CN110897904A

CN110897904A - Skin membrane repairing cream and preparation process thereof

Info

Publication number: CN110897904A
Application number: CN201911300676.1A
Authority: CN
Inventors: 彭再辉; 彭晓丹; 彭漆; 王玉苹; 陈小连; 彭斯祺
Original assignee: Guangzhou Sunshine Cosmetics Co Ltd
Current assignee: Guangzhou Sunshine Cosmetics Co Ltd
Priority date: 2019-12-17
Filing date: 2019-12-17
Publication date: 2020-03-24

Abstract

The invention relates to a skin membrane repair cream which is prepared from the following raw materials, by weight, 1-5 parts of caprylic/capric triglyceride, 1-5 parts of cyclopentadimethylsiloxane, 1.5-4 parts of emulsifier, 1-5 parts of polydimethylsiloxane, 1-2 parts of cetearyl alcohol, 0.15-0.3 part of laureth, 0.35-0.7 part of isoparaffin, 1-5 parts of hydroxyethyl urea, 5-10 parts of calamine lotion, 0.2-0.5 part of dipotassium glycyrrhizinate, 0.2-0.5 part of allantoin and 60-85 parts of water in phase A, 0.5-1 part of phase C component, 0.05-0.2 part of oat extract, 0.5-2.0 part of β -dextran, 0.3-1 part of chlorpheniramine, 0.5-1 part of phase D component PHL, 0.01-0.05 part of essence, 0.05 part of β -0.5 part of tocopherol acetate, 0.5-2.0.0.5 part of 355-2.0.0.3-1 part of phytol, 0.5-1 part of glucoside, 0.5-2 parts of phytol, 0.5-2 parts of glucoside and 0.3-2 parts of phytol.

Description

Skin membrane repairing cream and preparation process thereof

Technical Field

The invention relates to the technical field of cosmetics, in particular to a skin membrane repair cream and a preparation process thereof.

Background

As is well known, the skin membrane consists of the skin, which is the tissue structure of the skin, plus the membrane, which is a new layer after the outer secretions of the skin and the skin structure are integrated. The skin membrane protects our skin just like the earth's ozone layer, and with its existence, our skin will not pass through external stimuli, causing any skin problems. However, with age, the skin is gradually lost due to the pathological state of the body, and various skin problems are further treated with moving to and fro. The skin is uncomfortable and dry due to the influence of the external environment such as air pollution, dust and the like.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides a skin membrane repair cream and a manufacturing process thereof.

The purpose of the invention is realized by the following technical scheme:

a skin membrane repair cream is prepared from the following raw materials in parts by weight:

phase A component: 1-5 parts of caprylic/capric triglyceride, 1-5 parts of cyclopentadimethylsiloxane, 0.5-2 parts of A165 emulsifier, 1-5 parts of polydimethylsiloxane, 1-2 parts of M68 emulsifier, 1-2 parts of cetostearyl alcohol, 0.15-0.3 part of laureth, and 0.35-0.7 part of isoparaffin;

phase B component: 1-5 parts of hydroxyethyl urea, 5-10 parts of calamine lotion, 0.2-0.5 part of dipotassium glycyrrhizinate, 0.2-0.5 part of allantoin and 60-85 parts of water;

phase C component comprising SP 10000.5-5 parts, oat extract 0.05-0.2 part, β -dextran 0.5-2.0 parts, and chlorphenamine maleate 0.3-1 part;

phase D component: 0.5-1 part of PHL and 0.01-0.05 part of essence;

phase E component: 0.3-0.5 part of tocopherol acetate, 0.5-2 parts of phytosterol glucoside and 0.1-0.3 part of bisabolol;

phase F component: 5-8 parts of butanediol and 0.03-0.2 part of sodium hyaluronate.

