CN1109681C - Flavone chromium and its producing method and use - Google Patents
Flavone chromium and its producing method and use Download PDFInfo
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- CN1109681C CN1109681C CN00118913A CN00118913A CN1109681C CN 1109681 C CN1109681 C CN 1109681C CN 00118913 A CN00118913 A CN 00118913A CN 00118913 A CN00118913 A CN 00118913A CN 1109681 C CN1109681 C CN 1109681C
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Abstract
The present invention relates to a flavone chromium compound, a producing method thereof and purposes thereof. A flavonoid compound is utilized to react with a chromium compound so as to generate the flavone chromium compound. The defect of the difficult absorption of inorganic chromium by a human body is solved, and the comprehensive therapeutic effects of flavone and chromium are exerted. The sensitivity of insulin can be effectively promoted and enhanced, blood vessels can be softened and dilated, and microcirculation can be improved so as to regulate metabolism, and prevent and treat the diseases of diabetes, hyperlipemia, hypertension, cardio-cerebrovascular diseases, hypopsia, etc. The present invention has the advantages of simple preparation technology, easy acquisition of raw materials and low cost.
Description
Technical Field
The invention relates to flavone chromium and a production method and application thereof.
Background
Chromium is a trace element necessary for human body, and organic compounds of chromium can be found, such as chromium gluconate, chromium yeast, sodium chromium chlorophyllin and chromium picolinate. Trivalent chromium constitutes glucose tolerance factor in vivo and promotes glycometabolism. Chromium deficiency in humans can cause disturbances in glucose metabolism, leading to impaired glucose tolerance and diabetes. Inorganic chromium is not easy to be absorbed by human body, and the prior organic chromium compounds can only increase some nutrient substances such as vitamins, proteins and the like except for simple chromium supplement. The plant contains a large amount of flavonoid compounds such as rutin, licoflavone and the like, and the flavonoid compounds are used as a medicament, have pharmacological functions of softening and expanding blood vessels, normalizing microcirculation, reducing blood fat, protecting liver, resisting oxidation and the like, but have the function of improving glycometabolism due to no chromium.
Disclosure of Invention
The invention aims to provide flavone chromium, a production method andapplication thereof, which integrates the functions of flavone and chromium, is easy to prepare, has low cost and wide functions.
In order to achieve the purpose, the invention adopts the following technical scheme:
a chromoflavone is a complex formed by a flavonoid compound and trivalent chromium, and has a molecular general formula of RCrOH, wherein R is a large class of natural compounds containing a parent nucleus with the following structure:
the production method of the flavone chromium comprises the following specific steps:
(1) putting the flavonoid compound and the alcohol into a reaction kettle according to the proportion of 1: 40;
(2) adding a trivalent chromium compound according to the molar ratio of the flavonoid compound to chromium of 1: 1, heating for dissolving, heating for reaction at 60-80 ℃, slowly dropwise adding alcohol ammonia, performing reflux reaction for 0.5 hour when the pH of the solution is 6, continuously dropwise adding alcohol ammonia until a large amount of precipitate is generated, and completely precipitating when the pH of the solution is 7.5, wherein the precipitate is flavone chromium;
(3) vacuum filtering, washing the filter cake with diluted alcohol ammonia until no chloride ion exists, and drying to obtain the finished product.
The flavonoid compound is rutin, and the molecular formula of flavonoid chromium formed by the flavonoid compound and trivalent chromium is as follows: (C)27O16H31) CrOH, the reaction equation is:
the flavonoid compound is licoflavone with mother structure
The flavone chromium formed by the reaction of the flavone chromium and trivalent chromium has a molecular formula of RCrOH, wherein R is the structural formula.
In the process, when the alcohol ammonia is slowly dropped, the color of the solution is changed from green-yellow-brown in sequence, and when the pH value of the solution is 6, the color is dark brown.
The trivalent chromium is chromium trichloride or chromium sulfate.
The alcohol is methanol or ethanol.
The alcohol ammonia is methanol ammonia or ethanol ammonia.
The flavone chromium finished product is brown yellow powder.
The chromium flavone has the functions of effectively promoting and improving insulin sensitivity, softening and dilating blood vessels, improving microcirculation, regulating metabolism, and preventing and treating diabetes, hyperlipemia, hypertension, cardiovascular and cerebrovascular diseases, visual deterioration, etc.
The invention has the following effects and characteristics:
(1) the raw materials are easy to obtain, and the cost is low.
