CN110960630A - Preparation process of veterinary drug composition for improving pig immune function - Google Patents
Preparation process of veterinary drug composition for improving pig immune function Download PDFInfo
- Publication number
- CN110960630A CN110960630A CN201911420059.5A CN201911420059A CN110960630A CN 110960630 A CN110960630 A CN 110960630A CN 201911420059 A CN201911420059 A CN 201911420059A CN 110960630 A CN110960630 A CN 110960630A
- Authority
- CN
- China
- Prior art keywords
- fixed
- parts
- plate
- drug composition
- veterinary drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a preparation process of a veterinary drug composition for improving the immunologic function of pigs, which comprises the following steps: firstly, weighing the following raw materials in parts by weight: 30-40 parts of traditional Chinese medicine components, 2-3 parts of nucleotide, 4-5 parts of nutritional health-care agent and 7-9 parts of seaweed polysaccharide soluble powder; step two, uniformly mixing the traditional Chinese medicine components, nucleotide and seaweed polysaccharide soluble powder; step three, preparing a nutritional health-care agent, wherein the nutritional health-care agent is used as a spraying liquid; and fourthly, granulating by adopting a granulating device. The invention takes the traditional Chinese medicine components as basic substances, and each component in the traditional Chinese medicine components can play the roles of enhancing immunity and improving nutrition; the immunity of the pig body can be further improved by adding nucleotide and algal polysaccharide; the nutritional health-care agents are mixed into the powder through the granulating device, so that the production efficiency can be improved, the mixing uniformity can be improved, the effects of all the components can be fully exerted, and the quality of the veterinary drug composition is improved.
Description
Technical Field
The invention belongs to the technical field of veterinary drugs, and particularly relates to a preparation process of a veterinary drug composition for improving the immune function of pigs.
Background
With the rapid development of modern animal husbandry and the change of economic structure, the traditional breeding mode is gradually developing towards large-scale and intensification, but the large-scale and intensification development also brings many problems, on one hand, because the epidemic trend of animal epidemic diseases is intensified, the types of the epidemic diseases are more and more complicated, the multiple infection phenomenon is serious, and the difficulty of controlling the animal epidemic diseases by adopting the existing biological vaccines and chemical drugs is more and more large; on the other hand, the research and development of novel vaccines and the research and development of medicines are relatively lagged, the research and development of a new medicine, particularly the research and development of a new medicine of chemical and biological preparations, needs five years, even decades and decades, and obviously, the research and development speed can not obviously catch up with the actual production demand change of the livestock breeding industry, so the research and development of preventive health feed additives and veterinary medicines need to be increased.
The Chinese patent with the patent number of CN201810052965.3 discloses a veterinary drug composition, a preparation method and an application thereof, and the veterinary drug composition comprises the following raw materials in parts by weight: 5-25 parts of toltrazuril, 2.5-15 parts of decoquinate, 1-12 parts of pyrantel, 8-15 parts of cortex meliae, 2-8 parts of chenopodium ambrosioides, 2-6 parts of herba elephantopi, 5-10 parts of bighead atractylodes rhizome, 3-8 parts of dried orange peel and 5-10 parts of dark plum fruit. The composition is a compound preparation of Chinese and western medicines, has reasonable compatibility, quick response, little toxic and side effect, low cost and convenient use, and has very definite curative effect on intestinal injury, deficiency of spleen and stomach qi, poor appetite, emaciation and other diseases of livestock and poultry caused by coccidiosis. However, the veterinary drug composition is still deficient in improving various immunity indexes of pigs.
Disclosure of Invention
The invention aims to provide a preparation process of a veterinary drug composition for improving the immunologic function of pigs, wherein the veterinary drug composition takes traditional Chinese medicine components as basic substances, the traditional Chinese medicine components contain various effective components, and each component can play the roles of enhancing the immunity and improving the nutrition; the immunity of the pig body can be further improved by adding nucleotide and algal polysaccharide; the veterinary drug composition also comprises the nutritional health-care agent, and the nutritional health-care agent is mixed into powder of the veterinary drug composition by a special granulating device, so that the production efficiency can be improved, the mixing uniformity of the nutritional health-care agent can be improved, the effects of all components in the nutritional health-care agent can be fully exerted, and the quality of the veterinary drug composition can be improved.
The purpose of the invention can be realized by the following technical scheme:
a preparation process of a veterinary drug composition for improving the immunologic function of pigs comprises the following steps:
firstly, weighing the following raw materials in parts by weight: 30-40 parts of traditional Chinese medicine components, 2-3 parts of nucleotide, 4-5 parts of nutritional health-care agent and 7-9 parts of seaweed polysaccharide soluble powder;
step two, uniformly mixing the traditional Chinese medicine components, nucleotide and seaweed polysaccharide soluble powder to obtain premixed powder;
sequentially adding chitosan oligosaccharide, L-ascorbic acid, lactic acid and glutamine into purified water to form a nutritional health-care agent with the mass fraction of 18-20%, and placing the nutritional health-care agent in a spray liquid charging bucket as spray liquid;
and fourthly, adding the premixed powder into a feeding hopper of the granulating device, starting a valve of which the motor and the spraying mechanism are connected to a spraying liquid charging bucket, rotating the compression roller around the driving shaft rod while revolving under the action of the linkage mechanism, rolling the premixed powder, and forming particles of specifications under the forming action of the template to obtain the veterinary drug composition.
