CN110799542A - 抗-b7h3抗体用于治疗中枢神经系统癌症的用途 - Google Patents

抗-b7h3抗体用于治疗中枢神经系统癌症的用途 Download PDF

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Publication number
CN110799542A
CN110799542A CN201880040310.2A CN201880040310A CN110799542A CN 110799542 A CN110799542 A CN 110799542A CN 201880040310 A CN201880040310 A CN 201880040310A CN 110799542 A CN110799542 A CN 110799542A
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CN
China
Prior art keywords
antigen
antibody
binding fragment
seq
amino acid
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Pending
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CN201880040310.2A
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English (en)
Chinese (zh)
Inventor
K·克雷默
N-K·章
O·巴德斯加德
C·J·默勒圣佩德罗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Y Monoclonal Antibody Pharmaceutical Co Ltd
Memorial Sloan Kettering Cancer Center
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Y Monoclonal Antibody Pharmaceutical Co Ltd
Memorial Sloan Kettering Cancer Center
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Publication date
Application filed by Y Monoclonal Antibody Pharmaceutical Co Ltd, Memorial Sloan Kettering Cancer Center filed Critical Y Monoclonal Antibody Pharmaceutical Co Ltd
Publication of CN110799542A publication Critical patent/CN110799542A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Nuclear Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880040310.2A 2017-05-12 2018-05-14 抗-b7h3抗体用于治疗中枢神经系统癌症的用途 Pending CN110799542A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762505558P 2017-05-12 2017-05-12
US62/505,558 2017-05-12
PCT/US2018/032559 WO2018209346A1 (en) 2017-05-12 2018-05-14 Use of anti-b7h3 antibodies for treating cancer in the central nervous system

Publications (1)

Publication Number Publication Date
CN110799542A true CN110799542A (zh) 2020-02-14

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CN201880040310.2A Pending CN110799542A (zh) 2017-05-12 2018-05-14 抗-b7h3抗体用于治疗中枢神经系统癌症的用途

Country Status (11)

Country Link
US (2) US20200197546A1 (enExample)
EP (1) EP3635012A4 (enExample)
JP (2) JP2020520382A (enExample)
KR (1) KR20200008580A (enExample)
CN (1) CN110799542A (enExample)
AU (1) AU2018265888A1 (enExample)
BR (1) BR112019023776A2 (enExample)
CA (1) CA3062335A1 (enExample)
EA (1) EA201992683A1 (enExample)
RU (1) RU2019140833A (enExample)
WO (1) WO2018209346A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111662384A (zh) * 2020-06-30 2020-09-15 广州百暨基因科技有限公司 抗b7h3抗体及其应用
WO2021190586A1 (zh) * 2020-03-25 2021-09-30 江苏恒瑞医药股份有限公司 B7h3抗体-依喜替康类似物偶联物及其医药用途
CN113527487A (zh) * 2020-04-22 2021-10-22 复星凯特生物科技有限公司 抗人b7-h3的单克隆抗体及其应用
WO2023046047A1 (zh) * 2021-09-27 2023-03-30 盛禾(中国)生物制药有限公司 一种异源二聚体蛋白质及其应用
WO2024008039A1 (zh) * 2022-07-08 2024-01-11 盛禾(中国)生物制药有限公司 一种异源二聚体融合蛋白及其应用

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113853220A (zh) * 2019-03-11 2021-12-28 生物相容英国有限公司 用于中枢神经系统肿瘤治疗的放射性微球
EP4022313A1 (en) 2019-08-30 2022-07-06 Y-Mabs Therapeutics, Inc. Immunohistochemical assessment of b7-h3 expression
EP4138931A1 (en) 2020-04-24 2023-03-01 Y-Mabs Therapeutics, Inc. B7h3 antibodies with chelators
WO2022167052A1 (en) * 2021-02-08 2022-08-11 Y-Mabs Therapeutics, Inc. Use of ascorbic acid as stabilizing agent for anti b7-h3 antibodies
KR20230145038A (ko) 2021-02-09 2023-10-17 메디링크 테라퓨틱스 (쑤저우) 컴퍼니, 리미티드 생물활성 물질 접합체, 이의 제조방법 및 이의 용도
US20240199750A1 (en) 2021-03-26 2024-06-20 Innate Pharma Multispecific proteins comprising an nkp46-binding site, a cancer antgienge binding site fused to a cytokine for nk cell engaging
WO2022258678A1 (en) 2021-06-09 2022-12-15 Innate Pharma Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a
WO2022258691A1 (en) 2021-06-09 2022-12-15 Innate Pharma Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a
KR20240019297A (ko) 2021-06-09 2024-02-14 이나뜨 파르마 에스.에이. Nkp46, 사이토카인 수용체, 종양 항원 및 cd16a 에 결합하는 다중특이적 단백질
EP4480499A1 (en) 2022-02-16 2024-12-25 Medilink Therapeutics (Suzhou) Co., Ltd. Conjugate of antibody-eribulin or derivative thereof, intermediate thereof, preparation method therefor, pharmaceutical composition thereof and use thereof
CN119212733A (zh) 2022-05-18 2024-12-27 苏州宜联生物医药有限公司 包含蛋白降解剂类生物活性化合物的抗体药物偶联物及其制备方法和用途
WO2024208818A1 (en) 2023-04-04 2024-10-10 Innate Pharma Modular chimeric antigen receptor

