CN108042663B - Composition for whitening skin, removing freckles and preventing urinary system infection and preparation method and application thereof - Google Patents
Composition for whitening skin, removing freckles and preventing urinary system infection and preparation method and application thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
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- Public Health (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Polymers & Plastics (AREA)
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Abstract
The invention discloses a composition for whitening, removing freckles and preventing urinary system infection, and a preparation method and application thereof, wherein the composition for whitening, removing freckles and preventing urinary system infection comprises the following components in parts by weight: 40-60 parts of roselle extract, 10-20 parts of cranberry extract and 20-40 parts of grape seed extract. The composition for whitening, removing freckles and preventing urinary system infection is prepared by weighing the components in parts by weight and uniformly mixing. The invention also provides application of the composition in one or more fields of whitening, spot lightening and preventing and treating female urinary system infection. Compared with a single raw material, the composition disclosed by the invention can realize whitening and spot-lightening and prevent female urinary system infection from all-around and multi-target angles, and can achieve a better effect in a minimum amount. Aiming at the functions of the invention, the composition of the invention has obvious synergistic effect and good market popularization value.
Description
Technical Field
The invention relates to the technical field of health-care food. More particularly, relates to a composition for whitening skin, removing spots and preventing urinary system infection, and a preparation method and application thereof.
Background
For women, it is a constant topic for women to have beautiful appearance and a healthy body. In addition to the maintenance function of cosmetics, how to eat beautiful and healthy is also more and more concerned by women. With the age, living habits, stress, environmental influences and other factors, many women are troubled by two problems, one is the occurrence of brown spots, and the other is urinary system infection.
The color of human skin is mainly determined by the content and distribution of melanin, blackThe structure and number of the pigment cells directly influence the melanin content in the skin and are the determining factors for melanin production. The brown spot is caused by that melanocyte existing in the epidermis basal layer of skin extends to surrounding keratinocyte, the cytoplasm of the melanocyte contains melanosome, the melanocyte contains tyrosinase, the tyrosinase is activated by a plurality of factors such as ultraviolet rays, emotion, pressure, pregnancy and the like, and the tyrosinase is activated at O2The substance can be oxidized, catalyzed and polymerized to form melanin granules through different ways, and then transferred to the surface layer of skin under the promotion of cell metabolism, and color spots are formed by gradual accumulation and precipitation.
According to research and research, another common problem which causes female troubles with aging is urinary system infection, wherein more than 50% of women are statistically infected with urinary system diseases, 20% of women are infected repeatedly, and the main cause of urinary system infection in women is bacterial proliferation, and the pathogenic bacteria of the urinary system infection is mainly Escherichia coli. Currently, most women take lotions and medications to combat infection.
In the patent, cranberry, roselle and red bean cowberry extracts are matched to achieve the effect of treating urinary system infection, on one hand, the patent does not fully describe and verify the formula mechanism and the synergistic effect between materials, on the other hand, the test intake of the patent population is almost 1.5 times of that of the patent, and the invention can simultaneously achieve the effects of whitening and fading spots for women and preventing and treating the urinary system infection for women with smaller intake.
Therefore, the invention provides a composition for whitening, removing freckles, preventing and treating urinary system infection, and a preparation method and application thereof.
Disclosure of Invention
An object of the present invention is to provide a composition for whitening skin, removing spots, and preventing and treating urinary system infection; the composition is designed according to the induction mechanism of symptoms such as female brown spot generation, urinary tract infection and the like on the basis of female physiological characteristics, and aims to provide a composition for efficiently whitening and lightening spots and preventing urinary tract infection for vast females.
Another object of the present invention is to provide a method for preparing a composition for whitening skin, removing spots, and preventing and treating urinary system infection.
The third purpose of the invention is to provide the application of the composition for whitening, removing freckles and preventing urinary system infection.
In order to achieve the purpose, the invention adopts the following technical scheme:
a composition for whitening skin, removing freckles and preventing urinary system infection comprises the following components in parts by weight: 40-60 parts of roselle extract, 20-40 parts of grape seed extract and 10-20 parts of cranberry extract. The composition completely selects plant extracts, and aims to comprehensively, safely and effectively help women siblings to achieve the effects of lightening spots, whitening and reducing urinary system infection.