Further, the traditional Chinese medicine comprises the following raw materials in parts by weight: 10-14 parts of astragalus membranaceus, 11-13 parts of scutellaria baicalensis, 6-8 parts of echinacea purpurea, 5-7 parts of folium isatidis, 8-10 parts of epimedium, 10-12 parts of isatis roots, 5-6 parts of radix paeoniae alba, 4-5 parts of codonopsis pilosula, 5-6 parts of bighead atractylodes rhizome, 6-8 parts of pericarpium citri reticulatae, 5-6 parts of eucommia ulmoides leaves, 3-4 parts of liquorice and 5-6 parts of cinnamon;
mixing the traditional Chinese medicine substances in the traditional Chinese medicine components, and performing water extraction and spray drying to obtain the traditional Chinese medicine components.
Furthermore, the nutritional health-care agent is a liquid preparation formed by dissolving effective components in purified water, wherein the effective components comprise chitosan oligosaccharide, L-ascorbic acid, lactic acid and glutamine, and the mass ratio of the components is 0.1:10:5: 0.8.
Further, the granulating device comprises a bearing frame body and a granulating mechanism arranged on the bearing frame body;
the bearing frame body comprises a bearing plate frame, four upright posts are vertically fixed at four vertex angles of the upper surface of the bearing plate frame, a bearing plate is fixed on the surface of the other end of each upright post, and the bearing plate is arranged in parallel to the bearing plate frame; a transverse plate arranged along the width direction of the bearing plate frame is fixed on the inner side surface of the bearing plate frame, a vertical plate is fixed on the upper surface of the transverse plate, and the other end of the vertical plate is fixed on the lower surface of the bearing plate; the center of the surface of the bearing plate is provided with an installation through hole for installing the granulation mechanism;
the granulation mechanism comprises a motor, a connecting frame, a material grinding device and a feeding hopper which are sequentially arranged from bottom to top, the connecting frame comprises a gearbox, a connecting plate is fixed on the side surface of the gearbox, and the connecting plate is fixed on a vertical plate; the motor is fixed on the end side surface of the gearbox, and the output end of the motor extends into the gearbox; the material grinding device comprises a hopper base flange, the hopper base flange is fixed on a bearing plate through bolts, a hopper base is fixed on the surface of the hopper base flange, a tapered plate is fixed on the inner surface of the periphery of the hopper base, the tapered plate comprises a conical plate and a ring plate which is integrally formed with the conical plate, the ring plate is fixed on the inner surface of the periphery of the hopper base, an installation cylinder is fixedly penetrated through the tapered plate along the axis direction, a driving shaft rod is installed in the installation cylinder through a bearing, one end of the driving shaft rod penetrates through the bearing plate, extends into the gearbox and is connected with an output end in the gearbox; the inner surface of the periphery of the hopper base is also fixed with a template which is fixed on the inner surface of the periphery of the hopper base; the driving shaft rod penetrates through the template, a connecting cylinder is fixed at the upper end of the driving shaft rod, an annular clamping plate is fixed on the inner wall of the connecting cylinder, the annular clamping plate is fixed on the driving shaft rod, a linkage mechanism is installed in the connecting cylinder and comprises a first bevel gear, a fixing cylinder is fixed on the lower surface of the first bevel gear, the fixing cylinder is fixed on the template, a circular through hole is formed in the surface of the template, the circular through hole can penetrate through the driving shaft rod, the first bevel gear is fixed in the circular through hole of the template through the fixing cylinder, the driving shaft rod penetrates through the whole first bevel gear, the linkage mechanism further comprises three second bevel gears which are uniformly distributed along the circumferential direction, the second bevel gears are fixed on a connecting rod, the second bevel gears are meshed with the first bevel gears; the feeding funnel is a cylindrical funnel and is fixed on the upper end surface of the hopper base; still be equipped with spraying mechanism in the feed hopper, spraying mechanism is fixed in the initiative axostylus axostyle including solid fixed ring, gu on fixed ring, gu fixed ring's week side is fixed with the shower, the hole that sprays of equipartition is seted up on the surface of shower.
Furthermore, a first circular through hole is formed in the surface of the connecting plate, and the bolt penetrates through the first circular through hole to fix the whole connecting frame on the vertical plate.
Further, the hopper base comprises an annular connecting plate and a cylindrical hopper base integrally formed with the annular connecting plate, and a discharge hole is formed in the side wall of the cylindrical hopper base.
Furthermore, the template is a circular plate, and the surface of the template is provided with a granulation through hole with a standard aperture.
Further, the mounting groove has been seted up to the week side surface of template, through inserting the bolt in the mounting groove with the template be fixed in the hopper base, the upper surface of template flushes with the upper end surface of hopper base.
Further, solid fixed ring inside is the cavity structure, link up with spraying the hole, and the inlet has been seted up to solid fixed ring's upper surface, and the inlet communicates with the feed liquid bucket that stores and has sprayed liquid.
