CN110841015A

CN110841015A - Pharmaceutical formulation for treating leucoderma

Info

Publication number: CN110841015A
Application number: CN201911262789.7A
Authority: CN
Inventors: 符强
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-12-10
Filing date: 2019-12-10
Publication date: 2020-02-28

Abstract

The invention discloses a pharmaceutical formula for treating leucoderma, which comprises the following raw materials in parts by weight: 4-6 g of tribulus terrestris, 4-6 g of endothelium corneum gigeriae galli, 4-6 g of dendrobium, 4-6 g of radix ophiopogonis, 4-6 g of fried bighead atractylodes rhizome, 4-6 g of poria cocos, 4-6 g of caulis spatholobi, 4-6 g of salvia miltiorrhiza, 4-6 g of flatstem milkvetch seed, 4-6 g of fried malt, 4-6 g of polygonatum odoratum, 4-6 g of radix glehniae, 5-7 g of Chinese yam, 5-7 g of codonopsis pilosula, 5-7 g of fried astragalus membranaceus, 9-11 g of radix rehmanniae, 7-9 g of polygonum multiflorum, 6-8 g of black sesame and 14-16 g; the formula of the medicine for treating the leucoderma can be directly decocted by traditional Chinese medicines, can also be taken in pills, can be selected by patients according to self conditions, is humanized, can effectively treat the leucoderma after being taken, and has the characteristics of quick response, small side effect, difficult recurrence and the like.

Description

Pharmaceutical formulation for treating leucoderma

Technical Field

The invention belongs to the technical field of medicine, and particularly relates to a medicine formula for treating leucoderma.

Background

Vitiligo is a common acquired limited or generalized skin depigmentation disease. The loss of melanocyte function in the skin, but the mechanism is not clear. All parts of the body can occur, usually around the back, wrist, forearm, face, neck and genitals. Female genitalia can also occur, and young women are in large numbers, and vitiligo can be combined with autoimmune diseases, such as thyroid disease, diabetes, chronic adrenal hypofunction, pernicious anemia, rheumatic arthritis, malignant melanoma, etc. Antibodies specific to various organs, such as antithyroid antibody, anti-parietal cell antibody, anti-adrenal antibody, anti-parathyroid antibody, anti-smooth muscle antibody, anti-melanocyte antibody, etc., can also be detected in serum;

however, the vitiligo treatment medicine has the problems of slow effect, large side effect and easy recurrence when being taken orally, so the medicine formula for treating the vitiligo is provided.

Disclosure of Invention

The invention aims to provide a pharmaceutical formulation for treating vitiligo, so as to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme: a pharmaceutical formulation for treating vitiligo comprises the following raw materials by weight: 4-6 g of tribulus terrestris, 4-6 g of endothelium corneum gigeriae galli, 4-6 g of dendrobium, 4-6 g of radix ophiopogonis, 4-6 g of fried bighead atractylodes rhizome, 4-6 g of poria cocos, 4-6 g of caulis spatholobi, 4-6 g of salvia miltiorrhiza, 4-6 g of flatstem milkvetch seed, 4-6 g of fried malt, 4-6 g of polygonatum odoratum, 4-6 g of radix glehniae, 5-7 g of Chinese yam, 5-7 g of codonopsis pilosula, 5-7 g of fried astragalus membranaceus, 9-11 g of radix rehmanniae, 7-9 g of polygonum multiflorum, 6-8 g of black sesame and 14-16 g.

A preparation method of a medicine for treating vitiligo comprises two preparation methods of decocting traditional Chinese medicines and preparing honeyed pills, wherein the decocting steps of the traditional Chinese medicines are as follows:

s1, soaking: taking formula raw materials, namely tribulus terrestris, endothelium corneum gigeriae galli, dendrobe, radix ophiopogonis, fried bighead atractylodes rhizome, poria cocos, caulis spatholobi, salvia miltiorrhiza, flatstem milkvetch seed, fried malt, polygonatum odoratum, radix glehniae, Chinese yam, codonopsis pilosula, radix astragali preparata, radix rehmanniae, polygonum multiflorum, black sesame and fructus psoraleae, soaking in cold water, and taking out after 20 minutes;

s2, adding water: then placing the soaked formula raw materials into a vessel, and adding 700ml of water into the vessel, wherein the water is 1-3 cm higher than the surface of the medicinal materials;

s3, decocting: heating the vessel, boiling the liquid medicine with strong fire, slowly decocting with slow fire for 30-40 minutes until 400ml of liquid medicine remains, and pouring out the liquid medicine and the raw material residue respectively;

s4, decocting again: adding 700ml of water into the raw material residue poured out in the step S3, boiling the liquid medicine with strong fire, slowly decocting with slow fire for 20-30 minutes until 400ml of liquid medicine is remained, and pouring out the liquid medicine;

s5, sealing: sealing the liquid medicine poured out in the steps S3 and S4 in a closed container, and storing in a shade or a refrigerator;

the honey refining step is as follows:

