CN110960444B - Slow-release lasting antibacterial hand sanitizer and preparation method thereof - Google Patents
Slow-release lasting antibacterial hand sanitizer and preparation method thereof Download PDFInfo
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- CN110960444B CN110960444B CN202010010651.4A CN202010010651A CN110960444B CN 110960444 B CN110960444 B CN 110960444B CN 202010010651 A CN202010010651 A CN 202010010651A CN 110960444 B CN110960444 B CN 110960444B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8129—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Abstract
The invention belongs to the field of daily chemicals, and particularly relates to a slow-release lasting antibacterial hand sanitizer and a preparation method thereof. Dispersing the antibacterial agent in cross-linked polyvinyl alcohol which is water-resistant and easy to form a glue film to obtain polyvinyl alcohol antibacterial colloidal particles; uniformly dispersing 3-5 parts of polyvinyl alcohol antibacterial colloidal particles, 0.05-0.1 part of an antibacterial agent, 10-15 parts of cocamidopropyl betaine, 0.2-0.5 part of sodium chloride, 2-3 parts of polyglycerol-10, 0.5-1.5 parts of citric acid, 0.2-1 part of an ester-adding agent, 0.1-0.2 part of an anti-hard water agent and 30-35 parts of deionized water according to parts by weight to obtain the slow-release durable antibacterial hand sanitizer. The polyvinyl alcohol antibacterial colloidal particle dispersed hand sanitizer forms a glue film when kneading and washing hands, and achieves the effect of slowly releasing and persistently inhibiting bacteria.
Description
Technical Field
The invention relates to the field of daily chemicals, in particular to a slow-release long-lasting antibacterial hand sanitizer and a preparation method thereof.
Background
In life and work, hands inevitably contact with bacteria, and the bacteria can cause diseases. Ancient Chinese has ancient languages: the word "the disease enters from the mouth" is enough to be seen from ancient times, and Chinese pays great attention to hand hygiene. At present, the duty of washing hands is becoming a norm in terms of putting attention to hygiene. Especially, the antibacterial hand sanitizer can kill most of bacteria and is widely used. The antibacterial hand sanitizer is accepted by more and more consumers as a daily washing product, is applied to public occasions such as hospitals and schools, and has a good instant sterilization effect. Originally, due to the restriction of living conditions and markets, perfumed soaps, washing powders and the like are commonly used for washing hands of people, and although the perfumed soaps, the washing powders and the like can achieve certain cleaning effect, the perfumed soaps have stimulation effect on the skin and poor antibacterial effect.
Due to the wide application of the hand sanitizer, people have higher requirements on the hand sanitizer, and the hand sanitizer is expected to keep long-term antibacterial activity after hand washing while requiring excellent antibacterial effect. However, most of the existing antibacterial hand sanitizer is instant hand sanitizer, can only kill bacteria attached to hands, and cannot achieve a lasting sterilization effect after hand washing.
At present, a no-clean hand sanitizer appears on the market, which mainly disperses silver ions in glycerin and the like to play a role in skin care and sterilization, but has poor dirt-removing capability.
Disclosure of Invention
At present, most of the antibacterial hand sanitizer is instant hand sanitizer, can only kill bacteria attached to hands, and cannot realize a lasting sterilization effect after hand washing. Aiming at the problem, the invention provides a sustained-release and persistent antibacterial hand sanitizer, wherein polyvinyl alcohol antibacterial colloidal particles capable of forming a film are dispersed in the hand sanitizer, and the polyvinyl alcohol antibacterial colloidal particles have certain water resistance and are dispersed in the hand sanitizer in the form of micro colloidal particles. Furthermore, the invention provides a method for preparing the hand sanitizer with the sustained-release and lasting antibacterial activity.
