CN106721936A - A kind of mold toxin sorbent and preparation method thereof - Google Patents

A kind of mold toxin sorbent and preparation method thereof Download PDF

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Publication number
CN106721936A
CN106721936A CN201611084528.7A CN201611084528A CN106721936A CN 106721936 A CN106721936 A CN 106721936A CN 201611084528 A CN201611084528 A CN 201611084528A CN 106721936 A CN106721936 A CN 106721936A
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China
Prior art keywords
mold toxin
toxin sorbent
parts
additive
sorbent
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CN201611084528.7A
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Chinese (zh)
Inventor
艾琴
夏超笃
湛穗璋
方炳虎
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Guangdong Wens Dahuanong Biotechnology Co Ltd
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Guangdong Wens Dahuanong Biotechnology Co Ltd
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Priority to CN201611084528.7A priority Critical patent/CN106721936A/en
Publication of CN106721936A publication Critical patent/CN106721936A/en
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Fodder In General (AREA)

Abstract

The invention discloses a kind of mold toxin sorbent, including component following by weight:30 50 parts of bentonite, 15 parts of activated carbon, 30 40 parts of additive A, 5 39 parts of additive B;The additive A is yeast cell wall, and the additive B is Radix Glycyrrhizae or plant extracts, and the plant extracts is astragalus polyose or panaxan.The invention also discloses the preparation method of mold toxin sorbent.Mold toxin sorbent of the invention, has efficient adsorption effect to aflatoxin, zearalenone, it is adaptable to which addition is used in short term for the serious raw material of mycotoxin contamination and cultivation site.