The composition of the invention achieves the effects of spot-lightening and whitening and preventing urinary system infection through the synergistic multiplication effect and multiple defense mechanisms of all the components, and the main action mechanism is as follows: the composition for whitening and lightening the spots mainly comprises a grape seed extract and a cranberry extract, wherein the roselle extract contains procyanidine, anthocyanin and anthocyanin, and the components have strong oxidation resistance, can inhibit tyrosinase oxidation and reduce brown spot generation. The invention provides a composition for preventing female urinary infection, which mainly comprises the following components: the cranberry is rich in unique A-type procyanidine, and can effectively reduce the cell adhesion capability of bacteria; the roselle extractive contains certain organic acid which can reduce the survival rate of bacteria; the grape seed extract is rich in procyanidine, can regulate and activate the immune response of macrophages, has a certain anti-inflammatory effect, and can prevent or relieve female urinary system infection diseases from different angles.
A series of precise and large experiments prove that the roselle extract, the grape seed extract and the cranberry extract are matched with each other and have a synergistic effect, so that the effects of whitening, removing freckles and preventing urinary system infection are optimal, and the composition is weakened to different degrees in certain aspects due to the absence of any extract, the increase or decrease of the weight of any extract compared with the range of the invention, or the replacement of any extract by other extracts.
Preferably, the content of organic acid in the roselle extractive is 12-16%.
Preferably, the content of A-type procyanidin in the cranberry extract is 4.5-6.5%.
Preferably, the content of procyanidine in the grape seed extract is 85-95%.
A large number of experiments prove that when the content of organic acid in roselle is within the range of 12-16%, the content of A-type procyanidine in a cranberry extract is within the range of 4.5-6.5%, and the content of procyanidine in a grape seed extract is within the range of 85-95%, the freckle removing and bacteriostatic effect of the composition is better.
The invention also provides a preparation method of the composition, which comprises the following steps: weighing the components in parts by weight, and mixing uniformly.
Furthermore, the composition of the invention can be processed and prepared into tablets, oral liquid, solid beverage and the like by adding proper auxiliary materials according to the conventional technology in the field.
The composition is applied to one or more fields of whitening, spot lightening and preventing and treating female urinary system infection.
Preferably, the composition is used for the preparation of a medicament, food, health product or cosmetic in the above-mentioned fields.
It should be noted that, in the present invention, it is also within the scope of the present invention to replace the grape seed extract, the roselle extract and the cranberry extract with grape fruit powder, roselle powder or instant roselle powder and cranberry powder, respectively.
Unless otherwise specified, all starting materials for use in the present invention are commercially available and any range recited herein includes any endpoints and any numerical values therebetween and any subranges therebetween.
The invention has the following beneficial effects:
1. compared with a single raw material, the composition can realize whitening and spot-lightening, and prevention and treatment of female urinary system infection from all-round and multi-target angles, and can achieve better effect with minimum amount.
2. Aiming at the functions of the invention, the composition of the invention has obvious synergistic effect and good market popularization value.
3. The composition disclosed by the invention is simple in preparation method, and the effects of whitening and fading spots and preventing urinary system infection are achieved through the synergistic multiplication effect of the components and multiple defense mechanisms.
4. The composition disclosed by the invention selects the three raw materials which are all natural herbs, so that the composition has higher safety and can be used by a user at ease.
Detailed Description
To illustrate the invention more clearly, the invention is further described below in connection with preferred examples in which the invention incorporates the filling material sorbitol in such proportions as to ensure the intake of the roselle extract, cranberry extract and grape seed extract during the trial, without this material affecting the effectiveness of the composition. It is to be understood by persons skilled in the art that the following detailed description is illustrative and not restrictive, and is not to be taken as limiting the scope of the invention.
In the present invention, the preparation methods are all conventional methods unless otherwise specified. The starting materials used are commercially available from published sources unless otherwise specified.
Example 1A composition for whitening skin, removing spots and preventing urinary system infection
A preparation method of a composition for whitening skin, removing freckles and preventing urinary system infection comprises the following steps:
1) weighing the following components in parts by weight: 40 parts of roselle extract (with the organic acid content of 8%), 10 parts of cranberry extract (with the A-type procyanidin content of 2.5%) and 20 parts of grape seed extract (with the procyanidin content of 75%);
2) and uniformly mixing the weighed roselle extract, cranberry extract and grape seed extract in a three-dimensional mixer to obtain the rose-cranberry grape seed extract.
