WO2021139193A1 - Sustained-release long-lasting antibacterial hand sanitizer and preparation method therefor - Google Patents
Sustained-release long-lasting antibacterial hand sanitizer and preparation method therefor Download PDFInfo
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- WO2021139193A1 WO2021139193A1 PCT/CN2020/113972 CN2020113972W WO2021139193A1 WO 2021139193 A1 WO2021139193 A1 WO 2021139193A1 CN 2020113972 W CN2020113972 W CN 2020113972W WO 2021139193 A1 WO2021139193 A1 WO 2021139193A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8129—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Definitions
- the invention relates to the field of daily chemicals, in particular to a slow-release and durable antibacterial hand sanitizer and a preparation method.
- the present invention proposes a sustained-release and durable antibacterial hand sanitizer.
- the hand sanitizer is dispersed with polyvinyl alcohol antibacterial gel particles capable of forming a film. Because the polyvinyl alcohol antibacterial gel particles have certain water resistance, The hand sanitizer is dispersed in the form of fine rubber particles. When washing hands, as the rubbing occurs, the polyvinyl alcohol antibacterial rubber particles will gradually form a film to form a micro gel film on the surface of the hand. The antibacterial particles dispersed in the film The slow-release agent has a long-lasting antibacterial and antibacterial effect. Further, the present invention proposes a method for preparing the sustained-release and durable antibacterial hand sanitizer.
- the key to the invention is to obtain polyvinyl alcohol antibacterial colloidal particles.
- the purpose is to disperse the antibacterial agent in polyvinyl alcohol and form colloidal particles with fine morphology.
- This colloidal particle is called polyvinyl alcohol.
- Vinyl alcohol antibacterial rubber particles This rubber particle has the characteristics of being uniformly dispersed in liquid hand sanitizer for a long time, and has a certain degree of water resistance. It will not be dissolved by liquid hand sanitizer and destroy the shape of the gel particle, so as to meet the storage and application of hand sanitizer. Use; Further, the rubber particles will gradually form a glue film when rubbed strongly to form a layer of micro glue film on the surface of the hand, and the antibacterial agent dispersed in the glue film is slowly released to meet the lasting antibacterial and antibacterial effect.
- a preparation method of sustained-release and durable antibacterial hand sanitizer its key feature is: the specific preparation method is as follows:
- step (1) The aged materials in step (1) are stirred for cross-linking reaction with organic acid, ammonium persulfate, and glutaraldehyde at 50-60°C to obtain a cross-linked polyvinyl alcohol liquid;
- the polyvinyl alcohol, glycerin, and water described in step (1) are mixed and sealed uniformly in a mass ratio of 50:15:100-200.
- the purpose is to make the small molecules of glycerin and water fully penetrate the plasticized polyvinyl alcohol to make The hydroxyl groups of polyvinyl alcohol are fully exposed.
- the polyvinyl alcohol described in step (1) is 1788 polyvinyl alcohol. Its remarkable advantage is that it is water-soluble and has good water resistance after cross-linking treatment, so as to meet the requirements of the polyethylene prepared by the present invention.
- the alcohol antibacterial rubber particles can be dispersed in the hand sanitizer, and the rubber particles become film-like when rubbed.
- the materials aged in step (2), organic acid, ammonium persulfate, and glutaraldehyde are mixed in a mass ratio of 100:1-2:0.1-0.3:1 to 3, the purpose of which is to make polyvinyl alcohol cross-linked Water resistance.
- the organic acid is acetic acid.
- the cross-linking reaction in step (2) controls the cross-linking time within 1-2 hours.
- the antibacterial agent and the cross-linked polyvinyl alcohol liquid are dispersed in a mass ratio of 5:100, and the antibacterial agent is uniformly dispersed in the cross-linked polyvinyl alcohol liquid by stirring treatment at 60-70° C. for 3-5 minutes.
- the antibacterial agent is selected from at least one of 2,4,4'-trichloro-2'-hydroxydiphenyl ether, p-chloro-m-xylenol, and hexamidine diisethionate.
- 2,4,4'-trichloro-2'-hydroxydiphenyl ether is a white crystalline powder with a melting point of 56-58°C.
- Chloro-m-xylenol is a white crystalline powder, which can kill most Gram-positive and negative bacteria, fungi and molds without irritation
- hexamidine diisethionate is a white crystalline powder, white powder, It is soluble in water, ethanol and propylene glycol, has broad-spectrum antibacterial activity, has significant resistance and killing effect to Gram-positive and negative bacteria, yeast, mold, dermatophytes, etc., and has a high skin affinity.
- step (3) high-pressure atomization drying is adopted in step (3), the pressure of the atomization gun is controlled at 1.2-1.5 MPa, the gun caliber is controlled at 0.5-1 mm, and the drying temperature is controlled at 70-80°C.
- the particle size of the dried polyvinyl alcohol antibacterial colloidal particles is 50-100 ⁇ m. Too coarse particle size affects the dispersion in the hand sanitizer and the hand-washing feel; too fine particle size, because it is delicate, it is difficult to form a film by the rubber particles during kneading.
- the antibacterial agent in step (4) is selected from 2,4,4'-trichloro-2'-hydroxydiphenyl ether, p-chloro-m-xylenol, and hexamidine diisethionate At least one.
- the purpose is to achieve immediate sterilization when washing hands, which is a conventional choice for conventional antibacterial hand sanitizers.
- cocamidopropyl betaine is the main surface active ingredient in the hand sanitizer formula. Its basic function is to remove oily dirt and dirt on the hands, and produce a certain amount of foam. It is both acidic and alkaline. It has excellent stability, good compatibility, low irritation, easily soluble in water, and excellent flexibility.
- the surface active agent When the surface active agent is used to clean the dirt on the hands, it will remove the protective oils of the skin at the same time. Long-term use will cause the hand skin to be chapped, rough and lose elasticity.
- the esterification agent used in the present invention prevents the skin from degreasing and drying.
- the esterifying agent is selected from at least one of isopropyl myristate, glycerol coco-based polyethylene glycol ester, and octyl hydroxystearate.
- polyglycerol-10 has oil and water commonality. It associates through hydrogen bonds, locks water in a cage, and has good moisture retention; at the same time, it can continuously form a film on the skin to assist polyvinyl alcohol antibacterial colloidal particles in the After washing the hands, a film is formed on the surface of the hand to improve the texture discomfort that occurs on the surface of the hand after the polyvinyl alcohol antibacterial colloidal particle is formed into the film.
- step (4) EDTA-2Na is selected as the anti-hard water agent, in order to ensure that the hand sanitizer has a better washing effect in hard water.
- step (4) Human skin has a pH value of 5-6, which is acidic.
- citric acid is selected to adjust the hand sanitizer to be weakly acidic.
- the present invention provides a slow-release and durable antibacterial hand sanitizer prepared by the above method. It is characterized by containing a polyvinyl alcohol antibacterial colloidal particle capable of slow-release antibacterial agent.
