CN110810515A - Formula milk powder for pregnant and lying-in women and preparation method thereof - Google Patents
Formula milk powder for pregnant and lying-in women and preparation method thereof Download PDFInfo
- Publication number
- CN110810515A CN110810515A CN201911163355.1A CN201911163355A CN110810515A CN 110810515 A CN110810515 A CN 110810515A CN 201911163355 A CN201911163355 A CN 201911163355A CN 110810515 A CN110810515 A CN 110810515A
- Authority
- CN
- China
- Prior art keywords
- milk powder
- powder
- pregnant
- lying
- bifidobacterium lactis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000843 powder Substances 0.000 title claims abstract description 99
- 235000013350 formula milk Nutrition 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title abstract description 13
- 235000013336 milk Nutrition 0.000 claims abstract description 36
- 239000008267 milk Substances 0.000 claims abstract description 36
- 210000004080 milk Anatomy 0.000 claims abstract description 36
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims abstract description 28
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 claims abstract description 26
- 229940009289 bifidobacterium lactis Drugs 0.000 claims abstract description 26
- 238000001694 spray drying Methods 0.000 claims abstract description 23
- 235000021255 galacto-oligosaccharides Nutrition 0.000 claims abstract description 18
- 150000003271 galactooligosaccharides Chemical class 0.000 claims abstract description 18
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 18
- 239000011707 mineral Substances 0.000 claims abstract description 18
- 229940088594 vitamin Drugs 0.000 claims abstract description 18
- 229930003231 vitamin Natural products 0.000 claims abstract description 18
- 235000013343 vitamin Nutrition 0.000 claims abstract description 18
- 239000011782 vitamin Substances 0.000 claims abstract description 18
- 229920001202 Inulin Polymers 0.000 claims abstract description 17
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 17
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims abstract description 17
- 229940029339 inulin Drugs 0.000 claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 17
- 239000008101 lactose Substances 0.000 claims abstract description 16
- 108010046377 Whey Proteins Proteins 0.000 claims abstract description 14
- 102000007544 Whey Proteins Human genes 0.000 claims abstract description 14
- 229940090949 docosahexaenoic acid Drugs 0.000 claims abstract description 14
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims abstract description 14
- 235000020183 skimmed milk Nutrition 0.000 claims abstract description 14
- 239000000126 substance Substances 0.000 claims abstract description 14
- 235000021119 whey protein Nutrition 0.000 claims abstract description 14
- 235000008939 whole milk Nutrition 0.000 claims abstract description 14
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 12
- 239000004519 grease Substances 0.000 claims abstract description 12
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims abstract description 7
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 6
- 235000010755 mineral Nutrition 0.000 claims description 17
- 238000002156 mixing Methods 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 10
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 10
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 10
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 10
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 9
- 238000007580 dry-mixing Methods 0.000 claims description 8
- 238000001704 evaporation Methods 0.000 claims description 8
- 238000004806 packaging method and process Methods 0.000 claims description 8
- 238000007873 sieving Methods 0.000 claims description 8
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 claims description 6
- 235000008476 powdered milk Nutrition 0.000 claims description 6
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 5
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 5
- 235000002414 D-alpha-tocopherylacetate Nutrition 0.000 claims description 5
- 239000011740 D-alpha-tocopherylacetate Substances 0.000 claims description 5
- 239000002211 L-ascorbic acid Substances 0.000 claims description 5
- 235000000069 L-ascorbic acid Nutrition 0.000 claims description 5
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 5
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 5
- 229960005070 ascorbic acid Drugs 0.000 claims description 5
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 5
- 235000000639 cyanocobalamin Nutrition 0.000 claims description 5
- 239000011666 cyanocobalamin Substances 0.000 claims description 5
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 5
- 229940039770 d-alpha-tocopheryl acetate Drugs 0.000 claims description 5
- 239000011706 ferric diphosphate Substances 0.000 claims description 5
- 235000007144 ferric diphosphate Nutrition 0.000 claims description 5
- CADNYOZXMIKYPR-UHFFFAOYSA-B ferric pyrophosphate Chemical compound [Fe+3].[Fe+3].[Fe+3].[Fe+3].[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O CADNYOZXMIKYPR-UHFFFAOYSA-B 0.000 claims description 5
- 229940036404 ferric pyrophosphate Drugs 0.000 claims description 5
- 229960000304 folic acid Drugs 0.000 claims description 5
- 235000019152 folic acid Nutrition 0.000 claims description 5
- 239000011724 folic acid Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 239000000395 magnesium oxide Substances 0.000 claims description 5
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 5
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 5
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims description 5
