CN110973159A - Antibacterial composition containing cannabidiol and application thereof - Google Patents
Antibacterial composition containing cannabidiol and application thereof Download PDFInfo
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- CN110973159A CN110973159A CN201911043430.0A CN201911043430A CN110973159A CN 110973159 A CN110973159 A CN 110973159A CN 201911043430 A CN201911043430 A CN 201911043430A CN 110973159 A CN110973159 A CN 110973159A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
- A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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Abstract
The invention relates to an antibacterial composition containing cannabidiol and application thereof. The antibacterial composition containing cannabidiol comprises cannabidiol and an inorganic antibacterial agent. Compared with the prior art, the cannabidiol is compounded with the existing inorganic antibacterial agent, so that the cannabidiol can ensure the effectiveness of the inorganic antibacterial agent and enhance the antibacterial performance of the inorganic antibacterial agent; and can effectively stabilize inorganic antibacterial agent, so that it does not change colour and does not deteriorate.
Description
Technical Field
The invention belongs to the technical field of daily chemical production, and particularly relates to an antibacterial composition containing cannabidiol and application thereof.
Background
The heavy metal antibacterial agent is mainly prepared by loading heavy metals such as silver, copper, zinc and the like or heavy metal ions on the surface of an inorganic carrier such as zeolite, silica gel and other porous materials. Mercury and cadmium ions are harmful to human body; copper, nickel and cobalt ions have certain colors and influence the appearance of the product. The action strength of metal ions on the bacteria shows that the sterilization action sequence is Ag+>>Cu2+>Fe3+>Sn2+>Al3+>Zn2+>Co2+. Silver ions are seen to have a very good bactericidal effect compared to other metal ions, and for this reason, most of the inorganic antibacterial agents that are now commercially available are inorganic substances containing silver or silver ions.
The silver-based antibacterial agent has a long application history and plays a great role in human health. And in terms of safety and antibacterial effect, the inorganic silver antibacterial agent and the silver composite antibacterial agent have the advantages of long acting, high efficiency, broad spectrum, safety and the like. Silver has been found to have natural antibacterial properties and safety in ancient times. At that time, the ancient Egypt people know that the thin silver sheet covers the wound to prevent bacterial infection, the Mongolian people who accelerate wound healing know that the sheep milk contained in the silver container can keep fresh, and the Ministry physicians Li Shizhen in the compendium of materia medica of China has the effects of calming the five internal organs, calming the heart, stopping fright palpitation, eliminating pathogenic qi and the like, can take the sheep milk for a long time to lighten the body and prolong the life, has the raw silver taste and is pungent and cold, is nontoxic, and has the traditional Chinese medicine silver diagnosis and treatment related diseases, and the western medicine silver treatment has the record of over 100 years. In 1884, German obstetrician Crede dropped 1% silver nitrate solution into eyes of newborn infants to prevent conjunctivitis of newborn infants, and the blindness rate of infants was reduced from 10% to 0.2%. In 1893, tests show that silver has a killing effect on microorganisms such as bacteria, and the silver has a wider medical effect until today. 0.5% silver nitrate is a standard solution for treating burns and wounds; the silver nitrate with the concentration of 10-20% can be applied to treat the uterine erosion. Researches show that the silver has strong killing effect on various pathogenic bacteria such as escherichia coli, staphylococcus aureus and the like, the required concentration is extremely low, and the general dosage is 10-6And (mass fraction) sterilizing. In thatIn the aspect of safety, silver is one of tissue components in a human body, cells treated by silver ions with very low concentration have no obvious changes of cell aggregation, cell deformation, cell lysis, pH value and the like, and a small amount of silver ions have no obvious harm to the human body. Therefore, the silver-based antibacterial agent is used for improving the antibacterial function of the textile and has sufficient safety.
The silver antibacterial agent has many advantages as an inorganic antibacterial agent, but the silver antibacterial agent has unstable property, nano silver is easy to agglomerate and discolor, silver ions are easy to be converted into brown silver oxide or black simple substance silver through ultraviolet light catalytic reduction, and the external quality and antibacterial performance of the product are influenced. The composite antibacterial agent is a development direction of antibacterial materials, and many researches prove that the composite antibacterial agent has a better antibacterial effect than a single metal antibacterial agent.
Cannabidiol (Cannabidial) CBD is white to light yellow resin or crystal, melting point 66-67 deg.C, and is almost insoluble in water or 10% sodium hydroxide solution, and is dissolved in ethanol, methanol, ether, benzene, chloroform and petroleum ether.
Cannabidiol is a main chemical component in medicinal plant cannabis sativa, is extracted from female cannabis sativa plants, is a non-addictive component in cannabis sativa, and has pharmacological effects of resisting spasm, anxiety and inflammation. CBD not only can be used for treating various difficult and complicated diseases, but also can effectively eliminate the hallucinogenic effect of Tetrahydrocannabinol (THC) on human bodies, and is called as an anti-drug compound (anti-marijuana compound).
