CN110859988A - Active carbon fiber biological function dressing - Google Patents
Active carbon fiber biological function dressing Download PDFInfo
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- CN110859988A CN110859988A CN201911217923.1A CN201911217923A CN110859988A CN 110859988 A CN110859988 A CN 110859988A CN 201911217923 A CN201911217923 A CN 201911217923A CN 110859988 A CN110859988 A CN 110859988A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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Abstract
An active carbon fiber biological functional dressing comprises a wound repairing layer, an adhesive layer and a sealing release paper; the sealing release paper is adhered to two sides of the adhesive layer and seals the wound repairing layer; the wound repairing layer comprises a base layer and a coating layer, the base layer is an activated carbon fiber felt and is arranged in the middle of the pasting layer, and the coating layer is attached to the base layer. The invention has convenient use, excellent moisture absorption performance and antibacterial performance, good hemostatic effect, can rapidly absorb moisture, blood, exudate and other liquids on the surface of a wound, effectively prevent the wound from being soaked by tissue liquid secreted by the wound for a long time, can form a gel protective layer on the wound, plays a role in filling tissues to prevent pathogenic microorganisms from contacting with the wound, is beneficial to wound healing and effectively prevents infection.
Description
Technical Field
The invention relates to the technical field of active carbon fiber dressings, in particular to an active carbon fiber biological functional dressing.
Background
The dressing is auxiliary materials except for main materials of articles, mainly refers to hemostatic gauze, usually medical absorbent gauze, the traditional dressing mainly comprises dry gauze and oily gauze, and the modern wound dressing comprises interactive wound dressing, calcium alginate dressing, foam dressing, hydrocolloid dressing and hydrogel dressing;
however, the existing dressing has poor moisture absorption performance and antibacterial performance, is difficult to absorb tissue fluid and the like of a wound surface timely and effectively, is difficult to prevent bacteria and the like from infecting the wound surface effectively, has poor using effect and needs to be improved.
Disclosure of Invention
Objects of the invention
In order to solve the technical problems in the background art, the invention provides the active carbon fiber biological function dressing which is convenient to use, has excellent moisture absorption performance and antibacterial performance, has a good hemostatic effect, can quickly absorb moisture, blood, exudate and other liquids on the surface of a wound, effectively prevents the wound from being soaked by tissue liquid secreted by the wound for a long time, can form a gel protective layer on the wound, plays a role in filling tissues to prevent pathogenic microorganisms from contacting the wound, is favorable for wound healing, and effectively prevents infection.
(II) technical scheme
The invention provides an active carbon fiber biological functional dressing, which comprises a wound repairing layer, an adhesive layer and sealing release paper;
the sealing release paper is adhered to two sides of the adhesive layer and seals the wound repairing layer; the wound repairing layer comprises a base layer and a coating layer, the base layer is an activated carbon fiber felt and is arranged in the middle of the sticking layer, and the coating layer is attached to the base layer; the coating layer comprises the following raw materials in parts by weight:
epoxy resin: 15-20 parts of collagen: 12-15 parts of sodium alginate: 10-15 parts of glycerol: 10-12 parts of titanium dioxide sol, 8-10 parts of fluorocarbon resin: 7-8 parts of polyethylene glycol: 8-12 parts of chitosan: 4-6 parts of agar: 5-6 parts of hydroxyethyl starch: 7-8 parts of calcium chloride: 4-5 parts of diethylene glycol diethyl ether: 3-5 parts of a dispersing agent: 2-3 parts of a compatilizer: 2-3 parts of defoaming agent: 2-3 parts of catalyst: 2-3 parts of a stabilizer: 1-2 parts of an inhibitor: 1-2 parts.
Preferably, the coating layer comprises the following raw materials in parts by weight:
epoxy resin: 15 parts of ossein: 12 parts of sodium alginate: 10 parts of glycerol: 10 parts of titanium dioxide sol, 8 parts of fluorocarbon resin: 7 parts of polyethylene glycol: 8 parts of chitosan: 4 parts of agar: 5 parts of hydroxyethyl starch: 7 parts of calcium chloride: 4 parts, diethylene glycol diethyl ether: 3 parts of a dispersant: 2 parts of a compatilizer: 2 parts of defoaming agent: 2 parts of catalyst: 2 parts of a stabilizer: 1 part of inhibitor: 1 part.
