CN110831667A - 用于治疗先天性腹泻障碍的方法和组合物 - Google Patents

用于治疗先天性腹泻障碍的方法和组合物 Download PDF

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Publication number
CN110831667A
CN110831667A CN201880043974.4A CN201880043974A CN110831667A CN 110831667 A CN110831667 A CN 110831667A CN 201880043974 A CN201880043974 A CN 201880043974A CN 110831667 A CN110831667 A CN 110831667A
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CN
China
Prior art keywords
composition
day
crofelemer
subject
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880043974.4A
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English (en)
Chinese (zh)
Inventor
L·A·康特
P·R·查特维迪
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Napo Pharmaceuticals Inc
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Napo Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Napo Pharmaceuticals Inc filed Critical Napo Pharmaceuticals Inc
Publication of CN110831667A publication Critical patent/CN110831667A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
CN201880043974.4A 2017-05-31 2018-05-31 用于治疗先天性腹泻障碍的方法和组合物 Pending CN110831667A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762513251P 2017-05-31 2017-05-31
US62/513,251 2017-05-31
PCT/US2018/035468 WO2018222919A1 (en) 2017-05-31 2018-05-31 Methods and compositions for treating congenital diarrhea disorder

Publications (1)

Publication Number Publication Date
CN110831667A true CN110831667A (zh) 2020-02-21

Family

ID=64455032

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880043974.4A Pending CN110831667A (zh) 2017-05-31 2018-05-31 用于治疗先天性腹泻障碍的方法和组合物

Country Status (12)

Country Link
US (2) US11857510B2 (enExample)
EP (1) EP3634581B8 (enExample)
JP (1) JP2020525407A (enExample)
CN (1) CN110831667A (enExample)
AU (1) AU2018278312B2 (enExample)
CA (1) CA3065797A1 (enExample)
DK (1) DK3634581T3 (enExample)
ES (1) ES2988850T3 (enExample)
FI (1) FI3634581T3 (enExample)
IL (1) IL270984B1 (enExample)
JO (1) JOP20190275A1 (enExample)
WO (1) WO2018222919A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190276A1 (ar) 2017-05-31 2019-11-27 Napo Pharmaceuticals Inc طرق وتركيبات لعلاج إسهال الحمض الصفراوي، والإسهال المرتبط باستئصال الأمعاء الدقيقة أو إزالة المرارة، ومتلازمة الأمعاء القصيرة
JOP20190275A1 (ar) 2017-05-31 2019-11-27 Napo Pharmaceuticals Inc طرق وتركيبات لعلاج اضطراب إسهال خِلقي
WO2021257089A1 (en) * 2020-06-19 2021-12-23 Napo Pharmaceuticals, Inc. Methods and compositions for treating chemotherapy-induced diarrhea

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016111A1 (en) * 1996-10-16 1998-04-23 Shaman Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer antidiarrheal compositions
US20070254050A1 (en) * 2006-05-01 2007-11-01 Quart Barry D Method for treatment of diarrhea-predominant irritable bowel syndrome
US20120202876A1 (en) * 2009-10-06 2012-08-09 Napo Pharmaceuticals, Inc. Methods of treating diseases with proanthocyanidin oligomers such as crofelemer