The skin membrane repair cream is prepared from the following raw materials in parts by weight:

phase A component: 3 parts of caprylic/capric triglyceride, 3 parts of cyclopenta dimethyl silicone polymer, 1.3 parts of A165 emulsifier, 3 parts of dimethyl silicone polymer, 1.5 parts of M68 emulsifier, 1.5 parts of cetearyl alcohol, 0.4 part of laureth and 0.4 part of isoparaffin;

phase B component: 3 parts of hydroxyethyl urea, 7 parts of calamine lotion, 0.3 part of dipotassium glycyrrhizinate, 0.4 part of allantoin and 70 parts of water;

phase C comprises SP 10002.6 parts, oat extract 0.1 part, β -dextran 1.2 parts, and chlorphenamine maleate 0.7 part;

phase D component: 0.8 part of PHL and 0.03 part of essence;

phase E component: 0.4 part of tocopherol acetate, 1.2 parts of phytosterol glucoside and 0.2 part of bisabolol;

phase F component: 6.5 parts of butanediol and 0.1 part of sodium hyaluronate.

Further, the A165 emulsifier is a mixture of PEG-100 stearate and glyceryl stearate, and the volume ratio of the PEG-100 stearate to the glyceryl stearate is 1: 1.

Further, the M68 emulsifier is a mixture of cetearyl glucoside and cetearyl alcohol, and the volume ratio of the two is 1: 1.

Further, the isoparaffin is a C13-14 isoparaffin.

Further, the calamine lotion is a mixture of water, calamine, zinc oxide and glycerol, and the volume ratio of the calamine lotion to the glycerol is 16: 2: 1: 1.

further, the SP1000 is a mixture of lotus extract, tea extract and guava fruit extract, and the volume ratio of the mixture is 3:3: 4.

Further, the desmin is a mixture of 1, 2-pentanediol and hydroxyphenylpropionamide benzoic acid, and the volume ratio thereof is 2: 1.

Further, the PHL is a mixture of caprylhydroxamic acid, 1,2 hexanediol and 1,3 propanediol, and the volume ratio of the mixture is 1:6: 13.

The manufacturing process of the skin membrane repair cream comprises the following steps:

s1, heating the phase A component to 80-90 ℃, keeping the temperature for 15-25 min to 80 ℃, adding the phase E component, and stirring until the phase E component is completely dissolved;

s2, heating the phase B component to 80-90 ℃, fully dispersing the colloid substance, keeping the temperature for 15-25 min to 80 ℃, adding the pre-dispersed phase F component, and stirring until the phase B component is fully dissolved;

s3, pumping the mixed phase obtained in the step S2 into a preheated emulsifying pot, pumping the phase A component into the preheated emulsifying pot, pre-emulsifying for 8-12 min, homogenizing and stirring for 5-10 min at the stirring speed of 1500-2000 rpm, vacuumizing, defoaming and cooling;

s4, when the temperature is reduced to 50 ℃, adding the C phase component, stirring uniformly, and continuously reducing the temperature;

s5, when the temperature is reduced to 40 ℃, adding the phase D component, and stirring uniformly;

and S6, performing physical and chemical index inspection, and discharging after the product is qualified.

The invention has the following advantages:

1. the invention adopts a new preparation formula process, adds the calamine lotion, the phytosterol glucoside and various plant extracts, provides moisture required by the skin, relieves the problems of discomfort, dryness and the like of the skin caused by the influence of external environments such as air pollution, dust and the like, nourishes and moisturizes the skin, has good effects of diminishing inflammation, relieving itching, astringing and protecting the skin, is combined with a skin lipid membrane to form an ultrathin and permeable breathable moisture membrane, establishes a skin water-locking repair barrier, makes the skin fresh and cool and not greasy, moisturizes and has elasticity, and cares the fragile skin.

2. The invention has safe and reliable preparation and good functions of diminishing inflammation, relieving itching, nourishing, soothing, astringing and protecting.

3. The phytosterol glucoside can inhibit reproduction of bacteria and fungi, and has anti-infectious, epidermal barrier increasing, antipyretic and antiulcer effects. The calamine lotion is used for acute pruritic skin diseases such as urticaria and miliaria, and the calamine lotion has astringent and protective effects and weak antiseptic effect on calamine and zinc oxide. The plant extract SP1000 has the effects of diminishing inflammation, reducing redness and the like. The anti-allergy component is Demin. Traditional preservatives are receiving various challenges and challenges, and have been suspected by more and more consumers as the consumer's awareness of skin care continues to increase and as green, natural, and healthy skin care products are pursued. Nowadays, preservative zero-additive will become one of the main streams of skin care products in the future. The American England chemical company develops a plurality of antiseptic raw materials which can be declared to be free of additives by means of advanced technology, PHL is one of the raw materials, PHL does not contain bactericides and traditional antiseptic components, but has a good effect of inhibiting bacteria and fungi (containing mould), has broad-spectrum antibiosis, does not need to be matched with traditional preservatives, is mild in property, does not stimulate the skin, does not generate heat and prick pain after being used, has excellent water solubility, does not need solubilization, and is convenient to operate.

