CN110891582A - 制备混合人血小板裂解液的方法、混合人血小板裂解液及其用于治疗神经系统疾病的用途 - Google Patents

制备混合人血小板裂解液的方法、混合人血小板裂解液及其用于治疗神经系统疾病的用途 Download PDF

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Publication number
CN110891582A
CN110891582A CN201880047062.4A CN201880047062A CN110891582A CN 110891582 A CN110891582 A CN 110891582A CN 201880047062 A CN201880047062 A CN 201880047062A CN 110891582 A CN110891582 A CN 110891582A
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China
Prior art keywords
human platelet
platelet lysate
phpl
heat
treated
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Pending
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CN201880047062.4A
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English (en)
Chinese (zh)
Inventor
D·德沃斯
T·布努夫
J-C·德威德疆
周明礼
F·古埃尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coastal Opal Coast University
Institut National de la Sante et de la Recherche Medicale INSERM
Centre Hospitalier Universitaire de Lille
Universite de Lille
Taipei Medical University TMU
Original Assignee
Coastal Opal Coast University
Institut National de la Sante et de la Recherche Medicale INSERM
Centre Hospitalier Regional Universitaire de Lille CHRU
Universite de Lille
Taipei Medical University TMU
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Application filed by Coastal Opal Coast University, Institut National de la Sante et de la Recherche Medicale INSERM, Centre Hospitalier Regional Universitaire de Lille CHRU, Universite de Lille, Taipei Medical University TMU filed Critical Coastal Opal Coast University
Publication of CN110891582A publication Critical patent/CN110891582A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0644—Platelets; Megakaryocytes

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201880047062.4A 2017-06-16 2018-06-15 制备混合人血小板裂解液的方法、混合人血小板裂解液及其用于治疗神经系统疾病的用途 Pending CN110891582A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17305739 2017-06-16
EP17305739.9 2017-06-16
PCT/EP2018/066020 WO2018229278A1 (en) 2017-06-16 2018-06-15 Process for preparing a pooled human platelet lysate, pooled human platelet lysate and its use for treating neurological disorders

Publications (1)

Publication Number Publication Date
CN110891582A true CN110891582A (zh) 2020-03-17

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CN201880047062.4A Pending CN110891582A (zh) 2017-06-16 2018-06-15 制备混合人血小板裂解液的方法、混合人血小板裂解液及其用于治疗神经系统疾病的用途

Country Status (10)

Country Link
US (1) US11744863B2 (https=)
EP (1) EP3638263B1 (https=)
JP (1) JP7370870B2 (https=)
CN (1) CN110891582A (https=)
AU (1) AU2018284011B2 (https=)
BR (1) BR112019026846A2 (https=)
CA (1) CA3067294A1 (https=)
ES (1) ES2955282T3 (https=)
IL (1) IL271436B2 (https=)
WO (1) WO2018229278A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109310711A (zh) * 2016-03-23 2019-02-05 里尔大学中心医院 血小板沉淀裂解物的制备及其治疗神经系统疾病的用途
WO2023103744A1 (zh) * 2021-12-07 2023-06-15 无限发展有限公司 血小板内生长因子的提取方法
EP4393498A1 (en) 2022-12-30 2024-07-03 Spirit Scientific Co. LTD. Platelets-containing composition and preparation process thereof

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022519781A (ja) * 2019-02-07 2022-03-24 バイオブリッジ グローバル 血小板放出物および多血小板フィブリンに関する方法および組成物
EP3881858A1 (en) * 2020-03-20 2021-09-22 Rok Pangersic Heat-treated platelet-derived growth factor extract for use in a method of preventing or treating a tissue defect
EP4276173A1 (en) 2022-05-10 2023-11-15 Stemmatters, Biotecnologia e Medicina Regenerativa, S.A. Stable human platelet lysate composition, methods and uses thereof
KR20250108745A (ko) * 2022-12-02 2025-07-15 누와셀 바이오테크놀로지 코., 엘티디. 중뇌 도파민 작동성 전구 세포의 제조를 위한 배양 배지, 코팅 매트릭스 및 방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1891445A2 (en) * 2005-06-17 2008-02-27 Randox Laboratories Ltd. Method for diagnosing neurodegenerative disease
US20090305401A1 (en) * 2006-09-18 2009-12-10 Dirk Strunk Plasma-free platelet lysate for use as a supplement in cell cultures and for the preparation of cell therapeutics
CN102985101A (zh) * 2010-05-25 2013-03-20 国维联合科技股份有限公司 含有病毒去活化的生长因子且pdgf与vdgf耗尽的血小板裂解物及其制备方法