The key point of the invention is to obtain polyvinyl alcohol antibacterial colloidal particles, which aim to realize the dispersion of an antibacterial agent in polyvinyl alcohol and form colloidal particles with fine morphology, the colloidal particles are called as polyvinyl alcohol antibacterial colloidal particles, the colloidal particles have the characteristic of being uniformly dispersed in liquid hand sanitizer for a long time, have certain water resistance and can not be dissolved by the liquid hand sanitizer to damage the colloidal particle morphology, thereby meeting the requirements of storage and use of the hand sanitizer; furthermore, the colloidal particles can gradually form a glue film during strong rubbing so as to form a layer of micro glue film on the surface of the hand, and the antibacterial agent dispersed in the glue film is slowly released so as to meet the lasting antibacterial and bacteriostatic effect.
In order to achieve the technical purpose, the following technical scheme is adopted:
the preparation method of the sustained-release persistent antibacterial hand sanitizer is characterized by comprising the following steps: the preparation method comprises the following steps:
(1) uniformly stirring and mixing polyvinyl alcohol, glycerol and water, and aging in a sealed bag for 24 h;
(2) stirring the aged material in the step (1), organic acid, ammonium persulfate and glutaraldehyde at 50-60 ℃ for crosslinking reaction to obtain crosslinked polyvinyl alcohol solution;
(3) adding the antibacterial agent into the cross-linked polyvinyl alcohol solution, stirring at 60-70 deg.C for 3-5min, and high-pressure atomizing and drying to obtain antibacterial polyvinyl alcohol colloidal particles dispersed with the antibacterial agent;
(4) dispersing 3-5 parts of polyvinyl alcohol antibacterial colloidal particles, 0.05-0.1 part of an antibacterial agent, 10-15 parts of cocamidopropyl betaine, 0.2-0.5 part of sodium chloride, 2-3 parts of polyglycerol-10, 0.5-1.5 parts of citric acid, 0.2-1 part of an ester-adding agent, 0.1-0.2 part of an anti-hard water agent and 30-35 parts of deionized water uniformly and filling to obtain the slow-release lasting antibacterial hand sanitizer.
Preferably, in the step (1), the polyvinyl alcohol, the glycerol and the water are uniformly mixed and placed in a sealing manner at a mass ratio of 50:15: 100-.
Further, the polyvinyl alcohol with the model number of 1788 is preferably selected as the polyvinyl alcohol in the step (1), which has the remarkable advantages of water solubility and good water resistance after crosslinking treatment, so that the polyvinyl alcohol antibacterial colloidal particles prepared by the invention can be dispersed in the hand washing solution and become film-shaped during rubbing.
Preferably, the aged material in the step (2), the organic acid, the ammonium persulfate and the glutaraldehyde are mixed according to a mass ratio of 100:1-2: 0.1-0.3: 1-3, the purpose of which is to impart water resistance to the polyvinyl alcohol cross-linking. Further preferably, the organic acid is acetic acid.
Preferably, the crosslinking reaction in step (2) is controlled to have a crosslinking time of 1-2 h.
Preferably, the antibacterial agent and the cross-linked polyvinyl alcohol solution in the step (3) are dispersed according to the mass ratio of 5:100, and the antibacterial agent is uniformly dispersed in the cross-linked polyvinyl alcohol solution after stirring treatment at 60-70 ℃ for 3-5 min. The antibacterial agent is at least one of 2,4,4 '-trichloro-2' -hydroxydiphenyl ether, parachlorometaxylenol and hexamidine diisethionate. Wherein the 2,4,4 '-trichloro-2' -hydroxydiphenyl ether is white crystal powder, has melting point of 56-58 deg.C, and slightly soluble in water, and has antibacterial effect on intestinal pathogenic bacteria and pyococcus; the parachlorometaxylenol is white crystalline powder, has killing effects on most gram-positive and gram-negative bacteria, fungi and mould fungi and has no stimulation; hexamidine diisethionate is white powder in the form of white crystals, is soluble in water, ethanol and propylene glycol, has broad-spectrum antibacterial activity, has significant effects of resisting and killing gram-positive bacteria, gram-negative bacteria, yeast, mold, dermatophytes and the like, and has high skin affinity.