The invention has the beneficial effects that:
the veterinary drug composition takes traditional Chinese medicine components as basic substances, the traditional Chinese medicine components contain various effective components, and all the components can play roles of enhancing immunity and improving nutrition, wherein the main active components of the echinacea purpurea are caffeic acid and derivatives thereof, alkyl amide compounds, polysaccharides and glycoproteins, the caffeic acid derivatives have various biological activity effects, can inhibit hyaluronidase which is a key enzyme involved in bacterial infection, has obvious immune stimulation function and anti-inflammatory effect, and also has strong antioxidation; the scutellaria baicalensis contains various substances with antiviral effect, and has better prevention and control effects on various viral swine plagues such as swine influenza, herpes virus, hepatitis virus and the like; the Clerodendranthus spicatus has the effects of clearing heat, dissipating heat, expelling toxin and detoxifying in the prevention and treatment of the swine plague, and has certain prevention and treatment effects on pathogens such as influenza virus, salmonella, escherichia coli and the like;
the veterinary drug composition also comprises nucleotide, wherein the nucleotide can up-regulate the expression of genes (TLR-9, TLR-4 and TOLLIP) related to innate immunity and tight junction protein (Claudin-1 and ZO-1) in ileum, enhance the mechanical barrier function of intestinal tract and play a positive role in the innate immunity function of the intestinal tract; the nucleotide enhances cellular immunity by promoting lymphocyte proliferation and IFN-gamma secretion, enhances humoral immunity by increasing the content of immunoglobulin in blood and intestinal mucosa, enhances phagocytic capacity of macrophage, enhances NK cell activity to enhance nonspecific immunity of an organism, and finally enhances the immune function of the organism;
the composition also contains a small amount of nutritional health-care agent, and the chitosan oligosaccharide in the nutritional health-care agent can promote the growth of pigs, improve the feed conversion rate and reduce the diarrhea rate; the organic acid (lactic acid and L-ascorbic acid) can obviously reduce the pH value of gastric contents, improve the activity of pepsin, provide better conditions for digestion of protein and promote the growth of pigs; the exogenous glutamine can improve the indexes of immune organs of pigs, can obviously improve the indexes of livers and spleens, promotes the development of immune organs of weak pigs and further enhances the immune function of pig organisms;
the invention adopts a specially-made granulating device to granulate the traditional Chinese medicine composition, and the granulating device enables one motor to simultaneously control revolution and rotation of the compression roller through the specific position design of the linkage mechanism and the driving shaft lever, and double rolling is carried out on powder, so that the control is easy, and the granulating efficiency is high; in addition, the veterinary drug composition contains trace nutrient health-care agent which is directly added into the composition in a powder form and is difficult to disperse uniformly, the nutrient health-care agent is prepared into a liquid solution preparation which is added into the veterinary drug composition, the liquid preparation can ensure that all components in the nutrient health-care agent are uniformly mixed, but the moisture content is higher when the nutrient health-care agent is added into the composition, and the forming of particles can be directly influenced, the granulating device of the invention ensures that the nutrient health-care agent is mixed into the powder raw material in a spraying form in the granulating process of the powder raw material through the arrangement of a spraying mechanism, on one hand, the nutrient health-care agent is released in a spraying form, the humidity of the powder is not instantly increased, the forming effect of the granulating is not influenced, on the other hand, the nutrient health-care agent is released in a spraying form, the contact area of the powder and the, can fully play the role of each component in the veterinary drug composition and improve the quality of the veterinary drug composition.
Drawings
In order to facilitate understanding for those skilled in the art, the present invention will be further described with reference to the accompanying drawings.
FIG. 1 is a schematic view of a granulating apparatus according to the present invention;
FIG. 2 is a schematic structural diagram of a carrier body of the granulating apparatus of the present invention;
FIG. 3 is a schematic structural diagram of a granulating mechanism of the granulating apparatus of the present invention;
FIG. 4 is a schematic view of a partial structure of a granulating mechanism;
FIG. 5 is a schematic view of a partial structure of the granulating mechanism;
FIG. 6 is a schematic view of a portion of the structure of FIG. 5;
FIG. 7 is a partial schematic view of FIG. 5;
FIG. 8 is a partial schematic view of the pelletizing mechanism;
FIG. 9 is a schematic structural view of a spraying mechanism of the present invention;
fig. 10 is a schematic structural view of the spraying mechanism of the present invention.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
A preparation process of a veterinary drug composition for improving the immunologic function of pigs comprises the following steps:
firstly, weighing the following raw materials in parts by weight: 30-40 parts of traditional Chinese medicine components, 2-3 parts of nucleotide, 4-5 parts of nutritional health-care agent and 7-9 parts of seaweed polysaccharide soluble powder;
the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-14 parts of astragalus membranaceus, 11-13 parts of scutellaria baicalensis, 6-8 parts of echinacea purpurea, 5-7 parts of folium isatidis, 8-10 parts of epimedium, 10-12 parts of isatis roots, 5-6 parts of radix paeoniae alba, 4-5 parts of codonopsis pilosula, 5-6 parts of bighead atractylodes rhizome, 6-8 parts of pericarpium citri reticulatae, 5-6 parts of eucommia ulmoides leaves, 3-4 parts of liquorice and 5-6 parts of cinnamon;
mixing the traditional Chinese medicine substances in the traditional Chinese medicine components, and performing water extraction and spray drying to obtain the traditional Chinese medicine components;
the nutritional health agent is a liquid preparation formed by dissolving effective components in purified water, wherein the effective components comprise chitosan oligosaccharide, L-ascorbic acid (vitamin C), lactic acid and glutamine, and the mass ratio of each component is 0.1:10:5: 0.8;