Description

A kind of mold toxin sorbent and preparation method thereof
Technical field
The invention belongs to feed additive field, and in particular to a kind of adsorbent of absorbing mycotoxin and its preparation side Method.
Background technology
Mycotoxin is the secondary metabolic product that mould produces during its growth and breeding, the kind more than 300 being currently known In mycotoxin, have 20 to plant meeting and produce growth of animal more and endanger, especially with AFB1 (AFB1), zearalenone (ZEN) and vomitoxin is representative, its can cause the reduction of growth of animal performance, trigger clinical disease, even death etc. it is serious after Really.
Due to Present Global unusual weather conditions, the mould contamination of feedstuff has been aggravated.Since in November, 2014, corn Zearalenone and vomitoxin are seriously polluted in byproduct and fermented feed sample, vomitoxin pollution in wheat and wheat bran Seriously.Part of in August, 2015 is built bright CLS detections sample result and shows that the concentration of zearalenone exceedes in fermented feed 4000ug/kg (GB limitation 500ug/kg), the concentration of zearalenone has exceeded 300ug/kg in complete diet pellet and corn, The situation very severe of feed safety.It is to reduce mycotoxin harm, raising by mold toxin sorbent is added in feed The effective means of breeding performonce fo animals, therefore the exploitation of mold toxin sorbent product is great with dissemination.
Presently commercially available mold toxin sorbent product is divided into two classes.One class is absorbent-type product, thin with bentonite, yeast Based on cell wall;Another kind of is breakdown type product, based on bacillus.Shown according to correlation analysis result, absorbent-type product is to Huang The adsorption rate of aspertoxin B1 can reach 70%~85%, but be only 20%~30% to the adsorption rate of zearalenone; Breakdown type product to the degradation rate of AFB1 up to 100%, to the degradation rate of zearalenone up to more than 90%, But the Time in Vitro for reaching the effect above need to be larger with actual production conditions deviation up to more than 24h, and its bacterial strain safety Property is still to be tested.
In view of the foregoing, in the market is badly in need of safe efficient, the with strong points mold toxin sorbent product of a class.
The content of the invention
In order to overcome the deficiencies in the prior art, it is an object of the invention to provide a kind of mold toxin sorbent, it is to Huang Aspertoxin, zearalenone have efficient adsorption effect, it is adaptable to which the serious raw material of mycotoxin contamination and cultivation are existing The short-term addition in field is used.
It is a further object of the present invention to provide the preparation method of above-mentioned mold toxin sorbent.
The purpose of the present invention is realized using following technical scheme:
A kind of mold toxin sorbent, including component following by weight:Bentonite 30-50 parts, activated carbon 1-5 parts, Additive A 30-40 parts, additive B 5-39 parts;The additive A is yeast cell wall, and the additive B is Radix Glycyrrhizae or plant Thing extract, the plant extracts is astragalus polyose or panaxan.
In the present invention, bentonite and activated carbon all have very strong physisorption;Yeast cell wall can be by regulation Microorganism colonization in enteron aisle, so improve enteron aisle mechanochemistry barrier, protect intestinal health, and can improve body it is anti-oxidant and Cellular immune level, improves body immunity;Radix Glycyrrhizae, astragalus polyose and panaxan have removing toxic substances, antibacterial and improve immune The effect of power, can alleviate the clinical symptoms that mycotoxin causes.
Preferably, the yeast cell wall is brewing yeast cell wall.
Preferably, the bentonite is na-montmorillonite, and the activated carbon is medicinal carbon.
Preferably, in described mold toxin sorbent, the content of na-montmorillonite is 40 parts.
Preferably, in described mold toxin sorbent, the content of medicinal carbon is 3 parts.
Preferably, in described mold toxin sorbent, the content of yeast cell wall is 20 parts.
Preferably, in described mold toxin sorbent, the content of Radix Glycyrrhizae is 37 parts.
The invention also discloses the preparation method of above-mentioned mold toxin sorbent, comprise the following steps:
Bentonite, activated carbon, additive A and additive B are weighed in proportion, is well mixed, obtain final product the mycotoxin and inhale Attached dose.
Preferably, the Radix Glycyrrhizae is fine powder, standby after being sieved through 200 eye mesh screens.
Preferably, it in environment temperature is 20-25 DEG C that the mixing is, humidity is to carry out under conditions of 60%-70%.
Compared to existing technology, the beneficial effects of the present invention are:
The present invention is raw material by selecting bentonite, activated carbon, yeast cell wall, Radix Glycyrrhizae, plant extracts, so that fully The effect for having played each raw material, the mold toxin sorbent for obtaining, zearalenone and Huang that can be in efficient absorption feed The mycotoxins such as aspertoxin B1, the toxin of absorption can be wrapped in granule for absorbing and be excreted by animal alimentary canal;Its Secondary, mold toxin sorbent of the invention can improve resistivity of the animal body to mycotoxin;Additionally, mould of the invention Endotoxin adsorbent, the source of raw material is wide, low cost, and nontoxic pollution-free, is a kind of green adsorbent.
Mold toxin sorbent of the invention, it is adaptable to which the serious feed of mycotoxin contamination and cultivation site are added in short term Use.
Specific embodiment
Below, with reference to specific embodiment, the present invention is described further:
In detailed description below, purchased from Guangzhou tide along building materials Co., Ltd, wherein montmorillonite contains na-montmorillonite Amount is more than 88%, and medicinal carbon is bought from the equal activated carbon Co., Ltd in Xiamen, and Radix Glycyrrhizae, astragalus polyose, panaxan purchase From Xi'an Bioisystech Co., Ltd of Tianrui.
Embodiment 1
A kind of mold toxin sorbent, including component following by weight:30 parts of na-montmorillonite, medicinal carbon 5 Part, 40 parts of brewing yeast cell wall, 37 parts of Radix Glycyrrhizae.
