CN110786436A - 一种预防佝偻病、促进钙磷吸收的滴剂饮料 - Google Patents

一种预防佝偻病、促进钙磷吸收的滴剂饮料 Download PDF

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CN110786436A
CN110786436A CN201911180795.8A CN201911180795A CN110786436A CN 110786436 A CN110786436 A CN 110786436A CN 201911180795 A CN201911180795 A CN 201911180795A CN 110786436 A CN110786436 A CN 110786436A
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蔚晨歌
华力
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Abstract

本发明公开了一种预防佝偻病、促进钙磷吸收的滴剂饮料，由如下质量份的各组分组成：0.105%维生素D3和99.985%MCT；每个剂量单位中含有400国际单位（IU）的维生素D3。通过以下制备工艺获得：准确称取MCT油投入混料罐，同时开动罐上的搅拌器，加热，温度达到65‑70°C后，保持10‑15分钟；将该液体冷却至室温（20‑25°C），按比例加入维生素D3继续搅拌15分钟至均匀，然后分瓶灌装。本发明预防佝偻病，促进钙，磷吸收，运用滴剂饮料，儿童效果更乐于服用，大大提高了临床使用的顺应性。本发明的制备工艺简单，使用常用辅料，成本较低廉，具有良好的市场前景。

Description

一种预防佝偻病、促进钙磷吸收的滴剂饮料
技术领域
本发明属于保健饮品技术领域，具体涉及一种预防佝偻病、促进钙磷吸收的滴剂饮料。
背景技术
维生素D的发现是人们与佝偻症抗争的结果。早在1824年，有人发现鱼肝油可在治疗佝偻病中起重要作用。1918年，英国的梅兰比爵士证实佝偻病是一种营养缺乏症。但他误认为是缺乏维生素A所致。1930年Gottingen大学的A.Windaus教授首先确定了维生素D的化学结构，1932年经过紫外线照射麦角固醇而得到的维生素D2的化学特性被阐明。维生素D3的化学特性直到1936年才被确定。1913年，美国科学家Elmer McCollum和MargueriteDavis在鱼肝油里发现了一种物质，起名叫“维生素A”，后来，英国医生EdwardMellanby发现，喂了鱼肝油的狗不会得佝偻病，于是得出结论维生素A或者其协同因子可以预防佝偻病。1921年Elmer McCollum使用破坏掉鱼肝油中维生素A做同样的实验，结果相同，说明抗佝偻病并非维生素A所为。他将其命名为维生素D，即第四种维生素，但当时的人们还不知道，这种东西和其他维生素不同，因为只要有紫外线，人自己就可以而合成(有悖于维生素的定义)。
目前，维生素D滴剂是一种用于儿童佝偻病的预防和治疗的药物。经过大量循证医学研究和基础研究发现，维生素D滴剂对癌症、高血压、糖尿病、结核病、免疫功能异常的治疗具有一定的疗效。
发明内容
针对现有技术中的不足之处，本发明提供一种预防佝偻病、促进钙磷吸收的滴剂饮料。
为了达到上述目的，本发明技术方案如下：
一种预防佝偻病、促进钙磷吸收的滴剂饮料，包括维生素D3和MCT。
进一步的，所述维生素D滴剂由如下质量份的各组分组成：0.105％维生素D3和99.985％MCT。
进一步的，所述维生素D滴剂中，每个剂量单位中含有400国际单位(IU)的维生素D3。
本发明还提供了一种预防佝偻病、促进钙磷吸收的滴剂饮料的制备工艺，包括以下步骤：
(1)混合液体配料：按设备的生产能力准确称取MCT油投入混料罐，同时开动罐上的搅拌器，加热，温度达到65-70℃后，保持10-15分钟；将该液体冷却至室温(20-25℃)，按比例加入维生素D3继续搅拌15分钟至均匀；
(2)灌装：将混全均匀的液体转移至灌装机进行灌装；按灌装量调节灌装机；按要求配备灌装瓶和盖；灌装开始后每小时检测灌装量。
进一步的，步骤(2)中，每个灌装瓶内分装12ml的维生素D滴剂。
本发明维生素D滴剂通过口服给予。本领域技术人员可根据实际情况容易地确定给药剂量。如每天0.4ml，即一滴，含有400国际单位(IU)的维生素D3；因维生素D3的1IU＝0.025ug，则400IU＝10ug，符合国家标准2-15ug，适用于1-3岁幼儿用量。
本发明的原料：
(1)维生素D3：又名烟碱酸胺、胆骨化醇、胆钙化醇。提高肌体对钙、磷的吸收，使血浆钙和血浆磷的水平达到饱和程度；促进生长和骨骼钙化，促进牙齿健全；通过肠壁增加磷的吸收，并通过肾小管增加磷的再吸收；维持血液中柠檬酸盐的正常水平；防止氨基酸通过肾脏损失。用于佝偻病、骨软化症及婴儿手足搐搦症，佝偻病兼有龋齿者也可防治；
(2)MCT：是中链甘油三酯(Medium Chain Triglycerides)的简称，是由碳链长度6-12的饱和中链脂肪酸组成的甘油三酯。医药行业中常用作溶剂、载体和乳化剂，也可以作为食品行业中香精、色素和维生素的溶剂，其具有不易被胃酸分解，易在肠道中水解的特性。天然存在于棕榈仁油、椰子油等食品和母乳中，是膳食脂肪的来源之一。作为食品添加剂，中链甘油三酯仅由饱和脂肪酸构成，凝固点低，室温下为液体，粘度小。与大豆油比较，完全是无臭、无色的透明液体。与普通的油脂和氢化油脂相比，中链甘油三酯不饱和脂肪酸的含量极低，氧化稳定性非常好，其碘值不超过0.5，MCT在高温和低温下特别稳定。
有益效果：本发明预防佝偻病，促进钙，磷吸收，运用滴剂饮料，儿童效果更乐于服用，大大提高了临床使用的顺应性。本发明的制备工艺简单，使用常用辅料，成本较低廉，具有良好的市场前景。
具体实施方式
以下参照具体的实施例来说明本发明。本领域技术人员能够理解，这些实施例仅用于说明本发明，其不以任何方式限制本发明的范围。
一种预防佝偻病、促进钙磷吸收的滴剂饮料，由如下质量份的各组分组成：0.105％维生素D3和99.985％MCT。每个剂量单位中含有400国际单位(IU)的维生素D3。其制备工艺，包括以下步骤：
(1)混合液体配料：按设备的生产能力准确称取MCT油投入混料罐，同时开动罐上的搅拌器，加热，温度达到65-70℃后，保持10-15分钟；将该液体冷却至室温(20-25℃)，按比例加入维生素D3继续搅拌15分钟至均匀；将混全均匀的液体转移至灌装机进行灌装；
(2)灌装：按灌装量调节灌装机；按要求配备灌装瓶和盖；灌装开始后每小时检测灌装量，每个灌装瓶内分装12ml的维生素D滴剂。
维生素D滴剂的性能测试
分别取实施例1中所制备得到的维生素D滴剂进行性能评价，评价项目及结果如下表1-4。
表1实施例中维生素D滴剂感官指标及评价
项目 指标 实施例
色泽 淡黄色至黄色 符合指标
滋味、气味 无异味 符合指标
状态 澄清油状液体，无正常视力可见外来异物 符合指标
表2实施例中维生素D滴剂理化指标及评价
项目 指标 检验方法 实施例
铅(以Pb计)，mg/kg ≤0.02 GB5009.12 未检出
总砷(以As计)，mg/kg ≤0.3 GB5009.11 未检出
总汞(以Hg计)，mg/kg ≤0.02 GB5009.17 未检出
酸价，mg/g ≤4 GB5009.229 0.36
过氧化值，g/100g ≤0.25 GB5009.227 0.022
表3实施例中维生素D滴剂微生物指标及评价
项目 指标 检验方法 实施例
菌落总数，CFU/g ≤1000 GB 4789.2 ＜10
大肠菌群，mpn/g ≤0.43 GB 4789.3 ＜0.3
霉菌和酵母，CFU/g ≤50 GB 4789.15 ＜10
金黄色葡萄球菌 ≤0/25g GB 4789.10 未检出
沙门氏菌 ≤0/25g GB 4789.4 未检出
通过GB5009.82检测维生素D滴剂标志性成分：每瓶含维生素D(指标288-450ug)，以胆钙化醇计，300ug。

