CN112826892B - Traditional Chinese medicine for treating alopecia areata, androgenetic alopecia and white hair and preparation method of medicine thereof - Google Patents

Abstract

The invention relates to the preparation method for Chinese medicine and medicament for the treatment of alopecia areata, androgenetic alopecia and poliosis, the active ingredient that this Chinese medicine medicament contains is 10-25 of fructus Ligustri Lucidi, 10-30 of semen Sesami nigrum, 1-15 of spina Gleditsiae, 1-15 of folium mori, 1-15 of herba Agrimoniae, 10-30 of fructus mume, 10-25 of rhizoma Polygonati, 10-25 of fructus Lycii, 10-30 of radix rehmanniae, 1-5 of Scolopendra, 10-30 of radix Salviae Miltiorrhizae, 10-25 of cacumen Platycladi; also discloses a method for preparing the traditional Chinese medicine preparation. The traditional Chinese medicine preparation disclosed by the invention is used for treating alopecia areata, androgenetic alopecia and canities, and has the advantages of good curative effect, light side effect, low price, low recurrence rate and no generation of dependence.

Description

Traditional Chinese medicine for treating alopecia areata, androgenetic alopecia and white hair and preparation method of medicine thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine for treating alopecia areata, androgenetic alopecia and leukotrichia and a preparation method of the traditional Chinese medicine.

Background

The cause of alopecia areata is unclear. The disease is caused by the infiltration of lymphocytes around hair follicles and is sometimes combined with other autoimmune diseases such as vitiligo and atopic dermatitis, so that the occurrence of the disease is considered to have a possible autoimmune pathogenesis. Genetic predisposition is also an important factor, possibly associated with HLA type ii, with a family history in 25% of cases. In addition, it may be associated with nerve trauma, psychiatric disorders, infectious disease and endocrine disorders.

Alopecia areata can occur at any age, but is common in young and strong years, and the incidence rate of both sexes is not obviously different. Skin lesions appear as round or oval non-scarring alopecia, with "exclamation mark" -like hair often visible at the margin of alopecia areata. Hair falls completely or almost completely, called alopecia totalis. All hairs (including body hair) are lost throughout the body, called alopecia universalis. Creeping alopecia can also be seen. The skin of the affected area has no other abnormalities except for hairless skin.

The pathogenesis is not well understood. The hair follicle is damaged and scars are formed due to various reasons, so that permanent baldness is generated. Alopecia areata is an autoimmune disease that has been more prevalent in recent years. Alterations in humoral immunity include non-organ specific autoantibodies and organ specific autoantibodies. Anti-smooth muscle antibodies, antinuclear antibodies (mainly of the spot type), anti-mitochondrial antibodies, anti-basement membrane antibodies, and rheumatoid factors have been reported. Organ-specific autoantibodies have been reported to be antithyroid antibodies, anti-parietal cell antibodies, anti-adrenal gland antibodies, and the like. The rate of positive autoantibodies is related to the sex, age and severity of the condition of the patient. The cellular immunity changes into a large amount of lymphocyte infiltration around blood vessels and hair bulbs of alopecia areata skin lesions. The study also found that the hair follicles in the bald area have strong HLA class I, II immunoreactivity, and adhesion molecules involved in the migration of hematopoietic cells are abnormally expressed. These changes may be caused by cytokine release resulting from certain stimuli such as trauma, neuroinflammation or infection. Cytokines can be involved in a variety of immune response processes leading to the development of an immune response against antigens unique to the hair follicle. In recent years, studies on various immune-modulation-related cytokines in alopecia areata have been spotlighted. Although the mechanisms described above are prevalent, the exact etiology is unclear and no definitive autoantigens and virulence genes have been demonstrated. The genetic type of hair loss is not known. Polygenic genetic patterns with different rates and degrees of expression appear to be reasonable but are still affected by additional hormones and immunity.

Androgenetic alopecia, also known as seborrheic alopecia, tinea pedis, premature alopecia, sexual alopecia, male alopecia, diffuse alopecia, and alopecia universalis, is associated with heredity, androgenic alopecia, and seborrhea, and is commonly used in medicine such as seborrheic alopecia. The symptoms are that the grease secretion of the scalp is excessive, and the hair has greasy feeling. The clinical manifestations are that the scalp fat of the patient overflows excessively, which causes the scalp to be greasy and moist, and the dust and the scurf are mixed, so the scalp is dirty without washing the head for a few days and gives off odor, especially when the temperature is high; scalp itching and inflammation are also sometimes caused, mainly because of scalp dampness and bacterial multiplication infection to cause seborrheic dermatitis. Alopecia generally starts from the middle of the two forehead corners, forehead and vertex and then spreads over the vertex, but the hair around the head is not so much lost. In severe cases, the bald area becomes oily and shiny, and the remaining hair becomes thin, soft, withered and yellow.

The alopecia is common in men and rare in women, and brainworkers are more than physical workers. Clinically, it is likely to be related to endocrine function of the body, mainly androgen, mental state, heredity and some drug factors. Mainly in the young male, but in recent years there has been an increasing trend in the number of female patients. Patients generally have persistent alopecia from the second decade to the third decade, and generally have basic baldness from the fourth decade, which seriously affects beauty.