Rutin and licorice flavone are common flavonoid compounds, and are low in price and easy to obtain, and chromium compounds such as chromium trichloride and the like are low in price, so that the total cost for preparing flavone chromium is low, and the treatment cost of the medicine is extremely low.
(2) The preparation process is simple and practical, and is suitable for industrial production.
(3) The chromium supplement is safe.
(4) Can effectively promote and improve insulin sensitivity, soften blood vessel, dilate blood vessel, improve microcirculation, regulate metabolism, and prevent and treat diabetes, hyperlipemia, hypertension, cardiovascular and cerebrovascular diseases, visual deterioration, etc.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
The present invention will be described in further detail with reference to examples.
The first embodiment is as follows:
the chromoflavone is a complex formed by a flavonoid compound and trivalent chromium, and the molecular general formula of the chromoflavone is RCrOH, wherein R is a large class of natural compounds containing the following structural general formula:
the flavonoid compound is rutin, and the molecular formula of flavonoid chromium formed by the flavonoid compound and trivalent chromium is as follows:(C27O16H31) CrOH, the reaction equation is:
the production method of the flavone chromium comprises the following specific steps:
(1) putting rutin and methanol into a reaction kettle according to the proportion of 1: 40 (w/v);
(2) adding chromium trichloride according to the molar ratio of rutin to chromium of 1: 1, heating for dissolving, heating for reaction at 60-80 ℃, slowly dripping methanol ammonia, wherein the color of the solution is changed from green to yellow to brown, the color is dark brown when the pH of the solution is 6, carrying out reflux reaction for 0.5 hour, continuously dripping methanol ammonia to generate a large amount of precipitate, and completely precipitating when the pH of the solution is 7.5, wherein the precipitate is chromium flavone and is named as rutin chromium.
(3) Vacuum filtering, washing the filter cake with diluted methanol ammonia until no chloride ion exists, and drying to obtain the finished product of flavone chromium which is brown yellow powder.
Example two:
the chromoflavone is a complex formed by flavonoid compounds in liquorice and trivalent chromium, and the molecular general formula of the chromoflavone is RCrOH, wherein R is licoflavone containing the following structural general formula:
the production method of the flavone chromium comprises the following specific steps:
(1) putting licoflavone and methanol into a reaction kettle according to the ratio of 1: 40 (w/v);
(2) adding chromium trichloride according to the molar ratio of licoflavone to chromium of 1: 1, heating for dissolving, heating for reaction at 60-80 ℃, slowly dripping methanol ammonia, wherein the color of the solution is changed from green-yellow-brown, the color is dark brown when the pH of the solution is 6, refluxing for reaction for 0.5 h, continuously dripping methanol ammonia to generate a large amount of precipitate, and completely precipitating when the pH of the solution is 7.5, wherein the precipitate is chromoflavone, and is named as licoflavone chromium.
(3) Vacuum filtering, washing the filter cake with diluted methanol ammonia until no chloride ion exists, and drying to obtain the finished product of flavone chromium which is brown yellow powder.
In the above two embodiments, the chromium trichloride can be replaced by chromium sulfate, the methanol can be replaced by ethanol, and the methanolic ammoniacan be replaced by ethanolic ammonia.
The chromoflavone obtained in the two above examples has the following uses: can effectively promote and improve insulin sensitivity, soften and expand blood vessels, improve microcirculation, thereby regulating metabolism, and preventing and treating diabetes, hyperlipemia, hypertension, cardiovascular and cerebrovascular diseases, visual deterioration, etc.
The rutin chromium process for three people such as inventor Liu steel is as follows:
before taking
① blood sugar is 14.2, 13.5, 12.9;
② the fluctuation of blood sugar with food intake is large;
③ hypoglycemia reaction easily occurs, and the hypoglycemia phenomenon has large fluctuation with the dosage;
④ blurred vision, insomnia, and asthenia;
every person takes 2 rutin chromium capsules (each capsule contains 2.6 mg of rutin chromium) every day, and simultaneously takes 3 tablets of blood sugar reducing medicine for every day, and the medicine is taken by two times.
After 15 days, the Dameikang is reduced to 2.5 tablets/day;
after 1 month, the Dameikang is reduced to 2 tablets/day;
after 2 months, the Dameikang is reduced to 1 tablet/day;
① blood sugar of three people is reduced to 5.7-7.0;
② the fluctuation of blood sugar is small with the amount of food intake;
③ the phenomena of hypoglycemia, insomnia, and asthenia disappear;
④ the phenomenon of blurred vision disappears.