Family Cites Families (7)

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ES2006632A6 (es) 1987-04-21 1989-05-01 Green Cross Corp Procedimiento de tratamiento termico de fibrinogeno.
EP2077118A1 (en) * 2008-01-07 2009-07-08 Gwo Rei Biomedical Technology Corp. Clottable concentrate of platelet growth factors and preparation method thereof
IL210162A0 (en) 2010-12-21 2011-03-31 Omrix Biopharmaceuticals Viral inactivated platelet extract, use and preparation thereof
AU2012275562B2 (en) * 2011-06-27 2016-10-20 Children's Healthcare Of Atlanta, Inc. Compositions, uses, and preparation of platelet lysates
US20140176602A1 (en) 2011-08-18 2014-06-26 Nec Corporation Information processing system, information processing method, information processing apparatus, and control method and control program thereof
EP3848058A1 (en) * 2012-12-20 2021-07-14 Omrix Biopharmaceuticals Ltd. Viral inactivated biological mixture
CN114392274A (zh) * 2013-08-27 2022-04-26 库克通用生物技术有限责任公司 可来源于血小板浓缩液的生物活性组合物及其制备和使用方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1891445A2 (en) * 2005-06-17 2008-02-27 Randox Laboratories Ltd. Method for diagnosing neurodegenerative disease
US20090305401A1 (en) * 2006-09-18 2009-12-10 Dirk Strunk Plasma-free platelet lysate for use as a supplement in cell cultures and for the preparation of cell therapeutics
CN102985101A (zh) * 2010-05-25 2013-03-20 国维联合科技股份有限公司 含有病毒去活化的生长因子且pdgf与vdgf耗尽的血小板裂解物及其制备方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FLORE GOUEL等: "The protective effect of human platelet lysate in models of neurodegenerative disease: involvement of the Akt and MEK pathways" *
IAN B. COPLAND等: "The effect of platelet lysate fibrinogen on the functionality of MSCs in immunotherapy" *
张秀明等, 人民军医出版社 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109310711A (zh) * 2016-03-23 2019-02-05 里尔大学中心医院 血小板沉淀裂解物的制备及其治疗神经系统疾病的用途
CN109310711B (zh) * 2016-03-23 2022-06-10 里尔大学中心医院 血小板沉淀裂解物的制备及其治疗神经系统疾病的用途
WO2023103744A1 (zh) * 2021-12-07 2023-06-15 无限发展有限公司 血小板内生长因子的提取方法
EP4393498A1 (en) 2022-12-30 2024-07-03 Spirit Scientific Co. LTD. Platelets-containing composition and preparation process thereof

Also Published As

Publication number Publication date
RU2020101295A3 (https=) 2022-02-24
US11744863B2 (en) 2023-09-05
AU2018284011A1 (en) 2020-01-16
EP3638263C0 (en) 2023-08-23
CA3067294A1 (en) 2018-12-20
BR112019026846A2 (pt) 2020-06-30
AU2018284011B2 (en) 2024-05-30
JP7370870B2 (ja) 2023-10-30
IL271436B2 (en) 2024-02-01
US20200113942A1 (en) 2020-04-16
ES2955282T3 (es) 2023-11-29
IL271436B1 (en) 2023-10-01
JP2020523398A (ja) 2020-08-06
EP3638263B1 (en) 2023-08-23
RU2020101295A (ru) 2021-07-16
EP3638263A1 (en) 2020-04-22
WO2018229278A1 (en) 2018-12-20
IL271436A (en) 2020-01-30

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