The mold toxin sorbent is prepared from by following preparation method:
1) it is fine powder Radix Glycyrrhizae to be crushed through micronizer, is sieved through 200 eye mesh screens, obtains Radix Glycyrrhizae micropowder;
2) na-montmorillonite, medicinal carbon, brewing yeast cell wall and Radix Glycyrrhizae micropowder are weighed in proportion, are added to single shaft It it is 20-25 DEG C in environment temperature in paddle type mixer, humidity is obtained final product described to mix 5 minutes under conditions of 60%-70% Mold toxin sorbent.
Embodiment 2
A kind of mold toxin sorbent, including component following by weight:40 parts of na-montmorillonite, medicinal carbon 3 Part, 20 parts of brewing yeast cell wall, 37 parts of Radix Glycyrrhizae.
The mold toxin sorbent is prepared from by following preparation method:
1) it is fine powder Radix Glycyrrhizae to be crushed through micronizer, is sieved through 200 eye mesh screens, obtains Radix Glycyrrhizae micropowder;
2) na-montmorillonite, medicinal carbon, brewing yeast cell wall and Radix Glycyrrhizae micropowder are weighed in proportion, are added to single shaft It it is 20-25 DEG C in environment temperature in paddle type mixer, humidity is obtained final product described to mix 5 minutes under conditions of 60%-70% Mold toxin sorbent.
Embodiment 3
A kind of mold toxin sorbent, including component following by weight:50 parts of na-montmorillonite, medicinal carbon 1 Part, 30 parts of brewing yeast cell wall, 19 parts of Radix Glycyrrhizae.
The mold toxin sorbent is prepared from by following preparation method:
1) it is fine powder Radix Glycyrrhizae to be crushed through micronizer, is sieved through 200 eye mesh screens, obtains Radix Glycyrrhizae micropowder;
2) na-montmorillonite, medicinal carbon, brewing yeast cell wall and Radix Glycyrrhizae micropowder are weighed in proportion, are added to single shaft It it is 20-25 DEG C in environment temperature in paddle type mixer, humidity is obtained final product described to mix 5 minutes under conditions of 60%-70% Mold toxin sorbent.
Embodiment 4
A kind of mold toxin sorbent, including component following by weight:40 parts of na-montmorillonite, medicinal carbon 3 Part, 20 parts of brewing yeast cell wall, 37 parts of astragalus polyose.
The mold toxin sorbent is prepared from by following preparation method:
Na-montmorillonite, medicinal carbon, brewing yeast cell wall and astragalus polyose are weighed in proportion, are added to single shaft oar It it is 20-25 DEG C in environment temperature in leaf formula mixer, humidity is obtained final product described mould to mix 5 minutes under conditions of 60%-70% Verticillium toxin adsorbent.
Embodiment 5
A kind of mold toxin sorbent, including component following by weight:40 parts of na-montmorillonite, medicinal carbon 3 Part, 20 parts of brewing yeast cell wall, 37 parts of panaxan.
The mold toxin sorbent is prepared from by following preparation method:
Na-montmorillonite, medicinal carbon, brewing yeast cell wall and panaxan are weighed in proportion, are added to single shaft oar It it is 20-25 DEG C in environment temperature in leaf formula mixer, humidity is obtained final product described mould to mix 5 minutes under conditions of 60%-70% Verticillium toxin adsorbent.
Experimental example:Absorption and desorption experiment of the mold toxin sorbent to mycotoxin
1. adsorptivity and desorption of the mold toxin sorbent to AFB1 (AFB1) and zearalenone (ZEN) Property experiment
50ml tool plug centrifuge tubes are taken, the sample of sorbent 0.100g (being accurate to 0.001g) of embodiment 1-3 is weighed, number is recorded According to 3 repetitions of each sample.The mixed mark solution of AFB1 and ZEN is added, 20ml running water (pH=5.25) is subsequently adding.Tool plug, puts In 41 DEG C of constant temperature oscillation water-baths, 2.0h is adsorbed by 180r/min hunting of frequencys, mixed 1 time every 5min shakings therebetween.Inhale After reaction enclosure terminates, in 10min is centrifuged under 3000r/min, 15ml supernatants are pipetted, determine wherein AFB1 and ZEN contents.It is remaining 15ml pH=8.00 running water is added in residue, in 37 DEG C of constant temperature oscillation water-baths, is desorbed by 150r/min hunting of frequencys 1h, it is mixed 1 time every 30min shakings.Then, in 10min is centrifuged under 3000r/min, 15ml supernatants are pipetted, is determined wherein AFB1 and ZEN contents.Such continuous desorption 3 times, calculates 3 accumulation desorption quantities and desorption efficiency, and acquired results are as shown in table 1-2.
Absorption and desorption result of the adsorbent of the embodiment 1-3 of table 1 to AFB1
Absorption and desorption result of the adsorbent of the embodiment 1-3 of table 2 to ZEN
From table 1-2, mold toxin sorbent of the invention is to the adsorption rate of AFB1 up to 100.00%, and desorption efficiency 0.00%;To the adsorption rate of ZEN up to more than 99%, desorption efficiency is less than 4%.It can be seen that mold toxin sorbent of the invention is to AFB1 Good absorption property is respectively provided with ZEN, and desorption efficiency is low.
2. absorption and desorption experiment of the mold toxin sorbent to vitamin E and B1
Test procedure is with experiment 1.The effective addition of vitamin E is 5% (in terms of vitamin), the effective addition of vitamin B1 It is 2% (in terms of vitamin).
Experimental result shows, is not detected by vitamin E and B1 after adsorption reaction, in system, is not examined yet after desorbing repeatedly for 3 times It is 100% that vitamin E and B1, the i.e. adsorbent are measured to the adsorption rate of vitamin E and B1, and is desorbed.It can be seen that this hair Bright mold toxin sorbent also has very strong adsorption capacity to vitamin E and this kind of nutrients of B1, if being added to feeding for a long time In material, the loss of nutrient in feed can be caused.Therefore the mold toxin sorbent is only applicable to add in short term and uses.
It will be apparent to those skilled in the art that technical scheme that can be as described above and design, make other various It is corresponding to change and deformation, and all these change and deformation should all belong to the protection domain of the claims in the present invention Within.

