CN110812410A - External essential oil of radix codonopsis pilosulae and cortex cinnamomi for treating alopecia and promoting hair growth - Google Patents
External essential oil of radix codonopsis pilosulae and cortex cinnamomi for treating alopecia and promoting hair growth Download PDFInfo
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- CN110812410A CN110812410A CN201911306162.7A CN201911306162A CN110812410A CN 110812410 A CN110812410 A CN 110812410A CN 201911306162 A CN201911306162 A CN 201911306162A CN 110812410 A CN110812410 A CN 110812410A
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- essential oil
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- cacumen biotae
- saponin
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/483—Gleditsia (locust)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/025—Recovery by solvent extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Abstract
The invention relates to an externally applied essential oil of cassia bark, pine bark and ginseng for treating alopecia and promoting hair growth, which can effectively solve the problems of the externally applied essential oil for treating alopecia and promoting hair growth, and adopts the technical scheme that the externally applied essential oil of cassia bark, pine bark and ginseng comprises the following components: the traditional Chinese medicine composition is prepared by dissolving and uniformly mixing 4-6mL of cacumen biotae essential oil, 4-6mL of saponin essential oil, 4-6mL of pepper essential oil, 4-6mL of salvia miltiorrhiza essential oil, 4-6mL of rose essential oil and 2.5-3.5g of borneol.
Description
Technical Field
The invention relates to a medicine, in particular to an externally applied Guisong Shen essential oil for treating alopecia and promoting hair growth.
Background
Alopecia refers to the phenomenon of hair loss. The normal hair loss is the hair in the catagen and telogen phases, and the normal amount of hair can be maintained because the hair entering the catagen phase and the hair newly entering the anagen phase are constantly in dynamic balance. Pathological hair loss refers to abnormal or excessive loss of hair for a number of reasons.
Male Pattern Alopecia (MPA), also known as seborrheic alopecia and androgenetic alopecia, is a common hair disease caused by multiple factors, is frequently found in the vertex of the head and the frontotemporal region of young and old men (20-30 years old), develops gradually, is often accompanied by symptoms such as greasy skin, desquamation, pruritus and the like, and accounts for about 95% of all alopecia patients. Genetics, endocrine, occupation, diet, and stress are all causative factors of MPA.
The existing medicines for treating alopecia and promoting hair growth are various, such as minoxidil tincture for external application, finasteride for oral administration, octopus 101, kangwang and the like, and the use and the curative effect are not satisfactory for various reasons, so the improvement and innovation of the treatment medicines are imperative.
Disclosure of Invention
Aiming at the situation, in order to overcome the defects of the prior art, the invention aims to provide the cassia twig, pine and ginseng essential oil for treating alopecia and promoting hair growth by external application, which can effectively solve the problems of hair loss treatment and hair growth promotion by external application.
The technical scheme for solving the problem is that the externally applied Guisong Shen essential oil for treating alopecia and promoting hair growth comprises the following components: 4-6mL of cacumen biotae essential oil, 4-6mL of saponin essential oil, 4-6mL of pepper essential oil, 4-6mL of salvia miltiorrhiza essential oil, 4-6mL of rose essential oil and 2.5-3.5g of borneol are dissolved and uniformly mixed to prepare the traditional Chinese medicine composition, wherein:
the cacumen biotae essential oil is prepared by crushing cacumen biotae into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Extracting fluid, wherein the weight-volume ratio of liquid to material is 1: 10-20, the weight-volume ratio refers to that the solid is measured in g, the liquid is measured in mL (the same below), the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the cacumen biotae essential oil is obtained;
the saponin essential oil is prepared by crushing saponin into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Extracting with a fluid, wherein the weight-to-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain the saponin essential oil;
the pepper essential oil is prepared by crushing pepper into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Fluid extraction, liquid material weight volumeThe ratio of the raw materials to the raw materials is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the pepper essential oil is obtained.
The salvia essential oil is prepared by crushing salvia into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Extracting with a fluid, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain the salvia essential oil;
the rose essential oil is prepared by crushing rose into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Fluid extraction is carried out, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that rose essential oil is obtained;
the borneol is the borneol conforming to Chinese pharmacopoeia.
