CN110934760A - Alliin essence and preparation method thereof - Google Patents

Alliin essence and preparation method thereof Download PDF

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Publication number
CN110934760A
CN110934760A CN201911174999.0A CN201911174999A CN110934760A CN 110934760 A CN110934760 A CN 110934760A CN 201911174999 A CN201911174999 A CN 201911174999A CN 110934760 A CN110934760 A CN 110934760A
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parts
alliin
essence
stirring
composition
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沈衡平
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Ou Lulian Biotechnology Guangdong Co Ltd
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Ou Lulian Biotechnology Guangdong Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/447Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof containing sulfur
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/34Alcohols
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
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    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/645Proteins of vegetable origin; Derivatives or degradation products thereof
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    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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    • A61K8/9728Fungi, e.g. yeasts
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    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
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    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
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    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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    • A61K2800/782Enzyme inhibitors; Enzyme antagonists

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Abstract

The invention discloses an alliin essence and a preparation method thereof, wherein the alliin essence comprises the following components in parts by weight: 80-90 parts of alliin rose dew liquid, 6-7 parts of plant extract composition, 1-3 parts of small molecule active peptide composition, 2-5 parts of hyaluronic acid mixture, 5-10 parts of freckle removing compound and 1-3 parts of butanediol. The small molecule active peptide composition comprises hexapeptide-8 and snake venom peptide-3, and the mixture ratio of the hexapeptide-8: snake venom peptide-3 ═ 1-2: 1-2. According to the invention, the alliin rose juice is used as a substrate, the anti-aging effect of alliin is fully utilized, the essence can obtain a good anti-oxidation effect, and the anti-oxidation and anti-aging effects are further achieved; alliin is colorless and tasteless, is easily soluble in water, and has stable components; the moisturizing essence prepared by using alliin as a main component has the effects of effectively improving skin, strongly resisting oxidation, blackening and aging, preventing sun, preventing melanin deposition, removing stains and whitening.

Description

Alliin essence and preparation method thereof
Technical Field
The invention relates to the field of cosmetics, and particularly relates to alliin essence.
Background
Alliin (alliin) (alliin, S-Allyl-L-cysteine sulfoxide, S-Allyl-L- (+) -cysteine and amino acids of Sacs) is one of the main bioactive substances in garlic, and accounts for 0.6-2% of the dry weight of garlic.
The unique non-protein sulfur-containing amino acid in the garlic accounts for 0.6 to 2 percent of the dry weight of the garlic. It is very soluble in water, and insoluble in absolute ethanol, chloroform, acetone, ether and benzene, and can be crystallized with diluted acetone and ethanol to obtain white needle cluster crystal. Modern medicine shows that: alliin has various pharmacological effects of resisting tumor, synergistically lowering blood pressure, resisting bacteria and virus, eliminating free radicals, protecting liver, resisting diabetes and the like. Is a unique sulfur-containing compound in garlic.
Modern medical research proves that garlic sulfur-containing amino acid represented by alliin has unique pharmacological activity. Has obvious effects of reducing blood fat, improving body immunity, sterilizing, inhibiting bacteria, resisting cold, resisting aging, promoting blood circulation, preventing cancer and resisting cancer and the like after being taken for a long time. The bactericide has the effects of inhibiting and killing various pathogenic bacteria harmful to human beings, is natural phytoncide, and has obvious bacteriostatic and bactericidal effects on pathogenic staphylococcus, pyococcus, dysentery bacillus, escherichia coli, typhoid bacillus, tubercle bacillus, diphtheria bacillus, carbon maggot bacillus, bacillus subtilis, paratyphoid bacillus, meningitis, diplococcus, vibrio cholerae, streptococcus, staphylococcus albus, schoenophyton and the like; the traditional Chinese medicine composition has treatment and prevention values on various bacterial, fungal and protozoal infections, has great effects on research and development of biological medicines, and is called as one of the greatest magical discoveries in the field of natural food and medicines in the twenty-first century by the world medical community. Alliin, a polar monomer in garlic, has attracted much attention of various national scholars in recent years.
Garlic, also known as garlic, is the underground bulb of garlic (Allium sativum L.) of Allium of Liliaceae, and is a long-standing plant used as both medicine and food. Alliin, also known as allicin, is mainly present in the cells of garlic bulbs and is colorless and odorless. Alliin is unstable in nature and is rapidly converted into Allicin (Allicin) under the action of Allinase and water at normal temperature to produce acetone and ammonia. Wherein the allicin will be further decomposed into various sulfur-containing compounds. Animal experiments prove that alliin has the effects of resisting thrombus, killing fungi and the like. The current methods for preparing alliin mainly comprise two methods: one is an extraction method, which is generally obtained by a method of firstly freezing at low temperature, then centrifuging, and separating and purifying through a column. The method has the advantages that the product has full-natural property, but has the disadvantages of low alliin content in garlic, high separation cost and low efficiency.
Alliin is a substance found and extracted from garlic and has a wide range of biological activities: the bactericidal composition has a strong killing effect on common pathogenic bacteria such as staphylococcus aureus, tubercle bacillus, meningococcus and the like, and also has a remarkable curative effect on microbial infectious diseases such as fungal infection, protozoal disease and the like; in addition, the health-care tea also has good effects of reducing blood fat, improving human immunity, resisting aging, resisting and preventing cancers and the like. At present, alliin health care products are mainly used for preventing myocardial infarction, cerebral infarction, blood fat reduction and the like abroad. In view of the excellent curative effect of alliin in preventing and treating cardiovascular and cerebrovascular diseases, the product is expected by the foreign medical health-care community, and is expected to become a new plant medicine product for resisting cardiovascular and cerebrovascular diseases worldwide after the 'ginkgo fever'.
Alliin is currently used only in the fields of medicines and foods, and is not used in the field of cosmetics, and is considered to be applied to the field of cosmetics because of its effect of promoting blood circulation to human skin.