White hair, which is the complete or partial whitening of the finger hair. For instance, the white hair syndrome is recorded in the white hair syndrome in the "theory of various etiological factors: the kidney governs the bone marrow and it is manifesting on the hair. If the blood-qi is strong, the kidney-qi is strong, and the bone marrow is full of the kidney-qi, so it is moist and black; when blood qi is deficient, kidney qi becomes weak, and when kidney qi is weak, bone marrow becomes exhausted, so the hair becomes white.

White hair includes senile white hair and lack of white hair, senile white hair is a physiological phenomenon, and white hair diseases can be divided into congenital and acquired types. Congenital leukotrichia is accompanied with albinism, sometimes occurs in some hereditary diseases patients, and is characterized by familial inheritance. In addition to senile poliosis, premature poliosis is common in acquired poliosis, which may be genetically related, but also is an important factor for mental trauma, emotional agitation, pessimistic depression, malnutrition, and the like.

Generally, in the patients with alopecia areata, androgenetic alopecia and poliosis, in addition to the external symptoms such as alopecia and poliosis which are obvious to the body, the mental health status of the patients also has certain damage during the disease period.

Modern medicine considers that under normal conditions, human hair papilla has abundant blood vessels, which provides sufficient nutrition for hair papilla and hair bulb, so that hair growth hormone is smoothly synthesized. Various adverse stimuli (influence of hormone level, influence of neurostimulation, etc.) cause vasospasm of supplying hair nutrition, and dysfunction of nutrition-transporting function of hair papilla and hair bulb part. When nutrient synthesis is inhibited in the formation of papilla and bulbus pili, or when ATP having a cell energy function is produced due to some factor, production of ATP is inhibited. ATP, which is a heat source, is not produced, and thus protein synthesis of hair is not performed, hair mother cells lose activity, nutrients in medullary and cortex portions of hair are reduced, keratinization begins, hair follicles begin to atrophy or necrose, hair enters a resting stage in a large amount, and hair falls off in a large amount.

According to the theory of traditional Chinese medicine: the hair has a close relationship with liver and kidney, the kidney stores essence and liver and governs blood, the essence and blood are insufficient due to liver and kidney deficiency, the hair follicle cannot obtain sufficient nutrition, the capacity of synthesizing melanin is weakened, white hair appears, and the hair follicle is atrophied or necrotized to cause alopecia. Otherwise, the liver and kidney are strong and the upper part is good at the head, so the hair is thick and dark.

The current treatment scheme of western medicine for alopecia areata is as follows:

1. general treatment: the removal of the medicine can induce the etiology, and attention is paid to the overstrain and the rest of alopecia areata can be naturally cured within 6-12 months. For patients with wide baldness range or alopecia totalis and alopecia universalis, the wig should be worn to relieve psychological burden.

2. Topical drug therapy:

1) 2% or 5% minoxidil (minoxidil) solution, 10% capsicum tincture, etc. can improve local blood circulation and promote hair growth, and hair regeneration can occur in 2-3 months.

2) The bald area can be externally used or injected with glucocorticoid to relieve perifollicular inflammation, and prednisolone suspension or compound betamethasone injection can be injected intradermally, and can take effect after 3-4 times.

3. Systemic drug therapy: oral administration of cystine, calcium pantothenate, vitamin B group can help to promote hair growth. Prednisone can be orally administered to patients with mental stress, anxiety, and insomnia by administering other sedatives to patients with rapid and extensive alopecia including alopecia totalis and alopecia universalis. Can be used in combination with compound glycyrrhizin, total glucosides of paeony, blood nourishing and hair growth promoting capsules, thin sesame slices, polygonum multiflorum slices and the like.

4. Photoelectric treatment: researches report that PUVA therapy, long-wave ultraviolet rays, narrow-spectrum medium-wave ultraviolet rays, photodynamic therapy, 308nm single-frequency excimer light and excimer laser, a pulse infrared diode (904nm), low-energy laser, lattice carbon dioxide laser and the like all have a certain treatment effect on alopecia areata.

5. And others: moderate to severe alopecia areata (bald area > 50%) can be treated with topical contact sensitizers, Diphenylcyclopropenone (DPCP), leading to hair regrowth at the lesion site, mainly by inducing the development of contact dermatitis.

The current treatment scheme of western medicine for androgenetic alopecia is as follows:

1. systemic treatment: finasteride can inhibit II-5 alpha reductase and testosterone to DHT, and can be continuously administered for 6-12 months or more, if the curative effect needs to be maintained for a longer time. Cyproterone is suitable for female patients, especially patients complicated with acne and hirsutism.

2. The external medicine comprises: minoxidil is an external hair growth promoting drug, generally 5% concentration is recommended for men, 2% concentration is recommended for women, and contact dermatitis and hirsutism are common adverse reactions.

3. Hair transplantation: hair transplantation is a method in which hair follicles (generally, the occiput) in a congenital androgen-insensitive region are separated and transplanted to a bald area. Follicular unit hair transplantation technique (FUT) is one of the commonly used methods.

4. Other patients with severe AGA who are ineffectual to medication or surgery may be covered with hair pieces, wigs, etc.

At present, the western medicine aims at the treatment of the white hair, and no clinically effective medicine and treatment scheme exist.

