CN110974734A - Repairing type sunscreen composition and preparation method and application thereof - Google Patents
Repairing type sunscreen composition and preparation method and application thereof Download PDFInfo
- Publication number
- CN110974734A CN110974734A CN201911421674.8A CN201911421674A CN110974734A CN 110974734 A CN110974734 A CN 110974734A CN 201911421674 A CN201911421674 A CN 201911421674A CN 110974734 A CN110974734 A CN 110974734A
- Authority
- CN
- China
- Prior art keywords
- parts
- stirring
- sunscreen
- mixture
- sunscreen composition
- Prior art date
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- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract description 132
- 239000000516 sunscreening agent Substances 0.000 title claims abstract description 125
- 230000000475 sunscreen effect Effects 0.000 title claims abstract description 102
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 36
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 30
- 239000003755 preservative agent Substances 0.000 claims abstract description 29
- 230000002335 preservative effect Effects 0.000 claims abstract description 29
- 239000002562 thickening agent Substances 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000011780 sodium chloride Substances 0.000 claims abstract description 17
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 12
- 230000003750 conditioning effect Effects 0.000 claims abstract description 11
- 238000003756 stirring Methods 0.000 claims description 55
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 26
- 235000008524 evening primrose extract Nutrition 0.000 claims description 14
- 229940089020 evening primrose oil Drugs 0.000 claims description 14
- 239000010475 evening primrose oil Substances 0.000 claims description 14
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 13
- 229960000458 allantoin Drugs 0.000 claims description 13
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 12
- 238000001816 cooling Methods 0.000 claims description 12
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims description 12
- 238000010438 heat treatment Methods 0.000 claims description 12
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims description 11
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims description 11
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims description 11
- 229940036350 bisabolol Drugs 0.000 claims description 11
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims description 11
- 239000006071 cream Substances 0.000 claims description 11
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 11
- 239000006185 dispersion Substances 0.000 claims description 11
- -1 ethyl diethylamino hydroxybenzoyl benzoate Chemical compound 0.000 claims description 11
- 229960001295 tocopherol Drugs 0.000 claims description 11
- 229930003799 tocopherol Natural products 0.000 claims description 11
- 235000010384 tocopherol Nutrition 0.000 claims description 11
- 239000011732 tocopherol Substances 0.000 claims description 11
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 11
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 10
- 229920002125 Sokalan® Polymers 0.000 claims description 10
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical group OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 10
- 229960001631 carbomer Drugs 0.000 claims description 10
- HEOCBCNFKCOKBX-RELGSGGGSA-N (1s,2e,4r)-4,7,7-trimethyl-2-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-3-one Chemical compound C1=CC(C)=CC=C1\C=C/1C(=O)[C@]2(C)CC[C@H]\1C2(C)C HEOCBCNFKCOKBX-RELGSGGGSA-N 0.000 claims description 9
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 9
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 claims description 9
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N benzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 claims description 9
- 229960004697 enzacamene Drugs 0.000 claims description 9
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 9
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims description 9
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims description 9
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 9
- 229960001679 octinoxate Drugs 0.000 claims description 9
- 229960005323 phenoxyethanol Drugs 0.000 claims description 9
- 239000000230 xanthan gum Substances 0.000 claims description 9
- 229920001285 xanthan gum Polymers 0.000 claims description 9
- 229940082509 xanthan gum Drugs 0.000 claims description 9
- 235000010493 xanthan gum Nutrition 0.000 claims description 9
- 230000035876 healing Effects 0.000 claims description 8
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 7
- 230000000246 remedial effect Effects 0.000 claims description 7
- 230000001804 emulsifying effect Effects 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
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- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 230000008439 repair process Effects 0.000 abstract description 23
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- 238000007254 oxidation reaction Methods 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 34
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- 210000003491 skin Anatomy 0.000 description 13
- 230000000694 effects Effects 0.000 description 9
- 230000003078 antioxidant effect Effects 0.000 description 7
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 description 6
- 206010042496 Sunburn Diseases 0.000 description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 6
- 229940100524 ethylhexylglycerin Drugs 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 230000003385 bacteriostatic effect Effects 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000011056 performance test Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 239000004408 titanium dioxide Substances 0.000 description 3
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 2
- 206010019909 Hernia Diseases 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 208000003351 Melanosis Diseases 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 238000002211 ultraviolet spectrum Methods 0.000 description 2
- PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 description 1
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 description 1
- OCKGFTQIICXDQW-ZEQRLZLVSA-N 5-[(1r)-1-hydroxy-2-[4-[(2r)-2-hydroxy-2-(4-methyl-1-oxo-3h-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methyl-3h-2-benzofuran-1-one Chemical compound C1=C2C(=O)OCC2=C(C)C([C@@H](O)CN2CCN(CC2)C[C@H](O)C2=CC=C3C(=O)OCC3=C2C)=C1 OCKGFTQIICXDQW-ZEQRLZLVSA-N 0.000 description 1
