CN110881481B - Antibacterial composition containing cannabis sativa leaf extract and application thereof - Google Patents
Antibacterial composition containing cannabis sativa leaf extract and application thereof Download PDFInfo
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- CN110881481B CN110881481B CN201911044865.7A CN201911044865A CN110881481B CN 110881481 B CN110881481 B CN 110881481B CN 201911044865 A CN201911044865 A CN 201911044865A CN 110881481 B CN110881481 B CN 110881481B
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/20—Fabaceae or Leguminosae [Pea or Legume family], e.g. pea, lentil, soybean, clover, acacia, honey locust, derris or millettia
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Abstract
The invention relates to an antibacterial composition containing a cannabis leaf extract and application thereof. The antibacterial composition containing the cannabis sativa leaf extract comprises the cannabis sativa leaf extract and an inorganic antibacterial agent. Compared with the prior art, the antibacterial composition containing the cannabis leaf extract and the application thereof have the advantages that the cannabis leaf extract and the existing inorganic antibacterial agent are compounded, so that the effectiveness of the inorganic antibacterial agent can be guaranteed, and the antibacterial performance of the inorganic antibacterial agent can be enhanced. And it can also effectively stabilize inorganic antibacterial agent, and make it not change colour and deteriorate.
Description
Technical Field
The invention belongs to the technical field of daily chemical production, and particularly relates to an antibacterial composition containing a cannabis leaf extract and application thereof.
Background
The heavy metal antibacterial agent is mainly prepared by loading heavy metals such as silver, copper, zinc and the like or heavy metal ions on the surface of an inorganic carrier such as zeolite, silica gel and other porous materials. Mercury and cadmium ions are harmful to human body; copper, nickel and cobalt ions have certain colors and influence the appearance of the product. The action strength of metal ions on the bacteria shows that the sterilization action sequence is Ag+>>Cu2+>Fe3+>Sn2+>Al3+>Zn2+>Co2+. Silver ions are seen to have a very good bactericidal effect compared to other metal ions, and for this reason, most of the inorganic antibacterial agents that are now commercially available are inorganic substances containing silver or silver ions.
The silver-based antibacterial agent has a long application history and plays a great role in human health. And in terms of safety and antibacterial effect, the inorganic silver antibacterial agent and the silver composite antibacterial agent have the advantages of long acting, high efficiency, broad spectrum, safety and the like. Silver has been found to have natural antibacterial properties and safety in ancient times. At that time, the ancient Egypt people know that the thin silver sheet covers the wound to prevent bacterial infection, the Mongolian people who accelerate wound healing know that the sheep milk contained in the silver container can keep fresh, the modern medical scientist Li Shizhen in the Bencao gang mu of China has the effects of calming the five internal organs, calming the heart, stopping fright and palpitation, eliminating pathogenic qi and the like, can take the sheep milk for a long time to lighten the body and prolong the life, the crude silver has pungent and cold taste, the silver is used for diagnosing and treating related diseases in the traditional Chinese medicine without toxicity, and the silver is used for treating the ulcer in the western medicine for more than 100 years. In 1884, German obstetrician Crede dropped 1% silver nitrate solution into eyes of newborn infants to prevent conjunctivitis of newborn infants, and the blindness rate of infants was reduced from 10% to 0.2%. In 1893, tests show that silver has a killing effect on microorganisms such as bacteria, and the silver has a wider medical effect until today. 0.5% silver nitrate is a standard solution for treating burns and wounds; the silver nitrate with the concentration of 10-20% can be applied to treat the uterine erosion. Researches show that the silver has strong killing effect on various pathogenic bacteria such as escherichia coli, staphylococcus aureus and the like, the required concentration is extremely low, and the general dosage is 10-6And (mass fraction) sterilizing. In terms of safety, silver is one of tissue components in a human body, cells treated by silver ions with very low concentration have no obvious changes of cell aggregation, cell deformation, cell lysis, pH value and the like, and a small amount of silver ions have no obvious harm to the human body. Therefore, the silver-based antibacterial agent is used for improving the antibacterial function of the textile and has sufficient safety.