Example 2A composition for whitening skin and removing spots and preventing urinary system infection
A preparation method of a composition for whitening skin, removing freckles and preventing urinary system infection comprises the following steps:
1) weighing the following components in parts by weight: 40 parts of roselle extract (with the organic acid content of 8%), 15 parts of cranberry extract (with the A-type procyanidin content of 2.5%) and 30 parts of grape seed extract (with the procyanidin content of 75%);
2) and uniformly mixing the weighed roselle extract, cranberry extract and grape seed extract in a three-dimensional mixer to obtain the rose-cranberry grape seed extract.
Example 3A composition for whitening skin and removing spots and preventing urinary system infection
A preparation method of a composition for whitening skin, removing freckles and preventing urinary system infection comprises the following steps:
1) weighing the following components in parts by weight: 40 parts of roselle extract (with the organic acid content of 8%), 20 parts of cranberry extract (with the A-type procyanidin content of 2.5%) and 40 parts of grape seed extract (with the procyanidin content of 75%);
2) and uniformly mixing the weighed roselle extract, cranberry extract and grape seed extract in a three-dimensional mixer to obtain the rose-cranberry grape seed extract.
Example 4A composition for whitening skin and removing spots and preventing urinary system infection
A preparation method of a composition for whitening skin, removing freckles and preventing urinary system infection comprises the following steps:
1) weighing the following components in parts by weight: 50 parts of roselle extract (with the organic acid content of 8%), 10 parts of cranberry extract (with the A-type procyanidin content of 2.5%) and 30 parts of grape seed extract (with the procyanidin content of 75%);
2) and uniformly mixing the weighed roselle extract, cranberry extract and grape seed extract in a three-dimensional mixer to obtain the rose-cranberry grape seed extract.
Example 5A composition for whitening skin and removing spots and preventing urinary system infection
A preparation method of a composition for whitening skin, removing freckles and preventing urinary system infection comprises the following steps:
1) weighing the following components in parts by weight: 50 parts of roselle extract (with the organic acid content of 8%), 15 parts of cranberry extract (with the A-type procyanidin content of 2.5%) and 40 parts of grape seed extract (with the procyanidin content of 75%);
2) and uniformly mixing the weighed roselle extract, cranberry extract and grape seed extract in a three-dimensional mixer to obtain the rose-cranberry grape seed extract.
Example 6A composition for whitening skin and removing spots and preventing urinary system infection
A preparation method of a composition for whitening skin, removing freckles and preventing urinary system infection comprises the following steps:
1) weighing the following components in parts by weight: 50 parts of roselle extract (with the organic acid content of 8%), 20 parts of cranberry extract (with the A-type procyanidin content of 2.5%) and 20 parts of grape seed extract (with the procyanidin content of 75%);
2) and uniformly mixing the weighed roselle extract, cranberry extract and grape seed extract in a three-dimensional mixer to obtain the rose-cranberry grape seed extract.
Example 7A composition for whitening skin, removing spots and preventing urinary system infection
A preparation method of a composition for whitening skin, removing freckles and preventing urinary system infection comprises the following steps:
1) weighing the following components in parts by weight: 60 parts of roselle extract (with the organic acid content of 8%), 10 parts of cranberry extract (with the A-type procyanidin content of 2.5%) and 40 parts of grape seed extract (with the procyanidin content of 75%);
2) and uniformly mixing the weighed roselle extract, cranberry extract and grape seed extract in a three-dimensional mixer to obtain the rose-cranberry grape seed extract.
Example 8A composition for whitening skin, removing spots and preventing urinary system infection
A preparation method of a composition for whitening skin, removing freckles and preventing urinary system infection comprises the following steps:
1) weighing the following components in parts by weight: 60 parts of roselle extract (with the organic acid content of 8%), 15 parts of cranberry extract (with the A-type procyanidin content of 2.5%) and 20 parts of grape seed extract (with the procyanidin content of 75%);
2) and uniformly mixing the weighed roselle extract, cranberry extract and grape seed extract in a three-dimensional mixer to obtain the rose-cranberry grape seed extract.
Example 9A composition for whitening skin, removing spots and preventing urinary system infection
A preparation method of a composition for whitening skin, removing freckles and preventing urinary system infection comprises the following steps:
1) weighing the following components in parts by weight: 60 parts of roselle extract (with the organic acid content of 8%), 20 parts of cranberry extract (with the A-type procyanidin content of 2.5%) and 30 parts of grape seed extract (with the procyanidin content of 75%);
2) and uniformly mixing the weighed roselle extract, cranberry extract and grape seed extract in a three-dimensional mixer to obtain the rose-cranberry grape seed extract.