The alopecia treated by the formula belongs to the categories of alopecia areata and oily wind in the traditional Chinese medicine. In the formula, the salvia miltiorrhiza and the rose flower are used as monarch drugs for clearing heat, promoting blood circulation to remove blood stasis, promoting qi circulation and resolving stagnation. The Chinese arborvitae twig is a ministerial drug for clearing heat and removing toxicity, growing hair and blackening hair, and the Chinese honeylocust fruit and the pricklyash peel are used for killing parasites and relieving itching, are matched with borneol for promoting blood circulation and relieving itching, are externally applied to skin, and have the effects of promoting blood circulation and removing blood stasis, clearing heat and removing toxicity, relieving itching and growing hair, thereby achieving the effect of treating alopecia.
The hair-growing and hair-growing traditional Chinese medicine is rich in raw materials, simple in preparation method, easy to produce and prepare, convenient to use, good in effect, safe in medication, stable and reliable in curative effect, capable of being effectively used for treating alopecia and promoting hair growth, is an innovation in hair-growing and hair-growing medicines, and has remarkable economic and social benefits.
Detailed Description
The following examples are provided to explain the present invention in detail.
The invention may be embodied in the form of the following examples.
Example 1
In the specific implementation of the invention, the externally applied Guisong Shen essential oil for treating alopecia and promoting hair growth comprises the following components: 5mL of cacumen biotae essential oil, 5mL of saponin essential oil, 5mL of pepper essential oil, 5mL of salvia miltiorrhiza essential oil, 5mL of rose essential oil and 3g of borneol are dissolved and uniformly mixed to prepare the traditional Chinese medicine composition, wherein:
the cacumen biotae essential oil is prepared by crushing cacumen biotae into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Extracting fluid, wherein the weight-volume ratio of liquid to material is 1: 10-20, the weight-volume ratio refers to that the solid is measured in g, the liquid is measured in mL (the same below), the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the cacumen biotae essential oil is obtained;
the saponin essential oil is prepared by crushing saponin into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Extracting with a fluid, wherein the weight-to-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain the saponin essential oil;
the pepper essential oil is prepared by crushing pepper into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2And (3) fluid extraction, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that the pepper essential oil is obtained.
The salvia essential oil is prepared by crushing salvia into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Extracting with a fluid, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain the salvia essential oil;
the rose essential oil is prepared by crushing rose into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Fluid extraction is carried out, wherein the weight-volume ratio of liquid to material is 1: 10-20, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so that rose essential oil is obtained;
the borneol is the borneol conforming to Chinese pharmacopoeia.
Example 2
In the specific implementation of the invention, the externally applied Guisong Shen essential oil for treating alopecia and promoting hair growth comprises the following components: 4.5mL of cacumen biotae essential oil, 5.5mL of saponin essential oil, 4.5mL of pepper essential oil, 5.5mL of salvia miltiorrhiza essential oil, 4.5mL of rose essential oil and 3.3g of borneol are dissolved and mixed uniformly to prepare the traditional Chinese medicine composition, and the preparation method is the same as the example 1.
Example 3
In the specific implementation of the invention, the externally applied Guisong Shen essential oil for treating alopecia and promoting hair growth comprises the following components: 5.5mL of cacumen biotae essential oil, 4.5mL of saponin essential oil, 5.5mL of pepper essential oil, 4.5mL of salvia miltiorrhiza essential oil, 5.5mL of rose essential oil and 2.7g of borneol are dissolved and mixed uniformly to prepare the traditional Chinese medicine composition, and the preparation method is the same as the example 1.
The product of the invention has very good effect through experiments and clinical application, and the related data are as follows (taking the example 1 as an example):
1 laboratory animal
KM mice, male, 21-24g, SPF grade, 150. License number: SYXK (lu) 20140007;
quality certification of experimental animals: no.37009200011653, supplied by the Experimental animals centre in Shandong province. And (5) feeding in cages. Laboratory license number: SYXK 2015-.