Preferably, high-pressure atomization drying is adopted in the step (3), the pressure of an atomization gun is controlled to be 1.2-1.5MPa, the diameter of the gun is controlled to be 0.5-1mm, and the drying temperature is controlled to be 70-80 ℃. The particle size of the dried polyvinyl alcohol antibacterial colloidal particles is 50-100 mu m by controlling the pressure and the caliber of an atomizing gun. Too coarse particle size affects dispersion in the hand sanitizer and hand feel; the grain diameter is too fine, and the colloidal particles are difficult to form a film during kneading due to fineness.
Preferably, the antibacterial agent in step (4) is at least one of 2,4,4 '-trichloro-2' -hydroxydiphenyl ether, parachlorometaxylenol and hexamidine diisethionate. Aims to realize instant sterilization during hand washing, and belongs to the conventional selection of the conventional antibacterial hand sanitizer.
In the step (4), the cocamidopropyl betaine is a main surface active component in the hand sanitizer formula, has the basic functions of removing oil dirt and dirt on hands and generating certain foam, has excellent stability under acidic and alkaline conditions, and has good compatibility, small irritation, easy water solubility and excellent flexibility.
When the surfactant is used for cleaning dirt on hands, the protective grease for removing skin is removed, the hand skin is chapped, rough and lose elasticity after long-term use, and the ester adding agent is used for preventing the skin from being degreased and dried. Preferably, in the step (4), the ester adding agent is at least one of isopropyl myristate, glycerol cocoyl polyethylene glycol ester and octyl hydroxystearate.
In the step (4), the polyglycerol-10 has oil-water commonality, is associated through hydrogen bonds, locks water in a cage type, and has good moisture retention; meanwhile, the skin can be continuously filmed, the polyvinyl alcohol antibacterial colloidal particles are assisted to be filmed on the surface of hands after being washed, and the texture discomfort on the surface of hands after the polyvinyl alcohol antibacterial colloidal particles are filmed is improved.
In the step (4), EDTA-2Na is selected as the hard water resisting agent, so that the purpose is to ensure that the hand sanitizer has a good washing effect in hard water.
The pH value of the skin of a human body is 5-6 and is acidic, and in the step (4), citric acid is selected to adjust the hand sanitizer to be weakly acidic.
In addition, the invention provides the hand sanitizer with sustained release and lasting antibacterial activity, which is prepared by the method. The antibacterial agent is characterized by containing polyvinyl alcohol antibacterial colloidal particles capable of slowly releasing the antibacterial agent. According to the invention, the antibacterial agent is dispersed in the cross-linked polyvinyl alcohol, so that the obtained polyvinyl alcohol antibacterial colloidal particles have good water resistance and can be dispersed in the hand sanitizer, when hands are washed, the polyvinyl alcohol antibacterial colloidal particles are dispersed to form a microfilm under the rubbing action, and the antibacterial agent dispersed in the microfilm can be continuously slowly released, so that the antibacterial agent has a lasting antibacterial and bacteriostatic effect.
It is known that conventional antibacterial hand sanitizer is obtained by adding and dispersing an antibacterial agent into the hand sanitizer, is basically an instant hand sanitizer, kills bacteria attached to hands, and the antibacterial agent is washed and removed immediately after the hands are washed, so that a lasting sterilization effect cannot be realized. The invention provides the slow-release and durable antibacterial hand sanitizer based on the problem, and after the hand sanitizer washes hands, a micro-film is formed on the surfaces of the hands, and an antibacterial agent is dispersed in the micro-film to keep durable antibacterial and antibacterial properties. Particularly, the hand sanitizer has great application prospect for lasting antibacterial and bacteriostatic hand sanitizers for people who pass in and out of public places for a long time, such as hospitals, public transportation, office buildings and the like.
Compared with the prior art, the slow-release and lasting antibacterial hand sanitizer has the following beneficial effects:
(1) according to the invention, the antibacterial agent is dispersed in the cross-linked polyvinyl alcohol which is water-resistant and easy to form an adhesive film, so that the polyvinyl alcohol antibacterial colloidal particles are obtained, and the colloidal particles are used for the hand sanitizer to form the adhesive film during hand rubbing and kneading, thereby achieving the effect of slowly releasing and lasting bacteriostasis.