- 229960004172 pyridoxine hydrochloride Drugs 0.000 claims description 5
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 claims description 5
- 239000011764 pyridoxine hydrochloride Substances 0.000 claims description 5
- 229960000342 retinol acetate Drugs 0.000 claims description 5
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- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 5
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- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 4
- 239000008236 heating water Substances 0.000 claims description 4
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 3
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 2
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- 230000008774 maternal effect Effects 0.000 claims 5
- 241000186000 Bifidobacterium Species 0.000 abstract description 14
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 8
- 230000008569 process Effects 0.000 abstract description 7
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- 229930003451 Vitamin B1 Natural products 0.000 abstract description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract description 2
- 230000008855 peristalsis Effects 0.000 abstract description 2
- 238000005728 strengthening Methods 0.000 abstract description 2
- 229960003495 thiamine Drugs 0.000 abstract description 2
- 235000010374 vitamin B1 Nutrition 0.000 abstract description 2
- 239000011691 vitamin B1 Substances 0.000 abstract description 2
- 239000011701 zinc Substances 0.000 abstract description 2
- 229910052725 zinc Inorganic materials 0.000 abstract description 2
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
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- 229960002104 cyanocobalamin Drugs 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
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- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
- A23C9/1307—Milk products or derivatives; Fruit or vegetable juices; Sugars, sugar alcohols, sweeteners; Oligosaccharides; Organic acids or salts thereof or acidifying agents; Flavours, dyes or pigments; Inert or aerosol gases; Carbonation methods
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C1/00—Concentration, evaporation or drying
- A23C1/04—Concentration, evaporation or drying by spraying into a gas stream
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/1203—Addition of, or treatment with, enzymes or microorganisms other than lactobacteriaceae
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
- A23C9/1315—Non-milk proteins or fats; Seeds, pulses, cereals or soja; Fatty acids, phospholipids, mono- or diglycerides or derivatives therefrom; Egg products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
- A23C9/1322—Inorganic compounds; Minerals, including organic salts thereof, oligo-elements; Amino-acids, peptides, protein-hydrolysates or derivatives; Nucleic acids or derivatives; Yeast extract or autolysate; Vitamins; Antibiotics; Bacteriocins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/531—Lactis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a formula milk powder for pregnant and lying-in women and a preparation method thereof, wherein the formula milk powder comprises 30-55% of skim milk powder, 30-55% of whole milk powder, 1-8% of inulin, 1-8% of galacto-oligosaccharide, 1-6% of hydrolyzed whey protein powder, 0.2-1.2% of calcium carbonate, 0.1-1.1% of docosahexaenoic acid grease, 0.1-1% of lactose, 0.1-0.8% of mineral substances, 0.1-0.7% of vitamins and 0.02% of bifidobacterium lactis HN019 freeze-dried powder. The milk powder disclosed by the invention takes inulin and galactooligosaccharide as the strengthening factors of bifidobacterium lactis HN019, so that the concentration of bifidobacterium lactis in the excrement of pregnant women is increased, constipation is prevented or relieved, intestinal tract peristalsis is stimulated, the excrement wettability is increased, the intestinal tract flora balance and intestinal tract health are maintained, and the absorption of microelements such as vitamin B1 and zinc by pregnant and lying-in women is improved. The experimental result shows that the pregnant woman feces are obtained after eating the milk powderThe concentration of Bifidobacterium in feces reaches 1010Above cfu/g, the concentration of bifidobacteria in intestinal tract is obviously increased. The formula and the process of the milk powder can also effectively improve the wall sticking problem in the spray drying stage.
Description
Technical Field
The invention relates to the technical field of dairy products, in particular to formula milk powder for pregnant and lying-in women and a preparation method thereof.
Background
The milk powder for pregnant and lying-in women is developed according to the nutrient components required by mothers and infants in the pregnancy, is rich in various nutrients, and can provide sufficient nutrition for expectant mothers and fetus baby. The milk powder can be taken by pregnant women to avoid malnutrition of the pregnant women and the baby fetus, and promote health of the pregnant women and normal development of the baby fetus. The intestinal problems of constipation, flatulence and the like often occur due to the change of physique of women during pregnancy, corresponding nutrients are added into the milk powder for pregnant and lying-in women in the market at present mainly according to the nutritional requirements of the pregnant and lying-in women, and the trouble of the pregnant and lying-in women can be effectively solved from the aspects of improving intestinal flora, promoting digestion and absorption and the like.