The silver antibacterial agent has many advantages as an inorganic antibacterial agent, but the silver antibacterial agent has unstable property, nano silver is easy to agglomerate and discolor, silver ions are easy to be converted into brown silver oxide or black simple substance silver through ultraviolet light catalytic reduction, and the appearance of the product and the antibacterial performance are influenced. The composite antibacterial agent is a development direction of antibacterial materials, and many researches prove that the composite antibacterial agent has a better antibacterial effect than that of a single metal ion.
Pharmacological research shows that the hemp leaves have good effects in the aspects of resisting tumors and bacteria, treating glaucoma, liver cirrhosis, cardiovascular and cerebrovascular diseases, obesity and the like because of containing hemp phenols. The luteolin extracted from the hemp leaves has good effects on inhibiting tumor growth, eliminating and diffusing, and the like. The oleanolic acid obtained from the hemp leaves has better advantages in the aspects of protecting liver, reducing enzyme, reducing blood sugar, reducing blood fat and the like.
Disclosure of Invention
Based on this, the present invention aims to provide an antibacterial composition containing cannabis leaf extract and application thereof, so as to effectively overcome the defects in the prior art.
In order to achieve the purpose, the invention adopts the following technical scheme:
an antibacterial composition containing folium Cannabis extract comprises folium Cannabis extract and inorganic antibacterial agent.
Compared with the prior art, the antibacterial composition containing the cannabis leaf extract disclosed by the invention has the advantages that the cannabis leaf extract is compounded with the existing inorganic antibacterial agent, so that the effectiveness of the inorganic antibacterial agent can be ensured, the antibacterial performance of the inorganic antibacterial machine can be enhanced, and the inorganic antibacterial agent can be effectively stabilized and is not discolored or deteriorated.
Furthermore, the active ingredients of the hemp leaf extract are phenols and flavonoids. The active components of phenols and flavonoids in the hemp leaf extract can not only ensure the effectiveness of the inorganic antibacterial agent, but also enhance the antibacterial performance of the inorganic antibacterial machine.
Furthermore, the total content of phenolic substances in the hemp leaf extract is 0.5-5%, and the content of flavonoid substances is 0.05-3%.
Further, the solvent for extracting the hemp leaf extract is water, alcohol with a boiling point within 300 ℃ or a mixture of the two.
Further, the solvent for extracting the hemp leaf extract is one or more of water, ethanol, glycerol, 1, 3-propylene glycol and polyethylene glycol with molecular weight within 450.
Further, the inorganic antibacterial agent is a metal antibacterial agent, and the metal antibacterial agent is one or a mixture of more than one of colloidal silver simple substance, silver ions or silver complex ions. The silver-based antibacterial agent has many advantages, and has the characteristics of long acting, high efficiency, broad spectrum, safety and the like.
Further, the content of silver in the metal antibacterial agent is 150-1500 ppm. The antibacterial performance can be better exerted only when the silver content reaches a certain value.
Further, the weight ratio of the hemp leaf extract to the inorganic antibacterial agent is 1:1-1: 10.
The antibacterial composition containing the cannabis sativa leaf extract is applied to daily chemical products such as tableware detergents, fabric detergents, cosmetics, disinfectants and the like.
According to the antibacterial composition containing the hemp leaf extract, the effective components of phenols and flavonoids in the hemp leaves are compounded with the silver antibacterial agent to form the compound antibacterial composition, wherein the phenols and flavonoids can stabilize the metal antibacterial agent, ensure that silver does not generate chemical reaction, and the product does not yellow; the ionic silver does not react with chloride ions in the formula of the detergent, the effectiveness of the silver ions can be ensured, and the product is not precipitated. The hemp leaf extract can also enhance the bactericidal and bacteriostatic effects of the silver antibacterial agent.
For a better understanding and practice, the present invention is described in detail below.
Detailed Description
The present invention will be described in further detail with reference to examples
The invention provides an antibacterial composition containing a cannabis leaf extract and application thereof.
The active ingredients in the hemp leaf extract are phenols and flavonoids, and the total content of the phenols in the hemp leaf extract is 0.5-5%, and the content of the flavonoids is 0.05-3%.