The western medicine has strong dependence on alopecia areata and androgenetic alopecia and easily causes repeated side effects after generating drug dependence.

The external treatment methods of traditional Chinese medicine can be divided into two categories: external treatment with drugs, or external treatment without drugs. According to the different treatment routes, the external treatment methods can be divided into four categories, including integral treatment, treatment of skin, mucous membrane of sense organs and orifices, treatment of meridians and acupoints, and other treatments. The treatment of skin and mucosa of sense organ and orifice refers to the method of absorption of medicine through skin and mucosa of sense organ and orifice into local part or circulatory system of body for therapeutic effect, such as application therapy, fumigation therapy, etc. The traditional Chinese medicine external treatment is a traditional Chinese medicine treatment method characterized by outstanding traditional Chinese medicine external treatment, has unique curative effect, rapid action, long history, and the characteristics of simplicity, convenience, cheapness and verification, and therefore has important significance for the development of the traditional Chinese medicine external treatment method for treating alopecia areata, androgenetic alopecia and leukotrichia.

Disclosure of Invention

The present invention aims at providing Chinese medicine for treating alopecia areata, androgenetic alopecia and white hair and its preparation process.

The technical scheme adopted by the invention is as follows:

a Chinese medicament for treating alopecia areata, androgenetic alopecia and white hair,

the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 10-25 parts of glossy privet fruit, 10-30 parts of black sesame, 1-15 parts of spina gleditsiae, 1-15 parts of mulberry leaf, 1-15 parts of hairyvein agrimony, 10-30 parts of dark plum, 10-25 parts of rhizoma polygonati, 10-25 parts of medlar, 10-30 parts of radix rehmanniae recen, 1-5 parts of centipede, 10-30 parts of salvia miltiorrhiza and 10-25 parts of cacumen biotae.

Preferably, the traditional Chinese medicine comprises the following raw materials in parts by weight: 15 parts of glossy privet fruit, 20 parts of black sesame, 10 parts of Chinese honeylocust spine, 10 parts of mulberry leaf, 15 parts of hairyvein agrimony, 20 parts of dark plum fruit, 15 parts of rhizoma polygonati, 15 parts of medlar, 30 parts of radix rehmanniae recen, 3 parts of centipede, 20 parts of salvia miltiorrhiza and 15 parts of cacumen biotae.

The preparation method of the traditional Chinese medicine preparation for treating alopecia areata, androgenetic alopecia and white hair comprises the following process steps:

(1) weighing glossy privet fruit, black sesame, spina gleditsiae, mulberry leaf, hairyvein agrimony, dark plum fruit, rhizoma polygonati, medlar, radix rehmanniae recen, centipede, salvia miltiorrhiza and cacumen biotae according to the weight ratio for later use;

(2) pulverizing Scolopendra to fine powder, packaging with one-time decocting bag, placing in a glass chemical reagent bottle, adding ethanol, sealing, soaking for 1 week, and collecting supernatant;

(3) putting the glossy privet fruit, the black sesame, the spina gleditsiae, the mulberry leaf, the hairyvein agrimony, the dark plum, the sealwort, the medlar, the dried rehmannia root, the red sage root and the cacumen biotae into a wide-mouth reagent bottle according to the weight ratio, adding ethanol, sealing the cover, soaking for 3 weeks, and pouring out supernatant for later use;

(4) and (3) uniformly mixing the leaching solution obtained in the step (2) and the leaching solution obtained in the step (3), uniformly stirring, and filtering the drug residues to obtain the traditional Chinese medicine preparation.

Further, in the step (2), 1000ml of 75% ethanol was added.

Further, in step (3), 3000ml of 75% ethanol was added.

Preferably, the traditional Chinese medicine preparation is a tincture preparation.

The Chinese medicinal herbs used in the invention have the following medicinal properties:

glossy privet fruit: nature and taste: bitter and sweet, neutral; it enters liver, lung and kidney meridians; the functions are as follows: nourishing liver and kidney, strengthening waist and knee, improving eyesight and blackening hair; the main treatment is as follows: dizziness, vertigo, tinnitus, soreness and weakness of the loins and knees, early white beard and hair, dim and unclear vision.

Black sesame seed: nature and taste: sweet and mild; it enters liver, kidney and large intestine meridians; the functions are as follows: tonify liver and kidney, benefit essence and blood, moisten intestine dryness; the main treatment is as follows: dizziness, tinnitus, deafness, premature graying of hair, alopecia after illness, constipation due to intestinal dryness.

Spina gleditsiae: nature and taste: pungent and warm; entering liver and stomach meridians; the functions are as follows: detumescence, expelling toxin, expelling pus and killing parasites. The main treatment is as follows: early carbuncle and deep-rooted carbuncle or pus formed without ulceration; it is indicated for external treatment of scabies and leprosy.

Mulberry leaf: nature and taste: sweet, bitter and cold; entering lung and liver meridians; the functions are as follows: disperse wind-heat, clear lung-heat and moisten dryness, clear liver and improve vision; the main treatment is as follows: wind-heat type common cold, lung heat dryness cough, dizziness, headache, conjunctival congestion and blurred vision.