- a polyvinyl alcohol antibacterial colloidal particle capable of slow-release antibacterial agent.
- conventional antibacterial hand sanitizers are obtained by adding antibacterial agents to the hand sanitizer to disperse them. They are basically instant hand sanitizers that kill bacteria that have adhered to the hands. After washing the hands, the antibacterial agents are then rinsed and removed, which cannot achieve long-lasting Sterilization effect.
- the present invention is based on this problem and proposes a sustained-release and durable antibacterial hand sanitizer. After washing the hands, the hand sanitizer will form a micro-film on the surface of the hand, and the micro-film is dispersed with antibacterial agents to maintain long-lasting Antibacterial and antibacterial properties.
- the hand sanitizer has great application prospects for long-term antibacterial and antibacterial hand sanitizers for people who enter and exit public places for a long time, such as hospitals, public transportation, office buildings, etc.
- the present invention obtains polyvinyl alcohol antibacterial colloidal particles by dispersing the antibacterial agent in cross-linked polyvinyl alcohol with water resistance and easy to form a gel film.
- the rubber particles are used in hand sanitizers and form glue when rubbing and washing hands.
- Membrane to achieve a sustained-release and lasting antibacterial effect.
- Polyglycerol-10 is added to the hand sanitizer of the present invention to take advantage of its oil and water commonality. It associates through hydrogen bonds, locks water in a cage, and has good moisture retention; at the same time, it can continuously form a film on the skin to assist polyethylene Alcohol antibacterial rubber particles form a film on the surface of the hands after washing hands, which can improve the texture and discomfort that occurs on the surface of the hands after the polyvinyl alcohol antibacterial rubber particles are filmed.
- the present invention achieves long-lasting bacteriostasis, and can effectively reduce the number of times that people in and out of public places and staff wash their hands. It is especially suitable for the hands of people in hospitals, schools, hotels, banks, transportation, aviation, homes, and public places. Ministry of cleaning and sterilization to protect people's health and hygiene.
- the present invention has many of the above advantages and practical value, and there is no related publicly published technology in the prior art products, and it has significant progress compared with the existing technology, so it is more suitable for practical use, and has Extensively promote production value on a large scale.
- Figure 1 is a simplified flow chart of the preparation of the present invention.
- step (2) Mix the aged materials in step (1) with acetic acid, ammonium persulfate, and glutaraldehyde in a mass ratio of 100:2:0.1:1, and stir the cross-linking reaction at 60°C for 1 hour to obtain a cross-linked polyvinyl alcohol liquid;
- polyvinyl alcohol antibacterial rubber particles obtained in Example 1 3 parts of polyvinyl alcohol antibacterial rubber particles, 0.1 parts of the antibacterial agent hexamidine diisethionate, and 15 parts of cocamidopropyl betaine , 0.2 parts of sodium chloride, 2 parts of polyglycerol-10, 1.0 part of citric acid, 0.5 part of isopropyl myristate, 0.1 part of EDTA-2Na, 30 parts of deionized water, dispersed evenly to obtain a sustained-release and durable antibacterial hand sanitizer .
- polyvinyl alcohol antibacterial rubber particles obtained in Example 1 As the core additive, 5 parts of polyvinyl alcohol antibacterial rubber particles, 0.1 parts of the antibacterial agent hexamidine diisethionate, and 15 parts of cocamidopropyl betaine , 0.5 parts of sodium chloride, 3 parts of polyglycerol-10, 1.5 parts of citric acid, 0.2 parts of isopropyl myristate, 0.1 parts of EDTA-2Na, 30 parts of deionized water, dispersed evenly to obtain a sustained-release and lasting antibacterial hand sanitizer .
- Comparative example 1 greatly reduces the amount of polyvinyl alcohol antibacterial rubber particles. Due to the reduction of the amount of antibacterial rubber particles, after washing hands, there are fewer antibacterial films on the hands, which will affect the continuous antibacterial performance.
- Comparative Example 2 did not use polyglycerol-10. Due to the lack of auxiliary polyvinyl alcohol antibacterial colloidal particles to form a film on the surface of the hands after washing hands, the antibacterial durability was reduced to a certain extent.
- 0.1 parts of antibacterial agent hexamidine diisethionate, 15 parts of cocamidopropyl betaine, 0.2 parts of sodium chloride, 2 parts of polyglycerol-10, 1.0 part of citric acid, 0.5 part of myristic acid isocyanate Propyl ester, 0.1 part of EDTA-2Na, and 30 parts of deionized water are evenly dispersed to obtain a bacteriostatic hand sanitizer.
- Comparative Example 3 did not use polyvinyl alcohol antibacterial gel particles, and only relied on the antibacterial agent hexamidine diisethionate. Therefore, the hand sanitizer only has instant sterilization properties, while the lasting antibacterial properties after hand washing are relatively poor. .
- test bacteria used Staphylococcus aureus ATCC6538. After the third generation of culture, it was diluted with tryptone soy broth to prepare an average concentration of 1 ⁇ 10 4 cfu/mL.
- the antibacterial hand sanitizer of the present invention has a continuous antibacterial effect after washing hands, not only can effectively inhibit the reproduction of Staphylococcus aureus, but also has a good sterilization effect.
- Comparative Example 1 reduces the amount of polyvinyl alcohol antibacterial colloidal particles. Due to the reduction of the amount of antibacterial colloidal particles, after washing, less antibacterial film-forming material is formed, which will affect the continuous antibacterial performance.
- Comparative Example 2 did not use polyglycerol-10, due to the lack of auxiliary polyvinyl alcohol antibacterial colloidal particles for surface film formation, the antibacterial durability was reduced to a certain extent.
- Comparative Example 3 did not use polyvinyl alcohol antibacterial pellets, and only relied on the antibacterial agent hexamidine diisethionate. Therefore, it was difficult to form an antibacterial film after washing, and the lasting antibacterial performance was extremely poor. Poor, Staphylococcus aureus will multiply, so the number of colonies will increase.
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Abstract
A sustained-release long-lasting antibacterial hand sanitizer and a preparation method therefor. The method comprises: dispersing an antibacterial in a cross-linked polyvinyl alcohol which has water resistance and is easy to form a gel film to obtain polyvinyl alcohol antibacterial gel particles; and uniformly dispersing 3-5 parts of a polyvinyl alcohol antibacterial gel particle, 0.05-0.1 part of an antibacterial, 10-15 parts of cocamidopropyl betaine, 0.2-0.5 part of sodium chloride, 2-3 parts of polyglycerol-10, 0.5-1.5 parts of citric acid, 0.2-1 part of an esterifying agent, 0.1-0.2 part of a hard water-resistant agent, and 30-35 parts of deionized water to obtain a sustained-release long-lasting antibacterial hand sanitizer. The polyvinyl alcohol antibacterial gel particles disperse the hand sanitizer, which forms the gel film when rubbing and washing hands, thereby achieving a sustained-release and long-lasting antibacterial effect.
