CN109528790B - Preparation method of fresh pseudo-ginseng freeze-drying wall-breaking ultrafine powder - Google Patents
Preparation method of fresh pseudo-ginseng freeze-drying wall-breaking ultrafine powder Download PDFInfo
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- 239000000843 powder Substances 0.000 title claims abstract description 27
- 238000004108 freeze drying Methods 0.000 title claims abstract description 23
- 235000003181 Panax pseudoginseng Nutrition 0.000 title claims abstract description 20
- 244000131316 Panax pseudoginseng Species 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 26
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 26
- 238000000034 method Methods 0.000 claims abstract description 18
- 238000009777 vacuum freeze-drying Methods 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000002791 soaking Methods 0.000 claims abstract description 7
- 238000001238 wet grinding Methods 0.000 claims abstract description 6
- 238000009210 therapy by ultrasound Methods 0.000 claims description 12
- 238000010298 pulverizing process Methods 0.000 claims description 10
- 238000000227 grinding Methods 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 2
- 238000000527 sonication Methods 0.000 claims 1
- 238000009987 spinning Methods 0.000 claims 1
- 238000010792 warming Methods 0.000 claims 1
- 230000008569 process Effects 0.000 abstract description 5
- 230000007547 defect Effects 0.000 abstract description 4
- 238000005054 agglomeration Methods 0.000 abstract description 3
- 230000002776 aggregation Effects 0.000 abstract description 3
- 239000004480 active ingredient Substances 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 abstract description 2
- 210000002421 cell wall Anatomy 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- NEEQFPMRODQIKX-REOHCLBHSA-N N(3)-oxalyl-L-2,3-diaminopropionic acid Chemical compound OC(=O)[C@@H](N)CNC(=O)C(O)=O NEEQFPMRODQIKX-REOHCLBHSA-N 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000011882 ultra-fine particle Substances 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
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- Storage Of Fruits Or Vegetables (AREA)
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Abstract
The application discloses a preparation method of fresh pseudo-ginseng freeze-drying wall-breaking superfine powder, which comprises the following steps of (1) soaking fresh pseudo-ginseng in water, and carrying out wet grinding after soaking; (2) vacuum freeze drying wet pulverized Notoginseng radix powder; (3) breaking the wall of the vacuum freeze-dried pseudo-ginseng powder. The preparation method of the invention solves the defects of high loss, easy agglomeration, unstable fineness and the like of the traditional scattering process. And the preparation method of the freeze-drying wall-breaking ultrafine powder obviously changes the cell tissues of the panax notoginseng, breaks the cell walls, enables the active ingredients of the panax notoginseng to be better exposed, and greatly improves the biological utilization value of the panax notoginseng.
Description
Technical Field
The application relates to deep processing of medicinal materials, in particular to a preparation method of fresh pseudo-ginseng freeze-drying wall-breaking ultrafine powder.
Background
The Notoginseng radix powder has the same components as Notoginseng radix main root, is rich in Notoginseng radix saponin, Notoginseng radix polysaccharide, dencichine, and flavone effective components, and has effects of stopping bleeding, promoting blood circulation for removing blood stasis, relieving swelling and pain, nourishing, strengthening body, relieving fatigue, resisting anoxia, resisting aging, reducing blood lipid, lowering blood pressure, and improving immunity.
At present, the pseudo-ginseng powder is usually pulverized by adopting a small pulverizing machine, and the processing method is simple and easy to implement but has some defects. Firstly, the loss is large, and the severe loss directly causes the powdering cost to be high due to the high price of the pseudo-ginseng; secondly, the fresh pseudo-ginseng has larger water content, is easy to agglomerate and agglomerate after being directly powdered, and is easy to deteriorate in the later period; thirdly, the fineness of the powder prepared by the traditional process is unstable.
Disclosure of Invention
The invention provides a preparation method of fresh panax notoginseng freeze-drying wall-breaking ultrafine powder, which overcomes the defects of high loss, easy agglomeration, unstable fineness and the like of the traditional scattering process. And the preparation method of the freeze-drying wall-breaking ultrafine powder obviously changes the cell tissues of the panax notoginseng, breaks the cell walls, enables the active ingredients of the panax notoginseng to be better exposed, and greatly improves the biological utilization value of the panax notoginseng.