the chitosan oligosaccharide can promote the growth of pigs, improve the feed conversion rate and reduce the diarrhea rate; the organic acid (lactic acid and L-ascorbic acid) can obviously reduce the pH value of gastric contents, improve the activity of pepsin, provide better conditions for digestion of protein and promote the growth of pigs; the exogenous glutamine can improve the indexes of immune organs of pigs, can obviously improve the indexes of livers and spleens, promotes the development of immune organs of weak pigs and further enhances the immune function of pig organisms;
step two, uniformly mixing the traditional Chinese medicine components, nucleotide and seaweed polysaccharide soluble powder to obtain premixed powder;
thirdly, sequentially adding chitosan oligosaccharide, L-ascorbic acid (vitamin C), lactic acid and glutamine into purified water to form a nutritional health-care agent with the mass fraction of 18-20%, and placing the nutritional health-care agent serving as spraying liquid into a spraying liquid charging bucket;
fourthly, adding the premixed powder into a feeding hopper 24 of a granulating device, starting a valve of a motor 21 and a spraying mechanism 25 which are connected to a spraying liquid charging bucket, rotating a compression roller 2313 around a driving shaft lever 2306 while revolving under the action of a linkage mechanism, rolling the premixed powder, and forming granules of the specification under the forming action of a template 2307 to obtain the veterinary drug composition;
the nucleotide can up-regulate the expression of genes (TLR-9, TLR-4 and TOLLIP) related to the innate immunity and tight junction protein (Claudin-1 and ZO-1) in ileum, enhance the mechanical barrier function of intestinal tract and play a positive role in the innate immunity function of the intestinal tract; the nucleotide enhances cellular immunity by promoting lymphocyte proliferation and IFN-gamma secretion, enhances humoral immunity by increasing the content of immunoglobulin in blood and intestinal mucosa, enhances phagocytic capacity of macrophage, enhances NK cell activity to enhance nonspecific immunity of an organism, and finally enhances the immune function of the organism;
the main active ingredients of the echinacea purpurea are caffeic acid and derivatives thereof, alkyl amide compounds, polysaccharides and glycoproteins, the caffeic acid derivatives have various biological activity effects, can inhibit hyaluronidase which is a key enzyme involved in bacterial infection, has obvious immunostimulating function and anti-inflammatory effect, and also has strong antioxidation; the scutellaria baicalensis contains various substances with antiviral effect, and has better prevention and control effects on various viral swine plagues such as swine influenza, herpes virus, hepatitis virus and the like; the Clerodendranthus spicatus has the effects of clearing heat, dissipating heat, expelling toxin and detoxifying in the prevention and treatment of the swine plague, and has certain prevention and treatment effects on pathogens such as influenza virus, salmonella, escherichia coli and the like;
referring to fig. 1-10, the granulating apparatus includes a carrier 1 and a granulating mechanism 2 mounted on the carrier 1;
specifically, as shown in fig. 2, the carrier body 1 includes a carrier plate frame 11, and universal wheels 12 are mounted at four top corners of the lower surface of the carrier plate frame 11, so as to facilitate movement of the whole granulating device; four upright posts 13 are vertically fixed at four top corners of the upper surface of the bearing plate frame 11, a bearing plate 14 is fixed on the surface of the other end of each upright post 13, and the bearing plate 14 is arranged in parallel to the bearing plate frame 11; a transverse plate 15 arranged along the width direction of the bearing plate frame 11 is fixed on the inner side surface of the bearing plate frame, a vertical plate 16 is fixed on the upper surface of the transverse plate 15, and the other end of the vertical plate 16 is fixed on the lower surface of the bearing plate 14; it should be noted that the central position of the surface of the bearing plate 14 is provided with an installation through hole for installing the granulation mechanism 2;
as shown in fig. 3, the granulation mechanism 2 includes a motor 21, a connecting frame 22, a material grinding device 23 and a feeding funnel 24, which are sequentially arranged from bottom to top, specifically, the connecting frame 22 includes a gearbox 2201, a connecting plate 2202 is fixed on a side surface of the gearbox 2201, a first circular through hole 2203 is formed in a surface of the connecting plate 2202, a bolt passes through the first circular through hole 2203 to fix the whole connecting frame 22 on the vertical plate 16, the motor 21 is fixed on an end side surface of the gearbox 2201, and an output end of the motor extends into the gearbox 2201, it should be noted that the gearbox 2201 is a gearbox conventionally used in the art; the material grinding device 23 comprises a hopper base flange 2301, the hopper base flange 2301 is fixed on the bearing plate 14 through bolts, a hopper base 2302 is fixed on the surface of the hopper base flange 2301, the hopper base 2302 comprises an annular connecting plate and a cylindrical hopper base integrally formed with the annular connecting plate, and a discharge hole 2303 is formed in the side wall of the cylindrical hopper base and used for discharging materials; a tapered plate 2304 is fixed on the inner surface of the periphery of the hopper base 2302, the tapered plate 2304 comprises a tapered plate and an annular plate integrally formed with the tapered plate, the annular plate is fixed on the inner surface of the periphery of the hopper base 2302, the tapered plate 2304 penetrates through and is fixed with an installation cylinder 2305 along the axis direction, an active shaft lever 2306 is installed in the installation cylinder 2305 through a bearing, one end of the active shaft lever 2306 penetrates through the bearing plate 14, extends into the gearbox 2201 and is connected with the output end in the gearbox 2201; a template 2307 is further fixed on the inner surface of the peripheral side of the hopper base 2302, the template 2307 is a circular plate, a granulation through hole with a standard hole diameter is formed in the surface of the template 2307, an installation groove is formed in the outer surface of the peripheral side of the template 2307, the template 2307 is fixed in the hopper base 2302 by inserting a bolt into the installation groove, and preferably, the upper surface of the template 2307 is flush with the upper end surface