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0214317B1 (fr) 1985-08-30 1988-08-17 Societe Des Produits Nestle S.A. Produit diététique à activité dépurative et anti-diarrhéique et son procédé de préparation
US5211944A (en) 1990-10-12 1993-05-18 Shaman Pharmaceuticals, Inc. Proanthocyanidin polymers having antiviral activity and methods of obtaining same
SI9011933A (sl) 1990-10-15 1998-06-30 TANIN SEVNICA Kemična industrija p.o. Kostanjev taninski ekstrakt, postopek za njegovo pridobivanje in njegova uporaba
US7767203B2 (en) 1998-08-07 2010-08-03 Ganeden Biotech, Inc. Methods for the dietary management of irritable bowel syndrome and carbohydrate malabsorption
WO2000047062A2 (en) 1999-02-01 2000-08-17 Shaman Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same
US7235573B2 (en) 2002-09-30 2007-06-26 The Regents Of The University Of California Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors
SG195538A1 (en) 2006-05-01 2013-12-30 Napo Pharmaceuticals Inc Method for treatment of constipation-predominant irritable bowel syndrome
EP2529626B1 (en) 2006-05-01 2017-11-22 Napo Pharmaceuticals, Inc. Compositions and methods for treating or preventing colon cancer
CN103370101A (zh) 2010-10-31 2013-10-23 萨利克斯药品有限公司 用于治疗hiv相关性腹泻的方法和组合物
WO2017112953A1 (en) 2015-12-23 2017-06-29 Vanessa Research, Inc. Compositions and methods of treatment for mvid and related diseases
US11389424B2 (en) 2017-03-09 2022-07-19 Napo Pharmaceuticals, Inc. Methods and compositions for treating chemotherapy-induced diarrhea
JOP20190276A1 (ar) 2017-05-31 2019-11-27 Napo Pharmaceuticals Inc طرق وتركيبات لعلاج إسهال الحمض الصفراوي، والإسهال المرتبط باستئصال الأمعاء الدقيقة أو إزالة المرارة، ومتلازمة الأمعاء القصيرة
JOP20190275A1 (ar) 2017-05-31 2019-11-27 Napo Pharmaceuticals Inc طرق وتركيبات لعلاج اضطراب إسهال خِلقي

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016111A1 (en) * 1996-10-16 1998-04-23 Shaman Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer antidiarrheal compositions
US20070254050A1 (en) * 2006-05-01 2007-11-01 Quart Barry D Method for treatment of diarrhea-predominant irritable bowel syndrome
US20120202876A1 (en) * 2009-10-06 2012-08-09 Napo Pharmaceuticals, Inc. Methods of treating diseases with proanthocyanidin oligomers such as crofelemer

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
FERNANDO CALZADA: "Management of Secretory Diarrhea", 《HTTPS://WWW.RESEARCHGATE.NET/PUBLICATION/221921824》 *
JAY R. THIAGARAJAH: "Discovery and Development of Antisecretory Drugs for Treating Diarrheal Diseases", 《CLIN GASTROENTEROL HEPATOL》 *
JAY R. THIAGARAJAH: "Secretory diarrhoea: mechanisms and emerging therapies", 《NAT REV GASTROENTEROL HEPATOL》 *
KENNETH JONES: "Review of Sangre de Drago (Croton lechleri)—A South American Tree Sap in the Treatment of Diarrhea，Inflammation, Insect Bites, Viral Infections, and Wounds:Traditional Uses to Clinical Research", 《THE JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE》 *
LOCK 等: "Bioactive Compounds from plants used in peruvian traditional medicine", 《NATPROD COMMUN》 *
LUKMANEE TRADTRANTIP 等: "Crofelemer, an Antisecretory Antidiarrheal Proanthocyanidin Oligomer Extracted from Croton lechleri, Targets Two Distinct Intestinal Chloride Channels", 《MOLECULAR PHARMACOLOGY》 *
MRINALINI C.RAO: "Oral rehydration Therapy:New Explanations for an Old Remedy", 《ANNU.REV.PHYSIOL》 *
辛丽红: "《临床内科学》", 31 October 2016 *

Also Published As

Publication number Publication date
CA3065797A1 (en) 2018-12-06
AU2018278312A1 (en) 2020-01-02
ES2988850T3 (es) 2024-11-21
IL270984B1 (en) 2026-01-01
FI3634581T3 (fi) 2024-08-16
IL270984A (en) 2020-01-30
AU2018278312B2 (en) 2024-07-04
DK3634581T3 (da) 2024-08-26
US20240325346A1 (en) 2024-10-03
JP2020525407A (ja) 2020-08-27
US11857510B2 (en) 2024-01-02
WO2018222919A1 (en) 2018-12-06
EP3634581B8 (en) 2024-09-11
US20200108047A1 (en) 2020-04-09
JOP20190275A1 (ar) 2019-11-27
EP3634581B1 (en) 2024-07-31
EP3634581A1 (en) 2020-04-15
EP3634581A4 (en) 2021-02-24

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Application publication date: 20200221