Preferably, the coating layer comprises the following raw materials in parts by weight:
epoxy resin: 20 parts of collagen: 15 parts of sodium alginate: 15 parts of glycerol: 12 parts of titanium dioxide sol, 10 parts of fluorocarbon resin: 8 parts of polyethylene glycol: 12 parts of chitosan: 6 parts of agar: 6 parts of hydroxyethyl starch: 8 parts of calcium chloride: 5 parts, diethylene glycol diethyl ether: 5 parts of dispersant: 3 parts of a compatilizer: 3 parts of defoaming agent: 3 parts of catalyst: 3 parts of a stabilizer: 2 parts of inhibitor: and 2 parts.
Preferably, the coating layer comprises the following raw materials in parts by weight:
epoxy resin: 18 parts of collagen: 14 parts of sodium alginate: 12 parts of glycerol: 11 parts of titanium dioxide sol, 9 parts of fluorocarbon resin: 7 parts of polyethylene glycol: 10 parts of chitosan: 5 parts of agar: 5 parts of hydroxyethyl starch: 7 parts of calcium chloride: 4 parts, diethylene glycol diethyl ether: 4 parts of a dispersant: 3 parts of a compatilizer: 2.5 parts of defoaming agent: 2.5 parts of catalyst: 2.5 parts of stabilizer: 1.5 parts of inhibitor: 1.5 parts.
Preferably, the method for making the coating layer is as follows:
s1, weighing the raw materials in parts by weight;
s2, adding epoxy resin, collagen, titanium dioxide sol, fluorocarbon resin and chitosan into a sealed stirring kettle, mixing and stirring for 2-3 hours at the stirring temperature of 50-65 ℃, and preparing a mixture A;
s3, adding the weighed sodium alginate, agar, hydroxyethyl starch, calcium chloride, diethylene glycol diethyl ether, polyethylene glycol and glycerol into a sealed stirring kettle, mixing and stirring for 1.5-2.5 hours at the stirring temperature of 55-65 ℃ to obtain a mixture B;
s4, adding the mixture A and the mixture B into a closed stirring kettle for mixing, and adding the weighed dispersing agent, the compatilizer, the defoaming agent, the catalyst, the stabilizer and the inhibitor into the stirring kettle, wherein the mixing time is not less than 1.5h, and the mixing temperature is 50-55 ℃, so that the coating layer is prepared.
Preferably, the titania sol is prepared as follows:
separating the nano titanium dioxide particles by using a centrifugal machine, and soaking the separated nano titanium dioxide particles in isopropanol; then separating the nano titanium dioxide particles by using a centrifugal machine again, soaking the separated nano titanium dioxide particles by using water, and repeating the step for 4-5 times; and then dispersing the finally obtained nano titanium dioxide particles in an aqueous solution to prepare 4% nano titanium dioxide sol.
Preferably, the matrix layer is prepared as follows:
s1, putting the silver ion solution and the activated carbon fiber into a steam pressure container, heating to 115-130 ℃, reacting for 10-30 min, cooling, repeatedly washing with a washing medium, drying at 105-115 ℃, and standing to room temperature to obtain the silver-dyed activated carbon fiber;
s2, in a nitrogen environment, heating the precursor fiber dyed with silver from room temperature to 500-750 ℃ at a heating rate of 10-15 ℃/min to carry out carbonization, and carbonizing for 30-45 min to obtain the activated carbon fiber containing silver ions;
s3, increasing the temperature of the silver ion-containing activated carbon fiber from the carbonization temperature to 1000-1150 ℃ at a temperature increase rate of 5-15 ℃ for activation, wherein the activation time is 30-60 min, so that a silver ion antibacterial layer is formed on the surface of the activated carbon fiber, and the silver ion-containing activated carbon fiber is prepared;
s4, compounding an anti-adhesion net film on the silver ion activated carbon fiber to form cloth, and then cutting the cloth into pieces.
Preferably, the adhesive layer 2 is a medical non-woven adhesive plaster.
Preferably, the defoaming agent is one of a higher alcohol fatty acid ester complex, polyoxyethylene polyoxypropylene pentaerythritol ether, polyoxyethylene polyoxypropylene amine ether, polyoxypropylene glycerol ether and polyoxypropylene polyoxyethylene glycerol ether, and polydimethylsiloxane.
Preferably, the compatilizer is a terpolymer of ethylene, methyl acrylate and glycidyl methacrylate.
The technical scheme of the invention has the following beneficial technical effects:
the invention has convenient use, excellent moisture absorption performance and antibacterial performance, good hemostatic effect, can rapidly absorb moisture, blood, exudate and other liquids on the surface of a wound, effectively prevent the wound from being soaked by tissue liquid secreted by the wound for a long time, can form a gel protective layer on the wound, plays a role in filling tissues to prevent pathogenic microorganisms from contacting with the wound, is beneficial to wound healing and effectively prevents infection.
