CN110801011A - Anti-oxidation beautifying oral liquid and preparation method thereof - Google Patents

Abstract

The invention relates to an antioxidant beautifying oral liquid and a preparation method thereof, wherein the oral liquid is prepared from the following raw materials in parts by weight: 0.5-1 part of SOD, 150 parts of 100-one of angelica dahurica, 150 parts of 100-one of tuckahoe, 150 parts of 100-one of coix seed, 150 parts of 100-one of polygonum multiflorum, 0.5-1 part of lycopene powder, 25-40 parts of flavoring agent and 0.5-1 part of preservative. The invention has the beneficial effects that: through adding SOD and lycopene powder, the two synergistically act to remove free radicals and delay aging; radix Angelicae Dahuricae, Poria and Coicis semen can be added for invigorating spleen, tranquilizing, removing speckle, whitening skin, moistening skin, and removing wrinkle; the addition of radix Polygoni Multiflori can tonify kidney, supplement essence, invigorate qi and blood, and nourish hair.

Description

Anti-oxidation beautifying oral liquid and preparation method thereof

Technical Field

The invention belongs to the field of health care products, and particularly relates to a beautifying oral liquid added with SOD and traditional Chinese medicine components and a preparation method thereof.

Background

Fair skin and black and beautiful hair are pursued by many people. The traditional Chinese medicine considers that the white hair has very important relation with the functions of the liver, the kidney and the spleen. Anti-oxidation (Anti-Oxidant) is a short name for Anti-oxidation free radical. A complete set of antioxidant system is arranged in the organism, under normal physiological conditions, the organism can continuously generate free radicals and continuously remove the free radicals while carrying out oxidative metabolism, and the free radicals are removed in a relatively dynamic balance state in the organism. The production of free radical scavenger in the body is reduced due to aging, improper diet, stress, etc. During melanin formation, oxygen radicals play an initiating role. Scavenging free radicals can slow down melanin generation, and maintain skin elasticity. Reasonable dietary nutrition supplement and the intake of exogenous antioxidant nutrients can prevent the damage of free radicals to cells, delay senility, whiten skin and prevent related diseases.

Superoxide dismutase (SOD) is an important component of an antioxidant enzyme system in a biological system and is widely distributed in microorganisms, plants and animals. It can effectively eliminate free radicals in vivo. Excess free radicals in the body cause cellular damage and pigmentation, and human aging is a consequence of free radical accumulation and impaired clearance. Supplementing exogenous SOD can whiten skin and delay aging.

The patents related to the research content of the present invention are as follows:

CN1931034B discloses a beverage for whitening, removing freckles and beautifying and a preparation method thereof, wherein the beverage is a tea bag, a concentrated solution or an oral liquid prepared by a general preparation method from a mixture at least containing largehead atractylodes rhizome, white paeony root, white poria, liquorice, dahurian angelica root, tribulus terrestris, bletilla striata and dodder; the raw materials for preparing the beverage can also comprise polygonatum, Chinese waxgourd seed or flatstem milkvetch seed. The beverage can enhance the immunologic function of a human body, promote the metabolism of the skin, delay the aging of the skin, tonify qi and benefit blood, and has obvious effects on regulating the internal secretion of the human body, improving the sleep, removing freckles, removing acnes and whitening the skin.