Example 10A composition for whitening skin, removing spots and preventing urinary system infection
A preparation method of a composition for whitening skin, removing freckles and preventing urinary system infection comprises the following steps:
1) weighing the following components in parts by weight: 40 parts of roselle extract (with the organic acid content of 8%), 20 parts of cranberry extract (with the A-type procyanidin content of 4.5%) and 40 parts of grape seed extract (with the procyanidin content of 85%);
2) and uniformly mixing the weighed roselle extract, cranberry extract and grape seed extract in a three-dimensional mixer to obtain the rose-cranberry grape seed extract.
Example 11A composition for whitening skin, removing spots and preventing urinary system infection
A preparation method of a composition for whitening skin, removing freckles and preventing urinary system infection comprises the following steps:
1) weighing the following components in parts by weight: 40 parts of roselle extract (with the organic acid content of 8%), 20 parts of cranberry extract (with the A-type procyanidin content of 6.5%) and 40 parts of grape seed extract (with the procyanidin content of 95%);
2) and uniformly mixing the weighed roselle extract, cranberry extract and grape seed extract in a three-dimensional mixer to obtain the rose-cranberry grape seed extract.
Example 12A composition for whitening skin, removing freckles and preventing urinary system infection
A preparation method of a composition for whitening skin, removing freckles and preventing urinary system infection comprises the following steps:
1) weighing the following components in parts by weight: 40 parts of roselle extract (with the organic acid content of 12%), 20 parts of cranberry extract (with the A-type procyanidin content of 2.5%) and 40 parts of grape seed extract (with the procyanidin content of 85%);
2) and uniformly mixing the weighed roselle extract, cranberry extract and grape seed extract in a three-dimensional mixer to obtain the rose-cranberry grape seed extract.
Example 13A composition for whitening skin, removing spots and preventing urinary system infection
A preparation method of a composition for whitening skin, removing freckles and preventing urinary system infection comprises the following steps:
1) weighing the following components in parts by weight: 40 parts of roselle extract (with the organic acid content of 12%), 20 parts of cranberry extract (with the A-type procyanidin content of 4.5%) and 40 parts of grape seed extract (with the procyanidin content of 95%);
2) and uniformly mixing the weighed roselle extract, cranberry extract and grape seed extract in a three-dimensional mixer to obtain the rose-cranberry grape seed extract.
Example 14A composition for whitening skin, removing spots and preventing urinary system infection
A preparation method of a composition for whitening skin, removing freckles and preventing urinary system infection comprises the following steps:
1) weighing the following components in parts by weight: 40 parts of roselle extract (with the organic acid content of 12%), 20 parts of cranberry extract (with the A-type procyanidin content of 6.5%) and 40 parts of grape seed extract (with the procyanidin content of 75%);
2) and uniformly mixing the weighed roselle extract, cranberry extract and grape seed extract in a three-dimensional mixer to obtain the rose-cranberry grape seed extract.
Example 15A composition for whitening skin, removing spots and preventing urinary system infection
A preparation method of a composition for whitening skin, removing freckles and preventing urinary system infection comprises the following steps:
1) weighing the following components in parts by weight: 40 parts of roselle extract (with 16 percent of organic acid content), 20 parts of cranberry extract (with 2.5 percent of A-type procyanidin content) and 40 parts of grape seed extract (with 95 percent of procyanidin content);
2) and uniformly mixing the weighed roselle extract, cranberry extract and grape seed extract in a three-dimensional mixer to obtain the rose-cranberry grape seed extract.
Example 16A composition for whitening skin and resolving macula and preventing urinary system infection
A preparation method of a composition for whitening skin, removing freckles and preventing urinary system infection comprises the following steps:
1) weighing the following components in parts by weight: 40 parts of roselle extract (with 16 percent of organic acid content), 20 parts of cranberry extract (with 4.5 percent of A-type procyanidin content) and 40 parts of grape seed extract (with 75 percent of procyanidin content);
2) and uniformly mixing the weighed roselle extract, cranberry extract and grape seed extract in a three-dimensional mixer to obtain the rose-cranberry grape seed extract.
Example 17A composition for whitening skin, removing freckles and preventing urinary system infection
A preparation method of a composition for whitening skin, removing freckles and preventing urinary system infection comprises the following steps:
1) weighing the following components in parts by weight: 40 parts of roselle extract (with 16 percent of organic acid content), 20 parts of cranberry extract (with 6.5 percent of A-type procyanidin content) and 40 parts of grape seed extract (with 85 percent of procyanidin content);
2) and uniformly mixing the weighed roselle extract, cranberry extract and grape seed extract in a three-dimensional mixer to obtain the rose-cranberry grape seed extract.