Description
本发明涉及日化领域,特别涉及一种缓释持久抑菌性洗手液及制备方法。The invention relates to the field of daily chemicals, in particular to a slow-release and durable antibacterial hand sanitizer and a preparation method.
人们在生活工作中,双手不可避免地会接触细菌,这些细菌可能会导致疾病的发生。中国自古就有古语:“病从口入”的词语,足以见得自古以来,中国人对于手部卫生十分重视。目前,在注重卫生方面,勤洗手成为常态。特别是抗菌洗手液能够将大部分细菌杀灭,得到了广泛的使用。抗菌洗手液作为一种日常用洗涤用品被越来越多的消费者所接受,应用于医院、学校等公共场合,起到了良好的即时性杀菌效果。最初,受生活条件和市场的制约,人们洗手通常用的是香皂、肥皂和洗衣粉等,虽然它们能达到一定的清洁洗效果,但对皮肤有刺激作用、抗菌效果差。In people's life and work, their hands will inevitably come into contact with bacteria, which may cause diseases. There has been an old saying in China since ancient times: "Illness comes from the mouth", which is enough to show that since ancient times, Chinese people have attached great importance to hand hygiene. At present, in terms of hygiene, frequent hand washing has become the norm. In particular, the antibacterial hand sanitizer can kill most of the bacteria and has been widely used. Antibacterial hand sanitizer is accepted by more and more consumers as a daily cleaning product. It is used in hospitals, schools and other public places, and has a good instant sterilization effect. Initially, restricted by living conditions and the market, people usually wash their hands with soap, soap, and washing powder. Although they can achieve a certain cleaning effect, they have a stimulating effect on the skin and have poor antibacterial effects.
由于洗手液的广泛应用,人们对洗手液也有更高的要求,在要求杀菌效果优异的同时,希望洗手后能够保持长久的抑菌性。然而,目前抗菌洗手液大都为即时性洗手液,只能对已附着于手的细菌进行杀灭,洗手之后不能实现持久的杀菌效果。Due to the wide application of hand sanitizer, people also have higher requirements for hand sanitizer. While requiring excellent sterilization effect, it is hoped that after washing hands, it can maintain long-term antibacterial properties. However, most of the current antibacterial hand sanitizers are instant hand sanitizers, which can only kill bacteria that have adhered to the hands, and cannot achieve a long-lasting sterilization effect after washing the hands.
目前市面上出现了一种免洗式的洗手液,其主要是将银离子分散于甘油等起到护肤和杀菌的作用,但去污能力较差。At present, there is a kind of no-wash hand sanitizer on the market, which mainly disperses silver ions in glycerin for skin care and sterilization, but its decontamination ability is poor.
发明内容Summary of the invention
目前抗菌洗手液大都为即时性洗手液,只能对已附着于手的细菌进行杀灭,洗手之后不能实现持久的杀菌效果。针对这一问题,本发明提出一种缓释持久抑菌性洗手液,该洗手液中分散有能够成膜的聚乙烯醇抗菌胶粒,由于聚乙烯醇抗菌胶粒具有一定的耐水性,在洗手液中以微细胶粒形式分散,在洗手时, 随着搓揉发生,聚乙烯醇抗菌胶粒会逐步形成胶膜从而在手的表面形成一层微胶膜,该胶膜中分散的抗菌剂缓释从而具备持久的抑菌抗菌效果。进一步,本发明提出制备该缓释持久抑菌性洗手液的方法。At present, most antibacterial hand sanitizers are instant hand sanitizers, which can only kill bacteria that have adhered to the hands, and cannot achieve a long-lasting bactericidal effect after washing the hands. In response to this problem, the present invention proposes a sustained-release and durable antibacterial hand sanitizer. The hand sanitizer is dispersed with polyvinyl alcohol antibacterial gel particles capable of forming a film. Because the polyvinyl alcohol antibacterial gel particles have certain water resistance, The hand sanitizer is dispersed in the form of fine rubber particles. When washing hands, as the rubbing occurs, the polyvinyl alcohol antibacterial rubber particles will gradually form a film to form a micro gel film on the surface of the hand. The antibacterial particles dispersed in the film The slow-release agent has a long-lasting antibacterial and antibacterial effect. Further, the present invention proposes a method for preparing the sustained-release and durable antibacterial hand sanitizer.
作为本发明的技术核心构思,发明的关键是获取聚乙烯醇抗菌胶粒,目的是实现抗菌剂分散于聚乙烯醇中,并形成具有微细形态的胶粒,这一胶粒我们称之为聚乙烯醇抗菌胶粒,这一胶粒具备在液态洗手液中长时间均匀分散的特性,并具有一定的耐水性不会被液体洗手液溶解破坏胶粒形态,从而满足应用于洗手液的存储和使用;进一步的,该胶粒在强力搓揉时会逐步形成胶膜从而在手的表面形成一层微胶膜,该胶膜中分散的抗菌剂缓释从而满足持久的抑菌抗菌效果。As the technical core concept of the present invention, the key to the invention is to obtain polyvinyl alcohol antibacterial colloidal particles. The purpose is to disperse the antibacterial agent in polyvinyl alcohol and form colloidal particles with fine morphology. This colloidal particle is called polyvinyl alcohol. Vinyl alcohol antibacterial rubber particles. This rubber particle has the characteristics of being uniformly dispersed in liquid hand sanitizer for a long time, and has a certain degree of water resistance. It will not be dissolved by liquid hand sanitizer and destroy the shape of the gel particle, so as to meet the storage and application of hand sanitizer. Use; Further, the rubber particles will gradually form a glue film when rubbed strongly to form a layer of micro glue film on the surface of the hand, and the antibacterial agent dispersed in the glue film is slowly released to meet the lasting antibacterial and antibacterial effect.