Therefore, the invention applies the alliin to the essence liquid products in the field of cosmetics, so that the alliin can be well applied.
Disclosure of Invention
The invention aims to provide an alliin essence to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
the alliin essence comprises the following components in parts by weight:
80-90 parts of alliin rose dew liquid, 6-7 parts of plant extract composition, 1-3 parts of small molecule active peptide composition, 2-5 parts of hyaluronic acid mixture, 5-10 parts of freckle removing compound and 1-3 parts of butanediol.
As a further scheme of the invention: the freckle removing compound comprises the following components: the composition comprises phenethyl resorcinol, a natural truffle extract, bisabolol and a ginger root extract, wherein the proportion of the phenethyl resorcinol: natural truffle extract: bisabolol: 1-2 parts of ginger root extract: 2-3: 1-3: 1-2.
The freckle removing compound is combined with natural ingredients such as ginger root extract, komatsuna extract and the like, and is beneficial to reducing irritation of the freckle removing and whitening formula to skin and reducing adverse reactions such as skin redness and swelling. The skin whitening and freckle removing mask can block the formation and deepening of skin color spots through the combined action of various aspects such as tyrosinase inhibition, antioxidation, inflammation resistance, glycosylation resistance and the like, further effectively removes freckles and whitens the skin, is matched with the main component alliin, and assists in realizing the freckles removing function by utilizing the sterilization and antioxidation properties of the alliin.
As a further scheme of the invention: the small molecule active peptide composition comprises hexapeptide-8 and snake venom peptide-3, and the proportion of the hexapeptide-8: snake venom peptide-3 ═ 1-2: 1-2. The active peptide composition can be well matched with the antioxidant property of alliin to enhance the effect of resisting skin aging of the essence, and can be matched with the freckle removing compound to assist the realization of the freckle removing function by assisting the growth and recovery of damaged skin.
As a further scheme of the invention: the plant extract composition comprises the following components in parts by weight: 10-12 parts of lemon essence liquid, 5-10 parts of liquorice essence liquid, 1-3 parts of green tea carnitine, 10-15 parts of red date extract and 2-5 parts of ginseng essence liquid. The natural plant essence is mild and non-irritant, is beneficial to skin absorption, can supplement skin nutrition, keeps skin activity and elasticity, and assists growth and maintenance of skin collagen.
As a further scheme of the invention: the hyaluronic acid mixture is formed by mixing a macromolecular hyaluronic acid mixture and a micromolecular hyaluronic acid mixture, and the optimal ratio is 1: 10.
As a further scheme of the invention: the alliin essence comprises the following components in parts by weight:
80-90 parts of alliin rose juice, 6-7 parts of plant extract composition, 1-3 parts of small molecule active peptide composition, 2-5 parts of hyaluronic acid mixture, 5-10 parts of freckle removing compound, 1-3 parts of butanediol and 2-3 parts of plant protein composition.
As a further scheme of the invention: the vegetable protein composition is a composition of soybean protein, oat protein and corn protein, and the mixture ratio of the vegetable protein composition is that the soybean protein: oat protein: and (3) corn protein is 5-7: 1-2: 2 to 3.
The preparation method of the alliin essence comprises the following steps:
firstly, adding alliin rose juice into a magnetic sealed reaction kettle;
secondly, sequentially adding the lemon essence, the licorice essence, the green tea carnitine, the red date extract and the ginseng essence into a magnetic sealing reaction kettle, and stirring for 10-15 minutes after adding one variety; stirring for 5 hours after all the materials are added, and then standing for 2-3 hours;
thirdly, adding the freckle removing compound into a magnetic sealing reaction kettle, and stirring for 1 hour;
fourthly, adding the small molecule active peptide composition, the hyaluronic acid mixture and 1-3 butanediol into a magnetic sealing reaction kettle, and stirring for 1 hour;
fifthly, uniformly stirring, and aseptically filling to obtain the finished product.
The preparation method of the alliin essence added with the vegetable protein composition comprises the following steps:
firstly, adding alliin rose juice into a magnetic sealed reaction kettle;
secondly, sequentially adding the lemon essence, the licorice essence, the green tea carnitine, the red date extract and the ginseng essence into a magnetic sealing reaction kettle, and stirring for 10-15 minutes after adding one variety; stirring for 5 hours after all the materials are added, and then standing for 2-3 hours;
thirdly, adding the freckle removing compound into a magnetic sealing reaction kettle, and stirring for 1 hour;
fourthly, adding the vegetable protein composition into a magnetic sealing reaction kettle, and stirring for 30 min; then standing for 2-3 hours;
fifthly, adding the small molecule active peptide composition, the hyaluronic acid mixture and 1-3 butanediol into a magnetic sealing reaction kettle, and stirring for 1 hour;
sixthly, uniformly stirring, and carrying out sterile filling to obtain a finished product.
Compared with the prior art, the invention has the beneficial effects that:
the moisturizing essence prepared by using alliin as a main component has the effects of effectively improving skin, strongly resisting oxidation, resisting black, resisting aging, preventing sun, preventing melanin deposition, removing stains and whitening. The alliin has the effect of promoting blood circulation on human skin, has strong penetrability, and does not need to be added with chemical penetrant.
According to the invention, the alliin rose distillate is used as a main component, the anti-aging effect of alliin is fully utilized, and the essence liquid can obtain a good anti-oxidation effect, so that the anti-oxidation and anti-aging effects are achieved; alliin is colorless and tasteless, is easy to dissolve in water, has stable components, can prolong the shelf life of the prepared cosmetic for three years, does not have the special garlic smell of the alliin, is more convenient to add the smell of other components, and has better cosmetic effect.
The freckle-removing composition disclosed by the invention is combined with the freckle-removing compound fused with natural ingredients such as the ginger root extract and the truffle extract, and is beneficial to reducing irritation of the freckle-removing whitening formula to skin and reducing adverse reactions such as skin redness and swelling. The skin whitening and freckle removing mask can block the formation and deepening of skin color spots through the combined action of various aspects such as inhibition of tyrosinase, oxidation resistance, inflammation resistance, glycosylation resistance and the like, further effectively removes freckles and whitens the skin, is matched with the main component alliin, and utilizes the sterilization and oxidation resistance of the alliin to assist the realization of the freckles removing function.