Disclosure of Invention
Based on this, the present invention aims to provide an antibacterial composition containing cannabidiol and the application thereof, so as to effectively overcome the defects in the prior art.
In order to achieve the purpose, the invention adopts the following technical scheme:
an antibacterial composition containing cannabidiol comprises cannabidiol and inorganic antibacterial agent.
Compared with the prior art, the antibacterial composition containing the cannabidiol is prepared by compounding the cannabidiol with the existing inorganic antibacterial agent, and the cannabidiol can not only ensure the effectiveness of the inorganic antibacterial agent, but also enhance the antibacterial performance of the inorganic antibacterial machine. And it can also effectively stabilize inorganic antibacterial agent, and make it not change colour and deteriorate.
Further, the cannabidiol is derived from natural plant extracts or chemically synthesized.
Further, the inorganic antibacterial agent is a metal antibacterial agent.
Further, the metal antibacterial agent is one or more of colloidal silver simple substance, silver ions or silver complex ions; the solvent of the metal antibacterial agent is water. The silver-based antibacterial agent has many advantages, and has the characteristics of long acting, high efficiency, broad spectrum, safety and the like.
Further, the total silver content in the antibacterial composition is 150-1500ppm, and the cannabidiol content is 2.5-50 ppm. The antibacterial performance can be better exerted only when the silver content reaches a certain value.
Furthermore, the mass ratio of the cannabidiol to the total silver in the antibacterial composition is 1:3-1: 150.
Further, the preparation method of the antibacterial composition containing cannabidiol comprises the following steps: dissolving cannabidiol in a solvent, dispersing by microwave, adding an inorganic antibacterial agent, and uniformly stirring to obtain the cannabidiol.
Further, the frequency of the microwave dispersion is 1000 MHz-100 GHz.
Further, the solvent is ethanol, and the dosage of the ethanol is more than or equal to that of the cannabidiol.
Another object of the present invention is to provide an antibacterial composition comprising cannabidiol for use in daily use chemical products such as dish detergents, fabric detergents, cosmetics, and disinfectants.
According to the antibacterial composition containing cannabidiol, cannabidiol and a silver antibacterial agent are compounded to form a compound antibacterial composition, wherein the cannabidiol can stabilize a metal antibacterial agent, ensure that silver does not generate physical and chemical reactions, ionic silver does not react with chloride ions in a detergent formula, the effectiveness of the silver antibacterial agent can be ensured, and the product does not yellow. Cannabidiol can also enhance the bactericidal and bacteriostatic effects of the silver antibacterial agent.
For a better understanding and practice, the present invention is described in detail below.
Detailed Description
The present invention will be described in further detail with reference to examples
The invention provides an antibacterial composition containing cannabidiol and application thereof.
The cannabidiol is extracted from natural plants or chemically synthesized.
Plant extraction of cannabidiol: is extracted from mature industrial hemp stem with Tetrahydrocannabinol (THC) content less than 0.3%.
Biosynthetic pathway of cannabidiol: the C10 terpene moiety in the chemical structure of CBD is synthesized mainly through the deoxyxylulose phosphate pathway, and the phenol moiety comes from the polyketide-type reactivity sequence (polyketide-type reaction sequence), and geranyl diphosphate (GPP) and olyacetoxylic acid (oa) are considered as special intermediates in the hemp chemical composition synthesis pathway. CBD synthases have been found to synthesize CBD from Cannabigerol (CBG). Isopentene diphosphate (IPP) and dimethyl propenyl diphosphate (DM APP) react firstly, generated GPP reacts with OA to generate CBG, and CBG generates CBD, THC and carboxylic acid compounds thereof under the action of CBD synthase.
Chemical synthesis route of cannabidiol: the chemical synthesis pathway of cannabidiol is reported in many documents, and the most classical synthesis method is as follows:
the most classical synthesis of Cannabidiol (CBD)
P-mentha-2, 8-diene-1-ol (1) and 5-amyl-1, 3-benzenediol (2) in BF3The reaction is carried out under the catalysis of (1), 3 products are obtained, wherein the yield of CBD is 41%. Since the raw materials are easily available, the reaction is simple, and the CBD yield is high, the raw materials are used as synthetic CBD for a long timeThe general method of (1).
The inorganic antibacterial agent is a metal antibacterial agent, and the metal antibacterial agent is one or a mixture of more than one of colloidal silver simple substance, silver ions or silver complex ions. The solvent of the silver-based antibacterial agent is water. The silver-based antibacterial agent has many advantages, and has the characteristics of long acting, high efficiency, broad spectrum, safety and the like.
Preferably, the content of cannabidiol in the antibacterial composition is 2.5-50ppm, and the total silver content is 150-1500 ppm. And the mass ratio of cannabidiol to total silver in the antibacterial composition is 1:3-1: 150.
Preferably, when cannabidiol is extracted, the extraction method can be a carbon dioxide supercritical extraction method, and the extracted CBD crude extract is subjected to molecular distillation and resin adsorption to obtain high-purity CBD.