Comparative example 1A composition
A method of making a composition comprising the steps of:
1) weighing the following components in parts by weight: 10 parts of cranberry extract (the content of A-type procyanidin is 2.5%), 20 parts of grape seed extract (the content of procyanidin is 75%) and 70 parts of sorbitol;
2) and uniformly mixing the weighed cranberry extract, grape seed extract and sorbitol in a three-dimensional mixer to obtain the cranberry extract.
Comparative example 2A composition
A method of making a composition comprising the steps of:
1) weighing the following components in parts by weight: 15 parts of cranberry extract (the content of A-type procyanidin is 2.5%), 30 parts of grape seed extract (the content of procyanidin is 75%) and 55 parts of sorbitol;
2) and uniformly mixing the weighed cranberry extract, grape seed extract and sorbitol in a three-dimensional mixer to obtain the cranberry extract.
Comparative example 3A composition
A method of making a composition comprising the steps of:
1) weighing the following components in parts by weight: 20 parts of cranberry extract (the content of A-type procyanidin is 2.5%), 40 parts of grape seed extract (the content of procyanidin is 75%) and 40 parts of sorbitol;
2) and uniformly mixing the weighed cranberry extract, grape seed extract and sorbitol in a three-dimensional mixer to obtain the cranberry extract.
Comparative example 4A composition
A method of making a composition comprising the steps of:
1) weighing the following components in parts by weight: 40 parts of raspberry powder (with the organic acid content of 8%), 20 parts of cranberry extract (with the A-type procyanidin content of 2.5%) and 40 parts of grape seed extract (with the procyanidin content of 75%);
2) and uniformly mixing the weighed raspberry powder, the cranberry extract and the grape seed extract in a three-dimensional mixer to obtain the raspberry beverage.
Comparative example 5A composition
A method of making a composition comprising the steps of:
1) weighing the following components in parts by weight: 40 parts of raspberry powder (with the organic acid content of 8 percent) and 60 parts of sorbitol;
2) and uniformly mixing the weighed raspberry powder and sorbitol in a three-dimensional mixer to obtain the raspberry beverage.
Comparative example 6A composition
A method of making a composition comprising the steps of:
1) weighing the following components in parts by weight: 40 parts of roselle extractive (with the organic acid content of 8 percent) and 60 parts of sorbitol;
2) and uniformly mixing the weighed roselle extract and sorbitol in a three-dimensional mixer to obtain the rose hip beverage.
Comparative example 7A composition
A method of making a composition comprising the steps of:
1) weighing the following components in parts by weight: 40 parts of roselle extract (with the organic acid content of 8 percent), 40 parts of grape seed extract (with the procyanidin content of 75 percent) and 20 parts of sorbitol;
2) and uniformly mixing the weighed roselle extract, grape seed extract and sorbitol in a three-dimensional mixer to obtain the roselle grape seed extract.
Comparative example 8A composition
A method of making a composition comprising the steps of:
1) weighing the following components in parts by weight: 40 parts of roselle extract (with organic acid content of 8 percent), 20 parts of honeysuckle extract (with flavone content of 2.5 percent) and 40 parts of grape seed extract (with procyanidine content of 75 percent);
2) and uniformly mixing the weighed roselle extract, honeysuckle extract and grape seed extract in a three-dimensional mixer to obtain the rose grape seed extract.
Comparative example 9A composition
A method of making a composition comprising the steps of:
1) weighing the following components in parts by weight: 20 parts of honeysuckle extract (with flavone content of 2.5%) and 80 parts of sorbitol;
2) and (3) uniformly mixing the weighed honeysuckle extract and sorbitol in a three-dimensional mixer to obtain the honeysuckle flower beverage.
Comparative example 10A composition
A method of making a composition comprising the steps of:
1) weighing the following components in parts by weight: 20 parts of cranberry extract (the content of A-type procyanidin is 2.5 percent) and 80 parts of sorbitol;
2) and (3) uniformly mixing the weighed cranberry extract and sorbitol in a three-dimensional mixer to obtain the cranberry fruit beverage.
Comparative example 11A composition
A method of making a composition comprising the steps of:
1) weighing the following components in parts by weight: 40 parts of roselle extract (with the organic acid content of 8 percent), 20 parts of cranberry extract (with the A-type procyanidin content of 2.5 percent) and 40 parts of sorbitol;
2) and uniformly mixing the weighed roselle extract, cranberry extract and sorbitol in a three-dimensional mixer to obtain the rose hip beverage.