2 Experimental reagents and drugs
2.1 Experimental reagents
Rosin: source leaf organism, lot number: c11A8Z 33639; paraffin wax: shanghai Hualing rehabilitation machinery factory, batch number: 160323; testosterone: solarbio, lot number: no. 316B031; minoxidil tincture: xiamen america pharmaceutical limited, lot number: 170727; the product of example 1 of the invention.
2.2 grouping and Molding
The mice are adapted to be bred for 3 days, rosin and paraffin are heated and melted according to the ratio of 1:1, then mixed, 2cm multiplied by 2cm gauze is soaked in the mixture, the mixture is taken out and covered on the backs (70) of the anesthetized mice after being cooled to a proper temperature, the gauze is removed from the tails after the mixture is cooled and solidified, hairs are removed, and the hair follicles of the mice are induced to enter the growth phase from the resting phase. On the day 2, mice with clean hair removal and undamaged skin are selected and randomly divided into a blank group, a model group, a minoxidil tincture group, a large and small dose of cinnamomum japonicum essential oil group, and 12 mice in each group. 50% ethanol is smeared on the blank group depilatory area, 0.1% testosterone (prepared by 50% ethanol) 0.2 mL is smeared on the depilatory areas of other groups of mice every day, and a testosterone-induced pathological alopecia model is established. Spreading testosterone for 30 min, spreading the medicines in groups, each with 0.2 mL, spreading sterile water for blank group and model group 1 time per day, and continuously for 21 days.
3 measurement index
3.1 Hair growth Observation and Scoring Hair growth scoring is performed every 3 days before application, scoring criteria: hairless growth 0 point; less than 20% is 1 point; 20 to 40 percent of the total weight is 2 minutes; 40-60% of the total weight is 3 minutes; 60% -80% is 4 minutes; 80-100% is 5 minutes.
3.2 measurement of hormone content in blood mice were sacrificed 1 h after application of the drug on day 21 and blood was collected, left at room temperature for 20 min and centrifuged at 3000 r/min for 10 min, serum was separated, the content of testosterone (T) and estradiol (E2) in blood was measured according to the kit protocol, and the value of T/E2 was calculated.
3.3 histological observation day 21, 1cm × 1cm of skin tissue of mouse depilated region was taken, tightly adhered to a rigid plastic plate to prevent its shrinkage by curling, fixed with 4% formalin, prepared into conventional HE pathological section, and magnified 100 times under microscope to count hair follicle number and take pictures.
4 statistical treatment
Statistical processing of data using the SPSS 19.0 statistical software package for data analysis, mean. + -. standard deviation for data measurement: (
S) is expressed by adopting one-factor analysis of variance, the Least Significant Difference (LSD) method is adopted for the uniform variance testers, the Games-Howell method is adopted for the non-uniform variance testers, and the grade data is adoptedRaditAnd (6) checking.
5 results of the experiment
5.1 Effect on Hair regrowth score in bald mice
TABLE 1 influence of Guisong Shen essential oil on Hair regrowth score of mouse alopecia model ((
±s，n=12)
| Grouping | Day 8 | Day 12 | Day 16 | Day 20 |
| Blank group | 0.6±0.52 | 1.3±0.95 | 3.1±0.74 | 4.8±0.42 |
| Model set | 0.5±0.53 | 0.9±0.57# | 2±0.67## | 3.7±0.48## |
| Minoxidil tincture group | 0.6±0.52 | 1.7±0.82* | 3.1±0.57** | 4.6±0.52** |
| Guisong ginseng essential oil small dosage group | 0.5±0.53 | 1.2±0.79 | 2.8±0.63* | 4.4±0.52** |
| Guisong ginseng essential oil large dose group | 0.6±0.52 | 1.6±0.84* | 2.9±0.74* | 4.5±0.53** |
Note: in comparison to the blank set,## P<0.01，# P<0.05; as compared with model groupP<0.01，*P<0.05