of the hopper base 2302; the driving shaft 2306 penetrates through the template 2307, the upper end of the driving shaft 2306 is fixed with the connecting cylinder 2308, the inner wall of the connecting cylinder 2308 is fixed with the annular clamping plate 2309, the annular clamping plate 2309 is fixed on the driving shaft 2306, the connecting cylinder 2308 is internally provided with the linkage mechanism, the linkage mechanism comprises a first bevel gear 2310, the lower surface of the first bevel gear 2310 is fixed with the fixing cylinder 2314, the fixing cylinder 2314 is fixed on the template 2307, specifically, the surface of the template 2307 is provided with a circular through hole, the circular through hole can penetrate through the driving shaft 2306, the first bevel gear 2310 is fixed in the circular through hole of the template 2307 through the fixing cylinder 2314, the driving shaft 2306 penetrates through the whole first bevel gear 2310, the linkage mechanism further comprises three second bevel gears 2311 uniformly distributed along the circumferential direction, the second bevel gears 2311 are fixed on the connecting rod 2312, the second bevel gears 2311 are meshed with the first bevel gears 2310, the connecting rod, a pressure roller 2313 is fixed at the other end of the connecting rod 2312; the feed hopper 24 is a cylindrical hopper, and the feed hopper 24 is fixed to the upper end surface of the hopper base 2302; a spraying mechanism 25 is further arranged in the feeding hopper 24, as shown in fig. 9 and 10, the spraying mechanism 25 includes a fixing ring 2501, the fixing ring 2501 is fixed on the driving shaft rod 2306, spraying pipes 2502 are fixed on the periphery of the fixing ring 2501, and uniformly distributed spraying holes 2503 are formed in the surface of the spraying pipes 2501, it should be noted that the fixing ring 2501 is internally of a cavity structure and is communicated with the spraying holes 2503, a liquid inlet 2504 is formed in the upper surface of the fixing ring 2501, and the liquid inlet 2504 is communicated with a liquid barrel storing spraying liquid;
the granulation device has the working principle and the mode that:
the motor drives the driving shaft lever 2306 to rotate, and drives the connecting cylinder 2308 fixed on the driving shaft lever 2306 and the spraying mechanism 25 to rotate; the connecting cylinder 2308 rotates to drive the connecting rod 2312 mounted on the connecting cylinder to revolve around the driving shaft 2306, further, the pressure roller 2313 is driven to revolve around the driving shaft 2306, the other end of the connecting rod 2312 is fixed with the second bevel gear 2311, the second bevel gear 2311 revolves and simultaneously performs meshing transmission action of the bevel gears, the first bevel gear 2310 is fixed, and the second bevel gear 2311 not only revolves around the driving shaft 2306 but also performs rotation movement, so that the pressure roller 2313 rotates around the driving shaft 2306, materials are fed by the feeding hopper 24 and fall between the pressure roller 2313 and the die plate 2307, and under the double rolling action (revolution and rotation) of the pressure roller 2313 and the molding action of the die plate 2307, the materials form particles with the specification size, and the granulation process is completed;
in addition, the driving shaft lever 2306 of the invention is fixedly provided with the spraying mechanism 25, the spraying mechanism 25 rotates under the driving action of the driving shaft lever 2306, the rotating spraying pipe 2502 continuously sprays spraying liquid downwards, and in the granulation process, the spraying liquid is contacted with the powder particles in a spraying mode and is mixed with the material-separating mixing device to form veterinary drug composition particles with uniform components;
according to the granulating device, through the specific position design of the linkage mechanism and the driving shaft lever, one motor can simultaneously control revolution and rotation movement of the pressing roller, double rolling is carried out on powder, and therefore the granulating device is easy to control and high in granulating efficiency; in addition, the veterinary drug composition contains trace nutrient health-care agent which is directly added into the composition in a powder form and is difficult to disperse uniformly, the nutrient health-care agent is prepared into a liquid solution preparation which is added into the veterinary drug composition, the liquid preparation can ensure that all components in the nutrient health-care agent are uniformly mixed, but the moisture content is higher when the nutrient health-care agent is added into the composition, and the forming of particles can be directly influenced, the granulating device of the invention ensures that the nutrient health-care agent is mixed into the powder raw material in a spraying form in the granulating process of the powder raw material through the arrangement of a spraying mechanism, on one hand, the nutrient health-care agent is released in a spraying form, the humidity of the powder is not instantly increased, the forming effect of the granulating is not influenced, on the other hand, the nutrient health-care agent is released in a spraying form, the contact area of the powder and the, can fully play the role of each component in the veterinary drug composition and improve the quality of the veterinary drug composition.
Example 1
A preparation process of a veterinary drug composition for improving the immunologic function of pigs comprises the following steps:
firstly, weighing the following raw materials in parts by weight: 30-40 parts of traditional Chinese medicine components, 2-3 parts of nucleotide, 4-5 parts of nutritional health-care agent and 7-9 parts of seaweed polysaccharide soluble powder;
step two, uniformly mixing the traditional Chinese medicine components, nucleotide and seaweed polysaccharide soluble powder to obtain premixed powder;
sequentially adding chitosan oligosaccharide, L-ascorbic acid, lactic acid and glutamine into purified water to form a nutritional health-care agent with the mass fraction of 18-20%, and placing the nutritional health-care agent in a spray liquid charging bucket as spray liquid;
and fourthly, adding the premixed powder into a feeding hopper of the granulating device, starting a valve of which the motor and the spraying mechanism are connected to a spraying liquid charging bucket, rotating the compression roller around the driving shaft rod while revolving under the action of the linkage mechanism, rolling the premixed powder, and forming particles of specifications under the forming action of the template to obtain the veterinary drug composition.