- 102000016938 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- PGLIUCLTXOYQMV-UHFFFAOYSA-N Cetirizine hydrochloride Chemical compound Cl.Cl.C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 PGLIUCLTXOYQMV-UHFFFAOYSA-N 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 206010008570 Chloasma Diseases 0.000 description 1
- IUMSDRXLFWAGNT-UHFFFAOYSA-N Dodecamethylcyclohexasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 IUMSDRXLFWAGNT-UHFFFAOYSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010014970 Ephelides Diseases 0.000 description 1
- 241000237858 Gastropoda Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
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- 102000004316 Oxidoreductases Human genes 0.000 description 1
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- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000227425 Pieris rapae crucivora Species 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
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- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- 239000007853 buffer solution Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- MGJZITXUQXWAKY-UHFFFAOYSA-N diphenyl-(2,4,6-trinitrophenyl)iminoazanium Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1N=[N+](C=1C=CC=CC=1)C1=CC=CC=C1 MGJZITXUQXWAKY-UHFFFAOYSA-N 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- DHNGCHLFKUPGPX-RMKNXTFCSA-N ethyl trans-p-methoxycinnamate Chemical compound CCOC(=O)\C=C\C1=CC=C(OC)C=C1 DHNGCHLFKUPGPX-RMKNXTFCSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 230000003020 moisturizing effect Effects 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- MSRJTTSHWYDFIU-UHFFFAOYSA-N octyltriethoxysilane Chemical compound CCCCCCCC[Si](OCC)(OCC)OCC MSRJTTSHWYDFIU-UHFFFAOYSA-N 0.000 description 1
- 229960003493 octyltriethoxysilane Drugs 0.000 description 1
- AALKGALVYCZETF-UHFFFAOYSA-N pentane-1,2,3-triol Chemical compound CCC(O)C(O)CO AALKGALVYCZETF-UHFFFAOYSA-N 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000000191 radiation effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229940047670 sodium acrylate Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the field of cosmetics, and particularly relates to a repairing type sunscreen composition and a preparation method and application thereof. The repairing type sunscreen composition provided by the invention comprises the following components in parts by weight: 14-19 parts of sun-screening agent, 68-80 parts of water, 2-4 parts of butanediol, 0.3-0.7 part of NaCl, 0.2-0.6 part of thickening agent, 0.65-0.12 part of conditioning agent, 0.15-0.3 part of pH regulator, 1-3 parts of emulsifier and 0.15-0.45 part of preservative. The repair type sunscreen composition provided by the invention can play a role in sunscreen in offices, has long duration, does not need to be continuously made up, can effectively resist external stimulation, has the functions of repairing after sun and relieving skin sensitivity, and can resist bacteria and oxidation; meanwhile, the composition provided by the invention is in a gel texture, is easy to apply in use, and is cool and comfortable.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a repairing type sunscreen composition and a preparation method and application thereof.
Background
The damage of ultraviolet rays to human skin is more and more concerned by people, the ultraviolet rays not only can increase the temperature of the skin, dilate blood capillaries, increase the evaporation of water in epidermis and the like through the heat radiation effect of the ultraviolet rays, directly cause adverse effects on the skin, accelerate skin aging, but also can cause skin pigmentation, form various color spots such as freckles, chloasma and the like, and further influence the appearance of people, so that a plurality of beauty lovers pay more attention to sun protection. However, many current sunscreen products have a short lasting effect, and the effect is further reduced by sweating due to heat in the day, and skin of many people is allergic due to sunlight.
Chinese patent application CN108236600A discloses a sunscreen cream, which comprises 60-80 parts by mass of solvent, 20-30 parts by mass of additive, 0.5-10 parts by mass of common mussel melanin pulp and 6-13 parts by mass of anti-UV agent, wherein the additive comprises emulsifier, preservative, pH regulator and essence. The sunscreen cream provided by the invention has the characteristics of being safe to use, preventing chemical sunscreen substances from permeating into skin, being capable of being attached to proteins of skin cells, not being absorbed by the skin, greatly reducing free radicals generated under ultraviolet irradiation and reducing stimulation of the free radicals to the skin, but the sunscreen cream cannot play a role in repairing after-sun, and the sunscreen effect is not durable enough.
Chinese patent application CN107737088A discloses a multifunctional sunscreen cream, which is prepared by putting 40-50 parts of carbomer, 20-30 parts of chitosan liquid, 20-30 parts of polyvinyl alcohol liquid, 20-30 parts of snail mucus, 3-5 parts of preservative, 5-6 parts of superoxide dismutase, 2-3 parts of catalase, 2-3 parts of oxidase, 40-50 parts of water, 10-20 parts of vitamin, 10-20 parts of tea extract and 10-20 parts of plant essential oil into a mixer, and stirring and mixing at high speed for 30-50min under the condition that the rotating speed is 50-70 r/min. The multifunctional sunscreen cream provided by the invention is fresh and non-greasy, has a good moisturizing effect, and has an excellent sunscreen effect. However, the sunscreen cream cannot have the effects of preventing irritation, repairing after sunburn and soothing allergy, and although the sunscreen cream has a good sunscreen effect, the effect lasts for a short time.
At present, many sun cream have single effect, can not prevent the stimulation of the external world to the skin and the effect of after-sun repair and allergy relief well, and many sun cream need to be wiped for many times because the effect duration time of factors such as the day heat perspiration is shorter.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a repairing type sunscreen composition and a preparation method and application thereof. The repair type sunscreen composition provided by the invention can play a role in sunscreen in offices, has long duration, does not need to be continuously made up, can effectively resist external stimulation, has the functions of repairing after sun and relieving skin sensitivity, and can resist bacteria and oxidation; meanwhile, the composition provided by the invention is in a gel texture, is easy to apply in use, and is cool and comfortable.