Citations (3)

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CN101687021A (zh) * 2007-03-22 2010-03-31 斯隆-凯特琳癌症研究院 单克隆抗体8h9的应用
US20120294796A1 (en) * 2010-03-04 2012-11-22 Macrogenics, Inc. Antibodies Reactive with B7-H3 and Uses Thereof
WO2016033225A2 (en) * 2014-08-27 2016-03-03 Memorial Sloan Kettering Cancer Center Antibodies, compositions, and uses

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MY133346A (en) * 1999-03-01 2007-11-30 Biogen Inc Kit for radiolabeling ligands with yttrium-90
WO2016106004A1 (en) * 2014-12-23 2016-06-30 Full Spectrum Genetics, Inc. Novel anti-b7h3 binding compounds and uses thereof

Patent Citations (3)

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CN101687021A (zh) * 2007-03-22 2010-03-31 斯隆-凯特琳癌症研究院 单克隆抗体8h9的应用
US20120294796A1 (en) * 2010-03-04 2012-11-22 Macrogenics, Inc. Antibodies Reactive with B7-H3 and Uses Thereof
WO2016033225A2 (en) * 2014-08-27 2016-03-03 Memorial Sloan Kettering Cancer Center Antibodies, compositions, and uses

Non-Patent Citations (1)

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Title
BENJAMIN B.KASTEN等: "B7-H3-targeted 212Pb radioimmunotherapy of ovarian cancer in preclinical models", 《NUCLEAR MEDICINE AND BIOLOGY》 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021190586A1 (zh) * 2020-03-25 2021-09-30 江苏恒瑞医药股份有限公司 B7h3抗体-依喜替康类似物偶联物及其医药用途
CN113527487A (zh) * 2020-04-22 2021-10-22 复星凯特生物科技有限公司 抗人b7-h3的单克隆抗体及其应用
CN111662384A (zh) * 2020-06-30 2020-09-15 广州百暨基因科技有限公司 抗b7h3抗体及其应用
CN111662384B (zh) * 2020-06-30 2021-04-09 广州百暨基因科技有限公司 抗b7h3抗体及其应用
CN112961241A (zh) * 2020-06-30 2021-06-15 广州百暨基因科技有限公司 抗b7h3抗体及其应用
WO2022001020A1 (zh) * 2020-06-30 2022-01-06 广州百暨基因科技有限公司 抗b7h3抗体及其应用
WO2023046047A1 (zh) * 2021-09-27 2023-03-30 盛禾(中国)生物制药有限公司 一种异源二聚体蛋白质及其应用
WO2024008039A1 (zh) * 2022-07-08 2024-01-11 盛禾(中国)生物制药有限公司 一种异源二聚体融合蛋白及其应用

Also Published As

Publication number Publication date
KR20200008580A (ko) 2020-01-28
EA201992683A1 (ru) 2020-04-23
US20200197546A1 (en) 2020-06-25
CA3062335A1 (en) 2018-11-15
US20240415990A1 (en) 2024-12-19
JP2023016969A (ja) 2023-02-02
JP2020520382A (ja) 2020-07-09
RU2019140833A (ru) 2021-06-15
AU2018265888A1 (en) 2019-11-21
EP3635012A1 (en) 2020-04-15
RU2019140833A3 (enExample) 2022-02-07
WO2018209346A1 (en) 2018-11-15
EP3635012A4 (en) 2020-12-30
BR112019023776A2 (pt) 2020-07-28

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