Agrimony: nature and taste: bitter, astringent and mild; heart and liver meridian entered; the main treatment is as follows: astringe to stop bleeding, check malaria, stop dysentery, remove toxicity; the functions are as follows: hemoptysis, hematemesis, metrorrhagia, metrostaxis, malaria, dysentery with blood, overstrain injury, carbuncle, sore, itching vulva, leukorrhagia.

Dark plum: nature and taste: sour, astringent and flat; it enters liver, spleen, lung and large intestine meridians; the functions are as follows: astringe lung, astringe intestine, promote fluid production, relieve ascarid; the main treatment is as follows: chronic cough due to lung deficiency, chronic dysentery, intestine dryness, asthenia heat, diabetes, vomiting, abdominal pain due to ascariasis, and ascariasis of biliary tract.

Rhizoma polygonati: nature and taste: sweet and mild; entering spleen, lung and kidney meridians; the functions are as follows: invigorating qi, nourishing yin, invigorating spleen, moistening lung, and invigorating kidney; the main treatment is as follows: deficiency of spleen-stomach qi, tiredness, hypodynamia, deficiency of stomach yin, dry mouth, cough, blood deficiency, soreness and weakness of waist and knees, early white beard and hair, internal heat, diabetes.

Medlar: nature and taste: sweet and mild; entering liver and kidney meridians; the functions are as follows: nourishing liver and kidney, replenishing vital essence and improving eyesight; the main treatment is as follows: consumptive disease and essence deficiency, soreness and pain of waist and knees, vertigo, tinnitus, internal heat, diabetes, blood deficiency, sallow complexion, blurred vision, and blurred vision.

Dried rehmannia root: nature and taste: sweet and cold; heart, liver and kidney meridians entered; the functions are as follows: clearing heat and cooling blood, nourishing yin and promoting the production of body fluid; the main indications are as follows: a deep-red tongue with polydipsia, yin deficiency with internal heat, bone steaming with internal heat, internal heat with diabetes, hematemesis, epistaxis, macula and eruption.

Centipede: property and taste: pungent and warm; is toxic; entering liver meridian; the functions are as follows: wind-extinguishing, spasm-relieving, toxin-expelling, nodulation-dissipating, collateral-dredging and pain-relieving; the main indications are as follows: a deep-red tongue with polydipsia, yin deficiency with internal heat, bone steaming with internal heat, internal heat with diabetes, hematemesis, epistaxis, macula and eruption.

Red sage root: nature and taste: bitter and slightly cold; heart and liver meridian entered; the functions are as follows: removing blood stasis, relieving pain, promoting blood circulation, dredging channels, clearing away heart-fire, and relieving restlessness; the main treatment is as follows: menoxenia, amenorrhea, dysmenorrhea, abdominal mass, thoracico-abdominal pain, arthralgia due to heat, pyocutaneous disease, swelling and pain, vexation, and insomnia; hepatosplenomegaly, angina pectoris.

Cacumen biotae: nature and taste: bitter, astringent and cold; it enters lung, liver and spleen meridians; the functions are as follows: cooling blood, stopping bleeding, resolving phlegm, relieving cough, promoting hair growth and blackening hair; the main treatment is as follows: hematemesis, epistaxis, hemoptysis, hematochezia, metrorrhagia, metrostaxis, cough due to lung heat, alopecia due to blood heat, and premature graying of hair.

Compared with the prior art, the invention has the following beneficial effects: the traditional Chinese medicine preparation disclosed by the invention has the effects of tonifying qi and relieving alopecia, activating blood and nourishing yin, tonifying kidney and replenishing essence and blackening hair for a user, so that the symptoms of alopecia areata, androgenetic alopecia and poliosis are relieved, and meanwhile, on the basis of treating the symptoms of external alopecia and poliosis, the traditional Chinese medicine preparation disclosed by the invention has the effects of calming and relaxing mood for the user, relieves the psychological burden of the user and is beneficial to better treatment effect. According to clinical tests, the traditional Chinese medicine preparation has the advantages of good curative effect, light side effect and no generation of dependence. The invention adopts an immersion method to purify the effective components of the traditional Chinese medicine, has simple preparation and easy storage.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.

FIG. 1 is a flow chart of step (2) in the production method of the present invention.

FIG. 2 is a diagram showing selected starting materials in step (2) of the production process of the present invention.

FIG. 3 is a flow chart of step (3) in the production method of the present invention.

Detailed Description

The following examples may assist those skilled in the art in a more complete understanding of the present invention, but are not intended to limit the invention in any way.

Example 1

Referring to fig. 1-3, the traditional Chinese medicine for treating alopecia areata, androgenetic alopecia and leukotrichia is prepared from the following raw materials in parts by weight: 10-25 parts of glossy privet fruit, 10-30 parts of black sesame, 1-15 parts of spina gleditsiae, 1-15 parts of mulberry leaf, 1-15 parts of hairyvein agrimony, 10-30 parts of dark plum, 10-25 parts of rhizoma polygonati, 10-25 parts of medlar, 10-30 parts of radix rehmanniae recen, 1-5 parts of centipede, 10-30 parts of salvia miltiorrhiza and 10-25 parts of cacumen biotae.