A repairing type sunscreen composition is characterized by comprising the following components in parts by weight: 14-19 parts of sun-screening agent, 68-80 parts of water, 2-4 parts of butanediol, 0.3-0.7 part of NaCl, 0.2-0.6 part of thickening agent, 0.65-0.12 part of conditioner, 0.15-0.3 part of pH regulator and 1-3 parts of emulsifier.
Further, the sunscreen agent comprises sunscreen dispersion pulp, ethylhexyl methoxycinnamate, C12-15 alcohol benzoate, 4-methylbenzylidene camphor and ethyl diethylamino hydroxybenzoyl benzoate, and the mass ratio of the sunscreen dispersion pulp to the ethyl methoxycinnamate is 3-5: 3-5: 2-4: 2-4: 1-3.
Further, the conditioning agent comprises: allantoin, dipotassium glycyrrhizinate, 85% bisabolol, tocopherol, evening primrose oil and ethylhexyl glycerol, wherein the mass ratio of allantoin to dipotassium glycyrrhizinate to the mixture is 1-3: 1-3: 4-6: 4-6: 2-4: 3-7.
Further, the thickener is one or more selected from transparent xanthan gum, carbomer U21, SIMULGEL EG.
Further, the pH regulator is triethanolamine.
Further, the repairing type sunscreen composition also comprises 0.15-0.45 part of preservative.
Furthermore, the preservative is one or two of phenoxyethanol and ethylparaben.
Further, the emulsifier is SENSANOV WR.
Another object of the present invention is to provide a method for preparing the repairing type sunscreen composition, which comprises the following steps:
s1 adding the sun-screening agent and the emulsifying agent into an emulsifying tank, adjusting the temperature to 70-90 ℃ by a heater, heating while stirring at 40-60r/min, and stirring at 50-70r/min for 8-12 minutes when the temperature reaches 70-90 ℃ to obtain a mixture A;
s2, adding water, butanediol, NaCl and a conditioner into a water phase pot, adjusting the temperature to 70-90 ℃ by a heater, heating while stirring at 40-60r/min, and stirring at 50-70r/min for 8-12 minutes when the temperature reaches 70-90 ℃ to obtain a mixture B;
s3, adding the mixture B obtained in the step S2 into the mixture A obtained in the step S1, and stirring for 4-6 minutes at a speed of 50-70r/min to obtain a mixture C;
s4, stirring, opening a cooling system, cooling to 45 ℃, adding the dissolved thickening agent into the mixture C obtained in the step S3, stirring for 4-6 minutes at 50-70r/min, then adding a pH regulator to adjust the pH to 5.5-6.5, and stirring for 2-4 minutes at 50-70r/min to obtain a mixture D;
s5 adding preservative into the mixture D obtained in the step S4, and stirring for 4-6 minutes at a speed of 50-70 r/min.
The invention also aims to provide application of the repairing type sunscreen composition in preparation of sunscreen cream and sunscreen spray.
Compared with the prior art, the invention has the following advantages:
(1) the composition provided by the invention contains a conditioner consisting of evening primrose oil and ethylhexyl glycerin, and the addition of the conditioner enables the composition to resist external stimulation well and relieve skin sensitivity well for after-sun repair.
(2) The composition provided by the invention is fresh and comfortable to use, has long sunscreen effect duration, is suitable for daily office sunscreen use, and does not need makeup in the using process.
(3) The bisabolol added in the invention can enable the composition to have the functions of bacteriostasis and inflammation diminishing.
(4) The use of tocopherol and allantoin in the present invention can improve the antioxidant properties of the skin and can alleviate dry skin.
(5) The composition provided by the invention is simple in preparation process, safe, free of any toxic and side effects, and suitable for long-term use.
Detailed Description
The present invention is further described in the following description of the specific embodiments, which is not intended to limit the invention, but various modifications and improvements can be made by those skilled in the art according to the basic idea of the invention, within the scope of the invention, as long as they do not depart from the basic idea of the invention.
The sunscreen dispersion slurry is sold under the trade name of Covascreen TI AS D56, and the international cosmetic raw material is named AS titanium dioxide/triethoxyoctylsilane/cyclopentadecyldimethyl siloxane/cyclohexasiloxane/lauryl polyglycerol-3-dimethyl siloxyethyl dimethyl siloxane, and can be purchased from new daily chemical trade expansion limited company; the emulsifier is SENSANOV WR with chemical name of C20-22 phosphate ester (and) C20-22 fatty alcohol, and is Sabick emulsifier WR SENSANOV available from SEPPIC company; the thickener is SIMULGEL EG, and international cosmetic raw materials are sodium acrylate/sodium difloroyltaurate, isohexadecane, and polysorbate 80, and can be selected from SEPPIC company;
example 1A healing sunscreen composition
A repairing type sunscreen composition comprises the following components in parts by weight: 14 parts of sun-screening agent, 68 parts of water, 2 parts of butanediol, 0.3 part of NaCl, 0.2 part of thickening agent, 0.65 part of conditioning agent, 0.15 part of pH regulator, 1 part of emulsifier and 0.15 part of preservative.
