CN110944650B - 用于治疗和预防孤独症及相关障碍的肠选择性螯合剂 - Google Patents

用于治疗和预防孤独症及相关障碍的肠选择性螯合剂 Download PDF

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CN110944650B
CN110944650B CN201880034095.5A CN201880034095A CN110944650B CN 110944650 B CN110944650 B CN 110944650B CN 201880034095 A CN201880034095 A CN 201880034095A CN 110944650 B CN110944650 B CN 110944650B
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chelator
composition
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metabolite
intestinal
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CN110944650A (zh
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安托尼·斯图尔特·坎贝尔
戴维·H·多纳伯迪昂
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Axial Therapy Co
Axial Therapeutics Inc
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Axial Therapy Co
Axial Biotherapeutics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/44—Elemental carbon, e.g. charcoal, carbon black
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201880034095.5A 2017-03-31 2018-03-31 用于治疗和预防孤独症及相关障碍的肠选择性螯合剂 Active CN110944650B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210138407.5A CN114569633B (zh) 2017-03-31 2018-03-31 用于治疗和预防孤独症及相关障碍的肠选择性螯合剂

Applications Claiming Priority (3)

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US201762480039P 2017-03-31 2017-03-31
US62/480,039 2017-03-31
PCT/US2018/025607 WO2018183986A1 (en) 2017-03-31 2018-03-31 Gut-selective sequestering agents for the treatment and prevention of autism and related disorders

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CN202210138407.5A Active CN114569633B (zh) 2017-03-31 2018-03-31 用于治疗和预防孤独症及相关障碍的肠选择性螯合剂

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US (4) US10617718B2 (enExample)
EP (1) EP3600349A4 (enExample)
JP (1) JP6978122B2 (enExample)
KR (1) KR102328323B1 (enExample)
CN (2) CN110944650B (enExample)
AU (3) AU2018243836B9 (enExample)
BR (1) BR112019020289A2 (enExample)
CA (2) CA3191747A1 (enExample)
WO (1) WO2018183986A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3600349A4 (en) 2017-03-31 2020-09-30 Axial Biotherapeutics, Inc. SELECTIVE GUT SEQUESTRATION AGENTS FOR THE TREATMENT AND PREVENTION OF AUTISM AND RELATED DISORDERS
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
WO2021011481A1 (en) * 2019-07-12 2021-01-21 The General Hospital Corporation Anti-inflammatory factors
WO2021126220A1 (en) * 2019-12-19 2021-06-24 Hill's Pet Nutrition, Inc. Compositions and methods of treating and reducing risk of conditions associated with elevated 4-ethylphenyl sulfate in canines using tomato pomace and methods of identifying canines at risk of such conditions
WO2022026450A1 (en) * 2020-07-27 2022-02-03 Duke University Assessment and treatment of depression, anxiety, or related disorders
CN113440522B (zh) * 2021-07-29 2022-12-13 中山大学附属第七医院(深圳) 一种吲哚丙酸在制备用于治疗自闭症药物中的应用
CN115825314A (zh) * 2021-09-17 2023-03-21 中国科学院深圳先进技术研究院 一种阿尔兹海默症生物标志物s-甲基-5′-硫代腺苷及其应用
WO2023154547A1 (en) 2022-02-14 2023-08-17 Axial Therapeutics, Inc. Colon targeted drug delivery
WO2023154966A1 (en) * 2022-02-14 2023-08-17 Axial Therapeutics, Inc. Compositions and methods for sequestering metabolites in the gastrointestinal tract
CN116990395A (zh) * 2022-04-26 2023-11-03 中国科学院深圳先进技术研究院 一种基于粪便的阿尔兹海默症生物标志物及其应用

Citations (4)

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EP0029715A1 (en) * 1979-11-22 1981-06-03 Kureha Kagaku Kogyo Kabushiki Kaisha Porous spherical carbonaceous product and production thereof
US4761284A (en) * 1977-12-27 1988-08-02 Kureha Kagaku Kogy Kabushiki Kaisha Antidote including activated carbon particles
CN103491949A (zh) * 2011-03-04 2014-01-01 株式会社吴羽 片剂型的口服给药用组合物及其制造方法
WO2015150590A1 (en) * 2014-04-04 2015-10-08 Biotechnobel Sa Composition for prevention and/or treatment of chronic inflammation and concomitant biofilms in the gastrointestinal tract