(2) The polyglycerol-10 is added into the hand sanitizer, and the oil-water commonality of the polyglycerol-10 is utilized, and the polyglycerol-10 is associated through hydrogen bonds, so that the hand sanitizer has good moisture retention property and cage type water locking; meanwhile, the skin can be continuously filmed, the polyvinyl alcohol antibacterial colloidal particles are assisted to be filmed on the surface of hands after being washed, and the texture discomfort on the surface of hands after the polyvinyl alcohol antibacterial colloidal particles are filmed is improved.
(3) The invention realizes lasting antibacterial activity, can effectively reduce the times of washing hands of people who go in and out and workers in public places, and is particularly suitable for cleaning and sterilizing the hands of people in hospitals, schools, hotels, banks, transportation, aviation, families and public places, thereby ensuring the health and hygiene of people.
In conclusion, the invention has the advantages and practical value, and the related publicly published technologies are not found in the prior art products, so that the invention has obvious progress compared with the prior art, is more practical and has wide large-scale popularization and production values.
Drawings
In order to more clearly illustrate the technical core concept and technical solution of the present invention, the technical idea of the present invention will be shown in a schematic manner below.
FIG. 1 is a simple flow chart of the preparation of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. It is to be understood that the embodiments described are only a few embodiments of the present invention, and not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention. Meanwhile, on the basis of the conception of the invention, the hand sanitizer with certain fragrance prepared by adding various essences and the like is also within the protection scope of the invention.
Example 1
(1) Mixing 1788 polyvinyl alcohol, glycerol and water at a mass ratio of 50:15:200, stirring uniformly, sealing and standing for 24h to allow micromolecular glycerol and water to fully permeate and plasticize the polyvinyl alcohol;
(2) mixing the aged material obtained in the step (1) with acetic acid, ammonium persulfate and glutaraldehyde according to a mass ratio of 100:2: 0.1: 1, mixing, stirring at 60 ℃ for crosslinking reaction for 1h to obtain crosslinked polyvinyl alcohol solution;
(3) dispersing 2,4,4 '-trichloro-2' -hydroxydiphenyl ether of antibacterial agent and cross-linked polyvinyl alcohol liquid according to the mass ratio of 5:100, stirring at 60 ℃ for 5min to uniformly disperse the antibacterial agent in the cross-linked polyvinyl alcohol liquid, and then carrying out high-pressure atomization drying, wherein the pressure of an atomization gun is controlled at 1.5MPa, the diameter of the gun is controlled at 1mm, and the drying temperature is controlled at 80 ℃. The particle size of the dried polyvinyl alcohol antibacterial colloidal particles is maintained at 50-100 mu m by controlling the pressure and the caliber of an atomizing gun, so that the polyvinyl alcohol antibacterial colloidal particles with the antibacterial agent dispersed therein are obtained.
Example 2
With the polyvinyl alcohol antibacterial colloidal particles obtained in example 1 as core additives, 3 parts of polyvinyl alcohol antibacterial colloidal particles, 0.1 part of antibacterial agent hexamidine diisethionate, 15 parts of cocamidopropyl betaine, 0.2 part of sodium chloride, 2 parts of polyglycerol-10, 1.0 part of citric acid, 0.5 part of isopropyl myristate, 0.1 part of EDTA-2Na and 30 parts of deionized water are uniformly dispersed to obtain the slow-release durable antibacterial hand sanitizer.
Example 3
With the polyvinyl alcohol antibacterial colloidal particles obtained in example 1 as core additives, 5 parts of polyvinyl alcohol antibacterial colloidal particles, 0.1 part of antibacterial agent hexamidine diisethionate, 15 parts of cocamidopropyl betaine, 0.5 part of sodium chloride, 3 parts of polyglycerol-10, 1.5 parts of citric acid, 0.2 part of isopropyl myristate, 0.1 part of EDTA-2Na and 30 parts of deionized water are uniformly dispersed to obtain the slow-release durable antibacterial hand sanitizer.
