CN110950786A - 新型cyp-类二十烷酸衍生物 - Google Patents

新型cyp-类二十烷酸衍生物 Download PDF

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Publication number
CN110950786A
CN110950786A CN201911170917.5A CN201911170917A CN110950786A CN 110950786 A CN110950786 A CN 110950786A CN 201911170917 A CN201911170917 A CN 201911170917A CN 110950786 A CN110950786 A CN 110950786A
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alkyl
group
compound
fluorine
atom
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Chinese (zh)
Inventor
W-H·顺克
D·米勒
R·菲舍尔
G·瓦卢卡特
A·康克尔
J·R·法尔克
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Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft
University of Texas System
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Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft
University of Texas System
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Publication of CN110950786A publication Critical patent/CN110950786A/zh
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    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
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    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3826—Acyclic unsaturated acids
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/20—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
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    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
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    • C07D277/62—Benzothiazoles
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    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
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    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015—Esters of acyclic unsaturated acids

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  • Immunology (AREA)
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  • Pain & Pain Management (AREA)
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  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
CN201911170917.5A 2014-01-22 2015-01-21 新型cyp-类二十烷酸衍生物 Pending CN110950786A (zh)

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US201461930031P 2014-01-22 2014-01-22
US61/930,031 2014-01-22
CN201580005451.7A CN106061942B (zh) 2014-01-22 2015-01-21 新型cyp-类二十烷酸衍生物

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US11096910B2 (en) * 2015-07-22 2021-08-24 Max Delbruck-Centrum Fur Molekulare Medizin Metabolically robust analogs of CYP-eicosanoids for the treatment of cardiac disease
WO2017168007A1 (en) * 2016-04-01 2017-10-05 Omeicos Therapeutics Gmbh Analogs of cyp-eicosanoids for use in treating or preventing a disorder associated with neovascularization and/or inflammation
SI3435993T1 (sl) 2016-04-01 2025-03-31 Omeicos Therapeutics Gmbh Analog cyp-eikozanoidov za uporabo pri zdravljenju ali preprečevanju motnje, povezane z neovaskularizacijo in/ali vnetjem
JP7080826B2 (ja) * 2016-05-16 2022-06-06 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム カチオン性スルホンアミドアミノ脂質および両親媒性両性イオンアミノ脂質
JP2024542612A (ja) 2021-11-26 2024-11-15 オメイコス セラピューティクス ジーエムビーエイチ Ｇｄｆ１５血漿濃度の上昇に関連する疾患の治療および予防のための合成エイコサノイド類似体

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US20170008918A1 (en) 2017-01-12
DK3097076T3 (da) 2019-07-29
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ES2738701T3 (es) 2020-01-24
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JP6577951B2 (ja) 2019-09-18
KR20160111988A (ko) 2016-09-27
RU2730512C2 (ru) 2020-08-24
AU2015208416B2 (en) 2017-11-30
HRP20191315T1 (hr) 2019-10-18
EP3097076A1 (en) 2016-11-30
BR112016016139B1 (pt) 2023-04-25
RS59218B1 (sr) 2019-10-31
EP3097076B1 (en) 2019-05-08
HUE044703T2 (hu) 2019-11-28
JP2017505313A (ja) 2017-02-16
KR102392893B1 (ko) 2022-04-29
CN106061942B (zh) 2019-11-15
CY1122591T1 (el) 2021-01-27
LT3097076T (lt) 2019-08-26
PL3097076T3 (pl) 2019-10-31
CN106061942A (zh) 2016-10-26
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US11130772B2 (en) 2021-09-28

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