In the traditional Chinese medicine formula, the optimal mixture ratio is 15 parts of glossy privet fruit, 20 parts of black sesame, 10 parts of Chinese honeylocust spine, 10 parts of mulberry leaf, 15 parts of hairyvein agrimony, 20 parts of dark plum fruit, 15 parts of rhizoma polygonati, 15 parts of medlar, 30 parts of radix rehmanniae recen, 3 parts of centipede, 20 parts of salvia miltiorrhiza and 15 parts of cacumen biotae. The preparation method of the traditional Chinese medicine preparation for treating alopecia areata, androgenetic alopecia and white hair comprises the following steps:

(1) weighing glossy privet fruit, black sesame, spina gleditsiae, mulberry leaf, hairyvein agrimony, dark plum fruit, rhizoma polygonati, medlar, radix rehmanniae recen, centipede, salvia miltiorrhiza and cacumen biotae according to the weight ratio for later use;

(2) pulverizing Scolopendra into fine powder, packaging with one-time decocting bag, placing into a glass chemical reagent bottle, adding 1000ml 75% ethanol, sealing, soaking for 1 week, and collecting supernatant;

(3) putting fructus Ligustri Lucidi, semen Sesami Niger, spina Gleditsiae, folium Mori, herba et Gemma Agrimoniae, mume fructus, rhizoma Polygonati, fructus Lycii, radix rehmanniae, Saviae Miltiorrhizae radix, and folium Platycladi into a wide-mouth reagent bottle, adding 3000ml 75% ethanol, sealing, soaking for 3 weeks, and collecting supernatant;

(4) and (3) uniformly mixing the leaching solution obtained in the step (2) and the leaching solution obtained in the step (3), uniformly stirring, and filtering the drug residues to obtain the traditional Chinese medicine preparation.

In particular, alopecia areata (Chinese medicine 'oily wind'), androgenetic alopecia (Chinese medicine 'decayed hair tinea'), and white hair (Chinese medicine 'white hair').

Typical cases are as follows:

example 1:

a woman who is 66 years old, Shanxi Yuancheng people, 2019-07-18, can see a doctor and retire employees.

The spot-like alopecia on the vertex of the head is more than 2 months, the female company finds the spot-like alopecia on the occipital part after the head is washed at first, the spot-like alopecia is soybean-sized, the female company is informed that the patient is not aware of the spot-like alopecia, the alopecia also appears on the vertex after 1 week, then the alopecia is spread all over the head, and the female company is diagnosed in a local hospital and informed that the old is difficult to cure and returns to home for self-maintenance. During running, the traditional Chinese medicine is diagnosed at the department, is diagnosed as 'oily wind disease' and 'liver and kidney yin deficiency syndrome', is added or subtracted with 'glutinous rehmannia drink', is used for treating through percussive acupuncture and externally applied 'the traditional Chinese medicine prepared by the formula', once a day, the hair falls and stops after one week of treatment, the plaque is not externally developed, the hair at the hair loss part is regenerated after one month, the traditional Chinese medicine cannot stay at the western safe relative family for a long time, the traditional Chinese medicine is taken by the family after 14 times of taking the formula, and the prescription is taken once every month after the return diagnosis.

Example 2:

a certain person in a car, male, Shaanxi Xing Ping, a 39-year-old person, a 2019-11-15, and a national cadre.

The hair loss of the whole head is interrupted for more than 4 years, the work pressure is the cause at first, the attention is not paid, the hair loss is increased day by day in 2 years, the white hair of two temples is increased day by day, the hair is lackluster and spotty on the report of publicity every day, the sweating is accelerated due to the normal movement, and the waist and the knees are limp. The colleagues carry to the department for diagnosis, the disease is diagnosed as ' tinea mothis and ' lung and kidney qi deficiency syndrome ', the ' middle-jiao tonifying and qi benefiting decoction ' and the ' kidney qi pill ' are added or reduced, the plum blossom needles are matched for knocking and stabbing, the formula is externally used, the hair loss is already stopped after 2 weeks of treatment, and the hair is gradually increased and the white hair is turned into black after 1 month; after 2 months of treatment, the hair becomes dense, the decoction is changed into pills, and the treatment course lasts.

Example 3:

some old man, male, 30 years old, Shanxi Weinan, 2019-07-20, and the state officer.

After the car accident operation, the scar part sutured on the top of the head after the operation does not grow, the scalp is naked and obstructs the sight of the patient 5 years ago, the patient can seek medical treatment in multiple ways, the internal and external use of the medicine are not effective, and the unit recommends the operation of hair transplantation to seek medical treatment in our place. The diagnosis is ' tinea due to caries and ' blood stasis blocking collaterals syndrome ', the decoction for promoting blood circulation for dredging orifices is matched with the plum blossom needles and the percussores, the traditional Chinese medicine prepared by the formula is externally used for treating the disease for more than one month, the hair grows gradually after 1 month, the hair is gradually dense, and the treatment lasts.

Example 4:

some valley, female, 59 years old, Shanxi Weinan, 2019-05-11, and farmers.