Comparative example 12A composition
A method of making a composition comprising the steps of:
1) weighing the following components in parts by weight: 40 parts of roselle extract (with organic acid content of 8%), 20 parts of cranberry extract (with A-type procyanidin content of 2.5%) and 40 parts of cowberry extract (with procyanidin content of 65%);
2) and uniformly mixing the weighed roselle extract, cranberry fruit powder and cowberry fruit extract in a three-dimensional mixer to obtain the blueberry fruit juice beverage.
Comparative example 13A composition
A method of making a composition comprising the steps of:
1) weighing the following components in parts by weight: 40 parts of cowberry fruit extract (containing 65% of procyanidine) and 60 parts of sorbitol;
2) and (3) uniformly mixing the weighed cowberry fruit extract and sorbitol in a three-dimensional mixer to obtain the blueberry fruit beverage.
Comparative example 14A composition
A method of making a composition comprising the steps of:
1) weighing the following components in parts by weight: 40 parts of grape seed extract (with the procyanidin content of 75%) and 60 parts of sorbitol;
2) and (3) uniformly mixing the weighed grape seed extract and sorbitol in a three-dimensional mixer to obtain the grape seed extract.
Test example 1 measurement of whitening and freckle removing abilities of the present invention
The whitening and freckle-removing capabilities and the bacteriostatic effect of the examples 1 to 10 are tested, the area change of brown spots before and after being eaten by trial people and the inhibiting effect of Escherichia coli are used as evaluation indexes, the specific test method is as follows, and the results are shown in a table I and a table II.
Spot-removing capability experimental method
180 chloasma subjects were selected, 10 subjects were selected, 18 subjects were counted, 1-9 subjects corresponded to example 1, example 2, example 3, example 4, example 5, example 6, example 7, example 8 and example 9, respectively, group 10 was a control group, and 11-17 subjects corresponded to example 10, example 11, example 12, example 13, example 14, example 15, example 16, example 17 and example 18, respectively. The subject took 0.8g of the trial sample each time, and the control group took 0.8g of sorbitol 1 time in the morning and evening, respectively, for 180 consecutive days. The chloasma area of the subject is observed before and after the test, and is recorded and analyzed. The area of brown spot was measured using a ruler.
Bacteriostatic experimental method
The same amount of escherichia coli was applied to 10 petri dishes, and the same amount of the composition of the example (5g of the composition was dissolved in 250mL of water) was injected into the air on each petri dish for cultivation, the test number was consistent with the above freckle removal ability evaluation test, and the bacteriostatic effect was evaluated by the bacteriostatic area. Female urinary system infection is mainly caused by coliform bacteria, and the stronger the inhibition capability of the best compound on escherichia coli, the stronger the capability of treating and preventing female urinary system infection.
TABLE I, speckle removing and antibacterial effects of the compositions
TABLE II, composition with different contents for removing speckle and inhibiting bacteria
The results of the table I are subjected to orthogonal analysis, and compared with a control group, the composition disclosed by the invention has certain freckle removing and bacteriostatic capabilities. The factor with the largest influence in the freckle removing effect is the adding amount of the grape seed extract, then the adding amount of the roselle extract, the influence of the adding amount of the cranberry extract is the smallest, the optimal formula comprises 50 parts of the roselle extract, 15 parts of the cranberry extract and 40 parts of the grape seed extract, and the freckle removing effect is as high as 19.37 percent; the most influential factor in the bacteriostatic effect is the cranberry extract, and then the roselle extract, the influence of the addition amount of the grape seed extract is the least, the optimal formula is 60 parts of the roselle extract, 20 parts of the cranberry extract and 30 parts of the grape seed extract, and the bacteriostatic diameter reaches 11.7 mm.
Orthogonal analysis is carried out on the two results, the largest factor in the freckle removing result is the content of procyanidin in the grape seed extract, and then the content of organic acid in the roselle extract, the influence of the A-type procyanidin content in the cranberry extract is the smallest, and when 40 parts of roselle extract with 16% of organic acid content, 20 parts of cranberry extract with 2.5% of A-type procyanidin content and 40 parts of grape seed extract with 95% of procyanidin content are added, the area of brown spot can be reduced by 30.21%; the largest influencing factor in the antibacterial effect is the content of A-type procyanidin in the cranberry extract, the content of organic acid in the roselle extract is the second smallest influencing factor, and the antibacterial effect can reach 17.2mm when 40 parts of roselle extract with 16% of organic acid content, 20 parts of cranberry extract with 6.5% of A-type procyanidin content and 40 parts of grape seed extract with 85% of procyanidin content are added.