Detailed Description

The invention is further described below with reference to examples, but the scope of the invention is not limited to the following.

[ example 1 ]:

phase A component: 5 parts of caprylic/capric triglyceride, 1 part of cyclopenta dimethyl silicone polymer, 2 parts of A165 emulsifier, 1 part of dimethyl silicone polymer, 2 parts of M68 emulsifier, 1 part of cetearyl alcohol, 0.3 part of laureth, and 0.35 part of isoparaffin;

phase B component: 5 parts of hydroxyethyl urea, 5 parts of calamine lotion, 0.5 part of dipotassium glycyrrhizinate, 0.2 part of allantoin and 85 parts of water;

phase C comprises SP 10000.5 parts, oat extract 0.2 parts, β -dextran 0.5 parts, and chlorphenamine maleate 1 parts;

phase D component: 0.5 part of PHL and 0.05 part of essence;

phase E component: 0.3 part of tocopherol acetate, 2 parts of phytosterol glucoside and 0.1 part of bisabolol;

phase F component: 8 parts of butanediol and 0.03 part of sodium hyaluronate.

Further, the isoparaffin is a C13-14 isoparaffin.

s1, heating the phase A component to 90 ℃, keeping the temperature for 25min to 80 ℃, adding the phase E component, and stirring until the phase E component is completely dissolved;

s2, heating the phase B component to 80 ℃, completely dispersing the colloid substances, keeping the temperature for 25min to 80 ℃, adding the pre-dispersed phase F component, and stirring until the phase B component is completely dissolved;

s3, pumping the mixed phase obtained in the step S2 into a preheated emulsifying pot, pumping the phase A component into the preheated emulsifying pot, pre-emulsifying for 8min, homogenizing and stirring for 10min at the stirring speed of 1500rpm, vacuumizing, defoaming and cooling;

[ example 2 ]:

phase A component: 3 parts of caprylic/capric triglyceride, 3 parts of cyclopenta dimethyl silicone polymer, 1.3 parts of A165 emulsifier, 3 parts of dimethyl silicone polymer, 1.5 parts of M68 emulsifier, 1.5 parts of cetearyl alcohol, 0.25 part of laureth and 0.5 part of isoparaffin;

phase D component: 0.8 part of PHL and 0.03 part of essence;

phase F component: 6.5 parts of butanediol and 0.1 part of sodium hyaluronate.

Further, the isoparaffin is a C13-14 isoparaffin.

s1, heating the phase A component to 85 ℃, keeping the temperature for 20min to 80 ℃, adding the phase E component, and stirring until the phase A component is completely dissolved;

s2, heating the phase B component to 85 ℃, completely dispersing the colloid substances, keeping the temperature for 20min to 80 ℃, adding the pre-dispersed phase F component, and stirring until the phase B component is completely dissolved;

s3, pumping the mixed phase obtained in the step S2 into a preheated emulsifying pot, pumping the phase A component into the preheated emulsifying pot, pre-emulsifying for 10min, homogenizing and stirring for 7min at the stirring speed of 1800rpm, vacuumizing, defoaming and cooling;

[ example 3 ]:

phase A component: 4 parts of caprylic/capric triglyceride, 2 parts of cyclopenta dimethyl silicone polymer, 0.8 part of A165 emulsifier, 3 parts of dimethyl silicone polymer, 1.2 parts of M68 emulsifier, 1.2 parts of cetearyl alcohol, 0.2 part of laureth and 0.5 part of isoparaffin;

phase B component: 1 part of hydroxyethyl urea, 8 parts of calamine lotion, 0.3 part of dipotassium glycyrrhizinate, 0.4 part of allantoin and 78 parts of water;

phase C comprises SP 10003.5 parts, oat extract 0.15 parts, β -dextran 0.9 parts, and chlorphenamine maleate 0.8 parts;

phase D component: 0.6 part of PHL and 0.04 part of essence;

phase E component: 0.4 part of tocopherol acetate, 2 parts of phytosterol glucoside and 0.1 part of bisabolol;

phase F component: 5.5 parts of butanediol and 0.1 part of sodium hyaluronate.