为了实现上述技术目的,采用如下的技术方案:In order to achieve the above technical objectives, the following technical solutions are adopted:
一种缓释持久抑菌性洗手液的制备方法,其关键的特征是:具体制备方法如下:A preparation method of sustained-release and durable antibacterial hand sanitizer, its key feature is: the specific preparation method is as follows:
(1)将聚乙烯醇与甘油、水搅拌混合均匀,密封袋陈放24h;(1) Stir and mix the polyvinyl alcohol, glycerin and water evenly, and leave it in a sealed bag for 24 hours;
(2)将步骤(1)陈放的物料与有机酸、过硫酸铵、戊二醛在50-60℃搅拌交联反应,得到交联聚乙烯醇液;(2) The aged materials in step (1) are stirred for cross-linking reaction with organic acid, ammonium persulfate, and glutaraldehyde at 50-60°C to obtain a cross-linked polyvinyl alcohol liquid;
(3)将抗菌剂加入交联聚乙烯醇液,在60-70℃搅拌处理3-5min,然后高压雾化干燥,得到分散有抗菌剂的聚乙烯醇抗菌胶粒;(3) Add the antibacterial agent to the cross-linked polyvinyl alcohol solution, stir for 3-5 min at 60-70°C, and then high-pressure atomization and drying to obtain polyvinyl alcohol antibacterial gel particles dispersed with antibacterial agents;
(4)按重量份将3-5份聚乙烯醇抗菌胶粒、0.05-0.1份抗菌剂、10-15份椰油酰胺丙基甜菜碱、0.2-0.5份氯化钠、2-3份聚甘油-10、0.5-1.5份柠檬酸、0.2-1份加酯剂、0.1-0.2份抗硬水剂、30-35份去离子水分散均匀灌装得到一种缓释持久抑菌性洗手液。(4) According to parts by weight, combine 3-5 parts of polyvinyl alcohol antibacterial granules, 0.05-0.1 parts of antibacterial agent, 10-15 parts of cocamidopropyl betaine, 0.2-0.5 parts of sodium chloride, 2-3 parts of poly Glycerin-10, 0.5-1.5 parts of citric acid, 0.2-1 part of esterification agent, 0.1-0.2 part of anti-hardening agent, and 30-35 parts of deionized water are dispersed and evenly filled to obtain a sustained-release and lasting antibacterial hand sanitizer.
作为优选,步骤(1)中所述聚乙烯醇、甘油、水以质量比50∶15∶100-200混合均匀密封放置,目的是使小分子的甘油、水充分渗透增塑聚乙烯醇,使聚乙烯醇的羟基充分暴露。Preferably, the polyvinyl alcohol, glycerin, and water described in step (1) are mixed and sealed uniformly in a mass ratio of 50:15:100-200. The purpose is to make the small molecules of glycerin and water fully penetrate the plasticized polyvinyl alcohol to make The hydroxyl groups of polyvinyl alcohol are fully exposed.
进一步,作为优选,步骤(1)中所述聚乙烯醇选用型号为1788的聚乙烯醇,其显著的优点是具有水溶性,同时交联处理后耐水性能良好,以便满足本发明制备的聚乙烯醇抗菌胶粒能够在洗手液中分散,在使用搓揉时胶粒变为膜状。Further, as a preference, the polyvinyl alcohol described in step (1) is 1788 polyvinyl alcohol. Its remarkable advantage is that it is water-soluble and has good water resistance after cross-linking treatment, so as to meet the requirements of the polyethylene prepared by the present invention. The alcohol antibacterial rubber particles can be dispersed in the hand sanitizer, and the rubber particles become film-like when rubbed.
优选的,步骤(2)中陈放的物料、有机酸、过硫酸铵、戊二醛以质量比100∶1-2∶0.1-0.3∶1-3混合,其目的是使聚乙烯醇交联具有耐水性。进一步优选的,所述有机酸选用乙酸。Preferably, the materials aged in step (2), organic acid, ammonium persulfate, and glutaraldehyde are mixed in a mass ratio of 100:1-2:0.1-0.3:1 to 3, the purpose of which is to make polyvinyl alcohol cross-linked Water resistance. More preferably, the organic acid is acetic acid.
优选的,步骤(2)中所述的交联反应控制交联时间在1-2h。Preferably, the cross-linking reaction in step (2) controls the cross-linking time within 1-2 hours.
优选的,步骤(3)中抗菌剂与交联聚乙烯醇液以质量比5∶100分散,在60-70℃搅拌处理3-5min使抗菌剂均匀分散在交联聚乙烯醇液。所述抗菌剂选用2,4,4’-三氯-2’-羟基二苯醚、对氯间二甲苯酚、己脒定二羟乙基磺酸盐中的至少一种。其中,2,4,4’-三氯-2’-羟基二苯醚为白色晶体状粉末,熔点56-58℃,微溶于水对肠道致病菌、化脓性球菌有杀菌作用;对氯间二甲苯酚为白色结晶粉末,对多数革兰氏阳性、阴性菌,真菌,霉菌都有杀灭功效且无刺激;己脒定二羟乙基磺酸盐为白色晶体状粉末白色粉末,可溶于水、乙醇及丙二醇,具有广谱抗菌活性,对革兰氏阳性菌和阴性菌、酵母菌、霉菌、皮肤真菌等有显著的抵抗和灭杀作用,并具有高度的皮肤亲和力。Preferably, in step (3), the antibacterial agent and the cross-linked polyvinyl alcohol liquid are dispersed in a mass ratio of 5:100, and the antibacterial agent is uniformly dispersed in the cross-linked polyvinyl alcohol liquid by stirring treatment at 60-70° C. for 3-5 minutes. The antibacterial agent is selected from at least one of 2,4,4'-trichloro-2'-hydroxydiphenyl ether, p-chloro-m-xylenol, and hexamidine diisethionate. Among them, 2,4,4'-trichloro-2'-hydroxydiphenyl ether is a white crystalline powder with a melting point of 56-58°C. It is slightly soluble in water and has a bactericidal effect on intestinal pathogens and pyogenic cocci; Chloro-m-xylenol is a white crystalline powder, which can kill most Gram-positive and negative bacteria, fungi and molds without irritation; hexamidine diisethionate is a white crystalline powder, white powder, It is soluble in water, ethanol and propylene glycol, has broad-spectrum antibacterial activity, has significant resistance and killing effect to Gram-positive and negative bacteria, yeast, mold, dermatophytes, etc., and has a high skin affinity.
优选的,步骤(3)中采用高压雾化干燥,雾化枪的压力控制在1.2-1.5MPa,枪口径控制在0.5-1mm,干燥温度控制在70-80℃。通过控制雾化枪的压力和口径,使干燥后的聚乙烯醇抗菌胶粒粒径在50-100μm。粒径过粗影响在洗手液中 的分散和洗手的手感;粒径过细,由于细腻,难以通过搓揉时胶粒成膜。Preferably, high-pressure atomization drying is adopted in step (3), the pressure of the atomization gun is controlled at 1.2-1.5 MPa, the gun caliber is controlled at 0.5-1 mm, and the drying temperature is controlled at 70-80°C. By controlling the pressure and caliber of the atomizing gun, the particle size of the dried polyvinyl alcohol antibacterial colloidal particles is 50-100μm. Too coarse particle size affects the dispersion in the hand sanitizer and the hand-washing feel; too fine particle size, because it is delicate, it is difficult to form a film by the rubber particles during kneading.
优选的,步骤(4)中所述抗菌剂选用2,4,4’-三氯-2’-羟基二苯醚、对氯间二甲苯酚、己脒定二羟乙基磺酸盐中的至少一种。目的是实现洗手时的即时性杀菌,属于常规抗菌洗手液的常规选择。Preferably, the antibacterial agent in step (4) is selected from 2,4,4'-trichloro-2'-hydroxydiphenyl ether, p-chloro-m-xylenol, and hexamidine diisethionate At least one. The purpose is to achieve immediate sterilization when washing hands, which is a conventional choice for conventional antibacterial hand sanitizers.