CN107213354A discloses a hair-blacking pharmaceutical composition, a preparation method, a preparation and an application thereof. The hair-blackening medicinal composition comprises, by weight, 30-70 parts of prepared rehmannia root, 30-70 parts of Chinese yam, 20-50 parts of semen cuscutae, 20-50 parts of walnut kernel, 20-50 parts of cortex moutan, 20-50 parts of rhizoma alismatis, 20-50 parts of rhizoma gastrodiae, 20-50 parts of jujube peel, 20-50 parts of polygonum multiflorum, 5-15 parts of angelica sinensis, 5-15 parts of rehmannia root, 5-15 parts of cornus officinalis, 5-15 parts of black sesame, 5-15 parts of dried rehmannia root, 5-15 parts of cortex lycii radicis, 5-15 parts of rhizoma acori graminei, 5-15 parts of black bean, 3-7 parts of radix cyathulae, 3-7 parts of tortoise plastron, 3-7 parts of glossy privet fruit, 3-7 parts of dark plum, 3-7 parts of mulberry, 3-7 parts of cistanche, 3-7 parts of eclipta alba and 3-7. The preparation is tablets, powder, capsules, granules and pills which are prepared by adding pharmaceutically acceptable auxiliary materials into the hair-blacking pharmaceutical composition. The application is the application of the hair-blacking pharmaceutical composition in preparing hair-blacking medicines. The medicines of the invention are combined and have synergistic effect, thereby achieving the effect of blacking hair.

CN107156838A discloses an oral liquid with effects of resisting oxidation and improving skin condition, which comprises stigma croci Sativi extract, herba Saussureae Involueratae extract, fish collagen, sodium hyaluronate, cranberry extract, vitamin E, vitamin C, Haematococcus pluvialis extract, resveratrol, sweet taste regulator, sour taste regulator, fruit juice and purified water. The oral liquid is extracted and embedded by adopting specific raw materials, various functional components are reasonably compounded and absorbed more quickly, the effects of resisting oxidation and improving the skin state are achieved through the effects of resisting oxidation, regulating internal circulation, maintaining a skin framework, keeping skin moisture and the like, and the stability of all the functional components is improved through an embedding technology.

CN109619550A discloses an antioxidant anti-aging oral liquid and a preparation method thereof, wherein the oral liquid comprises the following raw materials by weight: 60-65 parts of liquid culture medium, 6.0-6.5 parts of tricholoma lobayense heim strain liquid, 1.0-2.0 parts of honey and 0.5-1.0 part of flavoring agent; the liquid culture medium comprises the following raw materials in parts by weight: 1.5-2.5 parts of oat, 1.0-2.0 parts of buckwheat, 1.0-2.0 parts of black bean, 1.0-1.5 parts of coix seed, 0.1-0.3 part of sodium chloride, 0.1-0.3 part of monopotassium phosphate and 50.5-55.5 parts of purified water.

CN108114093A discloses a cordyceps polysaccharide oral liquid with antioxidation and a preparation method thereof, wherein the cordyceps polysaccharide oral liquid comprises the following raw materials in parts by weight: 20-30 parts of cordyceps polysaccharide extract, 20-30 parts of grape seeds, 10-15 parts of protein powder, 10-15 parts of schisandra chinensis, 10-15 parts of ginkgo leaves, 10-15 parts of ginseng, 10-15 parts of lucid ganoderma, 5-10 parts of astragalus membranaceus, 5-10 parts of rhodiola rosea, 3-5 parts of pilose antler, 1-3 parts of centipedes and 5-10 parts of honey.

CN107865423A discloses an SOD oral liquid for resisting intestinal oxidation, which is prepared by taking ocean low-temperature SOD as a main raw material, adding safflower extract, medlar extract, ligusticum wallichii extract and Chinese date concentrated solution, uniformly stirring and carrying out vacuum packaging, wherein the specific mixture ratio is as follows: the SOD oral liquid for resisting intestinal oxidation can be directly taken after half an hour after a meal. The invention is characterized in that: marine low temperature SOD: 2-3 parts of a safflower water extract: 1-2 parts of a wolfberry fruit water extract: 1-2 parts of ligusticum wallichii water extract: 1-2 parts of jujube concentrated solution and 3-4 parts of jujube concentrated solution.