Drawings
Fig. 1 is a schematic structural diagram of an active carbon fiber biofunctional dressing provided by the invention.
Reference numerals: 1. a wound repair layer; 2. a bonding layer; 3. and sealing the release paper.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail with reference to the accompanying drawings in conjunction with the following detailed description. It should be understood that the description is intended to be exemplary only, and is not intended to limit the scope of the present invention. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present invention.
Example one
As shown in fig. 1, the active carbon fiber biofunctional dressing provided by the invention comprises a wound repair layer 1, an adhesive layer 2 and a sealing release paper 3;
the sealing release paper 3 is adhered to the two sides of the adhesive layer 2 and seals the wound repairing layer 1; the wound repairing layer 1 comprises a base layer and a coating layer, the base layer is an activated carbon fiber felt and is arranged in the middle of the sticking layer 2, and the coating layer is attached to the base layer; the coating layer comprises the following raw materials in parts by weight:
epoxy resin: 15-20 parts of collagen: 12-15 parts of sodium alginate: 10-15 parts of glycerol: 10-12 parts of titanium dioxide sol, 8-10 parts of fluorocarbon resin: 7-8 parts of polyethylene glycol: 8-12 parts of chitosan: 4-6 parts of agar: 5-6 parts of hydroxyethyl starch: 7-8 parts of calcium chloride: 4-5 parts of diethylene glycol diethyl ether: 3-5 parts of a dispersing agent: 2-3 parts of a compatilizer: 2-3 parts of defoaming agent: 2-3 parts of catalyst: 2-3 parts of a stabilizer: 1-2 parts of an inhibitor: 1-2 parts.
Further, the manufacturing method of the coating layer comprises the following steps:
s1, weighing the raw materials in parts by weight;
s2, adding epoxy resin, collagen, titanium dioxide sol, fluorocarbon resin and chitosan into a sealed stirring kettle, mixing and stirring for 2-3 hours at the stirring temperature of 50-65 ℃, and preparing a mixture A;
s3, adding the weighed sodium alginate, agar, hydroxyethyl starch, calcium chloride, diethylene glycol diethyl ether, polyethylene glycol and glycerol into a sealed stirring kettle, mixing and stirring for 1.5-2.5 hours at the stirring temperature of 55-65 ℃ to obtain a mixture B;
s4, adding the mixture A and the mixture B into a closed stirring kettle for mixing, and adding the weighed dispersing agent, the compatilizer, the defoaming agent, the catalyst, the stabilizer and the inhibitor into the stirring kettle, wherein the mixing time is not less than 1.5h, and the mixing temperature is 50-55 ℃, so that the coating layer is prepared.
Further, the preparation method of the titanium dioxide sol is as follows:
separating the nano titanium dioxide particles by using a centrifugal machine, and soaking the separated nano titanium dioxide particles in isopropanol; then separating the nano titanium dioxide particles by using a centrifugal machine again, soaking the separated nano titanium dioxide particles by using water, and repeating the step for 4-5 times; and then dispersing the finally obtained nano titanium dioxide particles in an aqueous solution to prepare 4% nano titanium dioxide sol.
Further, the preparation method of the matrix layer comprises the following steps:
s1, putting the silver ion solution and the activated carbon fiber into a steam pressure container, heating to 115-130 ℃, reacting for 10-30 min, cooling, repeatedly washing with a washing medium, drying at 105-115 ℃, and standing to room temperature to obtain the silver-dyed activated carbon fiber;
s2, in a nitrogen environment, heating the precursor fiber dyed with silver from room temperature to 500-750 ℃ at a heating rate of 10-15 ℃/min to carry out carbonization, and carbonizing for 30-45 min to obtain the activated carbon fiber containing silver ions;
s3, increasing the temperature of the silver ion-containing activated carbon fiber from the carbonization temperature to 1000-1150 ℃ at a temperature increase rate of 5-15 ℃ for activation, wherein the activation time is 30-60 min, so that a silver ion antibacterial layer is formed on the surface of the activated carbon fiber, and the silver ion-containing activated carbon fiber is prepared;
s4, compounding an anti-adhesion net film on the silver ion activated carbon fiber to form cloth, and then cutting the cloth into pieces.
Further, the adhesive layer 2 is a medical non-woven adhesive tape.
Further, the defoaming agent is one of a higher alcohol fatty acid ester complex, polyoxyethylene polyoxypropylene pentaerythritol ether, polyoxyethylene polyoxypropylene amine ether, polyoxypropylene glycerol ether, polyoxypropylene polyoxyethylene glycerol ether and polydimethylsiloxane.