A preparation method of fresh notoginseng freeze-drying wall-breaking superfine powder is characterized in that,
(1) soaking fresh Notoginseng radix in water, and wet pulverizing;
(2) vacuum freeze drying wet pulverized Notoginseng radix powder;
(3) breaking the wall of the vacuum freeze-dried pseudo-ginseng powder.
Alternatively, the wet pulverization employs a pulverizing instrument that spins at a high speed, thereby causing the pulverizing medium to pulverize the raw material particles into ultrafine particles in a short time. The whole crushing process is operated at the temperature close to room temperature, and has good compactness and no pollution.
Optionally, the crushing rotation speed is 700-900r/min, and the crushing time is 5-20 min;
optionally, the wet grinding is followed by a wet sieving step, wherein oversize products are returned to the grinding instrument to be ground together with the raw materials;
optionally, in the vacuum freeze-drying step, the thickness of the material is 0.5-1mm, the freeze-drying temperature is-15 to-5 ℃, and the freeze-drying vacuum degree is 5-15 Pa;
optionally, performing rapid temperature rise treatment after freeze-drying;
optionally, in the step of wall breaking, the wall breaking temperature is 10-30 deg.C, and the wall breaking time is 15-60 min;
optionally, before the step of wall breaking treatment, or after the step of wall breaking treatment, an ultrasonic treatment step is further included;
optionally, the ultrasonic treatment time is 10-70min, preferably 30-60 min;
optionally, a microwave heating treatment is performed during the ultrasonic treatment.
The invention has the following technical effects:
(1) the grinding effect on fresh pseudo-ginseng is better through wet grinding, the defect of easy agglomeration is well avoided, and the later-stage wall breaking efficiency of pseudo-ginseng wall breaking is remarkably improved through wet grinding; the method of soaking fresh pseudo-ginseng in water before grinding can effectively improve the wet grinding efficiency of pseudo-ginseng, and has the advantages of simple and convenient operation and low cost.
(2) The vacuum freeze-drying step can obviously improve the release of the effective components of the pseudo-ginseng and the utilization value of the pseudo-ginseng powder, and the wall breaking efficiency in the later period can be obviously improved by quickly heating after freeze-drying.
(3) According to the invention, ultrasonic treatment and ultrasonic-microwave heating combined treatment are carried out in the wall breaking treatment process, so that the wall breaking rate of the pseudo-ginseng powder is greatly improved, the grinding requirement of the wall breaking treatment is greatly reduced, the grinding energy consumption is reduced, and the cost is obviously reduced.
Detailed Description
Example 1
A method for preparing fresh notoginseng freeze-drying wall-breaking ultramicro powder,
(1) soaking fresh Notoginseng radix in water, and wet pulverizing;
(2) vacuum freeze drying wet pulverized Notoginseng radix powder;
(3) breaking the wall of the vacuum freeze-dried pseudo-ginseng powder.
The grinding speed is 900r/min, and the grinding time is 20 min; in the step of vacuum freeze drying, the thickness of the material is 0.5mm, the freeze-drying temperature is-10 ℃, and the freeze-drying vacuum degree is 5 Pa; carrying out rapid heating treatment after freeze-drying; in the step of wall breaking, the wall breaking temperature is 15 deg.C, and the wall breaking time is 20 min; the method also comprises an ultrasonic treatment step before the wall breaking treatment step; the ultrasonic treatment time is 40 min;
example 2
A method for preparing fresh notoginseng freeze-drying wall-breaking ultramicro powder,
(1) soaking fresh Notoginseng radix in water, and wet pulverizing;
(2) vacuum freeze drying wet pulverized Notoginseng radix powder;
(3) breaking the wall of the vacuum freeze-dried pseudo-ginseng powder.
