CN110869000A - 增强溶解度的含药制剂 - Google Patents

增强溶解度的含药制剂 Download PDF

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Publication number
CN110869000A
CN110869000A CN201880036754.9A CN201880036754A CN110869000A CN 110869000 A CN110869000 A CN 110869000A CN 201880036754 A CN201880036754 A CN 201880036754A CN 110869000 A CN110869000 A CN 110869000A
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CN
China
Prior art keywords
acid
composition
drug
acids
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201880036754.9A
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English (en)
Chinese (zh)
Inventor
M·L·赫里
D·奥斯托维奇
P·诺伊梅尔
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Steadymed Ltd
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Steadymed Ltd
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Publication date
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Publication of CN110869000A publication Critical patent/CN110869000A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880036754.9A 2017-05-11 2018-05-10 增强溶解度的含药制剂 Pending CN110869000A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762504546P 2017-05-11 2017-05-11
US62/504,546 2017-05-11
PCT/IL2018/050511 WO2018207188A1 (en) 2017-05-11 2018-05-10 Enhanced solubility drug-containing formulations

Publications (1)

Publication Number Publication Date
CN110869000A true CN110869000A (zh) 2020-03-06

Family

ID=62599659

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880036754.9A Pending CN110869000A (zh) 2017-05-11 2018-05-10 增强溶解度的含药制剂

Country Status (9)

Country Link
US (1) US11672863B2 (enExample)
EP (1) EP3621591A1 (enExample)
JP (1) JP2020519593A (enExample)
KR (1) KR20200018438A (enExample)
CN (1) CN110869000A (enExample)
AU (1) AU2018265624A1 (enExample)
CA (1) CA3063322A1 (enExample)
IL (1) IL271673A (enExample)
WO (1) WO2018207188A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200018438A (ko) 2017-05-11 2020-02-19 스테디메드 리미티드 향상된 용해도의 약물-함유 제형
JP7190077B2 (ja) * 2019-08-01 2022-12-14 インカーダ セラピューティクス， インコーポレイテッド 抗不整脈製剤

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902692A (en) * 1988-03-18 1990-02-20 Iolab Corporation Method and composition for ophthalmic anesthesia using rodocaine
CN1205629A (zh) * 1995-12-19 1999-01-20 艾博特公司 一种难溶碱性药物的控释制剂
US6045824A (en) * 1997-09-18 2000-04-04 Skyepharma Inc. Sustained-release liposomal anesthetic compositions
JP2006160607A (ja) * 2004-12-02 2006-06-22 Medorekkusu:Kk 局所麻酔薬物含有ゼリー剤
CN101744760A (zh) * 2008-12-18 2010-06-23 梁颖 用于难溶性或易分解性药物的缓释体
CN102106806A (zh) * 2009-12-29 2011-06-29 上海中西制药有限公司 一种固体制剂的制备方法及所得固体制剂
CN105682649A (zh) * 2014-07-15 2016-06-15 艾萨·欧蒂迪 减少过剂量的组合物和方法

Family Cites Families (19)

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US3910260A (en) 1972-03-01 1975-10-07 Survival Technology Method and apparatus of treating heart attack patients prior to the establishment of qualified direct contact personal care
US4004577A (en) 1972-12-04 1977-01-25 Survival Technology, Inc. Method of treating heart attack patients prior to the establishment of qualified direct contact personal care
US3941130A (en) 1975-03-18 1976-03-02 Tibbs Robert C Sequential trigger release for injection device
US4261358A (en) 1979-10-01 1981-04-14 Walter Vargas Automatic syringe plunger
US4795433A (en) 1985-05-20 1989-01-03 Survival Technology, Inc. Automatic injector for emergency treatment
US4689042A (en) 1985-05-20 1987-08-25 Survival Technology, Inc. Automatic medicament ingredient mixing and injecting apparatus
US5085642A (en) 1989-07-17 1992-02-04 Survival Technology, Inc. Conveniently carried frequent use autoinjector
US5102393A (en) 1989-07-17 1992-04-07 Survival Technology, Inc. Autoinjector converted from intramuscular to subcutaneous mode of injection
US5092843A (en) 1990-04-12 1992-03-03 Survival Technology, Inc. Dispersion multichamber auto-injector
US5267963A (en) 1992-08-21 1993-12-07 Nicholas Bachynsky Medication injection device
US5922340A (en) * 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US5618563A (en) * 1992-09-10 1997-04-08 Children's Medical Center Corporation Biodegradable polymer matrices for sustained delivery of local anesthetic agents
US5747060A (en) * 1996-03-26 1998-05-05 Euro-Celtique, S.A. Prolonged local anesthesia with colchicine
US6149626A (en) 1997-10-03 2000-11-21 Bachynsky; Nicholas Automatic injecting syringe apparatus
SE9803662D0 (sv) 1998-10-26 1998-10-26 Pharmacia & Upjohn Ab Autoinjector
US20060270708A1 (en) * 2005-05-25 2006-11-30 Navinta Llc Novel process for preparation of isotonic aqueous injection of ropivacaine
JP5535623B2 (ja) 2006-06-30 2014-07-02 アッヴィ バイオテクノロジー リミテッド 自動注射装置
AU2016352007B2 (en) * 2015-11-12 2022-03-17 Terumo Kabushiki Kaisha Sustained-release topically administered agent
KR20200018438A (ko) 2017-05-11 2020-02-19 스테디메드 리미티드 향상된 용해도의 약물-함유 제형

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902692A (en) * 1988-03-18 1990-02-20 Iolab Corporation Method and composition for ophthalmic anesthesia using rodocaine
CN1205629A (zh) * 1995-12-19 1999-01-20 艾博特公司 一种难溶碱性药物的控释制剂
US6045824A (en) * 1997-09-18 2000-04-04 Skyepharma Inc. Sustained-release liposomal anesthetic compositions
JP2006160607A (ja) * 2004-12-02 2006-06-22 Medorekkusu:Kk 局所麻酔薬物含有ゼリー剤
CN101744760A (zh) * 2008-12-18 2010-06-23 梁颖 用于难溶性或易分解性药物的缓释体
CN102106806A (zh) * 2009-12-29 2011-06-29 上海中西制药有限公司 一种固体制剂的制备方法及所得固体制剂
CN105682649A (zh) * 2014-07-15 2016-06-15 艾萨·欧蒂迪 减少过剂量的组合物和方法

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DENNIS E.COYLE等: "Effect of different acidification on in vitro human serum bupivacaine binding", 《BIOCHEMICAL PHARMACOLOGY》 *
H.A.ADAMS等: "Stability of local anesthetics in heparinized blood, plasma and sulfuric acid", 《ACTA ANAESTHESIOLOGICA SCANDINAVICA》 *
ZHAO LILI等: "Ropivacaine loaded microemulsion and microemulsion-based gel for transdermal delivery: Preparation, optimization, and evaluation", 《INTERNATIONAL JOURNAL OF PHARMACEUTICS》 *
曾慧琳等: "布比卡因长效制剂的研究进展", 《中南药学》 *
林瑞来: "难溶性药物溶解度的提高方法", 《中国医药指南》 *
王振军等: "盐基不同的盐类药物临床应用的比较分析", 《中国医院药学杂志》 *
郑斯骥等: "溶解-析出原理在减小固体制剂中难溶性药物粒径的应用", 《中国医药工业杂志》 *

Also Published As

Publication number Publication date
CA3063322A1 (en) 2018-11-15
IL271673A (en) 2020-02-27
JP2020519593A (ja) 2020-07-02
US11672863B2 (en) 2023-06-13
EP3621591A1 (en) 2020-03-18
KR20200018438A (ko) 2020-02-19
US20200054754A1 (en) 2020-02-20
AU2018265624A1 (en) 2019-12-05
WO2018207188A1 (en) 2018-11-15

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Application publication date: 20200306