步骤(4)中,椰油酰胺丙基甜菜碱是洗手液配方中的主要表面活性成分,其基本功能是去除手上的油垢和污垢,并产生一定的泡沫,在酸性及碱性条件下均具有优良的稳定性,其配伍性能良好,刺激性小,易溶于水,具有优良的柔软性。In step (4), cocamidopropyl betaine is the main surface active ingredient in the hand sanitizer formula. Its basic function is to remove oily dirt and dirt on the hands, and produce a certain amount of foam. It is both acidic and alkaline. It has excellent stability, good compatibility, low irritation, easily soluble in water, and excellent flexibility.
在使用表面活性剂清洗手上的污垢时,同时会除脱皮肤的防护油脂,长期使用会造成手皮肤皲裂、粗糙和失去弹性,本发明使用加酯剂是防止皮肤脱脂干燥。优选的,步骤(4)中,所述加酯剂选用肉豆蔻酸异丙酯、甘油椰油基聚乙二醇酯、辛基羟基硬脂酸酯中的至少一种。When the surface active agent is used to clean the dirt on the hands, it will remove the protective oils of the skin at the same time. Long-term use will cause the hand skin to be chapped, rough and lose elasticity. The esterification agent used in the present invention prevents the skin from degreasing and drying. Preferably, in step (4), the esterifying agent is selected from at least one of isopropyl myristate, glycerol coco-based polyethylene glycol ester, and octyl hydroxystearate.
步骤(4)中,聚甘油-10具有油水共性,其通过氢键缔合,笼式锁水,具有良好的保湿性;同时其在皮肤上能连续成膜,辅助聚乙烯醇抗菌胶粒在洗手后在手的表面成膜,改善聚乙烯醇抗菌胶粒成膜后在手表面出现的质感不适感。In step (4), polyglycerol-10 has oil and water commonality. It associates through hydrogen bonds, locks water in a cage, and has good moisture retention; at the same time, it can continuously form a film on the skin to assist polyvinyl alcohol antibacterial colloidal particles in the After washing the hands, a film is formed on the surface of the hand to improve the texture discomfort that occurs on the surface of the hand after the polyvinyl alcohol antibacterial colloidal particle is formed into the film.
步骤(4)中,所述抗硬水剂选用EDTA-2Na,目的是为保证洗手液在硬水中也有较好的洗涤效果。In step (4), EDTA-2Na is selected as the anti-hard water agent, in order to ensure that the hand sanitizer has a better washing effect in hard water.
人体的皮肤pH值为5~6,呈酸性,步骤(4)中,选用柠檬酸调节洗手液为弱酸性。Human skin has a pH value of 5-6, which is acidic. In step (4), citric acid is selected to adjust the hand sanitizer to be weakly acidic.
另外,本发明提供由上述方法制备得到的一种缓释持久抑菌性洗手液。其特征是含有一种能够缓释抗菌剂的聚乙烯醇抗菌胶粒。本发明通过将抗菌剂分散在交联聚乙烯醇中,得到的聚乙烯醇抗菌胶粒具有良好的耐水性,可以分散在洗手液中,当洗手时,在搓揉作用下聚乙烯醇抗菌胶粒散开形成微膜,该胶 微膜中分散的抗菌剂会不断缓释从而具备持久的抑菌抗菌效果。In addition, the present invention provides a slow-release and durable antibacterial hand sanitizer prepared by the above method. It is characterized by containing a polyvinyl alcohol antibacterial colloidal particle capable of slow-release antibacterial agent. By dispersing the antibacterial agent in the cross-linked polyvinyl alcohol, the obtained polyvinyl alcohol antibacterial rubber particles have good water resistance and can be dispersed in the hand sanitizer. When the hands are washed, the polyvinyl alcohol antibacterial glue is rubbed under the action of rubbing. The particles disperse to form a microfilm, and the antibacterial agent dispersed in the glue microfilm will be continuously released to have a long-lasting antibacterial and antibacterial effect.
公知的,常规的抗菌洗手液是将抗菌剂加入洗手液分散而得,基本为即时性洗手液,对已附着于手的细菌进行杀灭,洗手之后抗菌剂随即被冲洗除去,不能实现持久的杀菌效果。本发明正是基于这一问题,提出一种缓释持久抑菌性洗手液,该洗手液洗完手后,会在手的表面形成微膜,微膜中分散有抗菌剂,以保持持久的抑菌抗菌性。特别的,该洗手液对于长期在公共场进出的人员如医院、公共交通、写字楼等,持久的抗菌抑菌洗手液具有巨大的应用前景。It is well-known that conventional antibacterial hand sanitizers are obtained by adding antibacterial agents to the hand sanitizer to disperse them. They are basically instant hand sanitizers that kill bacteria that have adhered to the hands. After washing the hands, the antibacterial agents are then rinsed and removed, which cannot achieve long-lasting Sterilization effect. The present invention is based on this problem and proposes a sustained-release and durable antibacterial hand sanitizer. After washing the hands, the hand sanitizer will form a micro-film on the surface of the hand, and the micro-film is dispersed with antibacterial agents to maintain long-lasting Antibacterial and antibacterial properties. In particular, the hand sanitizer has great application prospects for long-term antibacterial and antibacterial hand sanitizers for people who enter and exit public places for a long time, such as hospitals, public transportation, office buildings, etc.
一种缓释持久抑菌性洗手液及制备方法,与现有技术相比具有如下有益效果:A slow-release and long-lasting antibacterial hand sanitizer and a preparation method thereof have the following beneficial effects compared with the prior art:
(1)本发明通过将抗菌剂分散在具有耐水、易于成胶膜的交联聚乙烯醇中,得到了聚乙烯醇抗菌胶粒,该胶粒用于洗手液,在搓揉洗手时形成胶膜,达到缓释持久抑菌的效果。(1) The present invention obtains polyvinyl alcohol antibacterial colloidal particles by dispersing the antibacterial agent in cross-linked polyvinyl alcohol with water resistance and easy to form a gel film. The rubber particles are used in hand sanitizers and form glue when rubbing and washing hands. Membrane to achieve a sustained-release and lasting antibacterial effect.
(2)本发明洗手液中加入聚甘油-10,利用其油水共性,其通过氢键缔合,笼式锁水,具有良好的保湿性;同时其在皮肤上能连续成膜,辅助聚乙烯醇抗菌胶粒在洗手后在手的表面成膜,改善聚乙烯醇抗菌胶粒成膜后在手表面出现的质感不适感。(2) Polyglycerol-10 is added to the hand sanitizer of the present invention to take advantage of its oil and water commonality. It associates through hydrogen bonds, locks water in a cage, and has good moisture retention; at the same time, it can continuously form a film on the skin to assist polyethylene Alcohol antibacterial rubber particles form a film on the surface of the hands after washing hands, which can improve the texture and discomfort that occurs on the surface of the hands after the polyvinyl alcohol antibacterial rubber particles are filmed.