Example 2
A preparation process of a veterinary drug composition for improving the immunologic function of pigs comprises the following steps:
firstly, weighing the following raw materials in parts by weight: 30-40 parts of traditional Chinese medicine components, 2-3 parts of nucleotide, 4-5 parts of nutritional health-care agent and 7-9 parts of seaweed polysaccharide soluble powder;
step two, uniformly mixing the traditional Chinese medicine components, nucleotide and seaweed polysaccharide soluble powder to obtain premixed powder;
sequentially adding chitosan oligosaccharide, L-ascorbic acid, lactic acid and glutamine into purified water to form a nutritional health-care agent with the mass fraction of 18-20%, and placing the nutritional health-care agent in a spray liquid charging bucket as spray liquid;
and fourthly, adding the premixed powder into a feeding hopper of the granulating device, starting a valve of which the motor and the spraying mechanism are connected to a spraying liquid charging bucket, rotating the compression roller around the driving shaft rod while revolving under the action of the linkage mechanism, rolling the premixed powder, and forming particles of specifications under the forming action of the template to obtain the veterinary drug composition.
Example 3
A preparation process of a veterinary drug composition for improving the immunologic function of pigs comprises the following steps:
firstly, weighing the following raw materials in parts by weight: 30-40 parts of traditional Chinese medicine components, 2-3 parts of nucleotide, 4-5 parts of nutritional health-care agent and 7-9 parts of seaweed polysaccharide soluble powder;
step two, uniformly mixing the traditional Chinese medicine components, nucleotide and seaweed polysaccharide soluble powder to obtain premixed powder;
sequentially adding chitosan oligosaccharide, L-ascorbic acid, lactic acid and glutamine into purified water to form a nutritional health-care agent with the mass fraction of 18-20%, and placing the nutritional health-care agent in a spray liquid charging bucket as spray liquid;
and fourthly, adding the premixed powder into a feeding hopper of the granulating device, starting a valve of which the motor and the spraying mechanism are connected to a spraying liquid charging bucket, rotating the compression roller around the driving shaft rod while revolving under the action of the linkage mechanism, rolling the premixed powder, and forming particles of specifications under the forming action of the template to obtain the veterinary drug composition.
Comparative example 1
The nucleotide material in example 1 was removed, and the remaining components and preparation process were unchanged.
Comparative example 2
The raw materials of the nutritional health-care agent in the embodiment 1 are removed, and the other components and the preparation process are not changed.
Comparative example 3
The herbal composition of example 1.
Comparative example 4
The nutritional health-care agent in the example 1 is changed into powder with the same effective components, and the powder is mixed with the rest raw materials and then granulated.
The veterinary drug compositions prepared in examples 1 to 3 and comparative examples 1 to 4 were subjected to the following performance tests:
randomly selecting 6 fattening pigs (2 pigs with weight close to average weight are selected repeatedly) from each group, collecting blood under neck with a blood collector before morning feeding, standing blood at normal temperature for 20min, centrifuging at 3000r/min, and storing the obtained serum in a refrigerator at-80 deg.C for use; the content of immunoglobulin (IgA, IgG, IgM) is determined by immunoturbidimetry; the total antioxidant capacity (T-AOC) and the activity of glutathione peroxidase (GSH-Px) are measured by a colorimetric method, and the test results are shown in the following table:
as can be seen from the above table, the veterinary drug compositions prepared in examples 1-3 have immunoglobulin (IgA, IgG, IgM) contents of 1.44-1.46 g.L, respectively-1、21.40-21.47g·L-1、2.32-2.39g·L-1The total antioxidant capacity (T-AOC) is 10.72-10.75 U.mL-1The value of glutathione peroxidase (GSH-Px) is 784.31-784.65 U.mL-1The veterinary drug composition prepared by the invention can obviously enhance the immunity of the fattening pigs and the oxidation resistance in the blood serum and tissues; the combination of the comparative example 1 and the comparative example 2 shows that the nucleotide and the nutritional health-care agent can enhance the immunity of the pigs to a certain extent; by combining the comparative example 4, the composition is granulated by the granulating device disclosed by the invention, so that the mixing uniformity of the nutritional health-care agent can be ensured, and the quality of the veterinary drug composition is further improved.
The preferred embodiments of the invention disclosed above are intended to be illustrative only. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.
Claims (9)
1. A preparation process of a veterinary drug composition for improving the immunologic function of pigs is characterized by comprising the following steps:
firstly, weighing the following raw materials in parts by weight: 30-40 parts of traditional Chinese medicine components, 2-3 parts of nucleotide, 4-5 parts of nutritional health-care agent and 7-9 parts of seaweed polysaccharide soluble powder;
step two, uniformly mixing the traditional Chinese medicine components, nucleotide and seaweed polysaccharide soluble powder to obtain premixed powder;
sequentially adding chitosan oligosaccharide, L-ascorbic acid, lactic acid and glutamine into purified water to form a nutritional health-care agent with the mass fraction of 18-20%, and placing the nutritional health-care agent in a spray liquid charging bucket as spray liquid;
and fourthly, adding the premixed powder into a feeding hopper (24) of a granulating device, starting a motor (21) and a spraying mechanism (25) to be connected to a valve of a spraying liquid charging bucket, rotating a compression roller (2313) while revolving around a driving shaft rod (2306) under the action of a linkage mechanism, rolling the premixed powder, and forming granules of the specification under the forming action of a template (2307) to obtain the veterinary drug composition.