The combined plant extract composition is formed by combining a plurality of natural plant essence components including lemon essence, liquorice essence, green tea carnitine, red date extract and ginseng essence, and can achieve good effects of repairing skin, resisting aging and resisting oxidation.
The active peptide composition and the freckle removing compound are combined, so that the anti-oxidation characteristic of alliin can be well matched to enhance the anti-skin aging effect of the essence, and the active peptide composition and the freckle removing compound can be matched to assist the realization of the freckle removing function through the effect of assisting the growth and recovery of damaged skin;
the vegetable protein composition compounded by the soy protein, the oat protein and the corn protein is adopted, the content of lysine in the soy protein in the vegetable protein composition is rich, the defects of the oat protein and the corn protein lysine are overcome, the proportion of essential amino acids of mixed protein is closer to the mode required by a human body, the nutritive value of the vegetable protein composition is improved, and the nutrition required by skin is provided by natural vegetable protein with high nutritive value.
Detailed Description
The present application is described in further detail below, and it should be noted that the following detailed description is provided for illustrative purposes only, and is not intended to limit the scope of the present application, which is defined by the appended claims.
Example one
The alliin essence comprises the following components in parts by weight:
alliin rose juice 80, plant extract composition 6, small molecule active peptide composition 1, hyaluronic acid mixture 2, freckle removing compound 5 and 1-3 butanediol 1;
the freckle removing compound comprises the following components: the composition comprises phenethyl resorcinol, a natural truffle extract, bisabolol and a ginger root extract, wherein the proportion of the phenethyl resorcinol: natural truffle extract: bisabolol: 1-2 parts of ginger root extract: 2-3: 1-3: 1-2.
The freckle removing compound is combined with natural ingredients such as ginger root extract, komatsuna extract and the like, and is beneficial to reducing irritation of the freckle removing and whitening formula to skin and reducing adverse reactions such as skin redness and swelling. The skin whitening and freckle removing mask can block the formation and deepening of skin color spots through the combined action of various aspects such as tyrosinase inhibition, antioxidation, inflammation resistance, glycosylation resistance and the like, further effectively removes freckles and whitens the skin, is matched with the main component alliin, and assists in realizing the freckles removing function by utilizing the sterilization and antioxidation properties of the alliin.
The small molecule active peptide composition comprises hexapeptide-8 and snake venom peptide-3, and the mixture ratio of the hexapeptide-8: snake venom peptide-3 ═ 1-2: 1-2. The active peptide composition can be well matched with the antioxidant property of alliin to enhance the effect of resisting skin aging of the essence, and can be matched with the freckle removing compound to assist the realization of the freckle removing function by assisting the growth and recovery of damaged skin.
The plant extract composition comprises the following components in parts by weight: 10-12 parts of lemon essence, 5-10 parts of licorice essence, 1-3 parts of green tea carnitine, 10-15 parts of red date extract and 2-5 parts of ginseng essence. The natural plant essence is mild and non-irritant, is beneficial to skin absorption, can supplement skin nutrition, keeps skin activity and elasticity, and assists growth and maintenance of skin collagen.
The hyaluronic acid mixture is prepared by mixing a macromolecular hyaluronic acid mixture and a small molecular hyaluronic acid mixture, and the optimal ratio is 1: 10.
The preparation method of the alliin essence comprises the following steps:
firstly, adding alliin rose juice into a magnetic sealed reaction kettle;
secondly, sequentially adding the lemon essence, the licorice essence, the green tea carnitine, the red date extract and the ginseng essence into a magnetic sealing reaction kettle, and stirring for 10-15 minutes after adding one variety; stirring for 5 hours after all the materials are added, and then standing for 2-3 hours;
thirdly, adding the freckle removing compound into a magnetic sealing reaction kettle, and stirring for 1 hour;
fourthly, adding the small molecule active peptide composition, the hyaluronic acid mixture and 1-3 butanediol into a magnetic sealing reaction kettle, and stirring for 1 hour;
fifthly, uniformly stirring, and aseptically filling to obtain the finished product.
Example two
The alliin essence comprises the following components in parts by weight:
alliin rose dew 85, plant extract composition 6.5, small molecule active peptide composition 1.2, hyaluronic acid mixture 2.5, speckle removing compound 6.5, and 1-3 butanediol 1.2;
the freckle removing compound comprises the following components: the composition comprises phenethyl resorcinol, a natural truffle extract, bisabolol and a ginger root extract, wherein the proportion of the phenethyl resorcinol: natural truffle extract: bisabolol: 1-2 parts of ginger root extract: 2-3: 1-3: 1-2.
The freckle removing compound is combined with natural ingredients such as ginger root extract, komatsuna extract and the like, and is beneficial to reducing irritation of the freckle removing and whitening formula to skin and reducing adverse reactions such as skin redness and swelling. The skin whitening and freckle removing mask can block the formation and deepening of skin color spots through the combined action of various aspects such as tyrosinase inhibition, antioxidation, inflammation resistance, glycosylation resistance and the like, further effectively removes freckles and whitens the skin, is matched with the main component alliin, and assists in realizing the freckles removing function by utilizing the sterilization and antioxidation properties of the alliin.
The small molecule active peptide composition comprises hexapeptide-8 and snake venom peptide-3, and the mixture ratio of the hexapeptide-8: snake venom peptide-3 ═ 1-2: 1-2. The active peptide composition can be well matched with the antioxidant property of alliin to enhance the effect of resisting skin aging of the essence, and can be matched with the freckle removing compound to assist the realization of the freckle removing function by assisting the growth and recovery of damaged skin.