The sunscreen agent is prepared from sunscreen dispersion pulp, ethylhexyl methoxycinnamate, C12-15 alcohol benzoate, 4-methylbenzylidene camphor and ethyl diethylamino hydroxybenzoyl benzoate according to the mass ratio of 3: 3: 2: 2: 1.
the conditioner is prepared from allantoin, dipotassium glycyrrhizinate, 85% bisabolol, tocopherol, evening primrose oil and ethyl glycerol according to the mass ratio of 1: 1: 4: 4: 2: 3, and (3).
The thickening agent is transparent xanthan gum.
The pH regulator is triethanolamine.
The preservative is prepared from phenoxyethanol and ethylparaben according to a mass ratio of 1: 1.
The emulsifier is Sensanov WR.
The preparation method of the repairing type sunscreen composition comprises the following steps:
s1 adding the sun-screening agent and the emulsifying agent into an emulsifying tank, adjusting the temperature to 70 ℃ by a heater, heating while stirring at 40r/min, and stirring at 50r/min for 12 minutes when the temperature reaches 70 ℃ to obtain a mixture A;
s2, adding water, butanediol, NaCl and a conditioner into a water phase pot, adjusting the temperature to 70 ℃ by a heater, heating while stirring at 40r/min, and stirring at 50r/min for 12 minutes when the temperature reaches 70 ℃ to obtain a mixture B;
s3, adding the mixture B obtained in the step S2 into the mixture A obtained in the step S1, and stirring for 6 minutes at the speed of 50r/min to obtain a mixture C;
s4, stirring, opening a cooling system, cooling to 45 ℃, adding the dissolved thickening agent into the mixture C obtained in the step S3, stirring for 6 minutes at 50r/min, then adding a pH regulator to adjust the pH to 5.5, and stirring for 4 minutes at 50r/min to obtain a mixture D;
s5 adding preservative into the mixture D obtained in the step S4, and stirring for 6 minutes at a speed of 50r/min to obtain the compound D.
Example 2A remedial sunscreen composition
A repairing type sunscreen composition comprises the following components in parts by weight: 19 parts of sun-screening agent, 80 parts of water, 4 parts of butanediol, 0.7 part of NaCl, 0.6 part of thickening agent, 0.12 part of conditioner, 0.3 part of pH regulator, 3 parts of emulsifier and 0.45 part of preservative.
The sunscreen agent is prepared from sunscreen dispersion pulp, ethylhexyl methoxycinnamate, C12-15 alcohol benzoate, 4-methylbenzylidene camphor and ethyl diethylamino hydroxybenzoyl benzoate according to the mass ratio of 5: 5: 4: 2-4: 3, and (3).
The conditioner is prepared from allantoin, dipotassium glycyrrhizinate, 85% bisabolol, tocopherol, evening primrose oil and ethylhexyl glycerol according to a mass ratio of 3: 3: 6: 6: 4: 3, and (3).
The thickening agent is prepared from transparent xanthan gum, carbomer U21 and SIMULGEL EG according to the mass ratio of 1: 1.5: 4.
The pH regulator is triethanolamine.
The preservative is phenoxyethanol.
The emulsifier is Sensanov WR.
The preparation method of the repairing type sunscreen composition comprises the following steps:
s1 adding the sun-screening agent and the emulsifying agent into an emulsifying tank, adjusting the temperature to 90 ℃ by a heater, heating while stirring at 60r/min, and stirring at 70r/min for 12 minutes when the temperature reaches 90 ℃ to obtain a mixture A;
s2, adding water, butanediol, NaCl and a conditioner into a water phase pot, adjusting the temperature to 90 ℃ by a heater, heating while stirring at 60r/min, and stirring at 70r/min for 8 minutes when the temperature reaches 90 ℃ to obtain a mixture B;
s3, adding the mixture B obtained in the step S2 into the mixture A obtained in the step S1, and stirring for 4 minutes at 70r/min to obtain a mixture C;
s4, stirring, opening a cooling system, cooling to 45 ℃, adding the dissolved thickening agent into the mixture C obtained in the step S3, stirring for 4 minutes at 70r/min, then adding a pH regulator to adjust the pH to 6.5, and stirring for 2 minutes at 70r/min to obtain a mixture D;
s5 adding preservative into the mixture D obtained in the step S4, and stirring for 4 minutes at 70r/min to obtain the compound D.
Example 3A healing sunscreen composition
A repairing type sunscreen composition comprises the following components in parts by weight: 16 parts of sun-screening agent, 75 parts of water, 3 parts of butanediol, 0.5 part of NaCl, 0.5 part of thickening agent, 0.99 part of conditioning agent, 0.25 part of pH regulator, 2 parts of emulsifier and 0.35 part of preservative.
The sunscreen agent is prepared from sunscreen dispersion pulp, ethylhexyl methoxycinnamate, C12-15 alcohol benzoate, 4-methylbenzylidene camphor and ethyl diethylamino hydroxybenzoyl benzoate according to the mass ratio of 4: 4: 3: 3: 2.
The conditioner is prepared from allantoin, dipotassium glycyrrhizinate, 85% bisabolol, tocopherol, evening primrose oil and ethylhexyl glycerol according to a mass ratio of 2: 2: 5: 5: 2: 5.
The thickening agent is prepared from transparent xanthan gum, carbomer U21 and SIMULGEL EG according to the mass ratio of 1: 1.5: 4.