2. The preparation process of the veterinary drug composition for improving the pig immune function according to claim 1, wherein the traditional Chinese medicine components comprise the following raw materials in parts by weight: 10-14 parts of astragalus membranaceus, 11-13 parts of scutellaria baicalensis, 6-8 parts of echinacea purpurea, 5-7 parts of folium isatidis, 8-10 parts of epimedium, 10-12 parts of isatis roots, 5-6 parts of radix paeoniae alba, 4-5 parts of codonopsis pilosula, 5-6 parts of bighead atractylodes rhizome, 6-8 parts of pericarpium citri reticulatae, 5-6 parts of eucommia ulmoides leaves, 3-4 parts of liquorice and 5-6 parts of cinnamon;
mixing the traditional Chinese medicine substances in the traditional Chinese medicine components, and performing water extraction and spray drying to obtain the traditional Chinese medicine components.
3. The preparation process of the veterinary drug composition for improving the pig immune function according to claim 1, wherein the nutritional health-care agent is a liquid preparation formed by dissolving effective components in purified water, wherein the effective components comprise chitosan oligosaccharide, L-ascorbic acid, lactic acid and glutamine, and the mass ratio of the components is 0.1:10:5: 0.8.
4. The preparation process of the veterinary drug composition for improving the pig immune function according to the claim 1, characterized in that the granulating device comprises a bearing frame body (1) and a granulating mechanism (2) arranged on the bearing frame body (1);
the bearing frame body (1) comprises a bearing plate frame (11), four upright posts (13) are vertically fixed at four vertex angles of the upper surface of the bearing plate frame (11), a bearing plate (14) is fixed on the surface of the other end of each upright post (13), and the bearing plate (14) is arranged in parallel to the bearing plate frame (11); a transverse plate (15) arranged along the width direction of the bearing plate frame (11) is fixed on the inner side surface of the bearing plate frame, a vertical plate (16) is fixed on the upper surface of the transverse plate (15), and the other end of the vertical plate (16) is fixed on the lower surface of the bearing plate (14); the center of the surface of the bearing plate (14) is provided with an installation through hole for installing the granulation mechanism (2);
the granulating mechanism (2) comprises a motor (21), a connecting frame (22), a material grinding device (23) and a feeding funnel (24) which are sequentially arranged from bottom to top, the connecting frame (22) comprises a gearbox (2201), a connecting plate (2202) is fixed on the side surface of the gearbox (2201), and the connecting plate (2202) is fixed on a vertical plate (16); the motor (21) is fixed on the end side surface of the gearbox (2201) and the output end of the motor extends into the gearbox (2201); the grinding device (23) comprises a hopper base flange (2301), the hopper base flange (2301) is fixed on a bearing plate (14) through bolts, the surface of the hopper base flange (2301) is fixed with a hopper base (2302), the inner surface of the periphery of the hopper base (2302) is fixed with a conical plate (2304), the conical plate (2304) comprises a conical plate and a ring plate which is integrally formed with the conical plate, the ring plate is fixed on the inner surface of the periphery of the hopper base (2302), the conical plate (2304) is fixedly penetrated through an installation cylinder (2305) along the axis direction, an active shaft lever (2306) is installed in the installation cylinder (2305) through a bearing, one end of the active shaft lever (2306) penetrates through the bearing plate (14), extends into a gearbox (2201), and is connected with an output end in the gearbox (2201); a template (2307) is further fixed on the inner surface of the periphery of the hopper base (2302), and the template (2307) is fixed on the inner surface of the periphery of the hopper base (2302); the driving shaft lever (2306) penetrates through the template (2307), the upper end of the driving shaft lever is fixed with the connecting cylinder (2308), the inner wall of the connecting cylinder (2308) is fixed with the annular clamping plate (2309), the annular clamping plate (2309) is fixed on the driving shaft lever (2306), the connecting cylinder (2308) is internally provided with the linkage mechanism, the linkage mechanism comprises a first bevel gear (2310), the lower surface of the first bevel gear (2310) is fixed with the fixing cylinder (2314), the fixing cylinder (2314) is fixed on the template (2307), the surface of the template (2307) is provided with a circular through hole, the circular through hole can penetrate through the driving shaft lever (2306), the first bevel gear (2310) is fixed in the circular through hole of the template (2307) through the fixing cylinder (2314), the driving shaft lever (2306) penetrates through the whole first bevel gear (2310), the linkage mechanism further comprises three second bevel gears (2311) uniformly distributed along the circumferential direction, and the second bevel gears (, the second bevel gear (2311) is meshed with the first bevel gear (2310), the connecting rod (2312) is arranged on the connecting cylinder (2308) in a penetrating mode through a bearing, and the other end of the connecting rod (2312) is fixedly provided with a pressing roller (2313); the feeding funnel (24) is a cylindrical funnel, and the feeding funnel (24) is fixed on the upper end surface of the hopper base (2302); still be equipped with spraying mechanism (25) in feed hopper (24), spraying mechanism (25) are including solid fixed ring (2501), gu fixed ring (2501) are fixed in on initiative axostylus axostyle (2306), gu fixed ring (2501) week side is fixed with shower (2502), the surface of shower (2501) is seted up the spraying hole (2503) of equipartition.