The patient finds 3 parts of left back occipital plate-like alopecia in 2018 and 10 months, the patient can take the 3 parts of the left back occipital plate-like alopecia by grinding the tuber fleeceflower into powder and taking the powder twice a day after taking the powder for 1 month by self, and after taking the powder for 2 months continuously, the alopecia at the left back occipital part is merged into one part which is the size of steamed bread, and the other parts also have alopecia. The symptoms are spot-like alopecia on the left back occipital part, palm size and tens of hair loss parts, the diagnosis is oil wind disease and liver and kidney yin deficiency syndrome, the addition and subtraction of Liuwei Dihuang Wan and the percussive acupuncture by a plum blossom needle are carried out, and the external traditional Chinese medicine prepared by the formula is used once a day. After 1 month of treatment, the hair loss part has no external extension, after 3 months of treatment, the hair grows gradually, and after 6 months of treatment, the hair at the hair loss part is dense.

Example 5:

some women, Shanxi Weinan people, 35 years old, 2018-09-11, and the employees.

The patient stays on the desk for a long time, continuously shifts for a plurality of days in nearly 2 months, finds two spots like plaque alopecia at the vertex when the patient suddenly washes the hair on one day, and visits the doctor at our place. The diagnosis is that 'oily wind disease' and 'liver depression and spleen deficiency' are added and subtracted by 'Xiaoyao pill' and 'Shenling Baizhu powder', then percuss with plum blossom needles and prickle, and 'the traditional Chinese medicine prepared by the formula is externally used', after 3 months, the hair at the alopecia part is denser.

Example 6:

somebody in yellow, a woman, 11 years old, Xian people in Shaanxi, 2018-11-01, and students.

The infant has a history of alopecia areata 2 years ago (9 years old), and the infant is treated in the Western medicine hospital and the second subsidiary hospital of the transportation university in succession, and is not taken after being cured. Parents find that the sick children have the alopecia scattered in spots in whole head again in the last 2 months, and the disease is diagnosed in our department today. The diagnosis is 'oily wind disease' and 'spleen and kidney qi deficiency syndrome', the 'middle-jiao tonifying and qi-benefiting pill' and 'six-ingredient rehmannia pill' are added and added, and matched with plum blossom needle and percussion, the 'nine-treasure hair growth tincture' is externally used, once a day, the intermittent treatment is carried out for 1 year, and alopecia areata is not obvious.

Example 7:

some Li, man, Shaanxi Xian, 26 years old, 2019-10-07 to see doctor, state officer.

The hair loss is obvious when the hair is washed after intensive night stay in an examination 4 years ago, the hairline gradually moves up, the scalp at the top of the peak is exposed obviously, a plurality of later medical treatment sites are diagnosed in the same place after ineffectiveness, the diagnosis is 'tinea mothed and tinea' liver-depression and kidney-deficiency syndrome ', liver-soothing and kidney-tonifying soup' (self-simulation) is given, and the plum blossom needles are matched with the percuss, so that the external traditional Chinese medicine prepared by the formula has no obvious hair loss after 1 month of treatment, no hair loss occurs when the pillow towel is taken up in the morning, the hair at the top of the peak is gradually dense, and the continuous treatment is performed.

Example 8:

li Shi, 34 years old, male, Shaanxi xi Xian, 2018-06-19 for doctor, national officer.

The patients with the symptoms of dysphoria, irritability, insomnia, dreaminess and the like after the work posts are mobilized 2 years ago, the apical plaque-like alopecia 2 is found 6 months ago and is peanut-sized, the number of blocks is increased, the patients can be treated at different places of the second subsidiary hospital of the western traffic university, and the health institute of shikim Liu Xiu village in Yi district of the western city, the effect is not good, and the areas are increased and expanded to pieces. The traditional Chinese medicine is externally used, no new plaque is added after 1 month of treatment, velvet appears after 2 months of treatment, hair covers at most plaques after 3 months of treatment, hair is dense after 6 months of treatment, and the original hair of the left occipital alopecia areata is not long and neat.

Example 9:

some Liu, male, 35 years old, Shaanxi xi' an, 2019-06-24 for doctor and worker.

The patient has yellow and soft hair from the young, the hair quantity is not abnormal, a great amount of hair loss is caused at home before 10 years, the hair loss is increasingly sparse and gradually has the tendency of falling off the crest, the patient is treated in the dermatology department of Zhangyitong clinic and Tangdu hospital in Changan area, the hair loss is gradually stopped after the patient takes the medicine, the new hair still does not occur, and the patient is listened to the patient in our place for treatment by multiple parties. The traditional Chinese medicine is prepared by adding, reducing and cutting Liuwei Dihuang pills and matching with plum blossom needles and percussion for external use, the hair growing is gradually generated after 2 months of treatment, and the color development turns black after 3 months of treatment, so that the treatment lasts.

Example 10:

liu Gong, male, 37 years old, Shaanxi Xian, 2019-07-25 for doctor, and State officer.

The patient found obvious alopecia 3 years ago, especially at forehead and vertex, the method of washing hair with 'zhuang 101 hair tonic', 'Hanyong 9+9 hair tonic' and local smearing with ginger is tried successively, the hair line is moved obviously, the patient can see a doctor in the Shikim Liu village sanitary room in Changan district of Western City, and the doctor can be treated with oral decoction (detailed) and acupoint injection, the effect is not good, and the doctor can see a doctor at our place through introduction. The diagnosis is ' tinea due to moth eating and ' syndrome of yin deficiency of liver and kidney ', modified ' Bolus for reinforcing yin ', matched with plum blossom needle and percussion, and externally applied ' traditional Chinese medicine prepared by the formula ', once a day. After 3 months of treatment, hair grows gradually, and the alopecia on the vertex is not obvious.