CN107541502A discloses a method for preparing SOD multienzyme alkaline oral liquid by using food crops rich in SOD multienzyme, which comprises the following steps: 1) pulverizing grain crops rich in SOD multienzyme to obtain powder, and mixing the powder with water to obtain mixed solution A; 2) adding amylase and an activating agent into the mixed solution A, and carrying out enzymolysis for 25-35 min at the temperature of 60-85 ℃ to obtain mixed solution B; adjusting the pH value of the mixed solution B to 8-12, adding alkaline cellulase and protease, and carrying out enzymolysis for 4-5 h at 40-50 ℃ to obtain a mixed solution C; adding beer complex enzyme and distiller's yeast into the mixed solution C, and performing anaerobic fermentation at 30-40 ℃ to obtain fermentation liquor; and adding alkaline pectinase into the fermentation liquor, stirring for reaction at 35-50 ℃, and filtering to obtain the product. The method maintains the original environment of multiple enzymes such as SOD in food crops, and has high activity of each functional factor and good health promotion function.

CN108835630A discloses an oral liquid with high SOD enzyme activity and a preparation method thereof, which comprises the steps of juicing edible plant raw materials, centrifuging (1000-4000rpm for 0-30min) to remove large particles, and separating by using two ultrafiltration membranes (a tubular membrane with the aperture of 60-120kD is adopted for the first separation, and a spiral membrane with the aperture of 8-30kD is adopted for the second separation); then, the ultrahigh pressure treatment is carried out, the pressure is 200-. The SOD enzyme is activated after the treatment by the method, the enzyme activity is improved to more than 10000U/ml, and the problem of low SOD enzyme activity in the product is effectively solved. The product prepared by the method is more beneficial to human health.

CN1072090 discloses a method for preparing superoxide dismutase oral liquid, which is a novel SOD-containing oral liquid preparation by processing, separating, extracting and protecting wild material Rosa roxburghii to obtain various effective components such as superoxide dismutase SOD, catalase CAT, selenium, VC, VE, tannin and the like, and matching with radix codonopsitis, astragalus, medlar, longan and Chinese date percolate.

Disclosure of Invention

The invention aims to provide the oral liquid which has the functions of resisting oxidation, tonifying liver and kidney, whitening skin and blackening beard and hair.

In order to realize the purpose, the following technical scheme is adopted:

the feed is prepared from the following raw materials in parts by weight: 0.5-1 part of SOD, 150 parts of 100-one of angelica dahurica, 150 parts of 100-one of tuckahoe, 150 parts of 100-one of coix seed, 150 parts of 100-one of polygonum multiflorum, 0.5-1 part of lycopene powder, 25-40 parts of flavoring agent and 0.5-1 part of preservative. Preferably, the feed additive is prepared from the following raw materials in parts by weight: 1.0 part of SOD, 150 parts of angelica dahurica, 150 parts of tuckahoe, 150 parts of coix seed, 150 parts of polygonum multiflorum, 1.0 part of lycopene powder, 40 parts of flavoring agent and 0.8 part of preservative.

Part of the raw material purchase information of the invention is as follows:

SOD, purchased from Wuhan remote science and technology development Limited;

the Chinese medicinal components are purchased from Meizhou city, Chaozhou Rui Tang pharmaceutical Co., Ltd;

lycopene powder, purchased from sienna tianrui biotechnology limited.

The preparation process comprises the following steps:

the method comprises the following steps: weighing coarse powder of radix angelicae, poria cocos, coix seeds and polygonum multiflorum, adding 8 times of water to soak for 2 hours, and heating and distilling by steam for 6 hours to extract volatile oil for later use;

step two: adding 8 times of water into the residue, soaking for 0.5 hr, decocting in water for 1 hr, filtering while hot, repeating twice, mixing the three decoctions, concentrating to concentration of 1:1, standing for 24 hr, and filtering;

step three: weighing SOD and lycopene powder, dissolving with water, and filtering;

step four: and (4) combining the standby solutions obtained in the first step to the third step, adding a flavoring agent and a preservative, and uniformly mixing. Adjusting pH to 5.5 with purified water to 500ml, subpackaging into 10ml bottles, and sterilizing.