Claims (9)

1. a kind of mold toxin sorbent, it is characterised in that including component following by weight:Bentonite 30-50 parts, activity Charcoal 1-5 parts, additive A 30-40 parts, additive B 5-39 parts;The additive A is yeast cell wall, and the additive B is Radix Glycyrrhizae or plant extracts, the plant extracts are astragalus polyose or panaxan.
2. mold toxin sorbent as claimed in claim 1, it is characterised in that the yeast cell wall is brewing yeast cell Wall.
3. mold toxin sorbent as claimed in claim 1, it is characterised in that the bentonite is na-montmorillonite, described Activated carbon is medicinal carbon.
4. mold toxin sorbent as claimed in claim 3, it is characterised in that in the mold toxin sorbent, sodium base is covered The content of de- stone is 40 parts.
5. mold toxin sorbent as claimed in claim 3, it is characterised in that in the mold toxin sorbent, medicinal work Property charcoal content be 3 parts.
6. mold toxin sorbent as claimed in claim 2, it is characterised in that in the mold toxin sorbent, ferment of making wine The content of mother cell wall is 20 parts.
7. mold toxin sorbent as claimed in claim 1, it is characterised in that in the mold toxin sorbent, Radix Glycyrrhizae Content is 37 parts.
8. a kind of preparation method of mold toxin sorbent as claimed in claim 1, it is characterised in that comprise the following steps:
Bentonite, activated carbon, additive A and additive B are weighed in proportion, is well mixed, obtain final product the mold toxin sorbent.
9. the preparation method of mold toxin sorbent as claimed in claim 8, it is characterised in that the mixing is in environment temperature To spend be 20-25 DEG C, and humidity is to carry out under conditions of 60%-70%.
CN201611084528.7A 2016-11-30 2016-11-30 A kind of mold toxin sorbent and preparation method thereof Pending CN106721936A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107519843A (en) * 2017-09-01 2017-12-29 华中农业大学 Toxin compound adsorbents of animal and fowl fodder T 2 and its preparation method and application
CN108094680A (en) * 2017-12-18 2018-06-01 广州美瑞泰科生物工程技术有限公司 A kind of feed detoxifying agent and preparation method and application
CN109619380A (en) * 2018-11-16 2019-04-16 华中农业大学 It a kind of mycotoxin compound adsorbent and its is applied in animal feed detoxification
CN109647339A (en) * 2019-01-25 2019-04-19 中国科学院兰州化学物理研究所 The method for preparing mold toxin sorbent using semicoke
CN112931706A (en) * 2021-02-08 2021-06-11 宁夏大洋饲料科技有限公司 Special compound premix feed for dairy cows in early perinatal period and preparation method thereof

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CN105211635A (en) * 2015-10-26 2016-01-06 金华傲农生物科技有限公司 A kind of feed addictive removing mycotoxin and preparation method thereof and application
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EP2289617A1 (en) * 2009-08-27 2011-03-02 Süd-Chemie AG Toxin adsorbent
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107519843A (en) * 2017-09-01 2017-12-29 华中农业大学 Toxin compound adsorbents of animal and fowl fodder T 2 and its preparation method and application
CN108094680A (en) * 2017-12-18 2018-06-01 广州美瑞泰科生物工程技术有限公司 A kind of feed detoxifying agent and preparation method and application
CN109619380A (en) * 2018-11-16 2019-04-16 华中农业大学 It a kind of mycotoxin compound adsorbent and its is applied in animal feed detoxification
CN109647339A (en) * 2019-01-25 2019-04-19 中国科学院兰州化学物理研究所 The method for preparing mold toxin sorbent using semicoke
CN112931706A (en) * 2021-02-08 2021-06-11 宁夏大洋饲料科技有限公司 Special compound premix feed for dairy cows in early perinatal period and preparation method thereof

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