Comparative example 1
Uniformly dispersing 0.5 part of polyvinyl alcohol antibacterial colloidal particles, 0.1 part of antibacterial agent hexamidine dihydroxyethyl sulfonate, 15 parts of cocamidopropyl betaine, 0.2 part of sodium chloride, 2 parts of polyglycerol-10, 1.0 part of citric acid, 0.5 part of isopropyl myristate, 0.1 part of EDTA-2Na and 30 parts of deionized water to obtain the antibacterial hand sanitizer.
Comparative example 1 the addition of polyvinyl alcohol antibacterial colloidal particles was greatly reduced, and due to the reduced amount of antibacterial colloidal particles, after washing hands, the antibacterial film-forming material on the hand surface was less, and the sustained antibacterial performance was affected.
Comparative example 2
Uniformly dispersing 5 parts of polyvinyl alcohol antibacterial colloidal particles, 0.5 part of antibacterial agent hexamidine dihydroxyethyl sulfonate, 15 parts of cocamidopropyl betaine, 0.2 part of sodium chloride, 1.0 part of citric acid, 0.5 part of isopropyl myristate, 0.1 part of EDTA-2Na and 30 parts of deionized water to obtain the slow-release lasting antibacterial hand sanitizer.
Comparative example 2 no polyglycerol-10 was used, and the antibacterial durability was somewhat reduced due to the absence of auxiliary polyvinyl alcohol antibacterial micelle that formed a film on the surface of the hands after washing the hands.
Comparative example 3
Uniformly dispersing 0.1 part of antibacterial agent hexamidine dihydroxyethyl sulfonate, 15 parts of cocamidopropyl betaine, 0.2 part of sodium chloride, 2 parts of polyglycerol-10, 1.0 part of citric acid, 0.5 part of isopropyl myristate, 0.1 part of EDTA-2Na and 30 parts of deionized water to obtain the antibacterial hand sanitizer.
Comparative example 3 does not use polyvinyl alcohol antibacterial colloidal particles and only relies on the antibacterial agent hexamidine diisethionate, so the hand sanitizer only has instant sterilization, and the lasting antibacterial performance after hand washing is relatively poor.
In order to verify the lasting antibacterial effect of the invention by qualitative comparison, the antibacterial test is carried out by partially referring to QB/T2738-. The method comprises the following specific steps:
1. and (3) sleeving the silica gel gloves on hands, and rubbing and washing the silica gel gloves by using the hand washing solutions obtained in the embodiments 2-3 and the comparative examples 1-3 respectively by using a simulated hand washing method to ensure that the rubbing force and time of the silica gel gloves are consistent. The washed silicone gloves were used as simulated washed hands;
2. the test bacteria are Staphylococcus aureus ATCC6538, cultured for the third generation, diluted with tryptone and soybean broth to obtain a medium concentration of 1 × 104cfu/mL。
3. And (3) dripping 20 mu L of bacterial liquid into a region with the diameter of 3cm of the silica gel glove, and testing the colony concentration of the staphylococcus aureus after 60min so as to measure the antibacterial performance. The test results are shown in table 1.
Table 1:
through tests, the antibacterial hand sanitizer disclosed by the invention has a continuous antibacterial effect after hand washing, can effectively inhibit the propagation of staphylococcus aureus, and has a good antibacterial effect. Comparative example 1 the addition of polyvinyl alcohol antibacterial colloidal particles was reduced, and due to the reduced amount of antibacterial colloidal particles, after washing, the antibacterial film-forming material formed was less and affected in the aspect of sustained bacteriostatic performance. Comparative example 2, in which polyglycerin-10 was not used, the antibacterial persistence was somewhat lowered due to the lack of surface filming of the auxiliary polyvinyl alcohol antibacterial colloidal particles. Comparative example 3 no polyvinyl alcohol antibacterial micelle was used and only hexamidine diisethionate was used as an antibacterial agent, so that it was difficult to form an antibacterial film after washing, the persistent antibacterial property was extremely poor, and the number of colonies was increased because staphylococcus aureus was also propagated due to poor antibacterial property.