Example 11:

some Liu, female, 22 years old, Sichuan Guangyuan people, 2019-07-05 for treatment and workers.

Patients suffered from alopecia areata (alopecia areata) two times before 5 years, the plaques on the whole head are all distributed and different in size, some soybeans are large, some elms are large, some persimmons are large, the shapes of the plaques are as depression, and hospitals in local, square, county and city are informed that treatment cannot be carried out, and families have to shave hair for one year after rest. After that, the hair grows, and the remaining three and five plaques are still alive. In the present year, after working in Xian, we know where to see the doctor. The diagnosis is ' oily wind disease ' and ' yin deficiency blood heat syndrome ', the addition and subtraction of ' Zhibai Dihuang decoction ', the addition and subtraction of ' plum blossom needle and percussion, external application of ' the traditional Chinese medicine prepared by the formula ', is carried out once a day. The alopecia areata after 1 month is treated and the alopecia areata after 3 months is not obvious.

Example 12:

anyone, male, 32 years old, Shanxi Typha, 2018-11-03, the state officer.

The patient found that hair loss is obvious when washing hair 6 years ago, hair traces move upwards obviously, and the work pressure is large, the patient often works on desk, is on duty at night, and hair is gradually sparse, so that the patient gives up no treatment and is introduced to the doctor of the department of China to see a doctor. The liver-soothing and kidney-tonifying soup is used for diagnosing the symptoms of tinea due to moth eating and liver depression and kidney deficiency, is matched with plum blossom needles and percussions, and is externally used as the traditional Chinese medicine prepared by the formula. After 1 month, no obvious alopecia exists, and after 3 months, the hair grows gradually.

Example 13:

shi Yi, female, 47 years old, Xian people in Shaanxi province, 2019-06-12 for diagnosis and worker.

The patients had loose white hair at the top of the head in the middle school period, and became more obvious after the adults, and the father had little white hair, and had been treated in the second subsidiary hospital of the western medicine institute, and the disease was diagnosed as 'premature gray white disease', and no treatment was considered after the patients were informed of no treatment scheme. The existing symptoms are full white hair and are diffuse, complaints are that hair is dyed once per month averagely, hair loss is not obvious, the disease is diagnosed as 'white hair disease' and 'liver depression and kidney deficiency syndrome', the Danzhi Xiaoyao pill 'and the Liuwei Dihuang pill' are added or subtracted, the traditional Chinese medicine prepared by the formula is externally used, after 2 months of treatment, the white hair gradually turns brown, and the treatment lasts nowadays.

Example 14:

some Wang, male, 49 years old, Gansu Zhengning, 2019-08-21, and State officer.

When a patient washes the hair before 2 months, the patient finds a hair loss block with the size of mung bean on the right occipital part, the patient is not conscious, then successively finds patch-like hair loss at the forehead hairline part and the left side temples, the diagnosis is alopecia areata in the skin department of the Xijing hospital, the 'Jingwu capsule' is orally taken, the nutrition nerve medicine is injected in cooperation with acupuncture points, infrared radiation is performed, after 2 weeks of treatment, the patch expands to the periphery, then the patch is introduced into a Tibetan medicine hair-growing room through other people, and after the Tibetan medicine is externally coated for 1 month, the patient still does not see a good turn. The diagnosis is 'oily wind disease' and 'liver and kidney yin deficiency syndrome', the addition and subtraction of 'Dihuang Yinzi' is performed, the plum blossom needles are matched for percussion, and the traditional Chinese medicine prepared by the formula is externally used, after 2 weeks of treatment, hair loss plaques do not expand outwards, after 2 months of treatment, hair at the hair loss part grows, and after 4 months of treatment, a large amount of hair at the hair loss part grows.

Example 15:

some Dian, women, 47 years old, Shaanxi xi Ann, 2019-07-16 for doctor and worker.

A patient has a large amount of alopecia before 10 years, the hair is washed, the white hair is obvious in 5 years, the patient complains about 6-8 times of hair dyeing every year, and the patient is diagnosed in the department of China through introduction of other people. The diagnosis is 'tinea moths', 'poliosis' and 'liver and kidney yin deficiency syndrome', the 'soup for blackening hair and strengthening kidney' (self-prepared) is applied, and is matched with plum blossom needles and percussion, and the 'traditional Chinese medicine prepared by the formula is externally used', the hair gradually grows after 3 months, and the hair is also turned into white brown.

Example 16:

some Dian, male, 46 years old, Shaanxi xi's person, 2018-07-18, the worker.

The patient and the family got noisy 2 months ago and then rolled over the back and sleepless all night, and if not, a small amount of hair falls on the pillow after morning. After sleepiness and insomnia gradually happen in many days continuously, a plurality of pieces of soybeans with the size of the pillow part are found to lose hair when the head is washed one day, the alopecia areata is diagnosed in the skin department of the Xijing hospital, and after the alopecia areata is treated for 2 weeks by orally taking the 'Jingwu capsule' in combination with the nutrient nerve medicament injected into acupuncture points, the plaques continue to increase and expand to the periphery, so that the doctor can see a doctor in my department. The Chinese medicament is externally used for treating alopecia spots which do not expand outwards after 2 weeks, alopecia part has hair growing after 2 months, and alopecia part has mass hair growing after 3 months, so the alopecia part is not obvious.