The pH regulator is triethanolamine.
The preservative is composed of phenoxyethanol and ethylparaben according to a mass ratio of 10: 1.
The emulsifier is Sensanov WR.
The preparation method of the repairing type sunscreen composition comprises the following steps:
s1 adding the sun-screening agent and the emulsifying agent into an emulsifying tank, adjusting the temperature to 80 ℃ by a heater, heating while stirring at 50r/min, and stirring at 50-70r/min for 10 minutes when the temperature reaches 80 ℃ to obtain a mixture A;
s2, adding water, butanediol, NaCl and a conditioner into a water phase pot, adjusting the temperature to 80 ℃ by a heater, heating while stirring at 50r/min, and stirring at 60r/min for 10 minutes when the temperature reaches 80 ℃ to obtain a mixture B;
s3, adding the mixture B obtained in the step S2 into the mixture A obtained in the step S1, and stirring for 5 minutes at the speed of 60r/min to obtain a mixture C;
s4, stirring, opening a cooling system, cooling to 45 ℃, adding the dissolved thickening agent into the mixture C obtained in the step S3, stirring for 5 minutes at 60r/min, then adding a pH regulator to adjust the pH to 6, and stirring for 3 minutes at 60r/min to obtain a mixture D;
s5 adding preservative into the mixture D obtained in the step S4, and stirring for 5 minutes at 60r/min to obtain the compound D.
Example 4A healing sunscreen composition
A repairing type sunscreen composition comprises the following components in parts by weight: 18 parts of sun-screening agent, 70 parts of water, 3 parts of butanediol, 0.5 part of NaCl, 0.4 part of thickening agent, 0.7 part of conditioning agent, 0.2 part of pH regulator, 2 parts of emulsifier and 0.2 part of preservative.
The sunscreen agent is prepared from sunscreen dispersion pulp, ethylhexyl methoxycinnamate, C12-15 alcohol benzoate, 4-methylbenzylidene camphor and ethyl diethylamino hydroxybenzoyl benzoate according to the mass ratio of 4: 1: 3: 3: 2.
The conditioner is prepared from allantoin, dipotassium glycyrrhizinate, 85% bisabolol, tocopherol, evening primrose oil and ethylhexyl glycerol according to the mass ratio of 2: 2: 5: 5: 3: 3, and (3).
The thickening agent is prepared from carbomer U21 and SIMULGEL EG according to the mass ratio of 1: 2.
The pH regulator is triethanolamine.
The preservative is ethylparaben.
The emulsifier is Sensanov WR.
The preparation method of the repairing type sunscreen composition comprises the following steps:
s1 adding the sun-screening agent and the emulsifying agent into an emulsifying tank, adjusting the temperature to 90 ℃ by a heater, heating while stirring at 60r/min, and stirring at 70r/min for 8 minutes when the temperature reaches 90 ℃ to obtain a mixture A;
s2, adding water, butanediol, NaCl and a conditioner into a water phase pot, adjusting the temperature to 90 ℃ by a heater, heating while stirring at 60r/min, and stirring at 70r/min for 8 minutes when the temperature reaches 90 ℃ to obtain a mixture B;
s3, adding the mixture B obtained in the step S2 into the mixture A obtained in the step S1, and stirring for 4 minutes at 70r/min to obtain a mixture C;
s4, stirring, opening a cooling system, cooling to 45 ℃, adding the dissolved thickening agent into the mixture C obtained in the step S3, stirring for 4 minutes at 70r/min, then adding a pH regulator to adjust the pH to 6.5, and stirring for 3 minutes at 70r/min to obtain a mixture D;
s5 adding preservative into the mixture D obtained in the step S4, and stirring for 5 minutes at 70r/min to obtain the compound D.
Comparative example 1A repairing type sunscreen composition
A repairing type sunscreen composition comprises the following components in parts by weight: 16 parts of sun-screening agent, 75 parts of water, 3 parts of butanediol, 0.5 part of NaCl, 0.5 part of thickening agent, 0.99 part of conditioning agent, 0.25 part of pH regulator, 2 parts of emulsifier and 0.35 part of preservative.
The sunscreen agent is prepared from sunscreen dispersion pulp, ethylhexyl methoxycinnamate, C12-15 alcohol benzoate, 4-methylbenzylidene camphor and ethyl diethylamino hydroxybenzoyl benzoate according to the mass ratio of 4: 4: 3: 3: 2.
The conditioner is prepared from allantoin, dipotassium glycyrrhizinate, 85% bisabolol, tocopherol and evening primrose oil in a mass ratio of 2: 2: 5: 5: 2.
The thickening agent is prepared from transparent xanthan gum, carbomer U21 and SIMULGEL EG according to the mass ratio of 1: 1.5: 4.
The pH regulator is triethanolamine.
The preservative is composed of phenoxyethanol and ethylparaben according to a mass ratio of 10: 1.
The emulsifier is Sensanov WR.
The preparation method of the repairing type sunscreen composition is similar to that of example 3. The difference from example 3 is that the conditioning agent does not contain ethylhexyl glycerin.