5. The preparation process of the veterinary drug composition for improving the pig immunity function according to claim 4, wherein the surface of the connecting plate (2202) is provided with a first circular through hole (2203), and a bolt penetrates through the first circular through hole (2203) to fix the whole connecting frame (22) on the vertical plate (16).
6. The preparation process of the veterinary drug composition for improving the pig immunity function according to claim 4, wherein the hopper base (2302) comprises an annular connection plate and a cylindrical hopper base integrally formed with the annular connection plate, and the side wall of the cylindrical hopper base is provided with a discharge hole (2303).
7. The preparation process of the veterinary drug composition for improving the pig immune function according to claim 4, wherein the template (2307) is a circular plate, and the surface of the template (2307) is provided with granulation through holes with standard pore diameters.
8. The preparation process of the veterinary drug composition for improving the pig immunity as claimed in claim 4, wherein the peripheral outer surface of the template (2307) is provided with an installation groove, the template (2307) is fixed in the hopper base (2302) by inserting a bolt into the installation groove, and the upper surface of the template (2307) is flush with the upper end surface of the hopper base (2302).
9. The preparation process of the veterinary drug composition for improving the pig immunity function according to claim 4, wherein the fixing ring (2501) is internally provided with a cavity structure and communicated with the spraying hole (2503), the upper surface of the fixing ring (2501) is provided with a liquid inlet (2504), and the liquid inlet (2504) is communicated with a liquid barrel for storing spraying liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911420059.5A CN110960630A (en) | 2019-12-31 | 2019-12-31 | Preparation process of veterinary drug composition for improving pig immune function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911420059.5A CN110960630A (en) | 2019-12-31 | 2019-12-31 | Preparation process of veterinary drug composition for improving pig immune function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110960630A true CN110960630A (en) | 2020-04-07 |
Family
ID=70037773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911420059.5A Withdrawn CN110960630A (en) | 2019-12-31 | 2019-12-31 | Preparation process of veterinary drug composition for improving pig immune function |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110960630A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113632889A (en) * | 2021-08-13 | 2021-11-12 | 河南惠通天下生物工程有限公司 | Traditional Chinese medicine compound type nonreactive and immunity-enhancing feed additive and preparation method thereof |
-
2019
- 2019-12-31 CN CN201911420059.5A patent/CN110960630A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113632889A (en) * | 2021-08-13 | 2021-11-12 | 河南惠通天下生物工程有限公司 | Traditional Chinese medicine compound type nonreactive and immunity-enhancing feed additive and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102949348B (en) | Enramycin dry suspension and preparation method thereof | |
| CN103156061B (en) | Compound microbial active additive | |
| CN111011643A (en) | Bacterium enzyme fermented traditional Chinese medicine for improving growth performance of broiler chicken and preparation method thereof | |
| CN110960630A (en) | Preparation process of veterinary drug composition for improving pig immune function | |
| CN112544809A (en) | Plant feed additive for preventing and treating diarrhea of weaned piglets and preparation method thereof | |
| CN106721936A (en) | A kind of mold toxin sorbent and preparation method thereof | |
| CN104082528B (en) | A kind of feed addictive and preparation method thereof | |
| CN1965993A (en) | Natural botanical extraction liquid for preventing and treating livestock and birds respiratory disease and preparation process thereof | |
| CN112535239B (en) | Compound Chinese herbal medicine feed additive for daily health care and growth promotion of livestock and preparation and application thereof | |
| CN1043296C (en) | Powder feed for chicken | |
| CN113455585A (en) | Natural anti-bacterial feed additive and preparation method thereof | |
| CN102895355A (en) | Chinese medicinal injection for treating livestock diarrhea and preparation method thereof | |
| CN112006176A (en) | Compound Chinese herbal medicine probiotic fermented feed additive for pigs | |
| CN107998381B (en) | Compound preparation for preventing and treating white feces disease of penaeus vannamei boone and preparation and use methods thereof | |
| CN107319546B (en) | Fermented traditional Chinese medicine powder and preparation method thereof | |
| CN101401617B (en) | Spirulina feedstuff additive for livestock, poultry biology and aquatic livestock, and method of preparing the same | |
| CN115606686A (en) | Method for fermenting Chinese herbal medicine by using microbial agent, fermentation product, chinese herbal medicine microecological premixed feed and application | |
| CN107691301A (en) | A kind of method of fish fast-growth | |
| CN112931712A (en) | Fermented traditional Chinese medicine premix feed for promoting growth of weaned piglets and preparation method and application thereof | |
| CN102550805A (en) | Chinese herbal medicine feed additive | |
| CN102232974A (en) | Preparation method of Chinese medicinal granule for poultry | |
| CN111938027A (en) | Sealwort overground part livestock feed and preparation method thereof | |
| CN1733052A (en) | Effervescence tablet with honeysuckle, Chinese gold thread and forsythia fruit and its preparation process | |
| CN1813783A (en) | Azithromycin micro-pill capsule and its preparing method | |
| CN115887556B (en) | Earthworm peptide fermented preparation for improving immunity and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20200407 |
|
| WW01 | Invention patent application withdrawn after publication |