A. grinding: taking formula raw materials, namely tribulus terrestris, endothelium corneum gigeriae galli, dendrobe, radix ophiopogonis, fried bighead atractylodes rhizome, poria cocos, caulis spatholobi, salvia miltiorrhiza, flatstem milkvetch seed, fried malt, polygonatum odoratum, radix glehniae, Chinese yam, codonopsis pilosula, radix astragali preparata, radix rehmanniae, polygonum multiflorum, black sesame and fructus psoraleae, keeping the humidity within 1.5-5%, grinding the traditional Chinese medicines into powder, sieving the powder by a 80-mesh sieve, and uniformly stirring the powder;

B. refining honey: heating the honey to boiling, wherein the honey is deep in color and viscous and loses 4.5-5.5% of water, continuously heating the honey to generate light red and glossy foam, and the honey is strong in viscosity and free of white silk when being twisted by hands;

C. mixing the medicines: mixing refined honey and the medicinal powder at a ratio of 1:1, kneading uniformly, and making into pill;

D. preparing strips and pills: placing the pill blocks for 6h, mixing Mel and medicinal powder components uniformly, kneading into strips after generating viscosity, cutting into small segments, and making into pill with a pill weight of 10 g;

E. packaging and storing: the pills are wrapped by wax paper, cellophane, plastic bag and wax shell and stored in a cool and dry place.

Preferably, in the slow-fire decoction process in S3 and S4, the medicinal materials in the vessel are stirred by a glass rod.

Preferably, the pot cover needs to be tightly closed when the medicine is decocted with strong fire in the steps S3 and S4, and after the medicine liquid is boiled, the pot cover needs to be supported by two chopsticks, so that a certain gap is reserved for discharging steam.

Preferably, the utensils in S2 and S3 are pottery pots, marmite or stainless steel utensils.

Preferably, the closed vessel with the liquid medicine sealed in the S5 can be stored in a cool place for 1.5-2.5 days, and can be stored in a refrigerator for 4.5-5.5 days.

Compared with the prior art, the invention has the beneficial effects that:

the formula of the medicine for treating the vitiligo can be directly decocted by traditional Chinese medicines or can be taken as pills, can be selected by patients according to self conditions, is humanized, can effectively treat the vitiligo after being taken, and has the characteristics of quick response, small side effect, difficult recurrence and the like.

Drawings

FIG. 1 is a schematic view of the process for decocting Chinese herbs in accordance with the present invention;

fig. 2 is a schematic view of the honey refining and pelletizing process of the invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to fig. 1-2, the present invention provides a technical solution: a pharmaceutical formulation for treating vitiligo comprises the following raw materials by weight: 5g of tribulus terrestris, 5g of endothelium corneum gigeriae galli, 5g of dendrobium, 5g of radix ophiopogonis, 5g of fried bighead atractylodes rhizome, 5g of poria cocos, 5g of caulis spatholobi, 5g of salvia miltiorrhiza, 5g of flatstem milkvetch seed, 5g of fried malt, 5g of polygonatum odoratum, 5g of radix glehniae, 6g of Chinese yam, 6g of codonopsis pilosula, 6g of roasted astragalus mongholicus, 10g of radix rehmanniae, 8g of polygonum multiflorum, 7g of black sesame and 15 g.

s2, adding water: then placing the soaked formula raw materials into a vessel, and then adding 700ml of water into the vessel, wherein the water is 2 cm higher than the surface of the medicinal materials;

s3, decocting: heating the vessel, boiling the liquid medicine with strong fire, slowly decocting with slow fire for 35 min until 400ml of liquid medicine remains, and respectively pouring out the liquid medicine and the raw material residue;

s4, decocting again: adding 700ml of water into the raw material residue poured out in the step S3, boiling the liquid medicine with strong fire, slowly decocting with slow fire for 25 minutes until 400ml of liquid medicine is remained, and pouring out the liquid medicine;

the honey refining step is as follows:

A. grinding: taking formula raw materials, namely tribulus terrestris, endothelium corneum gigeriae galli, dendrobe, radix ophiopogonis, fried bighead atractylodes rhizome, poria cocos, caulis spatholobi, salvia miltiorrhiza, flatstem milkvetch seed, fried malt, polygonatum odoratum, radix glehniae, Chinese yam, codonopsis pilosula, radix astragali preparata, radix rehmanniae, polygonum multiflorum, black sesame and fructus psoraleae, keeping the humidity at 3%, grinding the traditional Chinese medicines into powder, sieving the powder with a 80-mesh sieve, and uniformly stirring;

B. refining honey: heating Mel to boil, wherein the color becomes dark, the Mel has viscosity, and the water content is lost by 5%, heating Mel to give light red and glossy foam, and the honey has strong viscosity and no white silk;

Wherein, the medicinal materials in the vessel need to be stirred by a glass rod in the slow-fire decocting process in S3 and S4.