The crushing rotating speed is 700r/min, and the crushing time is 15 min; in the step of vacuum freeze drying, the thickness of the material is 0.8mm, the freeze-drying temperature is-15 ℃, and the freeze-drying vacuum degree is 10 Pa; in the step of wall breaking, the wall breaking temperature is 10 deg.C, and the wall breaking time is 40 min; the method also comprises an ultrasonic treatment step before the wall breaking treatment step; the ultrasonic treatment time is 70 min;
example 3
The process steps and parameters of the preparation method of example 1 are substantially the same, except that fresh notoginseng is not soaked in water.
Example 4
The process steps and parameters of the preparation method of example 1 were substantially the same except that the wet pulverized notoginseng powder was not vacuum freeze-dried.
Example 5
The preparation method of example 1 has substantially the same process steps and parameters, except that the wall breaking is not performed by ultrasonic wave treatment.
The experimental results for each example are as follows:
the above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (6)
1. A preparation method of fresh notoginseng freeze-drying wall-breaking superfine powder is characterized in that,
(1) soaking fresh Notoginseng radix in water, and wet pulverizing;
(2) vacuum freeze drying wet pulverized Notoginseng radix powder;
(3) carrying out ultrasonic treatment on the vacuum freeze-dried pseudo-ginseng powder, and then carrying out wall breaking treatment;
wherein the crushing rotating speed is 700-900r/min, and the crushing time is 15-20 min;
in the step of vacuum freeze drying, the thickness of the material is 0.5-0.8mm, the freeze-drying temperature is-15 to-10 ℃, and the freeze-drying vacuum degree is 5-10 Pa;
in the ultrasonic treatment step, the ultrasonic treatment time is 10-70min,
in the step of wall breaking, the wall breaking temperature is 10-15 deg.C, and the wall breaking time is 20-40 min.
2. The method of claim 1, wherein the wet pulverization employs a high speed spinning pulverization apparatus.
3. The method according to claim 1, wherein the wet grinding is followed by a wet sieving step, and the oversize product is returned to the grinding machine and ground again together with the raw material.
4. The method according to claim 1, wherein the lyophilization is followed by a rapid warming treatment.
5. The method of claim 1, wherein the preferred sonication time is 30-60 min.
6. The method according to claim 1, wherein the ultrasonic treatment is carried out by microwave heating.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201811408674.XA CN109528790B (en) | 2018-11-23 | 2018-11-23 | Preparation method of fresh pseudo-ginseng freeze-drying wall-breaking ultrafine powder |
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| CN201811408674.XA CN109528790B (en) | 2018-11-23 | 2018-11-23 | Preparation method of fresh pseudo-ginseng freeze-drying wall-breaking ultrafine powder |
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| CN109528790B true CN109528790B (en) | 2021-08-10 |
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| CN110339222A (en) * | 2019-07-05 | 2019-10-18 | 安徽省泽华国药饮片有限公司 | A kind of fresh Radix Notoginseng freezing broken wall preparation method |
| CN110974860A (en) * | 2019-12-31 | 2020-04-10 | 普洱淞茂滇草六味制药股份有限公司 | Preparation method of pseudo-ginseng wall-broken decoction pieces |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1633886A (en) * | 2003-12-31 | 2005-07-06 | 王汝辉 | Active notoginseng and its preparation |
| CN104490964A (en) * | 2014-11-26 | 2015-04-08 | 浙江尖峰健康科技有限公司 | Preparation method of active pseudo-ginseng ultramicro powder |
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- 2018-11-23 CN CN201811408674.XA patent/CN109528790B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1633886A (en) * | 2003-12-31 | 2005-07-06 | 王汝辉 | Active notoginseng and its preparation |
| CN104490964A (en) * | 2014-11-26 | 2015-04-08 | 浙江尖峰健康科技有限公司 | Preparation method of active pseudo-ginseng ultramicro powder |
Non-Patent Citations (2)
| Title |
|---|
| 活性超微三七粉质量特征研究;李琳等;《云南农业大学学报(自然科学)》;20161231;第30卷(第2期);第232-238页 * |
| 湿法粉碎在中药制备中的应用;谭养成;《中成药研究》;19841231(第7期);第5-6页，第5页右栏第2、3、5段 * |
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