The plant extract composition comprises the following components in parts by weight: 10-12 parts of lemon essence, 5-10 parts of licorice essence, 1-3 parts of green tea carnitine, 10-15 parts of red date extract and 2-5 parts of ginseng essence. The natural plant essence is mild and non-irritant, is beneficial to skin absorption, can supplement skin nutrition, keeps skin activity and elasticity, and assists growth and maintenance of skin collagen.
The hyaluronic acid mixture is prepared by mixing a macromolecular hyaluronic acid mixture and a small molecular hyaluronic acid mixture, and the optimal ratio is 1: 10.
The preparation method of the alliin essence comprises the following steps:
firstly, adding alliin rose juice into a magnetic sealed reaction kettle;
secondly, sequentially adding the lemon essence, the licorice essence, the green tea carnitine, the red date extract and the ginseng essence into a magnetic sealing reaction kettle, and stirring for 10-15 minutes after adding one variety; stirring for 5 hours after all the materials are added, and then standing for 2-3 hours;
thirdly, adding the freckle removing compound into a magnetic sealing reaction kettle, and stirring for 1 hour;
fourthly, adding the small molecule active peptide composition, the hyaluronic acid mixture and 1-3 butanediol into a magnetic sealing reaction kettle, and stirring for 1 hour;
fifthly, uniformly stirring, and aseptically filling to obtain the finished product.
EXAMPLE III
The alliin essence comprises the following components in parts by weight:
alliin rose juice 86, plant extract composition 6.8, small molecule active peptide composition 2.5, hyaluronic acid mixture 4, freckle removing compound 8, 1-3 butanediol 1.6;
the freckle removing compound comprises the following components: the composition comprises phenethyl resorcinol, a natural truffle extract, bisabolol and a ginger root extract, wherein the proportion of the phenethyl resorcinol: natural truffle extract: bisabolol: 1-2 parts of ginger root extract: 2-3: 1-3: 1-2.
The freckle removing compound is combined with natural ingredients such as ginger root extract, komatsuna extract and the like, and is beneficial to reducing irritation of the freckle removing and whitening formula to skin and reducing adverse reactions such as skin redness and swelling. The skin whitening and freckle removing mask can block the formation and deepening of skin color spots through the combined action of various aspects such as tyrosinase inhibition, antioxidation, inflammation resistance, glycosylation resistance and the like, further effectively removes freckles and whitens the skin, is matched with the main component alliin, and assists in realizing the freckles removing function by utilizing the sterilization and antioxidation properties of the alliin.
The small molecule active peptide composition comprises hexapeptide-8 and snake venom peptide-3, and the mixture ratio of the hexapeptide-8: snake venom peptide-3 ═ 1-2: 1-2. The active peptide composition can be well matched with the antioxidant property of alliin to enhance the effect of resisting skin aging of the essence, and can be matched with the freckle removing compound to assist the realization of the freckle removing function by assisting the growth and recovery of damaged skin.
The plant extract composition comprises the following components in parts by weight: 10-12 parts of lemon essence, 5-10 parts of licorice essence, 1-3 parts of green tea carnitine, 10-15 parts of red date extract and 2-5 parts of ginseng essence. The natural plant essence is mild and non-irritant, is beneficial to skin absorption, can supplement skin nutrition, keeps skin activity and elasticity, and assists growth and maintenance of skin collagen.
The hyaluronic acid mixture is prepared by mixing a macromolecular hyaluronic acid mixture and a small molecular hyaluronic acid mixture, and the optimal ratio is 1: 10.
The preparation method of the alliin essence comprises the following steps:
firstly, adding alliin rose juice into a magnetic sealed reaction kettle;
secondly, sequentially adding the lemon essence, the licorice essence, the green tea carnitine, the red date extract and the ginseng essence into a magnetic sealing reaction kettle, and stirring for 10-15 minutes after adding one variety; stirring for 5 hours after all the materials are added, and then standing for 2-3 hours;
thirdly, adding the freckle removing compound into a magnetic sealing reaction kettle, and stirring for 1 hour;
fourthly, adding the small molecule active peptide composition, the hyaluronic acid mixture and 1-3 butanediol into a magnetic sealing reaction kettle, and stirring for 1 hour;
fifthly, uniformly stirring, and aseptically filling to obtain the finished product.
Example four
The alliin essence comprises the following components in parts by weight:
alliin rose juice 90, plant extract composition 7, small molecule active peptide composition 3, hyaluronic acid mixture 5, freckle removing compound 10 and 1-3 butanediol 2;
the freckle removing compound comprises the following components: the composition comprises phenethyl resorcinol, a natural truffle extract, bisabolol and a ginger root extract, wherein the proportion of the phenethyl resorcinol: natural truffle extract: bisabolol: 1-2 parts of ginger root extract: 2-3: 1-3: 1-2.
The freckle removing compound is combined with natural ingredients such as ginger root extract, komatsuna extract and the like, and is beneficial to reducing irritation of the freckle removing and whitening formula to skin and reducing adverse reactions such as skin redness and swelling. The skin whitening and freckle removing mask can block the formation and deepening of skin color spots through the combined action of various aspects such as tyrosinase inhibition, antioxidation, inflammation resistance, glycosylation resistance and the like, further effectively removes freckles and whitens the skin, is matched with the main component alliin, and assists in realizing the freckles removing function by utilizing the sterilization and antioxidation properties of the alliin.
The small molecule active peptide composition comprises hexapeptide-8 and snake venom peptide-3, and the mixture ratio of the hexapeptide-8: snake venom peptide-3 ═ 1-2: 1-2. The active peptide composition can be well matched with the antioxidant property of alliin to enhance the effect of resisting skin aging of the essence, and can be matched with the freckle removing compound to assist the realization of the freckle removing function by assisting the growth and recovery of damaged skin.
The plant extract composition comprises the following components in parts by weight: 10-12 parts of lemon essence, 5-10 parts of licorice essence, 1-3 parts of green tea carnitine, 10-15 parts of red date extract and 2-5 parts of ginseng essence. The natural plant essence is mild and non-irritant, is beneficial to skin absorption, can supplement skin nutrition, keeps skin activity and elasticity, and assists growth and maintenance of skin collagen.