Comparative example 2 a repairing sunscreen composition
A repairing type sunscreen composition comprises the following components in parts by weight: 16 parts of sun-screening agent, 75 parts of water, 3 parts of butanediol, 0.5 part of NaCl, 0.5 part of thickening agent, 0.99 part of conditioning agent, 0.25 part of pH regulator, 2 parts of emulsifier and 0.35 part of preservative.
The sunscreen agent is prepared from sunscreen dispersion pulp, ethylhexyl methoxycinnamate, C12-15 alcohol benzoate, 4-methylbenzylidene camphor and ethyl diethylamino hydroxybenzoyl benzoate according to the mass ratio of 4: 4: 3: 3: 2.
The conditioner is prepared from allantoin, dipotassium glycyrrhizinate, 85% bisabolol, tocopherol and ethylhexyl glycerol according to the mass ratio of 2: 2: 5: 5: 5.
The thickening agent is prepared from transparent xanthan gum, carbomer U21 and SIMULGEL EG according to the mass ratio of 1: 1.5: 4.
The pH regulator is triethanolamine.
The preservative is composed of phenoxyethanol and ethylparaben according to a mass ratio of 10: 1.
The emulsifier is Sensanov WR.
The preparation method of the repairing type sunscreen composition is similar to that of example 3. The difference from example 3 is that the conditioner does not contain evening primrose oil.
Comparative example 3 a repairing sunscreen composition
A repairing type sunscreen composition comprises the following components in parts by weight: 16 parts of sun-screening agent, 75 parts of water, 3 parts of butanediol, 0.5 part of NaCl, 0.5 part of thickening agent, 0.99 part of conditioning agent, 0.25 part of pH regulator, 2 parts of emulsifier and 0.35 part of preservative.
The sunscreen agent is prepared from sunscreen dispersion pulp, ethylhexyl methoxycinnamate, C12-15 alcohol benzoate, 4-methylbenzylidene camphor and ethyl diethylamino hydroxybenzoyl benzoate according to the mass ratio of 4: 4: 3: 3: 2.
The conditioner is prepared from allantoin, dipotassium glycyrrhizinate, 85% bisabolol and tocopherol in a mass ratio of 2: 2: 5: 5.
The thickening agent is prepared from transparent xanthan gum, carbomer U21 and SIMULGEL EG according to the mass ratio of 1: 1.5: 4.
The pH regulator is triethanolamine.
The preservative is composed of phenoxyethanol and ethylparaben according to a mass ratio of 10: 1.
The emulsifier is Sensanov WR.
The preparation method of the repairing type sunscreen composition is similar to that of example 3. The difference from the example 3 is that the conditioner does not contain evening primrose oil and ethylhexyl glycerin.
Comparative example 4 a repairing type sunscreen composition
A repairing type sunscreen composition comprises the following components in parts by weight: 16 parts of sun-screening agent, 75 parts of water, 3 parts of butanediol, 0.5 part of NaCl, 0.5 part of thickening agent, 0.99 part of conditioning agent, 0.25 part of pH regulator, 2 parts of emulsifier and 0.35 part of preservative.
The sunscreen agent is titanium dioxide.
The conditioner is prepared from allantoin, dipotassium glycyrrhizinate, 85% bisabolol, tocopherol evening primrose oil and ethylhexyl glycerol according to a mass ratio of 2: 2: 5: 5: 2: 5.
The thickening agent is prepared from transparent xanthan gum, carbomer U21 and SIMULGEL EG according to the mass ratio of 1: 1.5: 4.
The pH regulator is triethanolamine.
The preservative is composed of phenoxyethanol and ethylparaben according to a mass ratio of 10: 1.
The emulsifier is Sensanov WR.
The preparation method of the repairing type sunscreen composition is similar to that of example 3. The difference from example 3 is that the sunscreen agent is titanium dioxide.
Test example 1 Performance testing of a healing sunscreen composition
1. Test materials: example 1, example 2, example 3, example 4, comparative example 1, comparative example 2, comparative example 3 and comparative example 4.
2. 70 volunteers were collected and randomly divided into 7 groups of 10 persons, and the repair type sunscreen compositions prepared in example 1, example 2, example 3, example 4, comparative example 1, comparative example 2 and comparative example 3 were irradiated with a hernia lamp solar simulator of a standard ultraviolet spectrum for 30min to measure the SPF value, and then the makeup duration of the compositions was measured.
3. The experimental results are as follows: the test results are shown in table 1.
Table 1 performance test results for repair-type sunscreen compositions
As can be seen from table 1, the values of the makeup holding times of the groups of example 1, example 2, example 3, example 4, comparative example 1, comparative example 2, and comparative example 3 were all higher than the value of comparative example 4, while the makeup holding times of the groups of comparative example 1, comparative example 2, and comparative example 3 were not much different from the values of the examples, indicating that ethylhexyl glycerin and evening primrose oil had little effect on the SPF value and the makeup holding time. Meanwhile, the sunscreen effect of comparative example 4 is better than that of the example, but the makeup time is very short, so that although the sunscreen effect of the composition provided by the invention is general, the makeup time is long, and the composition has excellent practicability for daily office sunscreen.
Test example 2 repair Performance test of repair type sunscreen composition
1. Test materials: example 1, example 2, example 3, example 4, comparative example 1, comparative example 2, comparative example 3 and comparative example 4.