(3)本发明实现了持久抑菌性,可以有效减少公共场进出人员、工作人员洗手的次数,特别适合用于在医院、学校、宾馆、银行、交通、航空、家庭、公共场所人员的手部清洁杀菌,保障人们的健康卫生。(3) The present invention achieves long-lasting bacteriostasis, and can effectively reduce the number of times that people in and out of public places and staff wash their hands. It is especially suitable for the hands of people in hospitals, schools, hotels, banks, transportation, aviation, homes, and public places. Ministry of cleaning and sterilization to protect people's health and hygiene.
综上所述,本发明具有上述诸多的优点及实用价值,并在现有技术产品中未见有相关公开发表的技术,较现有的技术具有显著的进步,从而较为适于实用,并具有广泛的规模化推广生产价值。In summary, the present invention has many of the above advantages and practical value, and there is no related publicly published technology in the prior art products, and it has significant progress compared with the existing technology, so it is more suitable for practical use, and has Extensively promote production value on a large scale.
为了更清楚地说明本发明的技术核心构思和技术方案,下面将以示意图的 方式表示本发明的技术思路。In order to more clearly illustrate the technical core concept and technical solution of the present invention, the technical idea of the present invention will be shown in a schematic diagram below.
图1是本发明制备简易流程图。Figure 1 is a simplified flow chart of the preparation of the present invention.
为使本发明的目的、技术方案和优点更加清楚,下面将结合本发明实施例,对本发明的技术方案进行清楚、完整地描述。显然,所描述的实施例是本发明的一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动的前提下所获得的所有其他实施例,都属于本发明保护的范围。同时,在本发明构思的基础上,将各类香精等加入而调制的具有一定香味的洗手液也是本发明所保护的范围。In order to make the objectives, technical solutions, and advantages of the present invention clearer, the technical solutions of the present invention will be described clearly and completely below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present invention. At the same time, on the basis of the concept of the present invention, a hand sanitizer with a certain fragrance prepared by adding various flavors and the like is also within the protection scope of the present invention.
实施例1Example 1
(1)将1788聚乙烯醇与甘油、水以质量比50∶15∶200混合搅拌均匀,然后密封放置24h,使小分子的甘油、水充分渗透增塑聚乙烯醇;(1) Mix 1788 polyvinyl alcohol with glycerin and water at a mass ratio of 50:15:200 and stir evenly, then seal and place for 24 hours to make the small molecules of glycerin and water fully penetrate the plasticized polyvinyl alcohol;
(2)将步骤(1)陈放的物料与乙酸、过硫酸铵、戊二醛以质量比100∶2∶0.1∶1混合,在60℃搅拌交联反应1h,得到交联聚乙烯醇液;(2) Mix the aged materials in step (1) with acetic acid, ammonium persulfate, and glutaraldehyde in a mass ratio of 100:2:0.1:1, and stir the cross-linking reaction at 60°C for 1 hour to obtain a cross-linked polyvinyl alcohol liquid;
(3)将抗菌剂2,4,4’-三氯-2’-羟基二苯醚与交联聚乙烯醇液以质量比5∶100分散,在60℃搅拌处理5min使抗菌剂均匀分散在交联聚乙烯醇液,然后采用高压雾化干燥,雾化枪的压力控制在1.5MPa,枪口径控制在1mm,干燥温度控制在80℃。通过控制雾化枪的压力和口径,使干燥后的聚乙烯醇抗菌胶粒粒径维持在50-100μm,得到分散有抗菌剂的聚乙烯醇抗菌胶粒。(3) Disperse the antibacterial agent 2,4,4'-trichloro-2'-hydroxydiphenyl ether and the cross-linked polyvinyl alcohol solution at a mass ratio of 5:100, and stir at 60°C for 5 minutes to make the antibacterial agent uniformly dispersed. The cross-linked polyvinyl alcohol liquid is then dried by high-pressure atomization, the pressure of the atomizing gun is controlled at 1.5MPa, the gun caliber is controlled at 1mm, and the drying temperature is controlled at 80°C. By controlling the pressure and caliber of the atomizing gun, the particle size of the dried polyvinyl alcohol antibacterial rubber particles is maintained at 50-100 μm, and the antibacterial agent dispersed polyvinyl alcohol antibacterial rubber particles are obtained.
实施例2Example 2
以实施例1得到的聚乙烯醇抗菌胶粒作为核心添加剂,将3份聚乙烯醇抗菌胶粒、0.1份抗菌剂己脒定二羟乙基磺酸盐、15份椰油酰胺丙基甜菜碱、0.2份氯化钠、2份聚甘油-10、1.0份柠檬酸、0.5份肉豆蔻酸异丙酯、0.1份EDTA-2Na、 30份去离子水分散均匀得到缓释持久抑菌性洗手液。Using the polyvinyl alcohol antibacterial rubber particles obtained in Example 1 as the core additive, 3 parts of polyvinyl alcohol antibacterial rubber particles, 0.1 parts of the antibacterial agent hexamidine diisethionate, and 15 parts of cocamidopropyl betaine , 0.2 parts of sodium chloride, 2 parts of polyglycerol-10, 1.0 part of citric acid, 0.5 part of isopropyl myristate, 0.1 part of EDTA-2Na, 30 parts of deionized water, dispersed evenly to obtain a sustained-release and durable antibacterial hand sanitizer .
实施例3Example 3
以实施例1得到的聚乙烯醇抗菌胶粒作为核心添加剂,将5份聚乙烯醇抗菌胶粒、0.1份抗菌剂己脒定二羟乙基磺酸盐、15份椰油酰胺丙基甜菜碱、0.5份氯化钠、3份聚甘油-10、1.5份柠檬酸、0.2份肉豆蔻酸异丙酯、0.1份EDTA-2Na、30份去离子水分散均匀得到缓释持久抑菌性洗手液。Using the polyvinyl alcohol antibacterial rubber particles obtained in Example 1 as the core additive, 5 parts of polyvinyl alcohol antibacterial rubber particles, 0.1 parts of the antibacterial agent hexamidine diisethionate, and 15 parts of cocamidopropyl betaine , 0.5 parts of sodium chloride, 3 parts of polyglycerol-10, 1.5 parts of citric acid, 0.2 parts of isopropyl myristate, 0.1 parts of EDTA-2Na, 30 parts of deionized water, dispersed evenly to obtain a sustained-release and lasting antibacterial hand sanitizer .