The hyaluronic acid mixture is prepared by mixing a macromolecular hyaluronic acid mixture and a small molecular hyaluronic acid mixture, and the optimal ratio is 1: 10.
The preparation method of the alliin essence comprises the following steps:
firstly, adding alliin rose juice into a magnetic sealed reaction kettle;
secondly, sequentially adding the lemon essence, the licorice essence, the green tea carnitine, the red date extract and the ginseng essence into a magnetic sealing reaction kettle, and stirring for 10-15 minutes after adding one variety; stirring for 5 hours after all the materials are added, and then standing for 2-3 hours;
thirdly, adding the freckle removing compound into a magnetic sealing reaction kettle, and stirring for 1 hour;
fourthly, adding the small molecule active peptide composition, the hyaluronic acid mixture and 1-3 butanediol into a magnetic sealing reaction kettle, and stirring for 1 hour;
fifthly, uniformly stirring, and aseptically filling to obtain the finished product.
EXAMPLE five
The alliin essence comprises the following components in parts by weight:
alliin rose liquor 80, plant extract composition 6, small molecule active peptide composition 1, hyaluronic acid mixture 2, freckle removing compound 5, 1-3 butanediol 1 and vegetable protein composition 2.
The vegetable protein composition is a composition of soybean protein, oat protein and corn protein, and the mixture ratio of the vegetable protein composition is soybean protein: oat protein: and (3) corn protein is 5-7: 1-2: 2-3;
the freckle removing compound comprises the following components: the composition comprises phenethyl resorcinol, a natural truffle extract, bisabolol and a ginger root extract, wherein the proportion of the phenethyl resorcinol: natural truffle extract: bisabolol: 1-2 parts of ginger root extract: 2-3: 1-3: 1-2.
The freckle removing compound is combined with natural ingredients such as ginger root extract, komatsuna extract and the like, and is beneficial to reducing irritation of the freckle removing and whitening formula to skin and reducing adverse reactions such as skin redness and swelling. The skin whitening and freckle removing mask can block the formation and deepening of skin color spots through the combined action of various aspects such as tyrosinase inhibition, antioxidation, inflammation resistance, glycosylation resistance and the like, further effectively removes freckles and whitens the skin, is matched with the main component alliin, and assists in realizing the freckles removing function by utilizing the sterilization and antioxidation properties of the alliin.
The small molecule active peptide composition comprises hexapeptide-8 and snake venom peptide-3, and the mixture ratio of the hexapeptide-8: snake venom peptide-3 ═ 1-2: 1-2. The active peptide composition can be well matched with the antioxidant property of alliin to enhance the effect of resisting skin aging of the essence, and can be matched with the freckle removing compound to assist the realization of the freckle removing function by assisting the growth and recovery of damaged skin.
The plant extract composition comprises the following components in parts by weight: 10-12 parts of lemon essence, 5-10 parts of licorice essence, 1-3 parts of green tea carnitine, 10-15 parts of red date extract and 2-5 parts of ginseng essence. The natural plant essence is mild and non-irritant, is beneficial to skin absorption, can supplement skin nutrition, keeps skin activity and elasticity, and assists growth and maintenance of skin collagen.
The hyaluronic acid mixture is prepared by mixing a macromolecular hyaluronic acid mixture and a small molecular hyaluronic acid mixture, and the optimal ratio is 1: 10.
The preparation method of the alliin essence comprises the following steps:
firstly, adding alliin rose juice into a magnetic sealed reaction kettle;
secondly, sequentially adding the lemon essence, the licorice essence, the green tea carnitine, the red date extract and the ginseng essence into a magnetic sealing reaction kettle, and stirring for 10-15 minutes after adding one variety; stirring for 5 hours after all the materials are added, and then standing for 2-3 hours;
thirdly, adding the freckle removing compound into a magnetic sealing reaction kettle, and stirring for 1 hour;
fourthly, adding the vegetable protein composition into a magnetic sealing reaction kettle, and stirring for 30 min; then standing for 2-3 hours;
fifthly, adding the small molecule active peptide composition, the hyaluronic acid mixture and 1-3 butanediol into a magnetic sealing reaction kettle, and stirring for 1 hour;
sixthly, uniformly stirring, and carrying out sterile filling to obtain a finished product.
EXAMPLE six
The alliin essence comprises the following components in parts by weight:
alliin rose liquor 85, plant extract composition 6.5, small molecule active peptide composition 1.2, hyaluronic acid mixture 2.5, speckle removing compound 6.5, 1-3 butanediol 1.2, and plant protein composition 2.5.
The vegetable protein composition is a composition of soybean protein, oat protein and corn protein, and the mixture ratio of the vegetable protein composition is soybean protein: oat protein: and (3) corn protein is 5-7: 1-2: 2-3;
the freckle removing compound comprises the following components: the composition comprises phenethyl resorcinol, a natural truffle extract, bisabolol and a ginger root extract, wherein the proportion of the phenethyl resorcinol: natural truffle extract: bisabolol: 1-2 parts of ginger root extract: 2-3: 1-3: 1-2.
The freckle removing compound is combined with natural ingredients such as ginger root extract, komatsuna extract and the like, and is beneficial to reducing irritation of the freckle removing and whitening formula to skin and reducing adverse reactions such as skin redness and swelling. The skin whitening and freckle removing mask can block the formation and deepening of skin color spots through the combined action of various aspects such as tyrosinase inhibition, antioxidation, inflammation resistance, glycosylation resistance and the like, further effectively removes freckles and whitens the skin, is matched with the main component alliin, and assists in realizing the freckles removing function by utilizing the sterilization and antioxidation properties of the alliin.