As can be seen from table 1: on day 12 of modeling, the hair regrowth score in the model group was significantly reduced compared to the blank group (P<0.05); compared with the model group, the Guisong Shen essential oil large dose group and the minoxidil tincture group can obviously improve the hair regeneration score (P<0.05). Significantly lower reduction in hair regrowth scores in the model group compared to the blank group on day 16 of molding: (P<0.01); compared with the model group, the big and small dosage groups of the essential oil of the cinnamomum cassia presl can obviously improve the hair regeneration score (P<0.05), Minoxidil tincture group can significantly improve hair regrowth score (P<0.01). On day 20 of molding, the hair regrowth score was significantly reduced in the model group compared to the blank group (P<0.01); compared with the model group, the Guisong Shen essential oil large dose group, the Guisong Shen essential oil small dose group and the minoxidil tincture group can obviously improve the hair regeneration score (P<0.01）。
5.2 Effect on serum hormone levels in baldness mice
TABLE 2 Effect of Guisong Shen essential oil on serum hormone levels in mouse alopecia model ((
±s，n=12)
| Grouping | T（pmol/mL） | E2（pmol/mL） | T/E2 |
| Blank group | 28.36±2.94 | 11.06±0.83 | 2.57±0.29 |
| Model set | 38.44±2.69## | 8.37±0.94## | 4.64±0.6## |
| Minoxidil tincture group | 30.98±1.93** | 9.96±1.03** | 3.13±0.35** |
| Guisong ginseng essential oil small dosage group | 35.03±3.26* | 9.15±0.69* | 3.85±0.46** |
| Guisong ginseng essential oil large dose group | 34.41±2.59** | 9.35±0.48** | 3.69±0.35** |
Note: in comparison to the blank set,## P<0.01，# P<0.05; as compared with model groupP<0.01，*P<0.05
As can be seen from table 2: the serum T, T/E2 levels in the model group were significantly elevated compared to the blank group (P<0.01), E2 is significantly reduced by (P<0.01); compared with the model group, the Guisong Shen essential oil large dose group and the minoxidil tincture group can obviously reduce the serum T level (P<0.01) the group with small dosage of the essential oil of the cinnamomum cassia presl can obviously reduce the level of the serum T (P<0.05); the Guisong ginseng essential oil large dose group and the minoxidil tincture group can obviously increase the serum E2 level (P<0.01) the group with small dosage of the essential oil of the cinnamomum cassia presl can obviously increase the level of serum E2 (P<0.05); the large and small dose groups of the Guirong Shen essential oil and the minoxidil tincture group can obviously reduce the serum T/E2 level (P<0.01）。
5.3 Effect of the test agent on the morphology of the skin tissue of the mice with alopecia
Effects on the skin pathological tissues of bald mice: blank group: the skin epidermis is covered with 2-3 layers of stratified squamous epithelium with the thickness of 18-30 um; the length of the hair is 500-800um, the diameter of the hair follicle is 50-100um, the thickness of the dermis is 300-600um, and the number of the hair follicle, the sebaceous gland and the sweat gland is normal. Model group: the epidermis of the skin is nearly normal, the hair follicles atrophy in reduced numbers, and the sebaceous and sweat glands are reduced in numbers. Minoxidil tincture group: the epidermis is normal, the number of hair follicles is constant, the hair follicle size becomes small, the hair bulb is atrophic, and the length of the hair is 300-. The large-dose group dosage group of the cinnamon, pine and ginseng essential oil comprises the following components: the skin epidermis is covered with 2-3 layers of stratified squamous epithelium with the thickness of 18-30 um; the length of the hair is 500-800um, and the diameter of the hair follicle is 50-100um; the hair bulb cells are actively proliferated; the thickness of the dermis is 300-; normal numbers of hair follicles, sebaceous glands and sweat glands. The small-dose group dosage group of the cinnamon, pine and ginseng essential oil comprises the following components: the epidermis is normal, the number of hair follicles is reduced, the function of the hair follicles is reduced, hair bulbs are atrophied, the length of hairs is slightly short, and the thickness of dermis is basically normal. .