Claims (9)
1. The flavone chromium is characterized in that the flavone chromium is a complex formed by a flavonoid compound and trivalent chromium, the molecular general formula of the complex is RCrOH, wherein R is a large class of natural compounds containing a parent nucleus with the following structure:
2. the production method of the flavone chromium comprises the following specific steps:
(1) putting the flavonoid compound and the alcohol into a reaction kettle according to the proportion of 1: 40;
(2) adding a trivalent chromium compound according to the molar ratio of the flavonoid compound to chromium of 1: 1, heating for dissolving, heating for reaction at 60-80 ℃, slowly dropwise adding alcohol ammonia, performing reflux reaction for 0.5 hour when the pH of the solution is 6, continuously dropwise adding alcohol ammonia until a large amount of precipitate is generated, and completely precipitating when the pH of the solution is 7.5, wherein the precipitate is flavone chromium;
(3) vacuum filtering, washing the filter cake with diluted alcohol ammonia until no chloride ion exists, and drying to obtain the finished product.
3. The method for producing chromium flavone as claimed in claim 2, wherein the flavonoid is rutin, and the molecular formula of chromium flavone formed by the flavonoid and trivalent chromium is: (C)27O16H31) CrOH, the reaction equation is:
4. the method for producing chromium flavone as claimedin claim 2, wherein said flavonoid compound is licoflavone having a mother body structure of glycyrrhetinic acid
The flavone chromium formed by the reaction of the compound with trivalent chromium has a molecular general formula of RCrOH, wherein R is a compound with the structural general formula.
5. The process for producing flavone chromium according to claim 2, wherein the color of the solution is changed from green to yellow to brown by slowly adding dropwise alcoholic ammonia, and the color is dark brown when the solution has a pH of 6.
6. The process for producing chromium flavone as claimed in claim 2, 3, 4 or 5, wherein said trivalent chromium is chromium trichloride or chromium sulfate.
7. The method for producing chromium flavonid according to claim 2, wherein said alcohol is methanol or ethanol.
8. The process for producing chromium flavone as claimed in claim 2 or 5, wherein said ammonia alcohol is methanolic ammonia or ethanolic ammonia.
9. The method for producing chromium flavone as claimed in claim 2, 3 or 4, wherein said chromium flavone is a brown-yellow powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00118913A CN1109681C (en) | 2000-06-15 | 2000-06-15 | Flavone chromium and its producing method and use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00118913A CN1109681C (en) | 2000-06-15 | 2000-06-15 | Flavone chromium and its producing method and use |
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| Publication Number | Publication Date |
|---|---|
| CN1290701A CN1290701A (en) | 2001-04-11 |
| CN1109681C true CN1109681C (en) | 2003-05-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00118913A Expired - Fee Related CN1109681C (en) | 2000-06-15 | 2000-06-15 | Flavone chromium and its producing method and use |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT501682A1 (en) * | 2005-01-14 | 2006-10-15 | Hermine Dr Engl | METHOD FOR PRODUCING AN ACTIVE SUBSTANCE MIXTURE |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1322132A (en) * | 1998-09-15 | 2001-11-14 | 韩国科学技术研究院 | Bioflavonoid as blood gloucose level lowering agent |
-
2000
- 2000-06-15 CN CN00118913A patent/CN1109681C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1322132A (en) * | 1998-09-15 | 2001-11-14 | 韩国科学技术研究院 | Bioflavonoid as blood gloucose level lowering agent |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT501682A1 (en) * | 2005-01-14 | 2006-10-15 | Hermine Dr Engl | METHOD FOR PRODUCING AN ACTIVE SUBSTANCE MIXTURE |
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| CN1290701A (en) | 2001-04-11 |
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Owner name: NINGXIA BAIXIN BIOLOGY SCIENCE CO., LTD. Free format text: FORMER OWNER: NINGXIA UNIV. Effective date: 20040625 |
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Effective date of registration: 20040625 Address after: 750002, 114, science and Technology Street, hi tech Zone, the Ningxia Hui Autonomous Region, Yinchuan Patentee after: Ningxia pashun Biological Technology Co Ltd Address before: 750021 Yinchuan New District, the Ningxia Hui Autonomous Region, Department of chemical engineering, Ningxia University Patentee before: Ningxia Univ |
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