Claims (2)
1. A preparation method of a slow-release and lasting antibacterial hand sanitizer is characterized by comprising the following steps: the preparation method comprises the following steps:
(1) mixing 1788 polyvinyl alcohol, glycerol and water at a mass ratio of 50:15:200, stirring uniformly, sealing and standing for 24h to allow micromolecular glycerol and water to fully permeate and plasticize the polyvinyl alcohol;
(2) mixing the aged material obtained in the step (1) with acetic acid, ammonium persulfate and glutaraldehyde according to a mass ratio of 100:2: 0.1: 1, mixing, stirring at 60 ℃ for crosslinking reaction for 1h to obtain crosslinked polyvinyl alcohol solution;
(3) dispersing 2,4,4 '-trichloro-2' -hydroxydiphenyl ether of an antibacterial agent and a cross-linked polyvinyl alcohol solution in a mass ratio of 5:100, stirring at 60 ℃ for 5min to uniformly disperse the antibacterial agent in the cross-linked polyvinyl alcohol solution, and then carrying out high-pressure atomization drying, wherein the pressure of an atomization gun is controlled at 1.5MPa, the diameter of the gun is controlled at 1mm, and the drying temperature is controlled at 80 ℃; the particle size of the dried polyvinyl alcohol antibacterial colloidal particles is maintained at 50-100 mu m by controlling the pressure and the caliber of an atomizing gun, so that the polyvinyl alcohol antibacterial colloidal particles with the antibacterial agent dispersed therein are obtained;
(4) dispersing 3-5 parts of polyvinyl alcohol antibacterial colloidal particles, 0.05-0.1 part of antibacterial hexamidine diisethionate, 10-15 parts of cocamidopropyl betaine, 0.2-0.5 part of sodium chloride, 2-3 parts of polyglycerol-10, 0.5-1.5 parts of citric acid, 0.2-1 part of ester-adding agent isopropyl myristate, 0.1-0.2 part of hard water resisting agent EDTA-2Na and 30-35 parts of deionized water uniformly by weight, and filling to obtain the slow-release durable antibacterial hand sanitizer.
2. The hand sanitizer with sustained release and lasting bacteriostasis prepared by the method of claim 1, which is characterized by containing polyvinyl alcohol antibacterial colloidal particles.
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| CN202010010651.4A CN110960444B (en) | 2020-01-06 | 2020-01-06 | Slow-release lasting antibacterial hand sanitizer and preparation method thereof |
| PCT/CN2020/113972 WO2021139193A1 (en) | 2020-01-06 | 2020-09-08 | Sustained-release long-lasting antibacterial hand sanitizer and preparation method therefor |
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| CN110960444B (en) * | 2020-01-06 | 2021-03-16 | 浙江美之源化妆品有限公司 | Slow-release lasting antibacterial hand sanitizer and preparation method thereof |
| CN114224780A (en) * | 2022-01-18 | 2022-03-25 | 永康市质量技术监测研究院 | Water-free decontamination hand sanitizer with sterilization function |
| CN114344192A (en) * | 2022-01-24 | 2022-04-15 | 耀然实业股份有限公司 | Personal care composition, personal care product and personal care product |
| CN114452434A (en) * | 2022-01-26 | 2022-05-10 | 武汉理工大学 | Broad-spectrum antibacterial polyurethane foam dressing and preparation method and application thereof |
| CN114568429A (en) * | 2022-03-29 | 2022-06-03 | 浙江绿岛科技有限公司 | Bacteriostatic and mildewproof aerosol based on self-film forming and preparation method thereof |
| CN115040427B (en) * | 2022-06-07 | 2024-02-02 | 全芯生物科技(澳门)有限公司 | Hand sanitizer with slow release effect and preparation method thereof |
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