Further, the isoparaffin is a C13-14 isoparaffin.

s1, heating the phase A component to 82 ℃, keeping the temperature for 19min to 80 ℃, adding the phase E component, and stirring until the phase E component is completely dissolved;

s2, heating the phase B component to 85 ℃, completely dispersing the colloid substances, keeping the temperature for 22min to 80 ℃, adding the pre-dispersed phase F component, and stirring until the phase B component is completely dissolved;

s3, pumping the mixed phase obtained in the step S2 into a preheated emulsification pot, pumping the phase A component, pre-emulsifying for 10min, homogenizing and stirring for 7min at the stirring speed of 1600rpm, vacuumizing, defoaming and cooling;

Example 4:

phase A component: 1 part of caprylic/capric triglyceride, 5 parts of cyclopenta dimethyl silicone polymer, 0.5 part of A165 emulsifier, 5 parts of dimethyl silicone polymer, 1 part of M68 emulsifier, 2 parts of cetearyl alcohol, 0.15 part of laureth, and 0.7 part of isoparaffin;

phase B component: 1 part of hydroxyethyl urea, 10 parts of calamine lotion, 0.2 part of dipotassium glycyrrhizinate, 0.5 part of allantoin and 60 parts of water;

phase C comprises SP 10005 parts, herba Avenae Fatuae extract 0.05 part, β -dextran 2.0 part, and chlorphenamine maleate 0.3 part;

phase D component: PHL1 parts, essence 0.01 part;

phase E component: 0.5 part of tocopherol acetate, 0.5 part of phytosterol glucoside and 0.3 part of bisabolol;

phase F component: 5 parts of butanediol and 0.2 part of sodium hyaluronate.

Further, the isoparaffin is a C13-14 isoparaffin.

s1, heating the phase A component to 80 ℃, keeping the temperature for 15min to 80 ℃, adding the phase E component, and stirring until the phase E component is completely dissolved;

s2, heating the phase B component to 90 ℃, completely dispersing the colloid substances, keeping the temperature for 15min to 80 ℃, adding the pre-dispersed phase F component, and stirring until the phase B component is completely dissolved;

s3, pumping the mixed phase obtained in the step S2 into a preheated emulsifying pot, pumping the phase A component into the preheated emulsifying pot, pre-emulsifying for 12min, homogenizing and stirring for 5min at the stirring speed of 2000rpm, vacuumizing, defoaming and cooling;

The product performance evaluation test is as follows:

firstly, skin irritation test:

selecting 40 healthy rabbits 2.5-3 kg, and shaving 20 parts of the back of each rabbit symmetrically by 2.5cm²The test is carried out by a self-control test method, 0.5g of the product or blank matrix is coated each time, the random administration is carried out twice a day on the left side or the right side, and the reaction phenomenon of the skin after 24 hours and 72 hours is observed and recorded.

The results show that: after the product of the invention is applied for 24 hours and 72 hours, local irritation reactions such as skin redness, eruption, water pimples and the like are not seen.

Second, evaluation of efficacy

120 volunteers were selected and divided into 4 test controls, each of which had 30 individuals, group 1 using the product of example 1, group 2 using the product obtained in example 2, group 3 using the product of example 3, and group 4 using the product of example 4, the product was applied to the face 3 times a week for a month.

Description of the effects:

it is obvious that: the repairing effect is excellent, acne is obviously reduced, and the skin is tight and elastic;

the improvement is that: the repairing effect is general.

The effect is poor: the skin changes substantially little.

The clinical test result of the product of the patent is as follows:

examples	The effect is obvious	Has the advantages of	The effect is poor	Allergic reaction	Description of the healing Effect
						Example 1	3	8	19	Is free of	General repairing effect
Example 2	22	5	3	Is free of	Good repairing effect
						Example 3	17	7	6	Is free of	The repairing effect is good
Example 4	4	8	18	Is free of	General repairing effect

From the results of clinical trials, all the examples showed no allergic reaction, and the product of example 2 showed the best efficacy in repairing.