Further, the compatilizer is a terpolymer of ethylene, methyl acrylate and glycidyl methacrylate.
Example two
As shown in fig. 1, the active carbon fiber biofunctional dressing provided by the invention comprises a wound repair layer 1, an adhesive layer 2 and a sealing release paper 3;
the sealing release paper 3 is adhered to the two sides of the adhesive layer 2 and seals the wound repairing layer 1; the wound repairing layer 1 comprises a base layer and a coating layer, the base layer is an activated carbon fiber felt and is arranged in the middle of the sticking layer 2, and the coating layer is attached to the base layer; the coating layer comprises the following raw materials in parts by weight:
epoxy resin: 15 parts of ossein: 12 parts of sodium alginate: 10 parts of glycerol: 10 parts of titanium dioxide sol, 8 parts of fluorocarbon resin: 7 parts of polyethylene glycol: 8 parts of chitosan: 4 parts of agar: 5 parts of hydroxyethyl starch: 7 parts of calcium chloride: 4 parts, diethylene glycol diethyl ether: 3 parts of a dispersant: 2 parts of a compatilizer: 2 parts of defoaming agent: 2 parts of catalyst: 2 parts of a stabilizer: 1 part of inhibitor: 1 part.
Further, the manufacturing method of the coating layer comprises the following steps:
s1, weighing the raw materials in parts by weight;
s2, adding epoxy resin, collagen, titanium dioxide sol, fluorocarbon resin and chitosan into a sealed stirring kettle, mixing and stirring for 2-3 hours at the stirring temperature of 50-65 ℃, and preparing a mixture A;
s3, adding the weighed sodium alginate, agar, hydroxyethyl starch, calcium chloride, diethylene glycol diethyl ether, polyethylene glycol and glycerol into a sealed stirring kettle, mixing and stirring for 1.5-2.5 hours at the stirring temperature of 55-65 ℃ to obtain a mixture B;
s4, adding the mixture A and the mixture B into a closed stirring kettle for mixing, and adding the weighed dispersing agent, the compatilizer, the defoaming agent, the catalyst, the stabilizer and the inhibitor into the stirring kettle, wherein the mixing time is not less than 1.5h, and the mixing temperature is 50-55 ℃, so that the coating layer is prepared.
Further, the preparation method of the titanium dioxide sol is as follows:
separating the nano titanium dioxide particles by using a centrifugal machine, and soaking the separated nano titanium dioxide particles in isopropanol; then separating the nano titanium dioxide particles by using a centrifugal machine again, soaking the separated nano titanium dioxide particles by using water, and repeating the step for 4-5 times; and then dispersing the finally obtained nano titanium dioxide particles in an aqueous solution to prepare 4% nano titanium dioxide sol.
Further, the preparation method of the matrix layer comprises the following steps:
s1, putting the silver ion solution and the activated carbon fiber into a steam pressure container, heating to 115-130 ℃, reacting for 10-30 min, cooling, repeatedly washing with a washing medium, drying at 105-115 ℃, and standing to room temperature to obtain the silver-dyed activated carbon fiber;
s2, in a nitrogen environment, heating the precursor fiber dyed with silver from room temperature to 500-750 ℃ at a heating rate of 10-15 ℃/min to carry out carbonization, and carbonizing for 30-45 min to obtain the activated carbon fiber containing silver ions;
s3, increasing the temperature of the silver ion-containing activated carbon fiber from the carbonization temperature to 1000-1150 ℃ at a temperature increase rate of 5-15 ℃ for activation, wherein the activation time is 30-60 min, so that a silver ion antibacterial layer is formed on the surface of the activated carbon fiber, and the silver ion-containing activated carbon fiber is prepared;
s4, compounding an anti-adhesion net film on the silver ion activated carbon fiber to form cloth, and then cutting the cloth into pieces.
Further, the adhesive layer 2 is a medical non-woven adhesive tape.
Further, the defoaming agent is one of a higher alcohol fatty acid ester complex, polyoxyethylene polyoxypropylene pentaerythritol ether, polyoxyethylene polyoxypropylene amine ether, polyoxypropylene glycerol ether, polyoxypropylene polyoxyethylene glycerol ether and polydimethylsiloxane.
Further, the compatilizer is a terpolymer of ethylene, methyl acrylate and glycidyl methacrylate.