The small molecule active peptide composition comprises hexapeptide-8 and snake venom peptide-3, and the mixture ratio of the hexapeptide-8: snake venom peptide-3 ═ 1-2: 1-2. The active peptide composition can be well matched with the antioxidant property of alliin to enhance the effect of resisting skin aging of the essence, and can be matched with the freckle removing compound to assist the realization of the freckle removing function by assisting the growth and recovery of damaged skin.
The plant extract composition comprises the following components in parts by weight: 10-12 parts of lemon essence, 5-10 parts of licorice essence, 1-3 parts of green tea carnitine, 10-15 parts of red date extract and 2-5 parts of ginseng essence. The natural plant essence is mild and non-irritant, is beneficial to skin absorption, can supplement skin nutrition, keeps skin activity and elasticity, and assists growth and maintenance of skin collagen.
The hyaluronic acid mixture is prepared by mixing a macromolecular hyaluronic acid mixture and a small molecular hyaluronic acid mixture, and the optimal ratio is 1: 10.
The preparation method of the alliin essence comprises the following steps:
firstly, adding alliin rose juice into a magnetic sealed reaction kettle;
secondly, sequentially adding the lemon essence, the licorice essence, the green tea carnitine, the red date extract and the ginseng essence into a magnetic sealing reaction kettle, and stirring for 10-15 minutes after adding one variety; stirring for 5 hours after all the materials are added, and then standing for 2-3 hours;
thirdly, adding the freckle removing compound into a magnetic sealing reaction kettle, and stirring for 1 hour;
fourthly, adding the vegetable protein composition into a magnetic sealing reaction kettle, and stirring for 30 min; then standing for 2-3 hours;
fifthly, adding the small molecule active peptide composition, the hyaluronic acid mixture and 1-3 butanediol into a magnetic sealing reaction kettle, and stirring for 1 hour;
sixthly, uniformly stirring, and carrying out sterile filling to obtain a finished product.
EXAMPLE seven
The alliin essence comprises the following components in parts by weight:
alliin rose liquor 86, plant extract composition 6.8, small molecule active peptide composition 2.5, hyaluronic acid mixture 4, freckle removing complex 8, 1-3 butanediol, and vegetable protein composition 2.8.
The vegetable protein composition is a composition of soybean protein, oat protein and corn protein, and the mixture ratio of the vegetable protein composition is soybean protein: oat protein: and (3) corn protein is 5-7: 1-2: 2-3;
the freckle removing compound comprises the following components: the composition comprises phenethyl resorcinol, a natural truffle extract, bisabolol and a ginger root extract, wherein the proportion of the phenethyl resorcinol: natural truffle extract: bisabolol: 1-2 parts of ginger root extract: 2-3: 1-3: 1-2.
The freckle removing compound is combined with natural ingredients such as ginger root extract, komatsuna extract and the like, and is beneficial to reducing irritation of the freckle removing and whitening formula to skin and reducing adverse reactions such as skin redness and swelling. The skin whitening and freckle removing mask can block the formation and deepening of skin color spots through the combined action of various aspects such as tyrosinase inhibition, antioxidation, inflammation resistance, glycosylation resistance and the like, further effectively removes freckles and whitens the skin, is matched with the main component alliin, and assists in realizing the freckles removing function by utilizing the sterilization and antioxidation properties of the alliin.
The small molecule active peptide composition comprises hexapeptide-8 and snake venom peptide-3, and the mixture ratio of the hexapeptide-8: snake venom peptide-3 ═ 1-2: 1-2. The active peptide composition can be well matched with the antioxidant property of alliin to enhance the effect of resisting skin aging of the essence, and can be matched with the freckle removing compound to assist the realization of the freckle removing function by assisting the growth and recovery of damaged skin.
The plant extract composition comprises the following components in parts by weight: 10-12 parts of lemon essence, 5-10 parts of licorice essence, 1-3 parts of green tea carnitine, 10-15 parts of red date extract and 2-5 parts of ginseng essence. The natural plant essence is mild and non-irritant, is beneficial to skin absorption, can supplement skin nutrition, keeps skin activity and elasticity, and assists growth and maintenance of skin collagen.
The hyaluronic acid mixture is prepared by mixing a macromolecular hyaluronic acid mixture and a small molecular hyaluronic acid mixture, and the optimal ratio is 1: 10.
The preparation method of the alliin essence comprises the following steps:
firstly, adding alliin rose juice into a magnetic sealed reaction kettle;
secondly, sequentially adding the lemon essence, the licorice essence, the green tea carnitine, the red date extract and the ginseng essence into a magnetic sealing reaction kettle, and stirring for 10-15 minutes after adding one variety; stirring for 5 hours after all the materials are added, and then standing for 2-3 hours;
thirdly, adding the freckle removing compound into a magnetic sealing reaction kettle, and stirring for 1 hour;
fourthly, adding the vegetable protein composition into a magnetic sealing reaction kettle, and stirring for 30 min; then standing for 2-3 hours;
fifthly, adding the small molecule active peptide composition, the hyaluronic acid mixture and 1-3 butanediol into a magnetic sealing reaction kettle, and stirring for 1 hour;
sixthly, uniformly stirring, and carrying out sterile filling to obtain a finished product.
Example eight
The alliin essence comprises the following components in parts by weight:
alliin rose liquid 90, plant extract composition 7, small molecule active peptide composition 3, hyaluronic acid mixture 5, freckle removing compound 10, 1-3 butanediol 2 and vegetable protein composition 3.
The vegetable protein composition is a composition of soybean protein, oat protein and corn protein, and the mixture ratio of the vegetable protein composition is soybean protein: oat protein: and (3) corn protein is 5-7: 1-2: 2-3;
the freckle removing compound comprises the following components: the composition comprises phenethyl resorcinol, a natural truffle extract, bisabolol and a ginger root extract, wherein the proportion of the phenethyl resorcinol: natural truffle extract: bisabolol: 1-2 parts of ginger root extract: 2-3: 1-3: 1-2.