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GB9611437D0 (en) 1995-08-03 1996-08-07 Secr Defence Biomaterial
US7651974B2 (en) 2002-11-01 2010-01-26 Kureha Chemical Industry Co., Ltd. Adsorbent for oral administration
JP2008523100A (ja) * 2004-12-13 2008-07-03 アリーナ ファーマシューティカルズ， インコーポレイテッド ５ｈｔ２ｃ受容体に関連した疾患の治療に有用な５ｈｔ２ｃ受容体のモジュレータとしてのｎ−ビアリール及びｎ−アリールヘテロアリール２−置換ピペラジン誘導体
SG174220A1 (en) * 2009-03-05 2011-10-28 Mithridion Inc Compounds and compositions for cognition-enhancement, methods of making, and methods of treating
US20140213534A1 (en) * 2011-05-23 2014-07-31 Thomas Jefferson University Intestinal hyperpermeability and prevention of systemic disease
GB201204696D0 (en) * 2012-03-16 2012-05-02 Ucl Business Plc Therapy
US10220089B2 (en) * 2012-08-29 2019-03-05 California Institute Of Technology Diagnosis and treatment of autism spectrum disorder
TWI520751B (zh) 2013-02-22 2016-02-11 吳羽股份有限公司 經口投予用吸附劑及腎疾病治療劑及肝疾病治療劑
MX2016000293A (es) 2013-07-09 2016-06-21 Stemina Biomarker Discovery Inc Biomarcadores del trastrono del espectro autista.
UA116567C2 (uk) * 2013-07-23 2018-04-10 Євро-Селтік С.А. Комбінація оксикодону та налоксону для застосування в лікуванні болю у пацієнтів, які страждають від болю та захворювання, що призводить до дисбактеріозу кишечнику та/або підвищує ризик кишкової бактеріальної транслокації
US20150111878A1 (en) * 2013-10-22 2015-04-23 Steven Hoffman Compositions and methods for treating intestinal hyperpermeability
US9763903B2 (en) * 2013-10-22 2017-09-19 Steven Hoffman Compositions and methods for treating intestinal hyperpermeability
EP3600349A4 (en) 2017-03-31 2020-09-30 Axial Biotherapeutics, Inc. SELECTIVE GUT SEQUESTRATION AGENTS FOR THE TREATMENT AND PREVENTION OF AUTISM AND RELATED DISORDERS

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761284A (en) * 1977-12-27 1988-08-02 Kureha Kagaku Kogy Kabushiki Kaisha Antidote including activated carbon particles
EP0029715A1 (en) * 1979-11-22 1981-06-03 Kureha Kagaku Kogyo Kabushiki Kaisha Porous spherical carbonaceous product and production thereof
CN103491949A (zh) * 2011-03-04 2014-01-01 株式会社吴羽 片剂型的口服给药用组合物及其制造方法
WO2015150590A1 (en) * 2014-04-04 2015-10-08 Biotechnobel Sa Composition for prevention and/or treatment of chronic inflammation and concomitant biofilms in the gastrointestinal tract

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Publication number Publication date
US20180303876A1 (en) 2018-10-25
CN114569633A (zh) 2022-06-03
US10617718B2 (en) 2020-04-14
AU2022200220A1 (en) 2022-02-10
BR112019020289A2 (pt) 2020-09-01
WO2018183986A1 (en) 2018-10-04
AU2021206871B2 (en) 2021-10-14
JP6978122B2 (ja) 2021-12-08
CN110944650A (zh) 2020-03-31
CA3095724A1 (en) 2018-10-04
EP3600349A4 (en) 2020-09-30
US20200368276A1 (en) 2020-11-26
CA3095724C (en) 2023-04-18
AU2018243836B2 (en) 2021-04-22
AU2021206871A1 (en) 2021-08-12
KR102328323B1 (ko) 2021-11-19
US11007219B2 (en) 2021-05-18
CA3191747A1 (en) 2018-10-04
CN114569633B (zh) 2023-11-17
EP3600349A1 (en) 2020-02-05
US20230364135A1 (en) 2023-11-16
AU2018243836A1 (en) 2019-11-21
NZ758692A (en) 2022-03-25
AU2018243836B9 (en) 2021-05-13
KR20200024133A (ko) 2020-03-06
JP2020513032A (ja) 2020-04-30
US20200390809A1 (en) 2020-12-17

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