EXAMPLE III
As shown in fig. 1, the active carbon fiber biofunctional dressing provided by the invention comprises a wound repair layer 1, an adhesive layer 2 and a sealing release paper 3;
the sealing release paper 3 is adhered to the two sides of the adhesive layer 2 and seals the wound repairing layer 1; the wound repairing layer 1 comprises a base layer and a coating layer, the base layer is an activated carbon fiber felt and is arranged in the middle of the sticking layer 2, and the coating layer is attached to the base layer; the coating layer comprises the following raw materials in parts by weight:
epoxy resin: 20 parts of collagen: 15 parts of sodium alginate: 15 parts of glycerol: 12 parts of titanium dioxide sol, 10 parts of fluorocarbon resin: 8 parts of polyethylene glycol: 12 parts of chitosan: 6 parts of agar: 6 parts of hydroxyethyl starch: 8 parts of calcium chloride: 5 parts, diethylene glycol diethyl ether: 5 parts of dispersant: 3 parts of a compatilizer: 3 parts of defoaming agent: 3 parts of catalyst: 3 parts of a stabilizer: 2 parts of inhibitor: and 2 parts.
Further, the manufacturing method of the coating layer comprises the following steps:
s1, weighing the raw materials in parts by weight;
s2, adding epoxy resin, collagen, titanium dioxide sol, fluorocarbon resin and chitosan into a sealed stirring kettle, mixing and stirring for 2-3 hours at the stirring temperature of 50-65 ℃, and preparing a mixture A;
s3, adding the weighed sodium alginate, agar, hydroxyethyl starch, calcium chloride, diethylene glycol diethyl ether, polyethylene glycol and glycerol into a sealed stirring kettle, mixing and stirring for 1.5-2.5 hours at the stirring temperature of 55-65 ℃ to obtain a mixture B;
s4, adding the mixture A and the mixture B into a closed stirring kettle for mixing, and adding the weighed dispersing agent, the compatilizer, the defoaming agent, the catalyst, the stabilizer and the inhibitor into the stirring kettle, wherein the mixing time is not less than 1.5h, and the mixing temperature is 50-55 ℃, so that the coating layer is prepared.
Further, the preparation method of the titanium dioxide sol is as follows:
separating the nano titanium dioxide particles by using a centrifugal machine, and soaking the separated nano titanium dioxide particles in isopropanol; then separating the nano titanium dioxide particles by using a centrifugal machine again, soaking the separated nano titanium dioxide particles by using water, and repeating the step for 4-5 times; and then dispersing the finally obtained nano titanium dioxide particles in an aqueous solution to prepare 4% nano titanium dioxide sol.
Further, the preparation method of the matrix layer comprises the following steps:
s1, putting the silver ion solution and the activated carbon fiber into a steam pressure container, heating to 115-130 ℃, reacting for 10-30 min, cooling, repeatedly washing with a washing medium, drying at 105-115 ℃, and standing to room temperature to obtain the silver-dyed activated carbon fiber;
s2, in a nitrogen environment, heating the precursor fiber dyed with silver from room temperature to 500-750 ℃ at a heating rate of 10-15 ℃/min to carry out carbonization, and carbonizing for 30-45 min to obtain the activated carbon fiber containing silver ions;
s3, increasing the temperature of the silver ion-containing activated carbon fiber from the carbonization temperature to 1000-1150 ℃ at a temperature increase rate of 5-15 ℃ for activation, wherein the activation time is 30-60 min, so that a silver ion antibacterial layer is formed on the surface of the activated carbon fiber, and the silver ion-containing activated carbon fiber is prepared;
s4, compounding an anti-adhesion net film on the silver ion activated carbon fiber to form cloth, and then cutting the cloth into pieces.
Further, the adhesive layer 2 is a medical non-woven adhesive tape.
Further, the defoaming agent is one of a higher alcohol fatty acid ester complex, polyoxyethylene polyoxypropylene pentaerythritol ether, polyoxyethylene polyoxypropylene amine ether, polyoxypropylene glycerol ether, polyoxypropylene polyoxyethylene glycerol ether and polydimethylsiloxane.
Further, the compatilizer is a terpolymer of ethylene, methyl acrylate and glycidyl methacrylate.
Example four
As shown in fig. 1, the active carbon fiber biofunctional dressing provided by the invention comprises a wound repair layer 1, an adhesive layer 2 and a sealing release paper 3;
the sealing release paper 3 is adhered to the two sides of the adhesive layer 2 and seals the wound repairing layer 1; the wound repairing layer 1 comprises a base layer and a coating layer, the base layer is an activated carbon fiber felt and is arranged in the middle of the sticking layer 2, and the coating layer is attached to the base layer; the coating layer comprises the following raw materials in parts by weight:
epoxy resin: 18 parts of collagen: 14 parts of sodium alginate: 12 parts of glycerol: 11 parts of titanium dioxide sol, 9 parts of fluorocarbon resin: 7 parts of polyethylene glycol: 10 parts of chitosan: 5 parts of agar: 5 parts of hydroxyethyl starch: 7 parts of calcium chloride: 4 parts, diethylene glycol diethyl ether: 4 parts of a dispersant: 3 parts of a compatilizer: 2.5 parts of defoaming agent: 2.5 parts of catalyst: 2.5 parts of stabilizer: 1.5 parts of inhibitor: 1.5 parts.