Specifically, the SOD used in the invention can remove superoxide anion free radicals and hydroxyl free radicals generated by organism metabolism, and simultaneously can be used as a substrate of superoxide anions to induce enzyme so as to protect organism cells from being damaged by aerobic metabolites. The SOD as a good free radical scavenger has good effects of improving the immunity of the organism, delaying aging and the like.

The angelica dahurica is warm in nature and pungent in taste, and has the activities of resisting inflammation, coagulation, virus, cancer, oxidation, pain and the like. Radix Angelicae Dahuricae is also a skin caring Chinese medicine which is preferred by physicians of all generations. In Ben Cao gang mu, it is recorded that Bai Zhi is good at growing skin, moistening skin and making face fat. The angelicin in the radix angelicae can inhibit the activity of tyrosinase and reduce the generation of melanin.

Poria, neutral in nature, sweet and bland in flavor, enters heart, lung, spleen and kidney meridians. Can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, palpitation, and insomnia. The chemical components of triterpenes and polysaccharides contained in Poria have antitumor, antibacterial and antioxidant biological activities.

Coix seed, cool in nature, sweet and bland in flavor. It enters spleen, stomach and lung meridians. The coix seed has the effects of promoting diuresis and eliminating dampness, strengthening spleen and relieving diarrhea, removing arthralgia, expelling pus and removing toxicity, resisting inflammation and easing pain, enhancing immunity and the like. The coix seed also has the effects of treating wart and acne, lightening spots, whitening skin, moistening skin, removing wrinkles and the like.

He shou Wu is slightly warm in nature, sweet, bitter and astringent in taste. The root tuber is used as medicine for tranquilization, nourishing blood, activating collaterals, removing toxic substance (malaria), resolving carbuncle, delaying aging, strengthening tendons and bones, blackening hair and beard, caring skin, and tranquilizing mind. The polygonum multiflorum can obviously increase the protein content in the brain and the liver and improve the DNA repair capacity of the elderly. Can also increase nucleic acid content of organism, enhance SOD activity in blood, resist oxidation, and further delay aging. The polygonum multiflorum has the effects of tonifying the kidney and replenishing essence, and the hair is dark, bright, glossy and elastic due to the sufficient kidney qi, and has no troubles of early whitening, withering, branching, breaking and hair loss; meanwhile, kidney qi is sufficient to strengthen the muscles and bones, so as to prevent osteoporosis, and improve symptoms such as weakness and hypodynamia of waist and knees, rheumatic arthralgia, arthritis and the like. The polygonum multiflorum can promote nerve excitation, enrich qi and blood, avoid dizziness caused by anemia, moisten the face and remove wrinkles, so that people can glow and gain the spirit; has obvious functions of resisting aging, improving neurasthenia and improving sleep quality.

Lycopene is an important carotenoid, widely present in red fruits and vegetables, with the highest content in tomatoes. It has antiaging, life prolonging, immunity enhancing, antioxidant, cancer preventing, and cardiovascular and cerebrovascular diseases preventing effects. Lycopene can improve SOD activity. The lycopene used in the present invention is extracted from tomato.

Compared with the prior art, the invention has the beneficial effects that: through adding SOD and lycopene powder, the two synergistically act to remove free radicals and delay aging; radix Angelicae Dahuricae, Poria and Coicis semen can be added for invigorating spleen, tranquilizing, removing speckle, whitening skin, moistening skin, and removing wrinkle; the addition of radix Polygoni Multiflori can tonify kidney, supplement essence, invigorate qi and blood, and nourish hair.

Drawings

FIG. 1 superoxide anion radical scavenging;

FIG. 2 hydroxyl radical clearance;

FIG. 3 skin brightness variation;

FIG. 4 melanin changes.

Detailed Description

The present invention is further described below by way of specific examples, but the present invention is not limited thereto.

Example one

The formula is as follows: 0.5g of SOD, 100 g of angelica dahurica, 100 g of tuckahoe, 100 g of coix seed, 100 g of polygonum multiflorum, 0.5g of lycopene powder, 40g of honey and 1g of sorbic acid.