In vitro itching-relieving experiments were performed for the anti-irritation verification.

Subject: three groups of 10 guinea pigs

Grouping experiments: control group, positive group (clobetasol propionate cream (10g:2mg)), experimental group (25% binacryisland, equivalent to 5% use concentration in human body).

The experimental method comprises the following steps: one day prior to the experiment, each group of guinea pigs was given the right hind instep once the sample of example 2. On the day of the experiment, the shaved area of the right hind paw of the animal was scratched with a coarse abrasive cloth about 1cm, and the sample of example 2 was applied thereto once again, and the blank group was given an equal amount of distilled water. After 10min, 0.01% histamine phosphate 0.5 ml/tube was dropped on the wound surface, and the concentration was increased by 0.01%, 0.02%, … every 3min, each time 0.5 ml/tube. Until the onset of right hind paw licking in guinea pigs, the sum of histamine phosphate administered when the guinea pig had finally turned back to lick the right hind paw was taken as the scratchy threshold, and the results are shown in the following table:

group/dose	Number of animals	Itch threshold (histamine phosphate Total (ug))	P
				Control group	10	41.2±23.7
Positive group	10	70.8±40.5	<0.001
				Experimental group	10	66.4±33.6	<0.001

Compared with the common repair cream, the involucra repair cream has unique advantages, can act on skin deeply, and enables effective components to be utilized more efficiently. However, various repair creams sold in the market at present generally have side effects, and the use frequency is greatly limited. The mild skin membrane repair cream is prepared by using a unique new formula process, overcomes the defects of the traditional repair cream, and is suitable for various skin types. The formula process can be popularized in various skin care products, such as acne removal, anti-aging and whitening, and can promote effective components to play more effective roles.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The skin membrane repair cream is characterized in that: the feed is prepared from the following raw materials in parts by weight:

phase D component: 0.5-1 part of PHL and 0.01-0.05 part of essence;

2. The skin membrane repair cream according to claim 1, wherein: the feed is prepared from the following raw materials in parts by weight:

phase D component: 0.8 part of PHL and 0.03 part of essence;

phase E component: 0.4 part of tocopherol acetate, 1.2 parts of phytosterol glucoside and 0.2 part of bisabolol; phase F component: 6.5 parts of butanediol and 0.1 part of sodium hyaluronate.

3. The skin membrane repair cream according to claim 1 or 2, wherein: the A165 emulsifier is a mixture of PEG-100 stearate and glyceryl stearate, and the volume ratio of the PEG-100 stearate to the glyceryl stearate is 1: 1.

4. The skin membrane repair cream according to claim 1 or 2, wherein: the M68 emulsifier is a mixture of cetearyl glucoside and cetearyl alcohol, and the volume ratio of the two is 1: 1.

5. The skin membrane repair cream according to claim 1 or 2, wherein: the isoparaffin is C13-14 isoparaffin.

6. The skin membrane repair cream according to claim 1 or 2, wherein: the calamine lotion is a mixture of water, calamine, zinc oxide and glycerol, and the volume ratio of the calamine lotion to the glycerol is 16: 2: 1: 1.

7. the skin membrane repair cream according to claim 1 or 2, wherein: the SP1000 is a mixture of lotus extract, tea extract and guava fruit extract, and the volume ratio of the mixture is 3:3: 4.

8. The skin membrane repair cream according to claim 1 or 2, wherein: the desmins are a mixture of 1, 2-pentanediol and hydroxyphenylpropionamide benzoic acid, and the volume ratio of the desmins to the hydroxyphenylpropionamide benzoic acid is 2: 1.

9. The skin membrane repair cream according to claim 1 or 2, wherein: the PHL is a mixture of caprylyl hydroximic acid, 1,2 hexanediol and 1,3 propanediol, and the volume ratio of the PHL to the 1:6: 13.

10. A process for preparing a pellicle repair cream as claimed in any of claims 1 to 9, characterised by: the method comprises the following steps: