CN110945030A - 使用april-taci相互作用的调节剂调节调控性t细胞、调控性b细胞和免疫响应的方法 - Google Patents
使用april-taci相互作用的调节剂调节调控性t细胞、调控性b细胞和免疫响应的方法 Download PDFInfo
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762522167P | 2017-06-20 | 2017-06-20 | |
| US62/522,167 | 2017-06-20 | ||
| US201762573264P | 2017-10-17 | 2017-10-17 | |
| US62/573,264 | 2017-10-17 | ||
| US201862677265P | 2018-05-29 | 2018-05-29 | |
| US62/677,265 | 2018-05-29 | ||
| PCT/US2018/038490 WO2018236995A2 (en) | 2017-06-20 | 2018-06-20 | Methods for modulating regulatory t cells, regulatory b cells, and immune responses using modulators of the april-taci interaction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110945030A true CN110945030A (zh) | 2020-03-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880048338.0A Pending CN110945030A (zh) | 2017-06-20 | 2018-06-20 | 使用april-taci相互作用的调节剂调节调控性t细胞、调控性b细胞和免疫响应的方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12005073B2 (enExample) |
| EP (1) | EP3642243A4 (enExample) |
| JP (1) | JP2020524149A (enExample) |
| CN (1) | CN110945030A (enExample) |
| AU (1) | AU2018289493B2 (enExample) |
| CA (1) | CA3064632A1 (enExample) |
| WO (1) | WO2018236995A2 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113368262A (zh) * | 2020-09-03 | 2021-09-10 | 上海易慕峰生物科技有限公司 | 通过实体肿瘤转移动物模型获取中间结果的方法 |
| CN114147343A (zh) * | 2021-12-08 | 2022-03-08 | 西安中科微精光子制造科技有限公司 | 一种激光加工方法、系统及计算机存储介质 |
| WO2022048314A1 (zh) * | 2020-09-03 | 2022-03-10 | 上海易慕峰生物科技有限公司 | 针对循环肿瘤细胞的免疫杀伤细胞在实体瘤治疗中的应用 |
| CN118126196A (zh) * | 2024-03-06 | 2024-06-04 | 中国医学科学院基础医学研究所 | 一种具有包含taci融合蛋白的基因工程化外泌体及其制备方法和应用 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11435370B2 (en) * | 2017-01-16 | 2022-09-06 | Shimadzu Corporation | Data analying device and program for data analysis |
| EP3642243A4 (en) | 2017-06-20 | 2021-04-28 | Dana-Farber Cancer Institute, Inc. | PROCESSES FOR MODULATION OF REGULATORY T-LYMPHOCYTES, REGULATORY B-LYMPHOCYTES AND IMMUNE RESPONSES USING MODULATORS OF THE AVRIL-TACI INTERACTION |
| EP3976100A4 (en) * | 2019-05-31 | 2023-07-12 | Medimmune, LLC | POLYTHERAPY |
| IL297981A (en) | 2020-05-08 | 2023-01-01 | Alpine Immune Sciences Inc | April and baff inhibitory immunomodulatory proteins with and without a t cell inhibitory protein and methods of use thereof |
| CA3194116A1 (en) * | 2020-09-29 | 2022-04-07 | Mingji Dai | Curcusone diterpenoids and uses thereof |
| CN113278619B (zh) * | 2021-07-19 | 2021-10-15 | 广东省农业科学院动物科学研究所 | 双sgRNA、基因敲除载体、基因敲除STING基因的猪成纤维细胞系及其构建方法 |
| CN120843525B (zh) * | 2025-09-23 | 2025-12-09 | 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) | 特异结合人april的中和核酸适体及其在抑制抗体分泌中的应用 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001087979A2 (en) * | 2000-05-12 | 2001-11-22 | Amgen Inc. | Methods and compositions of matter concerning april/g70, bcma, blys/agp-3, and taci |
| CN101323643A (zh) * | 2007-06-15 | 2008-12-17 | 烟台荣昌生物工程有限公司 | 优化的TACI-Fc融合蛋白 |
| WO2010075249A2 (en) * | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
| WO2011047121A1 (en) * | 2009-10-14 | 2011-04-21 | Schering Corporation | April antagonists and methods of use |
| CN102585016A (zh) * | 2012-03-06 | 2012-07-18 | 江苏健德生物药业有限公司 | 一种可同时抑制t、b淋巴细胞功能的免疫融合蛋白、其制备方法及其应用 |
| WO2016110587A1 (en) * | 2015-01-09 | 2016-07-14 | Aduro Biotech Holdings, Europe B.V. | Altered april binding antibodies |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ302719B6 (cs) * | 2000-12-01 | 2011-09-21 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití |
| EP3642243A4 (en) | 2017-06-20 | 2021-04-28 | Dana-Farber Cancer Institute, Inc. | PROCESSES FOR MODULATION OF REGULATORY T-LYMPHOCYTES, REGULATORY B-LYMPHOCYTES AND IMMUNE RESPONSES USING MODULATORS OF THE AVRIL-TACI INTERACTION |
-
2018
- 2018-06-20 EP EP18820336.8A patent/EP3642243A4/en active Pending
- 2018-06-20 CA CA3064632A patent/CA3064632A1/en active Pending
- 2018-06-20 JP JP2019569878A patent/JP2020524149A/ja active Pending
- 2018-06-20 US US16/612,938 patent/US12005073B2/en active Active
- 2018-06-20 WO PCT/US2018/038490 patent/WO2018236995A2/en not_active Ceased
- 2018-06-20 AU AU2018289493A patent/AU2018289493B2/en active Active
- 2018-06-20 CN CN201880048338.0A patent/CN110945030A/zh active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001087979A2 (en) * | 2000-05-12 | 2001-11-22 | Amgen Inc. | Methods and compositions of matter concerning april/g70, bcma, blys/agp-3, and taci |
| CN101323643A (zh) * | 2007-06-15 | 2008-12-17 | 烟台荣昌生物工程有限公司 | 优化的TACI-Fc融合蛋白 |
| WO2010075249A2 (en) * | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
| WO2011047121A1 (en) * | 2009-10-14 | 2011-04-21 | Schering Corporation | April antagonists and methods of use |
| CN102585016A (zh) * | 2012-03-06 | 2012-07-18 | 江苏健德生物药业有限公司 | 一种可同时抑制t、b淋巴细胞功能的免疫融合蛋白、其制备方法及其应用 |
| WO2016110587A1 (en) * | 2015-01-09 | 2016-07-14 | Aduro Biotech Holdings, Europe B.V. | Altered april binding antibodies |
Non-Patent Citations (6)
| Title |
|---|
| CHIH-HANG ANTHONY TANG 等: "Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells", CANCER RESEARCH, vol. 76, no. 8, pages 2137 - 2152, XP055451857, DOI: 10.1158/0008-5472.CAN-15-1885 * |
| GANG YU 等: "APRIL and TALL-1 and receptors BCMA and TACI: system for regulating humoral immunity", NATURE IMMUNOLOGY, vol. 1, no. 3 * |
| HANS-PETER HARTUNG 等: "Atacicept: targeting B cells in multiple sclerosis", THER ADV NEUROL DISORD, vol. 3, no. 4, pages 205 - 216, XP055568463, DOI: 10.1177/1756285610371146 * |
| JOHN DULOS 等: "Bion-1301: A Novel Fully Blocking APRIL Antibody for the Treatment of Multiple Myeloma", BLOOD, vol. 128, no. 22 * |
| 张健锋;毛振彪;: "APRIL及其受体在消化系肿瘤中的作用研究进展", 国际消化病杂志, no. 05, pages 336 - 338 * |
| 陆烈, 蔡洪培: "APRIL对肿瘤细胞增殖作用的研究进展", 中国肿瘤生物治疗杂志, no. 03, pages 217 - 219 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113368262A (zh) * | 2020-09-03 | 2021-09-10 | 上海易慕峰生物科技有限公司 | 通过实体肿瘤转移动物模型获取中间结果的方法 |
| WO2022048314A1 (zh) * | 2020-09-03 | 2022-03-10 | 上海易慕峰生物科技有限公司 | 针对循环肿瘤细胞的免疫杀伤细胞在实体瘤治疗中的应用 |
| CN114147343A (zh) * | 2021-12-08 | 2022-03-08 | 西安中科微精光子制造科技有限公司 | 一种激光加工方法、系统及计算机存储介质 |
| CN114147343B (zh) * | 2021-12-08 | 2024-08-16 | 西安中科微精光子科技股份有限公司 | 一种激光加工方法、系统及计算机存储介质 |
| CN118126196A (zh) * | 2024-03-06 | 2024-06-04 | 中国医学科学院基础医学研究所 | 一种具有包含taci融合蛋白的基因工程化外泌体及其制备方法和应用 |
| CN118126196B (zh) * | 2024-03-06 | 2024-08-16 | 中国医学科学院基础医学研究所 | 一种具有包含taci融合蛋白的基因工程化外泌体及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018289493A1 (en) | 2019-12-12 |
| EP3642243A2 (en) | 2020-04-29 |
| CA3064632A1 (en) | 2018-12-27 |
| AU2018289493B2 (en) | 2025-07-03 |
| WO2018236995A3 (en) | 2019-01-31 |
| JP2020524149A (ja) | 2020-08-13 |
| WO2018236995A2 (en) | 2018-12-27 |
| US20210113605A1 (en) | 2021-04-22 |
| EP3642243A4 (en) | 2021-04-28 |
| US12005073B2 (en) | 2024-06-11 |
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