Example 17:

liangyi, male, most ancient Shaanxi, 43 years old, 2019-07-31 for doctor, national officer.

The plaque-like alopecia is more than 6 months, only one place at the top of the vertex is in the size of soybean, the size of the vertex is gradually enlarged to be the size of elm money, the size of the vertex is increased to be three places, the effect is not achieved after the juice of the ginger is externally applied to the affected part for 1 month by self according to the partial formula, the weight is increased conversely, the alopecia is distributed over dozens of places of the whole head and has different sizes, and the effect is not achieved after the juice is applied to a hair-nourishing house near a unit for treating for more than 2 months. The diagnosis is introduced to the patient at the same place, the patient is diagnosed with the oily wind disease and the liver-qi stagnation and kidney deficiency syndrome, the liver-soothing and kidney-tonifying decoction is added or reduced, the plum blossom needles are matched with the percussion acupuncture, and the traditional Chinese medicine prepared by the formula is externally used, so that the alopecia part is treated after 2 weeks without external expansion and increase, and the hair at the alopecia part is gradually generated after 1 month; after 2 months of treatment, the hair becomes dense, after 4 months, the alopecia and the plaque are not obvious, and after 6 months, the planned treatment course is finished and is not different from that of normal people.

Example 18

Some Yang, male, Shaanxi Xiyao Yanyang man, 26 years old, 2019-04-01 for diagnosis and worker.

The hair loss of the whole head is interrupted for more than 3 years, the hair loss is caused by excessive staying up at night initially, the hair is obvious on the pillow and falls off in the morning in nearly 1 year, the hair is thin and visible, and the eyes are dry and astringent, the mouth is dry and polydipsia, and the waist and the knees are sour and soft. The family members are carried to one place to see a doctor, the disease is diagnosed as 'tinea moths' and 'liver and kidney yin deficiency syndrome', the liver nourishing and kidney tonifying formula is added or reduced, the plum blossom needles are matched for knocking and stabs, the 'traditional Chinese medicine prepared by the formula is externally used', the hair loss is already stopped after 1 month, the hair is gradually increased after 2 months, the hair is gradually thickened after 4 months, the decoction is changed into pills, and the treatment course is continued.

The traditional Chinese medicine preparation disclosed by the invention can be used for inhibiting the multiplication and infection of dermatophytes and bacteria, tonifying qi and removing hair, activating blood and nourishing yin to induce hair regeneration of a diseased part, tonifying kidney and replenishing essence and blackening hair aiming at a user with symptoms such as alopecia areata, androgenetic alopecia and poliosis, and can be used for relieving the external symptoms of alopecia areata, androgenetic alopecia and poliosis. According to clinical tests, the traditional Chinese medicine preparation has the advantages of good curative effect, light side effect and no generation of dependence. The traditional Chinese medicine preparation has no toxic or side effect by combining the pharmacological action of the raw materials of the traditional Chinese medicine preparation, and provides a test basis for clinical safe medication. The invention adopts an immersion method to purify the effective components of the traditional Chinese medicine preparation, and the obtained tincture preparation is simple to prepare, convenient to take and easy to store.

Claims (2)

1. The traditional Chinese medicine for treating alopecia areata, androgenetic alopecia and white hair is characterized by comprising the following raw materials in parts by weight: 15 parts of glossy privet fruit, 20 parts of black sesame, 10 parts of Chinese honeylocust spine, 10 parts of mulberry leaf, 15 parts of hairyvein agrimony, 20 parts of dark plum fruit, 15 parts of rhizoma polygonati, 15 parts of medlar, 30 parts of radix rehmanniae recen, 3 parts of centipede, 20 parts of salvia miltiorrhiza and 15 parts of cacumen biotae.

2. The method of preparing a traditional Chinese medicine for treating alopecia areata, androgenetic alopecia and gray hair as claimed in claim 1, comprising the following process steps:

(1) weighing glossy privet fruit, black sesame, spina gleditsiae, mulberry leaf, hairyvein agrimony, dark plum fruit, rhizoma polygonati, medlar, radix rehmanniae recen, centipede, salvia miltiorrhiza and cacumen biotae according to the weight ratio for later use;

(2) pulverizing Scolopendra to fine powder, packaging with one-time decocting bag, placing in a glass chemical reagent bottle, adding ethanol, sealing, soaking for 1 week, and collecting supernatant;

(3) putting the glossy privet fruit, the black sesame, the spina gleditsiae, the mulberry leaf, the hairyvein agrimony, the dark plum, the sealwort, the medlar, the dried rehmannia root, the red sage root and the cacumen biotae into a wide-mouth reagent bottle according to the weight ratio, adding ethanol, sealing the cover, soaking for 3 weeks, and pouring out supernatant for later use;

(4) uniformly mixing the leaching solution obtained in the step (2) and the leaching solution obtained in the step (3), uniformly stirring, and filtering the drug residues to obtain the traditional Chinese medicine;

in the step (2), 1000ml of 75% ethanol is added;

in step (3), 3000ml of 75% strength ethanol was added.

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