2. 80 mice were randomly divided into 8 groups, 10 mice each group were dehaired, the backs were shaved, local sunburn was caused by irradiation with an ultraviolet lamp, the area of sunburn skin was recorded as a1, then the repair type sunscreen compositions prepared in example 1, example 2, example 3, example 4, comparative example 1, comparative example 2, comparative example 3 and comparative example 4 were applied to the shaved backs of the mice, irradiation was performed with a hernia lamp solar simulator of standard ultraviolet spectrum for 10 hours per day for 2 days, the repair condition of the mice after sunburn was observed, the area of sunburn skin which had not been improved after repair was recorded as a2, and the repair rate after sunburn was calculated as (a1-a2)/a1 × 100%.
3. The experimental results are as follows: the test results are shown in table 2.
Table 2 post-sun repair test results for repair-type sunscreen compositions
As can be seen from the results in table 2, the after-sun repair rate of the groups of example 1, example 2, example 3 and example 4 is significantly higher than that of the groups of comparative example 1, comparative example 2 and comparative example 3, which shows that neither ethylhexyl glycerin nor evening primrose oil, which are single components, can significantly improve the after-sun repair performance of the composition, but when the two are used in combination, the after-sun repair performance of the composition can be significantly improved. And the after-sun repair performance of the comparative example 4 is still higher than that of the comparative example 1, the comparative example 2 and the comparative example 3 under the condition of poor sun-screening performance, and the combination of the ethylhexyl glycerin and the evening primrose oil can be further demonstrated to remarkably improve the after-sun repair performance of the composition.
Test example 3 comfort performance test for use of a sunscreen composition of the healing type
1. Test materials: example 1, example 2, example 3, example 4, the resulting remedial sunscreen composition and the commercially available white emulsion composition.
2. The test method comprises the following steps:
70 volunteers are collected and randomly divided into 7 groups, 10 persons in each group are allowed to use the repair type sunscreen composition prepared in the embodiment 1, the embodiment 2, the embodiment 3 and the embodiment 4 and the common white milky sunscreen cream on the market, after the repair type sunscreen composition is applied, the use refreshing comfort of the product of the volunteers is counted, the product is counted into 0-10 points, the higher the value is, the better the refreshing comfort is, and the final comfortable experience value is counted.
3. And (3) test results: the test results are shown in table 3.
Table 3 result of comfort test of use of the sunscreen composition of the restorative type
| Item | Example 1 | Example 2 | Example 3 | Example 4 | Common sunscreen cream |
| Score value | 8.8 | 9.0 | 9.5 | 8.9 | 6.3 |
As can be seen from the results in table 3, the comfort experience values for the compositions of the examples are higher than the comfort values for the common compositions, and the comfort value for example 3 is the highest.
Test example 4 bacteriostatic Property test of repairing type sunscreen composition
1. Test materials: example 1, example 2, example 3, and example 4.
2. The test method comprises the following steps: sterilizing the prepared 4 groups of repairing type sunscreen compositions by ultraviolet irradiation, respectively spreading 0.5mL on a culture dish, setting 0.5mL of normal saline, and respectively inoculating with 8.0 × 1040.5mL of CFU/mL of mold, and the number of the mold is determined by a microbial plate colony counting method after 30 min.
3. And (3) test results: the results are shown in Table 4.
TABLE 4 bacteriostatic Properties results for the sunscreen composition of the sunscreen type on repair
As can be seen from Table 4, the number of molds in each example group is significantly reduced compared with that in the normal saline group, which indicates that the repairing type sunscreen composition prepared by the invention has a good bacteriostatic effect, and the bacteriostatic effect of example 3 is the best.
Test example 5 antioxidant Performance test of a repairing sunscreen composition
1. Test materials: repair-type sunscreen compositions prepared in examples 1, 2, 3, 4, 1, 2 and 3.
2. The test method comprises the following steps: the method comprises the following steps:
(1) accurately taking 0.0197g of DPPH powder, using absolute ethyl alcohol to fix the volume to 250mL, preparing 0.2mmol/L DPPH stock solution, and measuring absorbance A at 517nm0Storing at 0 deg.C;
(2) taking 0.2mL of each of the repairing type sunscreen compositions prepared in the embodiments 1-4, mixing with 4mL of acetic acid buffer solution and 3.8mL of ethanol to obtain a sample to be detected, and measuring the absorbance A at 517 nm;
(3) respectively taking 0.5mL of each sample solution to be detected, adding 2.5mL of DPPH stock solution, reacting in a water bath kettle at a constant temperature of 28 ℃ for 30min, and measuring the absorbance A at 517nm by using an ultraviolet spectrophotometerbClearance of DPPH radical [ A ]0-(A－Ab)]/A0。
3. And (3) test results: the test results are shown in table 5.
TABLE 5 antioxidant test results for repairing sunscreen compositions
As can be seen from Table 5, the repair type sunscreen has an antioxidant property of more than 70% and a better antioxidant property.
In conclusion, the composition provided by the invention has good durability, after-sun repair performance, antibacterial and antioxidant performance, and is fresh and comfortable to use, and example 3 is obviously superior to other examples in terms of sun-proof durability, after-sun repair, antibacterial, antioxidant and use comfort, and is the best example of the invention.