The preparation method comprises the following steps:

the method comprises the following steps: weighing coarse powder of radix angelicae, poria cocos, coix seeds and polygonum multiflorum, adding 8 times of water to soak for 2 hours, and heating and distilling by steam for 6 hours to extract volatile oil for later use;

step two: adding 8 times of water into the residue, soaking for 0.5 hr, decocting in water for 1 hr, filtering while hot, repeating twice, mixing the three decoctions, concentrating to concentration of 1:1, standing for 24 hr, and filtering;

step three: weighing SOD and lycopene, dissolving with water, and filtering;

step four: and (4) combining the standby solutions obtained in the first step to the third step, adding a flavoring agent and a preservative, and uniformly mixing. Adjusting pH to 5.5 with purified water to 500ml, subpackaging into 10ml bottles, and sterilizing.

Example two

The formula is as follows: 0.6g of SOD, 110g of angelica dahurica, 110g of tuckahoe, 110g of coix seed, 110g of polygonum multiflorum, 0.6g of lycopene powder, 30g of simple syrup and 0.5g of benzoic acid.

The preparation process is the same as that of the first embodiment.

EXAMPLE III

The formula is as follows: 0.7g of SOD, 120g of angelica dahurica, 120g of tuckahoe, 120g of coix seed, 120g of fleece-flower root, 0.7g of lycopene powder, 25g of simple syrup and 1g of benzoic acid.

The preparation process is the same as that of the first embodiment.

Example four

The formula is as follows: 0.8g of SOD, 130g of angelica dahurica, 130g of tuckahoe, 130g of coix seed, 130g of polygonum multiflorum, 0.8g of lycopene powder, 25g of honey and 0.5g of sorbic acid.

The preparation process is the same as that of the first embodiment.

EXAMPLE five

The formula is as follows: 0.9g of SOD, 140g of angelica dahurica, 140g of tuckahoe, 140g of coix seed, 140g of polygonum multiflorum, 0.9g of lycopene powder, 40g of simple syrup and 0.8g of benzoic acid.

The preparation process is the same as that of the first embodiment.

EXAMPLE six

The formula is as follows: 1.0g of SOD, 150g of angelica dahurica, 150g of tuckahoe, 150g of coix seed, 150g of polygonum multiflorum, 1.0g of lycopene powder, 40g of honey and 0.8g of sorbic acid.

The preparation process is the same as that of the first embodiment.

Experiment one: in vitro antioxidant Activity test

The experiment was divided into three groups: SOD group, lycopene powder group, and SOD lycopene powder 1:1 composite group.

Experimental apparatus and reagents: BSA223S-G analytical balance (Shanghai Jingtian electronic instruments Co.), DR6000 ultraviolet-visible spectrophotometer (American Hash Co.), SIGMA3-18K refrigerated centrifuge (Beijing Boxixing instruments), intelligent digital display thermostat water bath (Jiangsu Jinyi instruments science and technology Co., Ltd.), superoxide anion kit and hydroxyl radical kit were all purchased from Nanjing to build the bioengineering institute.

The experimental method comprises the following steps: the assay was performed with reference to kit instructions.

The final experimental results are shown in fig. 1 and 2.

According to the experimental results, the SOD shows high superoxide anion free radical clearance and hydroxyl free radical clearance at lower concentration. The superoxide anion clearance rate of SOD at the concentration of 6mg/ml is 90.11%; the hydroxyl radical clearance rate is 90.08% when the concentration is 5 mg/ml. The compounding group combines SOD and lycopene powder 1:1 for use, and the superoxide anion clearance rate is increased to 97.13% and the hydroxyl radical clearance rate is increased to 97.84% at 4 mg/ml. The free radical scavenging rate is increased by compound use, and the lycopene powder is cheaper than SOD, so the cost can be saved. Example six SOD and lycopene powders were added in a ratio of 1:1 and a final concentration of 4 mg/ml. The radical scavenging efficiency is the best.