Further, the manufacturing method of the coating layer comprises the following steps:
s1, weighing the raw materials in parts by weight;
s2, adding epoxy resin, collagen, titanium dioxide sol, fluorocarbon resin and chitosan into a sealed stirring kettle, mixing and stirring for 2-3 hours at the stirring temperature of 50-65 ℃, and preparing a mixture A;
s3, adding the weighed sodium alginate, agar, hydroxyethyl starch, calcium chloride, diethylene glycol diethyl ether, polyethylene glycol and glycerol into a sealed stirring kettle, mixing and stirring for 1.5-2.5 hours at the stirring temperature of 55-65 ℃ to obtain a mixture B;
s4, adding the mixture A and the mixture B into a closed stirring kettle for mixing, and adding the weighed dispersing agent, the compatilizer, the defoaming agent, the catalyst, the stabilizer and the inhibitor into the stirring kettle, wherein the mixing time is not less than 1.5h, and the mixing temperature is 50-55 ℃, so that the coating layer is prepared.
Further, the preparation method of the titanium dioxide sol is as follows:
separating the nano titanium dioxide particles by using a centrifugal machine, and soaking the separated nano titanium dioxide particles in isopropanol; then separating the nano titanium dioxide particles by using a centrifugal machine again, soaking the separated nano titanium dioxide particles by using water, and repeating the step for 4-5 times; and then dispersing the finally obtained nano titanium dioxide particles in an aqueous solution to prepare 4% nano titanium dioxide sol.
Further, the preparation method of the matrix layer comprises the following steps:
s1, putting the silver ion solution and the activated carbon fiber into a steam pressure container, heating to 115-130 ℃, reacting for 10-30 min, cooling, repeatedly washing with a washing medium, drying at 105-115 ℃, and standing to room temperature to obtain the silver-dyed activated carbon fiber;
s2, in a nitrogen environment, heating the precursor fiber dyed with silver from room temperature to 500-750 ℃ at a heating rate of 10-15 ℃/min to carry out carbonization, and carbonizing for 30-45 min to obtain the activated carbon fiber containing silver ions;
s3, increasing the temperature of the silver ion-containing activated carbon fiber from the carbonization temperature to 1000-1150 ℃ at a temperature increase rate of 5-15 ℃ for activation, wherein the activation time is 30-60 min, so that a silver ion antibacterial layer is formed on the surface of the activated carbon fiber, and the silver ion-containing activated carbon fiber is prepared;
s4, compounding an anti-adhesion net film on the silver ion activated carbon fiber to form cloth, and then cutting the cloth into pieces.
Further, the adhesive layer 2 is a medical non-woven adhesive tape.
Further, the defoaming agent is one of a higher alcohol fatty acid ester complex, polyoxyethylene polyoxypropylene pentaerythritol ether, polyoxyethylene polyoxypropylene amine ether, polyoxypropylene glycerol ether, polyoxypropylene polyoxyethylene glycerol ether and polydimethylsiloxane.
Further, the compatilizer is a terpolymer of ethylene, methyl acrylate and glycidyl methacrylate.
When the wound repairing sheet is used, the sealing release paper 3 is torn down to two sides, the wound repairing layer 1 covers the wound surface, and the sticking layer 2 is stuck on the skin, so that the operation is simple and the using effect is good;
the wound dressing is convenient to use, good in using effect and excellent in moisture absorption performance, can rapidly absorb moisture, blood, exudate and other liquids on the surface of a wound, effectively prevents the wound from being soaked by tissue liquid secreted by the wound for a long time, has a good hemostatic effect, is beneficial to wound healing, can form a gel protective layer on the wound, plays a role in filling tissues to prevent pathogenic microorganisms such as helicobacter pylori from contacting with the wound, and effectively prevents infection;
the collagen is an important component for composing human muscle and skin, the chitosan is obtained by deacetylating chitin widely existing in the nature, and the chitosan has excellent biocompatibility, blood compatibility, safety, microbial degradability and the like, is beneficial to healing of a wound surface, and can be biodegraded and absorbed after the wound surface is healed;
and the base layer in the wound repairing layer 1 has the advantages of antibacterial property of silver ions and strong adsorption force of activated carbon fibers, so that the antibacterial effect and the moisture absorption performance are further improved.