The freckle removing compound is combined with natural ingredients such as ginger root extract, komatsuna extract and the like, and is beneficial to reducing irritation of the freckle removing and whitening formula to skin and reducing adverse reactions such as skin redness and swelling. The skin whitening and freckle removing mask can block the formation and deepening of skin color spots through the combined action of various aspects such as tyrosinase inhibition, antioxidation, inflammation resistance, glycosylation resistance and the like, further effectively removes freckles and whitens the skin, is matched with the main component alliin, and assists in realizing the freckles removing function by utilizing the sterilization and antioxidation properties of the alliin.
The small molecule active peptide composition comprises hexapeptide-8 and snake venom peptide-3, and the mixture ratio of the hexapeptide-8: snake venom peptide-3 ═ 1-2: 1-2. The active peptide composition can be well matched with the antioxidant property of alliin to enhance the effect of resisting skin aging of the essence, and can be matched with the freckle removing compound to assist the realization of the freckle removing function by assisting the growth and recovery of damaged skin.
The plant extract composition comprises the following components in parts by weight: 10-12 parts of lemon essence, 5-10 parts of licorice essence, 1-3 parts of green tea carnitine, 10-15 parts of red date extract and 2-5 parts of ginseng essence. The natural plant essence is mild and non-irritant, is beneficial to skin absorption, can supplement skin nutrition, keeps skin activity and elasticity, and assists growth and maintenance of skin collagen.
The hyaluronic acid mixture is prepared by mixing a macromolecular hyaluronic acid mixture and a small molecular hyaluronic acid mixture, and the optimal ratio is 1: 10.
The preparation method of the alliin essence comprises the following steps:
firstly, adding alliin rose juice into a magnetic sealed reaction kettle;
secondly, sequentially adding the lemon essence, the licorice essence, the green tea carnitine, the red date extract and the ginseng essence into a magnetic sealing reaction kettle, and stirring for 10-15 minutes after adding one variety; stirring for 5 hours after all the materials are added, and then standing for 2-3 hours;
thirdly, adding the freckle removing compound into a magnetic sealing reaction kettle, and stirring for 1 hour;
fourthly, adding the vegetable protein composition into a magnetic sealing reaction kettle, and stirring for 30 min; then standing for 2-3 hours;
fifthly, adding the small molecule active peptide composition, the hyaluronic acid mixture and 1-3 butanediol into a magnetic sealing reaction kettle, and stirring for 1 hour;
sixthly, uniformly stirring, and carrying out sterile filling to obtain a finished product.
Results of the experiment
The products of examples one to eight were used as samples for experiments and tests, and the experimental results were as follows:
Figure BDA0002289732850000151
in the moisture loss test, the average value of the moisture loss (%) in the control area was 41%.
Wherein, the following mixture ratio is adopted for fixing each component in the sampling:
the spot-removing compound comprises the following components: phenethyl resorcinol: natural truffle extract: bisabolol: 1-2 parts of ginger root extract: 2-3: 1-3: 1-2
The plant extract composition comprises the following components in parts by weight: lemon essence 10, licorice essence 5, green tea carnitine 1, red date extract 10 and ginseng essence 2;
the small molecule active peptide composition comprises hexapeptide-8 and snake venom peptide-3, and the mixture ratio of the hexapeptide-8: snake venom peptide-3 ═ 1: 1;
vegetable protein composition: soybean protein: oat protein: zein 5: 1: 2;
the above experimental results were obtained by the following experimental methods:
experimental method for determining antioxidant activity of essence by DPPH (denaturing high pH) method
Antioxidant is any substance that is present at low concentrations to effectively inhibit the oxidation reaction of free radicals, either by acting directly on the free radicals or by indirectly consuming substances that readily form free radicals, preventing further reactions from occurring.
The current research methods for free radical scavengers mainly belong to 2 types, one type is an in vitro model, and the other type is an in vivo model, wherein the DPPH method is the most common method in the in vitro model.
DPPH is also called 1, 1-diphenyl-2-trinitrophenylhydrazine, is a very stable free radical with a nitrogen center, and the stability of DPPH mainly comes from the steric hindrance of 3 benzene rings with resonance stabilization effect, so that unpaired electrons on the nitrogen atom in the middle cannot play the role of electron pairing. Its absolute ethyl alcohol solution is purple, and has maximum absorption at wavelength of 517nm, and its absorbance and concentration are in linear relation. . When a radical scavenger is added thereto, DPPH may be combined with or substituted for the radical scavenger, whereby the radical scavenging ability can be evaluated by decreasing the number of radicals, decreasing the absorbance, and decreasing the color of the solution. Namely, the antioxidant capacity was calculated by measuring the DPPH-removing effect of the sample at a wavelength of 517 nm.
Experimental materials: DPPH (1, 1-diphenyl-2-trinitrophenylhydrazine); absolute ethyl alcohol;
an experimental instrument: spectrophotometer
Preparation of DPPH stock solution
Accurately weighing 3.5mg of DPPH reagent, dissolving with absolute ethyl alcohol, quantitatively transferring into a 10mL volumetric flask, fixing the volume to a scale with the absolute ethyl alcohol, taking 2mL to 100mL volumetric flask, shaking up to obtain DPPH stock solution with the concentration of 0.0178mmol/L, and placing in a refrigerator for storage.
Measurement of two, DPPH and clearance
Adding 4.0mL of the LDPPH solution and the essence into a 10mL colorimetric tube in sequence, adding absolute ethyl alcohol to the scale, immediately mixing, measuring a light absorption value (A) at a wavelength of 517nm by using a 1cm cuvette, marking the light absorption value as Ai, then measuring the light absorption value after storing in a greenhouse in a dark place for 30min, marking the light absorption value as Aj, and marking the light absorption value as Ac in a contrast test by using an ethanol solution only added with DPPH. The radical clearance (K) was calculated as follows:
K(%)=[1-(Ai-Aj)/Ac]*100%
the test was repeated three times, and the average value was taken as the final result.