TABLE 3 Effect of Guisong Shen essential oil on local skin tissue morphology of mouse alopecia model
| Group of | Number only | - | + | ++ | +++ |
| Blank group | 12 | 12 | 0 | 0 | 0 |
| Model set | 12 | 0 | 4 | 6 | 2 |
| Minoxidil tincture group | 12 | 6 | 3 | 3 | 0 |
| Guisong ginseng essential oil small dosage group | 12 | 8 | 2 | 2 | 0 |
| Guisong ginseng essential oil large dose group | 12 | 4 | 3 | 3 | 2 |
-: the thickness of epidermis and dermis is normal, the length of hair is normal, the hair bulb volume and the cell activity are normal, and the skin attachment is normal; +: the thickness of epidermis and dermis is normal, the length of hair is slightly short, the volume of hair follicle and hair bulb is reduced, and the skin attachment is normal; ++: the thickness of epidermis and dermis is normal, the length of hair is obviously shortened, the volume of hair follicle and hair bulb is shrunk and reduced, and the skin attachment is reduced along with the reduction of the hair follicle; +++: the thickness of epidermis and dermis is normal, the length of hair is shortened, hair follicles and hair bulbs disappear, a little hair shaft and hair roots remain, and skin attachments are reduced along with the reduction of the hair follicles.
As can be seen from table 3: compared with the blank group, the local tissues of the model group have obvious pathological changes (P<0.01); compared with the model group, the Guisong Shen essential oil large dose group and the minoxidil tincture group can obviously reduce local pathological changes: (P<0.01), the group with small dosage of the essential oil of the cinnamomum cassia presl can obviously relieve local pathological changesP<0.05）。
Second, clinical application
Under the condition of ensuring safety in animal experiments, the composition is clinically applied to patients suffering from alopecia, and a very satisfactory curative effect is obtained, and specific data are as follows (taking example 1 as an example):
male Pattern Alopecia (MPA), also known as seborrheic alopecia and androgenetic alopecia, is a common hair disease caused by multiple factors, is frequently found in the vertex of the head and the frontotemporal region of young and old men (20-30 years old), develops gradually, is often accompanied by symptoms such as greasy skin, desquamation, pruritus and the like, and accounts for about 95% of all alopecia patients. Genetics, endocrine, occupation, diet, and stress are all causative factors of MPA.
20 male pattern alopecia patients have the onset age of 20-32 years and the disease course of 5 months-8 years. The inclusion standard meets the diagnosis standard of Chinese clinical dermatology and Chinese medicine dermatosis, and the patients do not use any hair growth promoting medicine and other local treatment within half a year before treatment. Exclusion criteria: infectious diseases or eczema exist in scalp, and organic diseases such as cardiovascular and cerebrovascular diseases, hypertension and the like are combined; other types of alopecia, such as alopecia areata, tinea capitis, trauma, etc.
The treatment scheme comprises the following steps: smearing the essential oil of radix Codonopsis Lanceolatae with a volume of 0.15mL/cm in a hair-shedding area every day2Externally applying the essential oil for 2 times every day, and massaging the local skin for 3-5 min by hands after applying the essential oil, wherein the treatment course is 21 d;
the therapeutic effect judgment standard is as follows: and (3) healing: the hair stops falling off, the new hair is complete and uniform in length, the glossiness of hair scales, the thickness of the hair and the distribution density of the hair scales are the same as those of a hair-care area, and sebum secretion is normal; the effect is shown: the disease condition is controlled, the new hair part grows (70%), the glossiness, the hair thickness and the distribution density of the hair scales are close to those of a hair-care area, and the sebum secretion is obviously reduced; the method has the following advantages: the disease condition is controlled, but only 30% of bald areas have new hair growth; and (4) invalidation: the hair continues to fall off and the hair loss is regenerated by less than 30%.
Statistical treatment results: 20 male alopecia patients are cured, 11 patients are cured, 6 patients are effective, 2 patients are effective, 1 patient is ineffective, and the total effective rate is 95%.
The same experiment is carried out on the example 1 and the examples 2 and 3 at the same time, and the same and similar results are obtained, which shows that the product has good quality and stable and reliable curative effect, and are not listed any more.
Conclusion
The medicine has the effects of preventing alopecia and promoting production, can be effectively used for treating alopecia and promoting hair growth, is easy to produce and prepare, convenient to use and good in effect, is an innovation in the medicine for treating alopecia and promoting hair growth, and has remarkable economic and social benefits.