It is to be understood that the above-described embodiments of the present invention are merely illustrative of or explaining the principles of the invention and are not to be construed as limiting the invention. Therefore, any modification, equivalent replacement, improvement and the like made without departing from the spirit and scope of the present invention should be included in the protection scope of the present invention. Further, it is intended that the appended claims cover all such variations and modifications as fall within the scope and boundaries of the appended claims or the equivalents of such scope and boundaries.
Claims (10)
1. The active carbon fiber biological functional dressing is characterized by comprising a wound repairing layer (1), an adhesive layer (2) and sealing release paper (3);
the sealing release paper (3) is adhered to the two sides of the adhesive layer (2) and seals the wound repairing layer (1); the wound repairing layer (1) comprises a base layer and a coating layer, the base layer is an activated carbon fiber felt and is arranged in the middle of the sticking layer (2), and the coating layer is attached to the base layer; the coating layer comprises the following raw materials in parts by weight:
epoxy resin: 15-20 parts of collagen: 12-15 parts of sodium alginate: 10-15 parts of glycerol: 10-12 parts of titanium dioxide sol, 8-10 parts of fluorocarbon resin: 7-8 parts of polyethylene glycol: 8-12 parts of chitosan: 4-6 parts of agar: 5-6 parts of hydroxyethyl starch: 7-8 parts of calcium chloride: 4-5 parts of diethylene glycol diethyl ether: 3-5 parts of a dispersing agent: 2-3 parts of a compatilizer: 2-3 parts of defoaming agent: 2-3 parts of catalyst: 2-3 parts of a stabilizer: 1-2 parts of an inhibitor: 1-2 parts.
2. The active carbon fiber biofunctional dressing according to claim 1, wherein the coating layer comprises the following raw materials in parts by weight:
epoxy resin: 15 parts of ossein: 12 parts of sodium alginate: 10 parts of glycerol: 10 parts of titanium dioxide sol, 8 parts of fluorocarbon resin: 7 parts of polyethylene glycol: 8 parts of chitosan: 4 parts of agar: 5 parts of hydroxyethyl starch: 7 parts of calcium chloride: 4 parts, diethylene glycol diethyl ether: 3 parts of a dispersant: 2 parts of a compatilizer: 2 parts of defoaming agent: 2 parts of catalyst: 2 parts of a stabilizer: 1 part of inhibitor: 1 part.
3. The active carbon fiber biofunctional dressing according to claim 1, wherein the coating layer comprises the following raw materials in parts by weight:
epoxy resin: 20 parts of collagen: 15 parts of sodium alginate: 15 parts of glycerol: 12 parts of titanium dioxide sol, 10 parts of fluorocarbon resin: 8 parts of polyethylene glycol: 12 parts of chitosan: 6 parts of agar: 6 parts of hydroxyethyl starch: 8 parts of calcium chloride: 5 parts, diethylene glycol diethyl ether: 5 parts of dispersant: 3 parts of a compatilizer: 3 parts of defoaming agent: 3 parts of catalyst: 3 parts of a stabilizer: 2 parts of inhibitor: and 2 parts.
4. The active carbon fiber biofunctional dressing according to claim 1, wherein the coating layer comprises the following raw materials in parts by weight:
epoxy resin: 18 parts of collagen: 14 parts of sodium alginate: 12 parts of glycerol: 11 parts of titanium dioxide sol, 9 parts of fluorocarbon resin: 7 parts of polyethylene glycol: 10 parts of chitosan: 5 parts of agar: 5 parts of hydroxyethyl starch: 7 parts of calcium chloride: 4 parts, diethylene glycol diethyl ether: 4 parts of a dispersant: 3 parts of a compatilizer: 2.5 parts of defoaming agent: 2.5 parts of catalyst: 2.5 parts of stabilizer: 1.5 parts of inhibitor: 1.5 parts.
5. The active carbon fiber biofunctional dressing according to any one of claims 1-4, wherein the coating layer is prepared by the following method:
s1, weighing the raw materials in parts by weight;
s2, adding epoxy resin, collagen, titanium dioxide sol, fluorocarbon resin and chitosan into a sealed stirring kettle, mixing and stirring for 2-3 hours at the stirring temperature of 50-65 ℃, and preparing a mixture A;
s3, adding the weighed sodium alginate, agar, hydroxyethyl starch, calcium chloride, diethylene glycol diethyl ether, polyethylene glycol and glycerol into a sealed stirring kettle, mixing and stirring for 1.5-2.5 hours at the stirring temperature of 55-65 ℃ to obtain a mixture B;
s4, adding the mixture A and the mixture B into a closed stirring kettle for mixing, and adding the weighed dispersing agent, the compatilizer, the defoaming agent, the catalyst, the stabilizer and the inhibitor into the stirring kettle, wherein the mixing time is not less than 1.5h, and the mixing temperature is 50-55 ℃, so that the coating layer is prepared.