Experiment two: whitening and freckle removing experiment

An experimental instrument: minolta Chromameter CM-700d (Meinenda, Japan), Mexameter MX18 skin melanin and heme tester (Courage + Khazak, Germany).

The experimental method comprises the following steps:

1. volunteer subjects were recruited 40 cases.

2. The subject takes 1 piece of the product every day, and each piece is 10 ml.

3. The skin condition of the subjects was measured with the instrument before, at week 4, week 8, and week 12, respectively, of the example six formulation. Skin lightness L values were measured using a Minolta Chromameter (CM-700d), 3 times per replicate, averaged, and the L values of all volunteers were re-averaged. The skin melanin values were measured using a Mexameter MX18, 3 replicates each time, averaged, the melanin reduction ratios calculated, and the melanin reduction ratios of all volunteers were then averaged.

The results of the experiment are shown in FIGS. 3 and 4.

Experiment three: hair blackening test

The experimental method comprises the following steps:

1. 40 volunteer subjects were recruited, the subjects being early-onset white hair due to disease.

2. The six formulations of the examples were taken and the effect was evaluated after 12 weeks.

3. The criteria for therapeutic effect are as follows: the hair turns yellow from white after treatment, and turns yellow, white and black without relapse; the number of effective white hairs is obviously reduced, and new hairs are completely blackened; and (4) invalidation: the white hair symptom is not improved.

The experimental results are as follows:

the medicine has the curative effect of 23 cases, the obvious effect of 15 cases and the ineffective effect of 2 cases.

The experimental results show that the product has the capability of removing superoxide anions and hydroxyl free radicals, and can improve the skin color and achieve the beautifying effect of blacking hair.

Claims (7)

1. The anti-oxidation beautifying oral liquid is characterized by being prepared from the following raw materials in parts by weight: 0.5-1 part of SOD, 150 parts of 100-one of angelica dahurica, 150 parts of 100-one of tuckahoe, 150 parts of 100-one of coix seed, 150 parts of 100-one of polygonum multiflorum, 0.5-1 part of lycopene powder, 25-40 parts of flavoring agent and 0.5-1 part of preservative.

2. The anti-oxidation beautifying oral liquid is characterized by being prepared from the following raw materials in parts by weight: 1.0 part of SOD, 150 parts of angelica dahurica, 150 parts of tuckahoe, 150 parts of coix seed, 150 parts of polygonum multiflorum, 1.0 part of lycopene powder, 40 parts of flavoring agent and 0.8 part of preservative.

3. The oral liquid as claimed in claim 1 or 2, wherein SOD is extracted from plants, and the enzyme activity of SOD is 100000U/g.

4. The oral liquid as claimed in claim 1 or 2, wherein the flavoring agent is honey or simple syrup.

5. The oral liquid as claimed in claim 1 or 2, wherein the preservative is sorbic acid or benzoic acid.

6. The oral liquid for resisting oxidation and beautifying face as claimed in claim 1 or 2, characterized in that lycopene is extracted from tomato, and the content of lycopene is greater than or equal to 12%.

7. The preparation method of the antioxidant beautifying oral liquid as claimed in claim 1 or 2, characterized by comprising the following steps:

the method comprises the following steps: weighing coarse powder of radix angelicae, poria cocos, coix seeds and polygonum multiflorum, adding 8 times of water to soak for 2 hours, and heating and distilling by steam for 6 hours to extract volatile oil for later use;

step two: adding 8 times of water into the residue, soaking for 0.5 hr, decocting in water for 1 hr, filtering while hot, repeating twice, mixing the three decoctions, concentrating to concentration of 1:1, standing for 24 hr, and filtering;

step three: weighing SOD and lycopene powder, dissolving with water, and filtering;

step four: mixing the solutions obtained in the first to third steps, adding correctant and antiseptic, and mixing; adjusting pH to 5.5 with purified water to 500ml, subpackaging into 10ml bottles, and sterilizing.

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