CN110974731A - 一种用于促进皮肤修复的美藤果油纳米纤维膜及其制备方法 - Google Patents
一种用于促进皮肤修复的美藤果油纳米纤维膜及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种用于促进皮肤修复的美藤果油纳米纤维膜及其制备方法,该纤维膜由聚乙烯醇1788、美藤果油、食品级吐温80和去离子水按比例配置成稳定的水包油乳液,再经静电纺丝技术制得。组成该膜的纤维粗细均匀,具有核壳结构,能将美藤果油包埋在纤维核层,达到缓慢释放美藤果油的效果。该发明提供的纤维膜对美藤果油的负载量可达到25.22%,包埋率为94.47%。
Description
技术领域
本发明涉及日化领域,具体地说,涉及一种包埋美藤果油的,用于皮肤修复的产品。
背景技术
皮肤是脊椎动物最大的器官,同时也是保护人体的第一道免疫屏障, 皮肤作为外部防御系统,可以保护人体内部组织免受微生物感染和致病体的侵害。在正常的生理条件下,人体皮肤具有自我修复能力,但当皮肤的正常结构和功能受到破坏时,人体皮肤的自我修复能力降低。
美藤果,又名印加果、印奇果,是一种大戟科木质藤本植物,已被南美印第安土著居民食用了3000多年。美藤果油是一种无毒、安全的食用植物油,富含a-亚麻酸、维生素E、多酚等脂质活性成分。Gonzalez-Aspajo等用美藤果油处理体外培养的粘附金黄色葡萄球菌的人皮肤外植体和角质形成细胞,结果表明,美藤果油作用于皮肤细胞是安全可靠的,能够有效的抑制金黄黄色葡萄球菌在皮肤上的粘附,可预防和治疗皮肤感染葡萄球菌。美藤果油用于皮肤上,可以隔离有害物质、减少皮肤被刺激,防止细菌、真菌滋生感染,促进皮肤修复,达到修护皮肤的目的。
聚乙烯醇是由聚醋酸乙烯酯水解而成的一种水溶性高分子聚合物,具有良好的亲水性能,无毒、生物相容性好,有很好的可纺性及成膜性,用静电纺丝法制备的PVA膜透湿透气性好及质地柔韧,适用于皮肤护理。
静电纺丝技术是利用聚合物溶液或熔体在高压电场作用下形成喷射流拉伸从而形成纳米或微米级直径纤维的技术。静电纺丝纤维具有生物相容性好、比表面积大、孔隙率高、易改性和成本低等优点,可用于合成核-壳结构纤维、中空结构纤维等新型生物材料,在再生医学、组织工程、创伤敷料,药物传递系统等领域研究广泛,作为皮肤护理领域具有良好的应用前景。
目前市面上促进皮肤修护的产品大多数都是膏药类产品或传统的敷料,这类产品易对皮肤产生刺激性且皮肤容易产生耐药性,患者使用感受不佳,在使用过程中常因患处不洁造成二次感染,加重患处的程度。
发明内容
本发明的目的是克服目前修护皮肤产品对皮肤产生刺激性且容易产生耐药性的缺陷,而提供一种用于促进皮肤修护的美藤果油纳米纤维膜及其制备方法。
为了实现上述目的,本发明采用如下技术方案:
一种用于促进皮肤修复的美藤果油纳米纤维膜,由如下质量份的组分制成:
聚乙烯醇1788 12-16,
美藤果油 3-7,
吐温80 0.6-1.2,
去离子水 84-88。
上述用于促进皮肤修复的美藤果油纳米纤维膜的制备方法,包括以下步骤:
(1)将聚乙烯醇1788溶解于去离子水中,得到水相溶液;
(2)将美藤果油与吐温80混合均匀,得到油相溶液;
(3)将上述水相溶液逐滴加入油相中,充分混合,搅拌均匀得到稳定的水包油型乳液;
(4)将上述水包油型乳液静电纺丝,得到含美藤果油的纳米纤维膜。纤维丝在纺丝机滚筒上沉积复合成膜,颜色为白色,即为美藤果油纳米纤维膜。
作为优选的,在上述制备方法中,步骤(2)中,将美藤果油与吐温80混合均匀的方法为:以1000~2000rpm的转速搅拌30min。
作为优选的,在上述制备方法中,步骤(3)中,将油相逐滴加入到水相中后,再以1000~2000rpm的转速搅拌240~300min。
作为优选的,在上述制备方法中,步骤(4)中,静电纺丝的电压为16~27kV,接收距离为10~16cm,乳液流速为0.5~1.0ml/h。
所述的美藤果油是由美藤果去壳破碎后低温压榨过滤制得,美藤果油含有丰富的多不饱和脂肪酸和维生素E,对人体皮肤有良好的亲和性、渗透性、抗氧化性和抗炎性,将美藤果油纳米纤维膜敷于皮肤上可以促进皮肤细胞新陈代谢,激活表皮细胞,并在皮肤表面形成保护膜,防止皮肤水分和功效物质流失,促进皮肤的修护。
与现有技术相比,本发明具有如下有益效果:本发明的美藤果油纳米纤维膜,形成的膜质地柔软,纤维丝具有核壳结构,能达到对美藤果油缓慢长效的释放效果,在提高美藤果油稳定性的同时改善了使用的效果,能够抗金黄色葡萄球菌黏附,促进皮肤修护。本发明制备工艺简单,无需复杂设备,各成分只需溶解后、搅拌混合均匀,经静电纺丝机按一定条件参数制备,所需控制的溶解条件、搅拌速度和纺丝条件易于实现,操作简单,生产风险小。