Experimental example 2 comparison of comparative example and example in order to remove freckles and inhibit bacteria
The whitening and freckle removing capabilities and the bacteriostatic effect of the whitening and freckle removing liquid are tested in example 1 and comparative examples 1-14 (the test methods are the same as above), and the results are shown in the third table.
Exterior three, each composition results in removing speckle
The results of the table three tests show that the addition ratios of the cranberry extract and the grape seed extract in the comparative examples 1 and 1, the comparative examples 2 and 2, and the comparative examples 3 and 3 are the same, and the brown spot removing and bacteriostatic effects of the examples are better than those of the corresponding comparative examples only due to the addition of the roselle extract, so that the addition of the roselle extract can enhance the brown spot removing and bacteriostatic effects.
The addition amount of the raspberry powder and the addition amount of the roselle extractive in the comparative examples 5 and 6 are 40 parts, the two do not show bacteriostatic ability, the speckle removing ability of the raspberry fruit powder is slightly higher than that of the roselle extractive, the trial results of the speckle removing and bacteriostatic of the examples 3 and 4 are better than that of the comparative example 3, the speckle removing and bacteriostatic effects of the example 3 are larger than the superposition value of the corresponding results of the comparative examples 3 and 6, and the speckle removing and bacteriostatic effects of the comparative example 4 are also larger than that of the comparative examples 3 and 5, but the speckle removing effect and the bacteriostatic effect are slightly lower than those of the example 3 due to the substitution of the raspberry powder for the roselle extractive in the comparative example 4, so that the speckle removing effect and the bacteriostatic effect can be improved by the addition of the raspberry powder and the roselle extractive, while the synergistic effect of the roselle extractive, the grape seed extractive and the cranberry extractive enables the speckle removing and bacteriostatic effects to be better, replacing the roselle extract with raspberry would destroy this synergistic effect, leading to a reduction in spot removal and bacteriostatic effects.
In comparative example 9 and comparative example 10, the addition amounts of the common cranberry fruit powder and the cranberry extract are both 20 parts, the freckle removing capability is not large, the bacteriostatic effect of the comparative example 10 is much higher than that of the comparative example 9, the result proves that the rationality of the cranberry extract containing a certain type A procyanidin in the patent of the invention is better than that of the comparative example 7, the freckle removing result of the comparative example 3 and the freckle removing result of the comparative example 8 are better than that of the comparative example 7, the freckle removing and bacteriostatic effect of the example 3 are both larger than the superposition value of the corresponding results of the comparative example 7 and the comparative example 10, and the freckle removing effect of the comparative example 8 is also larger than that of the corresponding results of the comparative example 7 and the comparative example 9, but the freckle removing effect is slightly worse than that of the example 3 and the bacteriostatic effect is much worse than that of the example 3 due to the adoption of the honeysuckle extract in the comparative example 8, however, the synergistic effect of the roselle extract, the grape seed extract and the cranberry extract is better in freckle removing and antibacterial effects, and the synergistic effect is destroyed by replacing the cranberry extract with the honeysuckle extract, so that the freckle removing and antibacterial effects are reduced.
Similarly, the addition amount of the cowberry fruit extract and the grape seed extract in the comparative example 13 and the comparative example 14 is 40 parts, both experiments do not show bacteriostatic effect, the freckle removing effect of the comparative example 14 is far higher than that of the comparative example 13, the result also proves the rationality of the grape seed extract preferred by the patent of the invention, the trial results of the examples 3 and 12 are better than that of the comparative example 11, the freckle removing and bacteriostatic effect of the example 3 is greater than the superposition value of the corresponding results of the comparative example 11 and the comparative example 14, the freckle removing and bacteriostatic effect of the comparative example 12 is also greater than that of the corresponding results of the comparative example 11 and the comparative example 13, but the freckle removing and bacteriostatic effects are both worse than that of the example 3 because the cowberry fruit extract is adopted to replace the grape seed extract in the comparative example 12, and the addition of the cowberry fruit extract and the grape seed extract can improve the freckle, however, the synergistic effect of the roselle extract, the grape seed extract and the cranberry extract is better in freckle removing and antibacterial effects, and the synergistic effect is destroyed by replacing the grape seed extract with the cowberry extract, so that the freckle removing and antibacterial effects are reduced.