Further, the preparation method of the antibacterial composition containing cannabidiol comprises the following steps: dissolving cannabidiol in a solvent, dispersing by microwave, adding an inorganic antibacterial agent, and uniformly stirring to obtain the cannabidiol.
The frequency of microwave irradiation is preferably 1000 MHz-100 GHz, and when cannabidiol is subjected to microwave irradiation, electrons on double bonds absorb energy and can be more effectively combined with silver or silver ions.
The antibacterial composition can be applied to daily chemical products such as tableware detergent, fabric detergent, cosmetics, disinfectant and the like.
The application and bacteriostatic, bactericidal and stabilizing effects of an antibacterial composition containing cannabidiol of the present invention will be specifically described by the following examples and comparative examples. In specific implementation, the antibacterial composition is used in an amount of 0.1% -3% in various applications.
The invention has made 7 groups of experiments altogether, each group of experiments is divided into an example and two control examples, and tables 1-4 list the composition situation of the sample in each example and control example. Tables 5 to 8 show the effects of the examples and the comparative examples.
Table 1
Table 2
Table 3
Table 4
Effect test
The following examples and comparative examples were tested to examine the bacteriostatic and bactericidal properties of the antibacterial composition of the present invention against various bacteria and the property of stabilizing silver in a silver-based antibacterial agent. Antibacterial and bacteriostatic properties: the method is carried out according to a 5.1.1 suspension quantitative antibacterial test and a 5.2.1 suspension quantitative antibacterial test in a standard WS/T650-2019 antibacterial and antibacterial effect evaluation method, wherein the test concentration is 1%. Tables 5 to 8 show the effects of the examples and the comparative examples.
Table 5
Table 6
Table 7
Table 8
The sample compositions of the examples and the comparative examples are shown in tables 1 to 4, and it can be seen from the tables that the antibacterial compositions of the present invention (including cannabidiol and silver antibacterial agent) were used in each of the examples, while the silver antibacterial agent was added only to the comparative example a group, and cannabidiol was added alone to the comparative example B group, in amounts corresponding to the respective examples.
As can be seen from the results of the experiments in tables 5 to 8, the antibacterial composition of the present invention (including cannabidiol and silver antibacterial agent) has better antibacterial performance and bactericidal performance than the silver antibacterial agent alone, and the sample has better stability and is not easy to discolor. The comparison between the examples and the comparative examples shows that the cannabidiol and the silver-based antibacterial agent are compounded with each other, so that the antibacterial performance and the bactericidal performance of the cannabidiol can be obviously improved, and the cannabidiol can also stabilize silver ions to prevent the silver ions from being oxidized and yellowed, enhance the stability of the cannabidiol and obviously improve the application of the cannabidiol in various daily chemical products.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.
Claims (10)
1. An antibacterial composition comprising cannabidiol, characterized in that it comprises cannabidiol and an inorganic antibacterial agent.
2. The antibacterial composition containing cannabidiol as claimed in claim 1, wherein: the cannabidiol is extracted from natural plants or chemically synthesized.
3. The antibacterial composition containing cannabidiol as claimed in claim 1, wherein: the inorganic antibacterial agent is a metal antibacterial agent.
4. The antibacterial composition containing cannabidiol as claimed in claim 3, wherein: the metal antibacterial agent is one or more of colloidal silver simple substance, silver ions or silver complex ions; the solvent of the metal antibacterial agent is water.
5. The antibacterial composition containing cannabidiol as claimed in claim 4, wherein: the content of cannabidiol in the antibacterial composition is 2.5-50ppm, and the total silver content is 150-1500 ppm.
6. The antibacterial composition containing cannabidiol as claimed in claim 5, wherein: the mass ratio of cannabidiol to total silver in the antibacterial composition is 1:3-1: 150.
7. The antibacterial composition containing cannabidiol as claimed in claim 1, wherein the antibacterial composition containing cannabidiol is prepared by: dissolving cannabidiol in a solvent, dispersing by microwave, adding an inorganic antibacterial agent, and uniformly stirring to obtain the cannabidiol.
8. The antibacterial composition containing cannabidiol as claimed in claim 7, wherein the frequency of the microwave is 1000MHz to 100 GHz.
9. The antibacterial composition containing cannabidiol as claimed in claim 7, wherein the solvent is ethanol, and the amount of ethanol is greater than or equal to the amount of cannabidiol.
10. Use of an antibacterial composition comprising cannabidiol as claimed in any one of claims 1 to 7.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113152094A (en) * | 2021-05-27 | 2021-07-23 | 烟台明远创意生活科技股份有限公司 | Bedding fabric and preparation method thereof |
| WO2022016269A1 (en) * | 2020-07-22 | 2022-01-27 | The University Of British Columbia | Silver enhanced cannabinoid antibiotics |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2022016269A1 (en) * | 2020-07-22 | 2022-01-27 | The University Of British Columbia | Silver enhanced cannabinoid antibiotics |
| CN113152094A (en) * | 2021-05-27 | 2021-07-23 | 烟台明远创意生活科技股份有限公司 | Bedding fabric and preparation method thereof |
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