Spray drying is generally adopted in the milk powder processing process, the wall sticking phenomenon is a common problem which is difficult to solve in the spray drying process, the wall sticking phenomenon not only causes material loss and reduces product quality, but also can cause the termination of the spray drying process and even production accidents in serious cases. From the research on the wall sticking problem at present, most scholars at home and abroad solve the wall sticking problem of the material from the aspects of hardware such as the atomization angle, the inner wall roughness and the like of the dryer, but the parameters of the dryer are usually determined by manufacturers and are not easy to change, and few people solve the wall sticking problem from the material angle at present.
Disclosure of Invention
In view of the defects of the prior art, the invention provides a pregnant and lying-in woman formula milk powder and a preparation method thereof.
The technical scheme adopted by the invention is as follows:
the formula milk powder for pregnant and lying-in women is characterized by comprising the following components in percentage by mass: 30-55% of skim milk powder, 30-55% of full cream milk powder, 1-8% of inulin, 1-8% of galacto-oligosaccharide, 1-6% of hydrolyzed whey protein powder, 0.2-1.2% of calcium carbonate, 0.1-1.1% of docosahexaenoic acid grease, 0.1-1% of lactose, 0.1-0.8% of mineral substances, 0.1-0.7% of vitamins and HN 0190.02% of bifidobacterium lactis. Each gram of freeze-dried powder contains bifidobacterium lactis HN019 (0.8-1) x 105cfu
Preferably, the minerals comprise: magnesium oxide, ferric pyrophosphate and zinc oxide. The mass ratio of the three is preferably 1 (2-3) to 2-5.
Preferably, the vitamins comprise L-ascorbic acid, D- α -tocopheryl acetate, nicotinamide, D-calcium pantothenate, pyridoxine hydrochloride, thiamine hydrochloride, riboflavin, retinyl acetate, folic acid, cholecalciferol and cyanocobalamine, and the mass ratio of the components is preferably 1 (3-5) to (2-4) to (2-3) to (1-6) to (0.7-1.2) to (2-3) to (3-8) to (1.0-1.5) to (2-4).
The invention provides a preparation method of a formula milk powder for pregnant and lying-in women, which comprises the following steps: adding water into skim milk powder and whole milk powder to mix into reduced milk, wherein the mass ratio of the milk powder to the water is 1 (2-3), adding inulin, galacto-oligosaccharide, hydrolyzed whey protein powder, docosahexaenoic acid grease, lactose and bifidobacterium lactis HN019 freeze-dried powder into the reduced milk, uniformly mixing, pasteurizing, evaporating at 60-70 ℃ until the volume is reduced by 20-30%, homogenizing, spray drying, adding mineral substances and vitamins, dry mixing, sieving and packaging.
The invention also provides another preferable preparation method, and the method is found to enable the material to form a semi-embedding-like effect, has a certain protection effect on the bifidobacterium lactis, and changes the viscosity and the particle size of the material, thereby improving the wall adhesion problem. The method comprises the following steps:
heating water to 55-60 ℃, adding inulin, galacto-oligosaccharide, lactose and hydrolyzed whey protein powder, uniformly mixing, adding docosahexaenoic acid grease and bifidobacterium lactis HN019, mixing, drying under reduced pressure until the volume is reduced by 10-20%, keeping the liquid temperature at 45-50 ℃, adding skim milk powder and whole milk powder, uniformly mixing, pasteurizing, evaporating at 60-70 ℃ until the volume is reduced by 20-30%, homogenizing, spray drying, adding mineral substances and vitamins, dry mixing, sieving and packaging.
The invention has the following beneficial effects:
1) the milk powder disclosed by the invention is added with bifidobacterium lactis HN019, inulin and Galactooligosaccharide (GOS), and the inulin and the galactooligosaccharide are used as strengthening factors of the bifidobacterium lactis HN019, so that the concentration of the bifidobacterium lactis in excrement of pregnant women is increased, constipation is prevented or relieved, intestinal peristalsis is stimulated, the excrement wettability is increased, the balance of intestinal flora and the health of intestinal tracts are maintained, and the absorption of trace elements such as vitamin B1 and zinc by the pregnant and lying-in women is improved. The experimental result shows that after the milk powder is eaten, the concentration of the bifidobacteria in the excrement of the pregnant women reaches 1010cfu/g above, compared with 10 before eating8cfu/g, the bifidobacteria concentration in the intestinal tract was significantly increased. The formula of the milk powder can also effectively improve the wall sticking problem in the spray drying stage.
