder |
| CN110961231A (en) * | 2019-12-23 | 2020-04-07 | 金晓飞 | Preparation method and application of macleaya cordata traditional Chinese medicinal material ultramicro wall-breaking powder |
| CN112076256A (en) * | 2020-09-24 | 2020-12-15 | 北京金崇光药业有限公司 | Low-temperature ultrafine grinding process |
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Application publication date: 20140730 |