对比例1Comparative example 1
将0.5份聚乙烯醇抗菌胶粒、0.1份抗菌剂己脒定二羟乙基磺酸盐、15份椰油酰胺丙基甜菜碱、0.2份氯化钠、2份聚甘油-10、1.0份柠檬酸、0.5份肉豆蔻酸异丙酯、0.1份EDTA-2Na、30份去离子水分散均匀得到抑菌性洗手液。Combine 0.5 parts of polyvinyl alcohol antibacterial granules, 0.1 parts of antibacterial agent hexamidine diisethionate, 15 parts of cocamidopropyl betaine, 0.2 parts of sodium chloride, 2 parts of polyglycerol-10, 1.0 parts Citric acid, 0.5 parts of isopropyl myristate, 0.1 parts of EDTA-2Na, and 30 parts of deionized water are evenly dispersed to obtain a bacteriostatic hand sanitizer.
对比例1大幅减少聚乙烯醇抗菌胶粒的添加量,由于减少抗菌胶粒的用量,在洗手后,手面的抗菌成膜物较少,在持续抑菌性能方面会受到影响。Comparative example 1 greatly reduces the amount of polyvinyl alcohol antibacterial rubber particles. Due to the reduction of the amount of antibacterial rubber particles, after washing hands, there are fewer antibacterial films on the hands, which will affect the continuous antibacterial performance.
对比例2Comparative example 2
将5份聚乙烯醇抗菌胶粒、0.5份抗菌剂己脒定二羟乙基磺酸盐、15份椰油酰胺丙基甜菜碱、0.2份氯化钠、1.0份柠檬酸、0.5份肉豆蔻酸异丙酯、0.1份EDTA-2Na、30份去离子水分散均匀得到缓释持久抑菌性洗手液。Combine 5 parts of polyvinyl alcohol antibacterial pellets, 0.5 parts of antibacterial agent hexamidine diisethionate, 15 parts of cocamidopropyl betaine, 0.2 parts of sodium chloride, 1.0 part of citric acid, 0.5 part of nutmeg Isopropyl acid, 0.1 part of EDTA-2Na, and 30 parts of deionized water are evenly dispersed to obtain a sustained-release and durable antibacterial hand sanitizer.
对比例2没有使用聚甘油-10,由于缺少辅助聚乙烯醇抗菌胶粒在洗手后在手的表面成膜,抗菌持久性有一定的降低。Comparative Example 2 did not use polyglycerol-10. Due to the lack of auxiliary polyvinyl alcohol antibacterial colloidal particles to form a film on the surface of the hands after washing hands, the antibacterial durability was reduced to a certain extent.
对比例3Comparative example 3
将0.1份抗菌剂己脒定二羟乙基磺酸盐、15份椰油酰胺丙基甜菜碱、0.2份氯化钠、2份聚甘油-10、1.0份柠檬酸、0.5份肉豆蔻酸异丙酯、0.1份EDTA-2Na、30份去离子水分散均匀得到抑菌性洗手液。0.1 parts of antibacterial agent hexamidine diisethionate, 15 parts of cocamidopropyl betaine, 0.2 parts of sodium chloride, 2 parts of polyglycerol-10, 1.0 part of citric acid, 0.5 part of myristic acid isocyanate Propyl ester, 0.1 part of EDTA-2Na, and 30 parts of deionized water are evenly dispersed to obtain a bacteriostatic hand sanitizer.
对比例3没有使用聚乙烯醇抗菌胶粒,只依靠抗菌剂己脒定二羟乙基磺酸 盐,因此该洗手液只具备即时性杀菌性,而洗手后的持久性抑菌性能相对较差。Comparative Example 3 did not use polyvinyl alcohol antibacterial gel particles, and only relied on the antibacterial agent hexamidine diisethionate. Therefore, the hand sanitizer only has instant sterilization properties, while the lasting antibacterial properties after hand washing are relatively poor. .
为了定性的对比验证本发明的持久抑菌效果,部分参考QB/T 2738-2005《日化产品抗菌抑菌效果的评价方法》进行抑菌试验。具体如下:In order to qualitatively compare and verify the long-lasting antibacterial effect of the present invention, part of QB/T 2738-2005 "Evaluation Method of Antibacterial and Antibacterial Effects of Daily Chemical Products" was used for antibacterial tests. details as follows:
1、将硅胶手套套在手上,模拟洗手方法分别利用实施例2-3、对比例1-3得到的洗手液进行搓揉洗硅胶手套,使硅胶手套,保证搓洗的力度、时间一致。将洗涤的硅胶手套作为模拟的已洗涤的手;1. Put the silicone gloves on the hands, and use the hand sanitizers obtained in Examples 2-3 and 1-3 to simulate the hand washing method to rub and wash the silicone gloves, so that the silicone gloves can ensure the same scrubbing strength and time. Use washed silicone gloves as simulated washed hands;
2、试验菌采用金黄色葡萄球菌ATCC6538,培养第三代后,利用胰蛋白胨大豆肉汤稀释调制均浓度为为1×10
4cfu/mL。
2. The test bacteria used Staphylococcus aureus ATCC6538. After the third generation of culture, it was diluted with tryptone soy broth to prepare an average concentration of 1×10 4 cfu/mL.
3、在硅胶手套直径为3cm的区域滴入20μL菌液,60min后测试金黄色葡萄球菌菌落数浓度,以此衡量抑菌性能。测试结果如表1所示。3. Drop 20 μL of bacterial solution in the area of the silicone glove with a diameter of 3 cm, and test the concentration of Staphylococcus aureus colonies after 60 minutes to measure the antibacterial performance. The test results are shown in Table 1.
表1:Table 1:
通过测试,本发明的抑菌洗手液在洗手后具有持续的抑菌效果,不但能够有效抑制金黄色葡萄球菌的繁殖,而且杀菌效果良好。对比例1减少聚乙烯醇抗菌胶粒的添加量,由于减少抗菌胶粒的用量,在洗后,形成的抗菌成膜物较少,在持续抑菌性能方面会受到影响。对比例2没有使用聚甘油-10,由于缺少辅助聚乙烯醇抗菌胶粒的表面成膜,抗菌持久性有一定的降低。对比例3没有使用聚乙烯醇抗菌胶粒,只依靠抗菌剂己脒定二羟乙基磺酸盐,因此该洗后难以形成抑菌膜,持久性抑菌性能极差,由于抑菌性较差,金黄色葡萄球菌还会繁殖,因此菌落数还会增加。Through testing, the antibacterial hand sanitizer of the present invention has a continuous antibacterial effect after washing hands, not only can effectively inhibit the reproduction of Staphylococcus aureus, but also has a good sterilization effect. Comparative Example 1 reduces the amount of polyvinyl alcohol antibacterial colloidal particles. Due to the reduction of the amount of antibacterial colloidal particles, after washing, less antibacterial film-forming material is formed, which will affect the continuous antibacterial performance. Comparative Example 2 did not use polyglycerol-10, due to the lack of auxiliary polyvinyl alcohol antibacterial colloidal particles for surface film formation, the antibacterial durability was reduced to a certain extent. Comparative Example 3 did not use polyvinyl alcohol antibacterial pellets, and only relied on the antibacterial agent hexamidine diisethionate. Therefore, it was difficult to form an antibacterial film after washing, and the lasting antibacterial performance was extremely poor. Poor, Staphylococcus aureus will multiply, so the number of colonies will increase.