2) The invention improves the wall sticking phenomenon in the process of spray drying of the milk powder from the aspects of material selection, processing method and the like. The micro morphology of the milk powder particles prepared by the method is basically consistent, the milk powder particles are spherical or quasi-spherical, the particle size is distributed in the range of 20-30 um, the particle dispersibility is good, the obvious particle agglomeration phenomenon is avoided, the wall adhesion rate can be reduced to 0.8%, and the water content is reduced to 2.2%. In addition, the invention also avoids the problems of nutrient loss and the reduction of the survival rate of the bifidobacterium lactis HN019 caused by the preparation process, and experimental results show that the method can successfully maintain higher viable count of the bifidobacterium and 1.7 multiplied by 10 viable count in milk powder7CFU/100g。
3) According to the GB19644-2010 food safety national standard milk powder, the milk powder is tested, and the result shows that all indexes meet the requirements.
Detailed Description
The present invention will be described in further detail with reference to the following embodiments.
In the examples and comparative examples, the addition amount of Bifidobacterium lactis in milk powder was 1.8X 107CFU/100g。
Example 1
The formula milk powder for pregnant and lying-in women comprises the following components in percentage by mass: 30% of skim milk powder, 55% of whole milk powder, 8% of inulin, 1.84% of galacto-oligosaccharide, 1% of hydrolyzed whey protein powder, 1.2% of calcium carbonate, 1.1% of docosahexaenoic acid grease, 1% of lactose, 0.74% of minerals, 0.1% of vitamins and 0.02% of bifidobacterium lactis HN019 freeze-dried powder.
Minerals: magnesium oxide, ferric pyrophosphate and zinc oxide (1:3: 5).
Vitamins L-ascorbic acid, D- α -tocopheryl acetate, niacinamide, calcium D-pantothenate, pyridoxine hydrochloride, thiamine hydrochloride, riboflavin, retinyl acetate, folic acid, cholecalciferol and cyanocobalamin (1:3:3:2:2:1:0.7:2:3:1.0: 2).
Example 2
The formula milk powder for pregnant and lying-in women comprises the following components in percentage by mass: 55% of skim milk powder, 30% of whole milk powder, 1% of inulin, 6.78% of galacto-oligosaccharide, 6% of hydrolyzed whey protein powder, 0.2% of calcium carbonate, 0.1% of docosahexaenoic acid grease, 0.1% of lactose, 0.1% of mineral substances, 0.7% of vitamins and 0.02% of bifidobacterium lactis HN019 freeze-dried powder.
Minerals: magnesium oxide, ferric pyrophosphate and zinc oxide (1:2: 2).
The vitamin comprises L-ascorbic acid, D- α -tocopheryl acetate, nicotinamide, D-calcium pantothenate, pyridoxine hydrochloride, thiamine hydrochloride, riboflavin, retinyl acetate, folic acid, cholecalciferol and cyanocobalamine, and the mass ratio of the components is (1:5:5:4:3:6:1.2:3:8:1.5: 4).
The preparation method of the embodiment 1-2 comprises the following steps:
adding water into the skim milk powder and the whole milk powder to mix into reduced milk, wherein the mass ratio of the milk powder to the water is 1:2, adding inulin, galacto-oligosaccharide, hydrolyzed whey protein powder, docosahexaenoic acid grease, lactose and bifidobacterium lactis HN019 freeze-dried powder into the reduced milk, uniformly mixing, pasteurizing, evaporating at 70 ℃ until the volume is reduced by 20%, homogenizing, spray drying, adding mineral substances and vitamins, dry mixing, sieving and packaging.
Example 3
The preparation method of example 1 is as follows:
adding water into the skim milk powder and the whole milk powder to mix into reduced milk, wherein the mass ratio of the milk powder to the water is 1:3, adding inulin, galacto-oligosaccharide, hydrolyzed whey protein powder, docosahexaenoic acid grease, lactose and bifidobacterium lactis HN019 freeze-dried powder into the reduced milk, uniformly mixing, pasteurizing, evaporating at 60 ℃ until the volume is reduced by 30%, homogenizing, spray drying, adding mineral substances and vitamins, dry mixing, sieving and packaging.