Test example 3 determination of the ability of the composition of the present invention to treat urinary system infections
The compositions of examples 1 to 3 and comparative examples 1 to 14 were tested for the prevention of urinary system infection, and the effect of the compositions on the treatment of urinary system infection was evaluated as an index, and the specific test methods were as follows, and the results are shown in table four.
Experimental method for treating female urinary infection
180 urinary infection subjects (occasionally, a symptomatic group) were selected, 10 subjects were selected as one group, 18 groups were counted, and 1 to 18 groups were respectively corresponding to example 1, example 2, example 3, comparative example 1, comparative example 2, comparative example 3, comparative example 4, comparative example 5, comparative example 6, comparative example 7, comparative example 8, comparative example 9, comparative example 10, comparative example 11, comparative example 12, comparative example 13, comparative example 14, and a control group. The test subjects took 0.8g of the trial sample each time, and the control group took 0.8g of sorbitol 1 time each in the morning and evening for 180 consecutive days.
Before and after the test, urinary system infection conditions of the testee are observed and scored respectively (0-3 points: no effect, 4-6 points: improvement, 7-10 points: obvious effect), and the analysis results are shown in the table three.
TABLE IV compositions for treating urinary system infection results
| Group of | Trial prescription | Post-consumption scoring |
| 1 | Example 1 | 5.6 |
| 2 | Example 2 | 7.4 |
| 3 | Example 3 | 9 |
| 4 | Comparative example 1 | 4.5 |
| 5 | Comparative example 2 | 6 |
| 6 | Comparative example 3 | 8.3 |
| 7 | Comparative example 4 | 7.4 |
| 8 | Comparative example 5 | - |
| 9 | Comparative example 6 | 2.7 |
| 10 | Comparative example 7 | - |
| 11 | Comparative example 8 | - |
| 12 | Comparative example 9 | - |
| 13 | Comparative example 10 | 7 |
| 14 | Comparative example 11 | 8.5 |
| 15 | Comparative example 12 | 8.5 |
| 16 | Comparative example 13 | - |
| 17 | Comparative example 14 | - |
| 18 | Control group | - |
As can be seen from table four, the score of example 3 is the highest, and the test result of the population is basically consistent with the bacteriostatic result, while comparative example 6 only contains the roselle extract, and does not show the bacteriostatic effect, but the score is 2.7 in the experiment, which is inferred to be possibly caused by that the roselle contains certain organic acid to inhibit the bacterial proliferation. The composition of the invention can really achieve the effect of preventing and treating female urinary system infection.
The results in the table one, the table two, the table three and the table four show that the roselle extract, the cranberry extract and the grape seed extract really have a certain synergistic effect in the aspects of freckle removing and bacteriostasis effects, and when the content of organic acid in the roselle is within the range of 12-16%, the content of A-type procyanidine in the cranberry extract is within the range of 4.5-6.5% and the content of procyanidine in the grape seed extract is within the range of 85-95%, the freckle removing and bacteriostasis effects of the composition are better.
It should be understood that the above-mentioned embodiments of the present invention are only examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention, and it will be obvious to those skilled in the art that other variations or modifications may be made on the basis of the above description, and all embodiments may not be exhaustive, and all obvious variations or modifications may be included within the scope of the present invention.
Claims (3)
1. The composition for whitening, removing freckles and preventing urinary system infection is characterized by comprising the following components in parts by weight: 40-60 parts of roselle extract, 10-20 parts of cranberry extract and 20-40 parts of grape seed extract; wherein the content of organic acid in the roselle extract is 12-16%; the content of A-type procyanidine in the cranberry extract is 4.5-6.5%; the content of procyanidine in the grape seed extract is 85-95%.
2. A method for preparing the composition for whitening skin, removing spots and preventing urinary system infection according to claim 1, comprising: weighing the components in parts by weight according to the claim 1, and mixing uniformly.
3. Use of the composition for whitening, removing freckles and preventing urinary system infection according to claim 1 in the preparation of a product for whitening, lightening freckles and preventing urinary system infection in women.
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| CN101095764B (en) * | 2007-07-13 | 2010-05-19 | 天津天狮生物发展有限公司 | Health-care food having assisted function of treating female urinary tract taint |
| CN105558537B (en) * | 2014-10-16 | 2018-08-17 | 理想科技集团有限公司 | A kind of whitening spot-eliminating composition |
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