The inorganic antibacterial agent is a metal antibacterial agent, and the metal antibacterial agent is one or a mixture of more than one of colloidal silver simple substance, silver ions or silver complex ions. The silver-based antibacterial agent has many advantages, and has the characteristics of long acting, high efficiency, broad spectrum, safety and the like. The silver content in the metal antibacterial agent is 150-1500 ppm.
When in use, the weight ratio of the hemp leaf extract to the inorganic antibacterial agent is 1:1-1: 10.
Preferably, the solvent used in the extraction of cannabis leaves is water, alcohol with a boiling point of up to 300 ℃, or a mixture of both.
More specifically, the solvent used for extracting the hemp leaf extract is one or more of water, ethanol, glycerol, 1, 3-propylene glycol and polyethylene glycol with molecular weight within 450.
The antibacterial composition can be applied to daily chemical products such as tableware detergent, fabric detergent, cosmetics, disinfectant and the like.
The application and bacteriostatic, bactericidal and stabilizing effects of an antibacterial composition containing a cannabis leaf extract according to the present invention will be specifically described below by way of several sets of examples and comparative examples. In specific implementation, the antibacterial composition is used in an amount of 0.1% -3% in various applications.
The invention has made 7 groups of experiments altogether, each group of experiments is divided into an example and two control examples, and tables 1-4 list the composition situation of the sample in each example and control example. Tables 5 to 8 show the effects of the examples and the comparative examples.
Table 1
Table 2
Table 3
Table 4
Effect test
The following examples and comparative examples were tested to examine the bacteriostatic and bactericidal properties of the antibacterial composition of the present invention against various bacteria and to stabilize silver ions in silver-based antibacterial agents. Antibacterial and bacteriostatic properties: the method is carried out according to a 5.1.1 suspension quantitative antibacterial test and a 5.2.1 suspension quantitative antibacterial test in a standard WST 650-2019 antibacterial and antibacterial effect evaluation method, wherein the test concentration is 1%. Tables 5 to 8 show the effects of the examples and the comparative examples.
Table 5
Table 6
Table 7
Table 8
The sample compositions of the examples and the comparative examples are shown in tables 1 to 4, and it can be seen from the tables that each example uses the antibacterial composition of the present invention (including the hemp leaf extract and the silver antibacterial agent), while each comparative example a group is added with only the silver antibacterial agent, and each comparative example B group is added with the hemp leaf extract alone, and the addition amounts correspond to each example.
As can be seen from the results of the experiments in tables 5 to 8, the antibacterial composition of the present invention (including the hemp leaf extract and the silver antibacterial agent) has better antibacterial and bactericidal properties than the silver antibacterial agent alone, and the sample has better stability and is not easy to discolor. The comparison between the examples and the comparative examples shows that the combination of the hemp leaf extract and the silver-based antibacterial agent can significantly improve the antibacterial performance and the bactericidal performance, and the hemp leaf extract can also stabilize silver, prevent the silver from yellowing, enhance the stability and significantly improve the application of the hemp leaf extract in various daily chemical products.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.
Claims (5)
1. An antibacterial composition containing a cannabis leaf extract, characterized by consisting of a cannabis leaf extract and an inorganic antibacterial agent;
the active ingredients of the hemp leaf extract are phenols and flavonoids;
the inorganic antibacterial agent is a metal antibacterial agent, and the metal antibacterial agent is one or a mixture of more than one of colloidal silver simple substance, silver ions or silver complex ions;
the silver content in the metal antibacterial agent is 150-1500 ppm;
the weight ratio of the hemp leaf extract to the inorganic antibacterial agent is 1:1-1: 10.
2. The antibacterial composition containing cannabis leaf extract as claimed in claim 1, wherein: the content of phenolic substances in the hemp leaf extract is 0.5-5%, and the content of flavonoid substances is 0.05-3%.
3. An antibacterial composition comprising a cannabis leaf extract as claimed in any one of claims 1-2, wherein: the solvent for extracting the folium Cannabis extract is water, alcohol with boiling point within 300 deg.C or mixture thereof.