Claims (10)
1. A repairing type sunscreen composition is characterized by comprising the following components in parts by weight: 14-19 parts of sun-screening agent, 68-80 parts of water, 2-4 parts of butanediol, 0.3-0.7 part of NaCl, 0.2-0.6 part of thickening agent, 0.65-0.12 part of conditioner, 0.15-0.3 part of pH regulator and 1-3 parts of emulsifier.
2. A remedial sunscreen composition according to claim 1, wherein the sunscreen comprises sunscreen dispersion paste, ethylhexyl methoxycinnamate, C12-15 alcohol benzoate, 4-methylbenzylidene camphor, ethyl diethylamino hydroxybenzoyl benzoate in a mass ratio of 3-5: 3-5: 2-4: 2-4: 1-3.
3. A remedial sunscreen composition according to claim 1 wherein the conditioning agent comprises: allantoin, dipotassium glycyrrhizinate, 85% bisabolol, tocopherol, evening primrose oil and ethylhexyl glycerol, wherein the mass ratio of allantoin to dipotassium glycyrrhizinate to the mixture is 1-3: 1-3: 4-6: 4-6: 2-4: 3-7.
4. A remedial sun protection composition according to claim 1 wherein the thickener is selected from one or more of transparent xanthan gum, carbomer U21, SIMULGEL EG.
5. The remedial sunscreen composition according to claim 1, wherein the pH adjusting agent is triethanolamine.
6. The healing sun-screening composition according to claim 1, further comprising 0.15 to 0.45 parts of a preservative.
7. A repairing type sunscreen composition according to claim 6, characterized in that the preservative is one or two of phenoxyethanol and ethylparaben.
8. A sunscreen composition for healing according to claim 1 wherein said emulsifier is SENSANOVWR.
9. Process for the preparation of a healing sunscreen composition according to any of claims 1 to 8, characterized in that it comprises the following steps:
s1 adding the sun-screening agent and the emulsifying agent into an emulsifying tank, adjusting the temperature to 70-90 ℃ by a heater, heating while stirring at 40-60r/min, and stirring at 50-70r/min for 8-12 minutes when the temperature reaches 70-90 ℃ to obtain a mixture A;
s2, adding water, butanediol, NaCl and a conditioner into a water phase pot, adjusting the temperature to 70-90 ℃ by a heater, heating while stirring at 40-60r/min, and stirring at 50-70r/min for 8-12 minutes when the temperature reaches 70-90 ℃ to obtain a mixture B;
s3, adding the mixture B obtained in the step S2 into the mixture A obtained in the step S1, and stirring for 4-6 minutes at a speed of 50-70r/min to obtain a mixture C;
s4, stirring, opening a cooling system, cooling to 45 ℃, adding the dissolved thickening agent into the mixture C obtained in the step S3, stirring for 4-6 minutes at 50-70r/min, then adding a pH regulator to adjust the pH to 5.5-6.5, and stirring for 2-4 minutes at 50-70r/min to obtain a mixture D;
s5 adding preservative into the mixture D obtained in the step S4, and stirring for 4-6 minutes at a speed of 50-70 r/min.
10. Use of a remedial sunscreen composition according to any of claims 1 to 8 in the preparation of a sunscreen cream, a sunscreen spray.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007106697A (en) * | 2005-10-13 | 2007-04-26 | Sederma Sa | New tyramine derivative, method for production of the same, cosmetic composition including the derivative or medicinal composition for skin |
| CN103189046A (en) * | 2010-09-09 | 2013-07-03 | 玫琳凯有限公司 | Topical skin care formulations comprising plant extracts |
| CN107233220A (en) * | 2017-07-20 | 2017-10-10 | 广州环亚化妆品科技有限公司 | A kind of alcohol radical sunblock lotion and preparation method thereof |
| CN107693385A (en) * | 2017-08-25 | 2018-02-16 | 漳浦彩露华化妆品有限公司 | A kind of sun-proof reparation cream base and preparation method thereof |
| CN108635274A (en) * | 2018-07-26 | 2018-10-12 | 广州环亚化妆品科技有限公司 | A kind of photoprotective composition and its preparation method and application |
-
2019
- 2019-12-31 CN CN201911421674.8A patent/CN110974734A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007106697A (en) * | 2005-10-13 | 2007-04-26 | Sederma Sa | New tyramine derivative, method for production of the same, cosmetic composition including the derivative or medicinal composition for skin |
| CN103189046A (en) * | 2010-09-09 | 2013-07-03 | 玫琳凯有限公司 | Topical skin care formulations comprising plant extracts |
| CN107233220A (en) * | 2017-07-20 | 2017-10-10 | 广州环亚化妆品科技有限公司 | A kind of alcohol radical sunblock lotion and preparation method thereof |
| CN107693385A (en) * | 2017-08-25 | 2018-02-16 | 漳浦彩露华化妆品有限公司 | A kind of sun-proof reparation cream base and preparation method thereof |
| CN108635274A (en) * | 2018-07-26 | 2018-10-12 | 广州环亚化妆品科技有限公司 | A kind of photoprotective composition and its preparation method and application |
Non-Patent Citations (2)
| Title |
|---|
| 上海康美国际生化有限公司: ""AURIC润色防护隔离霜"", 《国产非特殊用途化妆品备案信息服务平台》 * |
| 广州科盈化妆品有限公司: ""栖木 清新防护隔离乳"", 《国产非特殊用途化妆品备案信息服务平台》 * |
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