6. The active carbon fiber biofunctional dressing according to claim 5, wherein the titanium dioxide sol is prepared by the following steps:
separating the nano titanium dioxide particles by using a centrifugal machine, and soaking the separated nano titanium dioxide particles in isopropanol; then separating the nano titanium dioxide particles by using a centrifugal machine again, soaking the separated nano titanium dioxide particles by using water, and repeating the step for 4-5 times; and then dispersing the finally obtained nano titanium dioxide particles in an aqueous solution to prepare 4% nano titanium dioxide sol.
7. The active carbon fiber biofunctional dressing according to claim 1, wherein the matrix layer is prepared by the following method:
s1, putting the silver ion solution and the activated carbon fiber into a steam pressure container, heating to 115-130 ℃, reacting for 10-30 min, cooling, repeatedly washing with a washing medium, drying at 105-115 ℃, and standing to room temperature to obtain the silver-dyed activated carbon fiber;
s2, in a nitrogen environment, heating the precursor fiber dyed with silver from room temperature to 500-750 ℃ at a heating rate of 10-15 ℃/min to carry out carbonization, and carbonizing for 30-45 min to obtain the activated carbon fiber containing silver ions;
s3, increasing the temperature of the silver ion-containing activated carbon fiber from the carbonization temperature to 1000-1150 ℃ at a temperature increase rate of 5-15 ℃ for activation, wherein the activation time is 30-60 min, so that a silver ion antibacterial layer is formed on the surface of the activated carbon fiber, and the silver ion-containing activated carbon fiber is prepared;
s4, compounding an anti-adhesion net film on the silver ion activated carbon fiber to form cloth, and then cutting the cloth into pieces.
8. The active carbon fiber biofunctional dressing as claimed in claim 1, wherein the adhesive layer 2 is a medical non-woven adhesive plaster.
9. The active carbon fiber biofunctional dressing according to claim 5, wherein the antifoaming agent is one of a higher alcohol fatty acid ester complex, polyoxyethylene polyoxypropylene pentaerythritol ether, polyoxyethylene polyoxypropylene amine ether, polyoxypropylene glycerol ether and polyoxypropylene polyoxyethylene glycerol ether, and polydimethylsiloxane.
10. The active carbon fiber biofunctional dressing according to claim 5, wherein the compatilizer is a terpolymer of ethylene, methyl acrylate and glycidyl methacrylate.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102133420A (en) * | 2011-03-02 | 2011-07-27 | 长沙海润生物技术有限公司 | Silver ion active carbon antimicrobial dressing and preparation method thereof |
| CN106378199A (en) * | 2016-08-22 | 2017-02-08 | 广州光纳环保科技有限公司 | A photocatalyst air cleaning agent and a preparing method thereof |
| CN107325592A (en) * | 2017-05-19 | 2017-11-07 | 浙江帝恒实业有限公司 | A kind of antiseptic dressing |
| CN108014361A (en) * | 2018-02-07 | 2018-05-11 | 苏州元禾医疗器械有限公司 | A kind of wound dressing |
| CN108434513A (en) * | 2018-04-16 | 2018-08-24 | 山东威高药业股份有限公司 | A kind of Wound dressing |
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2019
- 2019-12-03 CN CN201911217923.1A patent/CN110859988A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102133420A (en) * | 2011-03-02 | 2011-07-27 | 长沙海润生物技术有限公司 | Silver ion active carbon antimicrobial dressing and preparation method thereof |
| CN106378199A (en) * | 2016-08-22 | 2017-02-08 | 广州光纳环保科技有限公司 | A photocatalyst air cleaning agent and a preparing method thereof |
| CN107325592A (en) * | 2017-05-19 | 2017-11-07 | 浙江帝恒实业有限公司 | A kind of antiseptic dressing |
| CN108014361A (en) * | 2018-02-07 | 2018-05-11 | 苏州元禾医疗器械有限公司 | A kind of wound dressing |
| CN108434513A (en) * | 2018-04-16 | 2018-08-24 | 山东威高药业股份有限公司 | A kind of Wound dressing |
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Application publication date: 20200306 |