本发明最大的创新在于:筛选组分和配比,制成稳定的水包油乳液,利用静电纺丝技术制得具有核壳结构的纳米纤维膜,使美藤果油包埋在核层,缓慢释放美藤果油,可抗金黄色葡萄球菌黏附,制备过程安全无毒,工艺简单。组成该膜的纤维粗细均匀,具有核壳结构,能将美藤果油包埋在纤维核层,达到缓慢释放美藤果油的效果。该发明提供的纤维膜对美藤果油的负载量可达到25.22%,包埋率为94.47%。
具体实施方式
为详细说明本发明的技术内容、所实现目的及效果,以下结合实施例对本发明进一步详细说明。
实施例1:
一种美藤果油纳米纤维膜,由以下原料组分及重量份配比而成:组分A:聚乙烯醇1788,14,去离子水86;组分B:美藤果油5,吐温80,1.0;
制备方法如下:a.将组分A混合,搅拌溶解,充分混合;
b.将组分B混合,搅拌均匀,搅拌速度为2000rpm/min,搅拌30min;
c.将A相溶液逐滴滴加到B相溶液,以1500rpm的转速搅拌300min,混合均匀;
d.将配置好的乳液装至注射器中,使用静电纺丝机制备,纺丝的电压为24kV,接收距离为16cm,乳液流速为1.0ml/h;纤维丝在纺丝机滚筒上接收,沉积复合成膜状,颜色为白色,即为美藤果油纳米纤维膜。,本发明以美藤果油为油相,与水和聚乙烯醇为水相溶液,通过低能相转变法制备成水包油乳液后,经静电纺丝而成膜状制品,达到了美藤果油的缓慢释放,可抑制金黄色葡萄球菌的黏附,促进皮肤伤口的愈合。所得纤维膜对美藤果油的负载量可达到25.22%,包埋率为94.47%。
实施例2:
一种美藤果油纳米纤维膜,由以下原料组分及重量份配比而成:组分A:聚乙烯醇1788,16,去离子水84组分B:美藤果油6,吐温80,1.2;
制备方法如下:a.将组分A混合,搅拌溶解,充分混合;
b.将组分B混合,搅拌均匀,搅拌速度为2000rpm/min,搅拌30min;
c.将A相溶液逐滴滴加到B相溶液,以1500rpm的转速搅拌300min,混合均匀;
d.将配置好的乳液装至注射器中,使用静电纺丝机制备,纺丝的电压为24kV,接收距离为16cm,乳液流速为1.0ml/h;纤维丝在纺丝机滚筒上接收,沉积复合成膜状,颜色为白色,即为美藤果油纳米纤维膜。,本发明以美藤果油为油相,与水和聚乙烯醇为水相溶液,通过低能相转变法制备成水包油乳液后,经静电纺丝而成膜状制品,达到了美藤果油的缓慢释放,可抑制金黄色葡萄球菌的黏附,促进皮肤伤口的愈合。
实施例3:
一种美藤果油纳米纤维膜,由以下原料组分及重量份配比而成:组分A:聚乙烯醇1788,12,去离子水88;组分B:美藤果油3,吐温80,0.6;
制备方法如下:a.将组分A混合,搅拌溶解,充分混合;
b.将组分B混合,搅拌均匀,搅拌速度为2000rpm/min,搅拌30min;
c.将A相溶液逐滴滴加到B相溶液,以1500rpm的转速搅拌300min,混合均匀;
d.将配置好的乳液装至注射器中,使用静电纺丝机制备,纺丝的电压为24kV,接收距离为16cm,乳液流速为1.0ml/h;纤维丝在纺丝机滚筒上接收,沉积复合成膜状,颜色为白色,即为美藤果油纳米纤维膜。,本发明以美藤果油为油相,与水和聚乙烯醇为水相溶液,通过低能相转变法制备成水包油乳液后,经静电纺丝而成膜状制品,达到了美藤果油的缓慢释放,可抑制金黄色葡萄球菌的黏附,促进皮肤伤口的愈合。
Claims (5)
1.一种用于促进皮肤修复的美藤果油纳米纤维膜,其特征在于,由如下质量份的组分制成:
聚乙烯醇1788 12-16,
美藤果油 3-7,
吐温80 0.6-1.2,
去离子水 84-88。
2.权利要求1所述用于促进皮肤修复的美藤果油纳米纤维膜的制备方法,其特征在于,包括以下步骤:
(1)将聚乙烯醇1788溶解于去离子水中,得到水相溶液;
(2)将美藤果油与吐温80混合均匀,得到油相溶液;
(3)将上述水相溶液逐滴加入油相中,充分混合,搅拌均匀得到稳定的水包油型乳液;
(4)将上述水包油型乳液静电纺丝,得到含美藤果油的纳米纤维膜。
3.根据权利要求2所述的制备方法,其特征在于,步骤(2)中,将美藤果油与吐温80混合均匀的方法为:以1000~2000rpm的转速搅拌30min。
4.根据权利要求2所述的制备方法,其特征在于,步骤(3)中,将油相逐滴加入到水相中后,再以1000~2000rpm的转速搅拌240~300min。
5.根据权利要求2所述的制备方法,其特征在于,步骤(4)中,静电纺丝的电压为16~27kV,接收距离为10~16cm,乳液流速为0.5~1.0ml/h。
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CN114687073A (zh) * | 2022-03-30 | 2022-07-01 | 华南农业大学 | 一种负载β-胡萝卜素的木质素乳液电纺纳米纤维膜及其制备方法和应用 |
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