Medicine preparation: DPPH (1, 1-diphenyl-2-trinitrophenylhydrazine);
the manufacturer: shanghai such as Ji Biotech development Inc. or Beijing Nuo Bo Laide technology Inc.;
and (4) quotation: 380 yuan/bottle; 500 yuan/bottle;
specification: 1 g/bottle;
the content is as follows: 99 percent;
the producing area: imported from Japan.
Method for testing moisture loss rate
An experimental instrument: the model is as follows:
percutaneous water loss (TEWL) determinator for AS-VT100RS
1) Subjects were uniformly cleaned of the inside of the forearm by laboratory test personnel. The subject sits still in a laboratory at a temperature of 21 + -1 deg.C, 50 + -5% RH for at least 20 minutes, during which time water and drink cannot be consumed, the forearm is exposed and remains relaxed;
2) selecting and marking two face areas, namely a product area and a comparison area, wherein the area of each area is 2cm multiplied by 2 cm;
3) testing stratum corneum water content basic value of the face area of the subject;
4) using the test sample in the product area according to the product use requirement;
5) the stratum corneum moisture content measurements of the test subject product and control zones were taken 3h later (fan on side to accelerate moisture loss).
Water loss rate (%) (measured value of water content in horny layer-water content basis value of horny layer)/water content basis value of horny layer.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the spirit of the invention, which falls within the scope of the invention.

Claims (9)

1. The alliin essence is characterized by comprising the following components in parts by weight:
80-90 parts of alliin rose dew liquid, 6-7 parts of plant extract composition, 1-3 parts of small molecule active peptide composition, 2-5 parts of hyaluronic acid mixture, 5-10 parts of freckle removing compound and 1-3 parts of butanediol.
2. The alliin essence of claim 1, wherein the spot-removing complex comprises the following components: the composition comprises phenethyl resorcinol, a natural truffle extract, bisabolol and a ginger root extract, wherein the proportion of the phenethyl resorcinol: natural truffle extract: bisabolol: 1-2 parts of ginger root extract: 2-3: 1-3: 1-2.
3. The alliin essence of claim 1, wherein the small molecule active peptide composition comprises hexapeptide-8 and snake venom peptide-3, and the ratio of the hexapeptide-8: snake venom peptide-3 ═ 1-2: 1-2.
4. The alliin essence of claim 1, wherein the plant extract composition comprises the following components in parts by weight: 10-12 parts of lemon essence, 5-10 parts of licorice essence, 1-3 parts of green tea carnitine, 10-15 parts of red date extract and 2-5 parts of ginseng essence.
5. The alliin essence of claim 1, wherein the hyaluronic acid mixture is prepared by mixing a macromolecular hyaluronic acid mixture and a small-molecular hyaluronic acid mixture, preferably in a ratio of 1: 10.
6. The alliin essence of claim 1, which comprises the following components in parts by weight:
80-90 parts of alliin rose juice, 6-7 parts of plant extract composition, 1-3 parts of small molecule active peptide composition, 2-5 parts of hyaluronic acid mixture, 5-10 parts of freckle removing compound, 1-3 parts of butanediol and 2-3 parts of plant protein composition.
7. The alliin essence of claim 1, wherein the vegetable protein composition is a soy protein, oat protein and corn protein composition, and the ratio of soy protein: oat protein: and (3) corn protein is 5-7: 1-2: 2 to 3.
8. The method for preparing the alliin essence according to any one of claims 1 to 5, comprising the steps of:
firstly, adding alliin rose juice into a magnetic sealed reaction kettle;
secondly, sequentially adding the lemon essence, the licorice essence, the green tea carnitine, the red date extract and the ginseng essence into a magnetic sealing reaction kettle, and stirring for 10-15 minutes after adding one variety; stirring for 5 hours after all the materials are added, and then standing for 2-3 hours;
thirdly, adding the freckle removing compound into a magnetic sealing reaction kettle, and stirring for 1 hour;
fourthly, adding the small molecule active peptide composition, the hyaluronic acid mixture and 1-3 butanediol into a magnetic sealing reaction kettle, and stirring for 1 hour;
fifthly, uniformly stirring, and aseptically filling to obtain the finished product.
9. The method for preparing the alliin essence according to any one of claims 6 to 7, comprising the following steps:
firstly, adding alliin rose juice into a magnetic sealed reaction kettle;
secondly, sequentially adding the lemon essence, the licorice essence, the green tea carnitine, the red date extract and the ginseng essence into a magnetic sealing reaction kettle, and stirring for 10-15 minutes after adding one variety; stirring for 5 hours after all the materials are added, and then standing for 2-3 hours;
thirdly, adding the freckle removing compound into a magnetic sealing reaction kettle, and stirring for 1 hour;
fourthly, adding the vegetable protein composition into a magnetic sealing reaction kettle, and stirring for 30 min; then standing for 2-3 hours;
fifthly, adding the small molecule active peptide composition, the hyaluronic acid mixture and 1-3 butanediol into a magnetic sealing reaction kettle, and stirring for 1 hour;
sixthly, uniformly stirring, and carrying out sterile filling to obtain a finished product.
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CN111568838A (en) * 2020-04-23 2020-08-25 浙江美姿婷化妆品有限公司 Natural bamboo vinegar sheep placenta essence shampoo and preparation method thereof
CN111568838B (en) * 2020-04-23 2022-11-18 浙江美姿婷化妆品有限公司 Natural bamboo vinegar sheep placenta essence shampoo and preparation method thereof
CN111494283A (en) * 2020-05-30 2020-08-07 欧露莲生物科技(广东)有限公司 Garlic extract composition skin care product containing garlic peptide and preparation process thereof
CN111494283B (en) * 2020-05-30 2020-12-25 欧露莲生物科技(广东)有限公司 Garlic extract composition skin care product containing garlic peptide and preparation process thereof
CN111870554A (en) * 2020-09-28 2020-11-03 德之馨(上海)有限公司 Whitening composition and preparation method thereof

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