4. The antibacterial composition containing cannabis leaf extract as claimed in claim 3, wherein: the solvent for extracting folium Cannabis extract is one or more of water, ethanol, glycerol, 1, 3-propylene glycol, and polyethylene glycol with molecular weight of 450 or less.
5. The use of an antibacterial composition comprising a cannabis leaf extract as claimed in claim 1, for antibacterial use.
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| CN201911044865.7A CN110881481B (en) | 2019-10-30 | 2019-10-30 | Antibacterial composition containing cannabis sativa leaf extract and application thereof |
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| CN201911044865.7A CN110881481B (en) | 2019-10-30 | 2019-10-30 | Antibacterial composition containing cannabis sativa leaf extract and application thereof |
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| CN110881481B true CN110881481B (en) | 2021-04-06 |
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| WO2007044693A2 (en) * | 2005-10-07 | 2007-04-19 | The University Of Alabama | Multi-functional ionic liquid compositions |
| CN110152050A (en) * | 2019-05-30 | 2019-08-23 | 厦门梓素生物科技有限公司 | A kind of functional sanitary towel of the extract containing cannabidiol and preparation method thereof |
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| JP3273269B2 (en) * | 1993-02-17 | 2002-04-08 | 株式会社サトーセン | Method for imparting antibacterial and antifungal properties to textiles |
| CN101731283A (en) * | 2008-11-12 | 2010-06-16 | 仵东星 | Anesthetic assistant |
| EP2756846A1 (en) * | 2013-01-17 | 2014-07-23 | University of Graz | Antimicrobial cellulose material and process of its production |
| CN103891782B (en) * | 2014-03-05 | 2017-12-19 | 云南玉溪水松纸厂 | A kind of bactericidal composition, its preparation method and its purposes in anti-bacteria paper preparation |
| CN105981748B (en) * | 2015-05-07 | 2018-12-04 | 博约生物科技(苏州)有限公司 | A method of extracting natural bacteriostatic agent effective component |
| FR3066117B1 (en) * | 2017-05-12 | 2021-02-12 | Walter Jean Jacques | NEW BACTERICIDES AND ANTIFUNGALS |
| CN109419665A (en) * | 2017-08-25 | 2019-03-05 | 汉义生物科技（北京）有限公司 | A kind of active matter rapid osmotic system containing Cannador or cannabidiol |
| CN109568389B (en) * | 2017-09-29 | 2022-02-08 | 汉义生物科技（北京）有限公司 | Preparation method of high-purity cannabinol extract |
| AT16262U1 (en) * | 2017-10-12 | 2019-05-15 | Weihtrager Harald | Germicidal and mold-avoiding surface coating without organic biocides |
| CN110075028A (en) * | 2019-05-07 | 2019-08-02 | 栾云鹏 | A kind of hand cleanser and preparation method thereof with bactericidal |
| CN110055753A (en) * | 2019-05-15 | 2019-07-26 | 中国农业科学院麻类研究所 | A kind of nano-antibacterial bast-fibre and its preparation method and application |
| CN110330409B (en) * | 2019-07-24 | 2022-04-19 | 汉义生物科技（北京）有限公司 | Preparation method of industrial hemp extract |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007044693A2 (en) * | 2005-10-07 | 2007-04-19 | The University Of Alabama | Multi-functional ionic liquid compositions |
| CN110152050A (en) * | 2019-05-30 | 2019-08-23 | 厦门梓素生物科技有限公司 | A kind of functional sanitary towel of the extract containing cannabidiol and preparation method thereof |
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Effective date of registration: 20230616 Address after: 511455 No. 8 Xiaohu South Third Road, Xiaohu Island, Huangge Town, Nansha District, Guangzhou City, Guangdong Province Patentee after: GUANGZHOU LANGQI DAILY NECESSITIES CO.,LTD. Address before: No. 128, Huangpu Avenue East, Tianhe District, Guangzhou, Guangdong 510660 Patentee before: GUANGZHOU LONKEY INDUSTRIAL Co.,Ltd. |