Claims (4)
1. An externally applied essential oil of cassia twig, pine and ginseng for treating alopecia and promoting hair growth is characterized by comprising the following components: 4-6mL of cacumen biotae essential oil, 4-6mL of saponin essential oil, 4-6mL of pepper essential oil, 4-6mL of salvia miltiorrhiza essential oil, 4-6mL of rose essential oil and 2.5-3.5g of borneol are dissolved and uniformly mixed to prepare the traditional Chinese medicine composition, wherein:
the cacumen biotae essential oil is prepared by crushing cacumen biotae into coarse powder which is sieved by a sieve of 10-20 meshes and supercritical CO2Extracting fluid, wherein the weight-volume ratio of liquid to material is 1: 10-20, the weight-volume ratio refers to that the solid is counted by g, the liquid is counted by mL, the extraction temperature is 42-50 ℃, the extraction pressure is 20-25 MPa, the separation temperature is 50-60 ℃, the separation pressure is 4.5-5.5 MPa, and the extraction time is 1.5-2.5 h, so as to obtain the cacumen biotae essential oil;
the preparation methods of the saponin essential oil, the pepper essential oil, the salvia essential oil and the rose essential oil are the same as the cypress leaf essential oil.
2. The externally applied cassia pine and ginseng essential oil for treating alopecia and promoting hair growth according to claim 1, which is characterized by comprising the following components: 5mL of cacumen biotae essential oil, 5mL of saponin essential oil, 5mL of pepper essential oil, 5mL of salvia miltiorrhiza essential oil, 5mL of rose essential oil and 3g of borneol are dissolved and mixed evenly to prepare the traditional Chinese medicine.
3. The externally applied cassia pine and ginseng essential oil for treating alopecia and promoting hair growth according to claim 1, which is characterized by comprising the following components: 4.5mL of cacumen biotae essential oil, 5.5mL of saponin essential oil, 4.5mL of pepper essential oil, 5.5mL of salvia miltiorrhiza essential oil, 4.5mL of rose essential oil and 3.3g of borneol are dissolved and mixed to prepare the traditional Chinese medicine.
4. The externally applied cassia pine and ginseng essential oil for treating alopecia and promoting hair growth according to claim 1, which is characterized by comprising the following components: 5.5mL of cacumen biotae essential oil, 4.5mL of saponin essential oil, 5.5mL of pepper essential oil, 4.5mL of salvia miltiorrhiza essential oil, 5.5mL of rose essential oil and 2.7g of borneol are dissolved and mixed to prepare the traditional Chinese medicine.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106362119A (en) * | 2016-10-26 | 2017-02-01 | 肖瑞彬 | Hair growth embrocation containing ginseng and preparation method of hair growth embrocation |
| CN107812103A (en) * | 2016-09-12 | 2018-03-20 | 孙红元 | A kind of Chinese medicine of hair growth |
| CN109125474A (en) * | 2018-10-15 | 2019-01-04 | 河南中医药大学 | A kind of silver yellow ginseng essential oil for treating solar dermatitis |
-
2019
- 2019-12-18 CN CN201911306162.7A patent/CN110812410A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107812103A (en) * | 2016-09-12 | 2018-03-20 | 孙红元 | A kind of Chinese medicine of hair growth |
| CN106362119A (en) * | 2016-10-26 | 2017-02-01 | 肖瑞彬 | Hair growth embrocation containing ginseng and preparation method of hair growth embrocation |
| CN109125474A (en) * | 2018-10-15 | 2019-01-04 | 河南中医药大学 | A kind of silver yellow ginseng essential oil for treating solar dermatitis |
Non-Patent Citations (1)
| Title |
|---|
| 韩月等: "祛脂活血生发汤联合梅花针治疗脂溢性脱发", 《实用中西医结合临床》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117357624A (en) * | 2023-11-17 | 2024-01-09 | 四川省天府香疗健康技术研究院有限公司 | Hair-growing and hair-loss-preventing traditional Chinese medicine essential oil composition and preparation method and application thereof |
| CN117357624B (en) * | 2023-11-17 | 2024-03-26 | 四川省天府香疗健康技术研究院有限公司 | Hair-growing and hair-loss-preventing traditional Chinese medicine essential oil composition and preparation method and application thereof |
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