Example 4
The preparation method of example 1 was replaced by:
heating water to 55 deg.C, adding inulin, galacto-oligosaccharide, lactose and hydrolyzed whey protein powder, mixing, adding docosahexaenoic acid oil and Bifidobacterium lactis HN019 lyophilized powder, mixing, drying under reduced pressure until volume is reduced by 20%, maintaining liquid temperature at 45 deg.C, adding skimmed milk powder and whole milk powder, mixing, pasteurizing, evaporating at 70 deg.C until volume is reduced by 30%, homogenizing, spray drying, adding minerals and vitamins, dry mixing, sieving, and packaging.
Example 5
The preparation method of example 1 is as follows:
heating water to 60 ℃, adding inulin, galacto-oligosaccharide, lactose and hydrolyzed whey protein powder, uniformly mixing, adding docosahexaenoic acid oil and bifidobacterium lactis HN019 freeze-dried powder, mixing, drying under reduced pressure until the volume is reduced by 10%, keeping the liquid temperature at 50 ℃, adding skim milk powder and whole milk powder, uniformly mixing, pasteurizing, evaporating at 60 ℃ until the volume is reduced by 20%, homogenizing, spray drying, adding mineral substances and vitamins, dry mixing, sieving and packaging.
Comparative example 1
The differences between comparative example 1 and example 1 are: different proportions of the components
The formula milk powder for pregnant and lying-in women comprises the following components in percentage by mass: 30% of skim milk powder, 55% of whole milk powder, 9% of inulin, 1% of galacto-oligosaccharide, 1% of hydrolyzed whey protein powder, 0.2% of calcium carbonate, 0.58% of docosahexaenoic acid grease, 3% of lactose, 0.1% of minerals, 0.1% of vitamins and HN 0190.02% of bifidobacterium lactis.
Comparative example 2:
the differences between the comparative examples and example 1 are:
lactose was replaced by glucose.
Experimental example 1
The milk powder was prepared by using the example and comparative example respectively, the wall sticking rate and the water content were calculated in the spray drying stage, and the average value was taken 10 times repeatedly, and the results are shown in table 1.
The spray drying process comprises the following steps: spray drying is carried out by adopting a TPG-5 spray dryer, wherein the spray drying condition is that the air inlet temperature is 180 ℃, the feeding speed is 11.0mL/min, and the rotating speed is 25000 rpm.
Detecting items:
1. wall sticking rate
And in the spray drying stage, the mass of the dried powder and the mass of the dried substance before drying are respectively recorded, and the wall sticking rate is calculated. The lower the wall-sticking rate, the better.
The wall sticking rate was [1- (mass of powder after drying/mass of dry matter in raw material liquid before drying) ]. multidot.100%
2. Water content
After spray drying, a1 g of sample was placed in a vacuum oven at 70 ℃ under 500mbar for 24h, and after cooling to room temperature in a dish, the sample was weighed as a2 g. The lower the moisture content of the powder, the better.
The water content is [ (A1-A2)/A1 ]. multidot.100%
3. Bifidobacterium lactis detection
According to GB 4789.34-2016, a sample after spray drying is taken to detect the colony number of the bifidobacteria.
Table 1: the result of the detection
| Wall sticking rate/%) | Water content/%) | Colony count cfu/100g | |
| Example 1 | 3.5 | 3.2 | 1.5×106 |
| Example 2 | 3.1 | 3.0 | 1.6×106 |
| Example 4 | 0.8 | 2.2 | 1.7×107 |
| Example 5 | 1.1 | 2.7 | 1.7×107 |
| Comparative example 1 | 4.8 | 3.8 | 1.2×106 |
| Comparative example 2 | 4.3 | 4.1 | 1.5×106 |
During spray drying, as the temperature increases, the droplets change from a glassy state to a rubbery state and a viscous state, and when in the viscous state, severe wall sticking or agglomeration of the particles occurs. The milk powder material contains lactose and other substances, and the substances are easily transformed from a glass state to a viscous state along with the rise of temperature, so that wall sticking is easily caused. Higher drying temperatures also lead to inactivation of bifidobacterium lactis. Lower temperature can lead to incomplete drying, higher water content of the granules and more serious wall sticking phenomenon. The invention reduces the wall sticking phenomenon in the spray drying process by improving the milk powder raw material and the processing technology. The results in table 1 show that the wall adhesion rate can be reduced to 0.8% and the water content can be reduced to 2.2% by adopting the scheme of the invention. In addition, the embodiment 5 and the embodiment 6 can successfully maintain higher viable count of the bifidobacteria by improving the preparation method, and the method has minimal influence on the activity of the bifidobacteria.