Claims (10)
- 一种缓释持久抑菌性洗手液的制备方法,其特征是:具体制备方法如下:A preparation method of sustained-release and long-lasting antibacterial hand sanitizer is characterized in that: the specific preparation method is as follows:(1)将聚乙烯醇与甘油、水搅拌混合均匀,密封袋陈放24h;(1) Stir and mix the polyvinyl alcohol, glycerin and water evenly, and leave it in a sealed bag for 24 hours;(2)将步骤(1)陈放的物料与有机酸、过硫酸铵、戊二醛在50-60℃搅拌交联反应,得到交联聚乙烯醇液;(2) The aged materials in step (1) are stirred for cross-linking reaction with organic acid, ammonium persulfate, and glutaraldehyde at 50-60°C to obtain a cross-linked polyvinyl alcohol liquid;(3)将抗菌剂加入交联聚乙烯醇液,在60-70℃搅拌处理3-5min,然后高压雾化干燥,得到分散有抗菌剂的聚乙烯醇抗菌胶粒;(3) Add the antibacterial agent to the cross-linked polyvinyl alcohol solution, stir for 3-5 min at 60-70°C, and then high-pressure atomization and drying to obtain polyvinyl alcohol antibacterial gel particles dispersed with antibacterial agents;(4)按重量份将3-5份聚乙烯醇抗菌胶粒、0.05-0.1份抗菌剂、10-15份椰油酰胺丙基甜菜碱、0.2-0.5份氯化钠、2-3份聚甘油-10、0.5-1.5份柠檬酸、0.2-1份加酯剂、0.1-0.2份抗硬水剂、30-35份去离子水分散均匀灌装得到一种缓释持久抑菌性洗手液。(4) According to parts by weight, combine 3-5 parts of polyvinyl alcohol antibacterial granules, 0.05-0.1 parts of antibacterial agent, 10-15 parts of cocamidopropyl betaine, 0.2-0.5 parts of sodium chloride, 2-3 parts of poly Glycerin-10, 0.5-1.5 parts of citric acid, 0.2-1 part of esterification agent, 0.1-0.2 part of anti-hardening agent, and 30-35 parts of deionized water are dispersed and evenly filled to obtain a sustained-release and lasting antibacterial hand sanitizer.
- 根据权利要求1所述一种缓释持久抑菌性洗手液的制备方法,其特征是:步骤(1)中所述聚乙烯醇、甘油、水以质量比50∶15∶100-200混合均匀密封放置。The method for preparing a sustained-release and durable antibacterial hand sanitizer according to claim 1, wherein the polyvinyl alcohol, glycerin, and water in step (1) are mixed uniformly in a mass ratio of 50:15:100-200 Sealed and placed.
- 根据权利要求1所述一种缓释持久抑菌性洗手液的制备方法,其特征是:步骤(1)中所述聚乙烯醇选用型号为1788的聚乙烯醇。The method for preparing a sustained-release and long-lasting antibacterial hand sanitizer according to claim 1, wherein the polyvinyl alcohol in step (1) is 1788 polyvinyl alcohol.
- 根据权利要求1所述一种缓释持久抑菌性洗手液的制备方法,其特征是:步骤(2)中陈放的物料、有机酸、过硫酸铵、戊二醛以质量比100∶1-2∶0.1-0.3∶1-3混合;所述有机酸选用乙酸。The preparation method of a sustained-release and long-lasting antibacterial hand sanitizer according to claim 1, characterized in that the materials, organic acid, ammonium persulfate, and glutaraldehyde aged in step (2) are in a mass ratio of 100:1 2:0.1-0.3:1-3 mixed; the organic acid is acetic acid.
- 根据权利要求1所述一种缓释持久抑菌性洗手液的制备方法,其特征是:步骤(2)中所述的交联反应控制交联时间在1-2h。The method for preparing a sustained-release and durable bacteriostatic hand sanitizer according to claim 1, wherein the cross-linking reaction in step (2) controls the cross-linking time within 1-2 hours.
- 根据权利要求1所述一种缓释持久抑菌性洗手液的制备方法,其特征是:步骤(3)中抗菌剂与交联聚乙烯醇液以质量比5∶100分散。The method for preparing a sustained-release and durable antibacterial hand sanitizer according to claim 1, characterized in that in step (3), the antibacterial agent and the cross-linked polyvinyl alcohol liquid are dispersed in a mass ratio of 5:100.
- 根据权利要求1所述一种缓释持久抑菌性洗手液的制备方法,其特征是:步骤(3)中所述抗菌剂选用2,4,4’-三氯-2’-羟基二苯醚、对氯间二甲苯酚、己脒定二羟乙基磺酸盐中的至少一种。The method for preparing a sustained-release and durable bacteriostatic hand sanitizer according to claim 1, wherein the antibacterial agent in step (3) is 2,4,4'-trichloro-2'-hydroxydiphenyl At least one of ether, p-chloro-m-xylenol, and hexamidine diisethionate.
- 根据权利要求1所述一种缓释持久抑菌性洗手液的制备方法,其特征是:步骤(3)中采用高压雾化干燥,雾化枪的压力控制在1.2-1.5MPa,枪口径控制在0.5-1mm,干燥温度控制在70-80℃。The method for preparing a sustained-release and durable antibacterial hand sanitizer according to claim 1, characterized in that: in step (3), high-pressure atomization is used for drying, the pressure of the atomizing gun is controlled at 1.2-1.5MPa, and the gun caliber is controlled At 0.5-1mm, the drying temperature is controlled at 70-80℃.
- 根据权利要求1所述一种缓释持久抑菌性洗手液的制备方法,其特征是:步骤(4)中所述抗菌剂选用2,4,4’-三氯-2’-羟基二苯醚、对氯间二甲苯酚、己脒定二羟乙基磺酸盐中的至少一种;所述加酯剂选用肉豆蔻酸异丙酯、甘油椰油基聚乙二醇酯、辛基羟基硬脂酸酯中的至少一种;所述抗硬水剂选用EDTA-2Na。The preparation method of a sustained-release and durable antibacterial hand sanitizer according to claim 1, wherein the antibacterial agent in step (4) is 2,4,4'-trichloro-2'-hydroxydiphenyl At least one of ether, p-chloro-m-xylenol, and hexamidine diisethionate; the esterifying agent is selected from isopropyl myristate, glycerol coco-based polyethylene glycol ester, and octyl At least one of hydroxystearate; the anti-hardening agent is EDTA-2Na.
- 由权利要求1-9任一项所述的方法制备得到一种缓释持久抑菌性洗手液,其特征是含有聚乙烯醇抗菌胶粒。A sustained-release and durable antibacterial hand sanitizer prepared by the method according to any one of claims 1-9 is characterized by containing polyvinyl alcohol antibacterial colloidal particles.
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