Wherein, the pot cover is required to be tightly closed when the medicine is decocted by strong fire in the steps S3 and S4, and after the medicine liquid is boiled, the pot cover is required to be supported by two chopsticks, and a certain gap is reserved for discharging steam.

Wherein, the utensils in S2 and S3 are ceramic pots.

Wherein the sealed vessel with the liquid medicine sealed in S5 can be stored in shade for 3 days, and can be stored in refrigerator for 5 days.

The application and dosage of the traditional Chinese medicine decoction are as follows: drinking 400ml each time, and matching with oral vitamin E (5mg), 3 times a day, 1 granule each time, one tablet of carotene each time (taken before sleeping at night), 2 times a day of vitamin B complex, two tablets each time (morning and evening);

the dosage of the honeyed pill is as follows: 3 pills (30g) are orally taken with warm water 3 times a day each time, and are matched with oral vitamin E (5mg) for 3 times a day and 1 granule each time, carotene is taken one tablet each day (taken before sleeping at night), and vitamin B complex is taken 2 times a day and two tablets each time (morning and evening);

the traditional Chinese medicine is decocted or refined with honey to be pills for oral administration, and the external medicine is required for auxiliary treatment: 15g of external halometasone emulsifiable paste and 30ml of compound karizinum cyminum tincture, and the using method and the using amount are as follows: the halometasone cream is applied to the affected part in a thin layer twice a day, and is gently rubbed, and after 30 minutes, the compound carizium cuminum tincture is uniformly applied to the affected part.

The effect table of the patient is as follows:

patient's health	Sex	Age (age)	Affected part	Duration of disease	Time to cure
						King of a certain	For male	Age 45	Face and neck	8 months old	30 days
Lie somewhere	Woman	Age 36	Arms and limbs	1 year	60 days
						Zhang-a	Woman	Age 12 years old	Back and neck	3 months old	3 months old

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The pharmaceutical formulation for treating leucoderma is characterized by comprising the following raw materials in parts by weight: 4-6 g of tribulus terrestris, 4-6 g of endothelium corneum gigeriae galli, 4-6 g of dendrobium, 4-6 g of radix ophiopogonis, 4-6 g of fried bighead atractylodes rhizome, 4-6 g of poria cocos, 4-6 g of caulis spatholobi, 4-6 g of salvia miltiorrhiza, 4-6 g of flatstem milkvetch seed, 4-6 g of fried malt, 4-6 g of polygonatum odoratum, 4-6 g of radix glehniae, 5-7 g of Chinese yam, 5-7 g of codonopsis pilosula, 5-7 g of fried astragalus membranaceus, 9-11 g of radix rehmanniae, 7-9 g of polygonum multiflorum, 6-8 g of black sesame and 14-16 g.

2. The preparation method of the medicine for treating the leucoderma is characterized by comprising two preparation methods of decocting traditional Chinese medicines and preparing honeyed pills, wherein the decocting steps of the traditional Chinese medicines are as follows:

the honey refining step is as follows:

3. The method for preparing a medicament for the treatment of vitiligo according to claim 2, wherein: in the slow-fire decoction process of S3 and S4, the medicinal materials in the vessel are stirred by a glass rod.

4. The method for preparing a medicament for the treatment of vitiligo according to claim 2, wherein: in the steps S3 and S4, the pot cover needs to be tightly closed when the medicine is decocted by strong fire, and after the medicine liquid is boiled, the pot cover needs to be supported by two chopsticks, so that a certain gap is reserved for discharging steam.

5. The method for preparing a medicament for the treatment of vitiligo according to claim 2, wherein: the utensils in S2 and S3 need to be ceramic pots, marmite or stainless steel utensils.

6. The method for preparing a medicament for the treatment of vitiligo according to claim 2, wherein: the sealed vessel with the liquid medicine sealed in the S5 can be stored in a cool place for 1.5-2.5 days, and can be stored in a refrigerator for 4.5-5.5 days.