Experimental example 2 detection of Bifidobacterium in intestinal tract
Subject: selecting pregnant women which are healthy, have no chronic basic diseases and no special medicines, have the gestational period of 12-24 weeks and the age of 25-35 years, taking 20 persons as a group, randomly grouping, and recommending the groups to use the milk powder of the examples and the comparative examples respectively.
The usage and dosage are as follows: 60-70 g of the composition is taken with warm boiled water at 40-50 ℃ every day for 7 days.
The detection method comprises the following steps:
the subject eats the food for 0 day and 7 days, 2g of the fecal sample is collected, and the content of the bifidobacteria in the fecal is detected by a real-time quantitative PCR method. The results are shown in Table 2.
TABLE 2
The results show that the fecal bifidobacteria concentration reached 10 days after the intervention10cfu/g above, compared with 10 before eating8cfu/g, the concentration of the bifidobacteria in intestinal tracts is obviously increased, which shows that the milk powder can effectively increase the concentration of the bifidobacteria in the feces of pregnant women. The consumption of the milk powder of the comparative example can also affect the intestinal flora, but the concentration of the bifidobacteria is obviously lower than that of the milk powder of the invention.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (7)
1. The formula milk powder for pregnant and lying-in women is characterized by comprising the following components in percentage by mass: 30-55% of skim milk powder, 30-55% of full cream milk powder, 1-8% of inulin, 1-8% of galacto-oligosaccharide, 1-6% of hydrolyzed whey protein powder, 0.2-1.2% of calcium carbonate, 0.1-1.1% of docosahexaenoic acid grease, 0.1-1% of lactose, 0.1-0.8% of mineral substances, 0.1-0.7% of vitamins and 0.02% of bifidobacterium lactis HN019 freeze-dried powder; each gram of freeze-dried powder contains bifidobacterium lactis HN019 (0.8-1) x 105cfu。
2. Maternal formula according to claim 1, wherein said minerals comprise: magnesium oxide, ferric pyrophosphate and zinc oxide.
3. The maternal and maternal formula milk powder according to claim 2, wherein the mass ratio of magnesium oxide, ferric pyrophosphate and zinc oxide is 1 (2-3) to (2-5).
4. The maternal formula of claim 1 wherein said vitamins include L-ascorbic acid, D- α -tocopheryl acetate, niacinamide, D-calcium pantothenate, pyridoxine hydrochloride, thiamine hydrochloride, riboflavin, retinyl acetate, folic acid, cholecalciferol and cyanocobalamine.
5. The maternal formula milk powder according to claim 4, wherein the mass ratio of L-ascorbic acid, D- α -tocopheryl acetate, nicotinamide, D-calcium pantothenate, pyridoxine hydrochloride, thiamine hydrochloride, riboflavin, retinyl acetate, folic acid, cholecalciferol and cyanocobalamine is 1 (3-5), (2-4), (2-3), (1-6), (0.7-1.2), (2-3), (3-8), (1.0-1.5) and (2-4).
6. The method for preparing the pregnant and lying-in woman formula milk powder according to any one of claims 1 to 5, wherein the method comprises the following steps: adding water into skim milk powder and whole milk powder to mix into reduced milk, wherein the mass ratio of the milk powder to the water is 1 (2-3), adding inulin, galacto-oligosaccharide, hydrolyzed whey protein powder, docosahexaenoic acid grease, lactose and bifidobacterium lactis HN019 freeze-dried powder into the reduced milk, uniformly mixing, pasteurizing, evaporating at 60-70 ℃ until the volume is reduced by 20-30%, homogenizing, spray drying, adding mineral substances and vitamins, dry mixing, sieving and packaging.
7. The method for preparing the pregnant and lying-in woman formula milk powder according to any one of claims 1 to 5, wherein the method comprises the following steps:
heating water to 55-60 ℃, adding inulin, galacto-oligosaccharide, lactose and hydrolyzed whey protein powder, uniformly mixing, adding docosahexaenoic acid grease and bifidobacterium lactis HN019 freeze-dried powder, mixing, drying under reduced pressure until the volume is reduced by 10-20%, keeping the liquid temperature at 45-50 ℃, adding skim milk powder and whole milk powder, uniformly mixing, pasteurizing, evaporating at 60-70 ℃ until the volume is reduced by 20-30%, homogenizing, spray drying, adding mineral substances and vitamins, dry mixing, sieving and packaging.
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