Claims (5)

1.一种预防佝偻病、促进钙磷吸收的滴剂饮料，其特征在于：包括维生素D3和MCT。
2.如权利要求1所述的预防佝偻病、促进钙磷吸收的滴剂饮料，其特征在于：所述维生素D滴剂由如下质量份的各组分组成：0.105%维生素D3和99.985%MCT。
3.如权利要求1所述的预防佝偻病、促进钙磷吸收的滴剂饮料，其特征在于：所述维生素D滴剂中，每个剂量单位中含有400国际单位（IU）的维生素D3。
4.如权利要求1至3所述的预防佝偻病、促进钙磷吸收的滴剂饮料，其特征在于：其制备工艺，包括以下步骤：
（1）混合液体配料：按设备的生产能力准确称取MCT油投入混料罐，同时开动罐上的搅拌器，加热，温度达到65-70°C后，保持10-15分钟；将该液体冷却至室温（20-25°C ），按比例加入维生素D3继续搅拌15分钟至均匀；
（2）分瓶灌装：将混全均匀的液体转移至灌装机进行灌装；按灌装量调节灌装机；按要求配备灌装瓶和盖；灌装开始后每小时检测灌装量。
5.如权利要求4所述的预防佝偻病、促进钙磷吸收的滴剂饮料，其特征在于：步骤（2）中，每个灌装瓶内分装12ml的维生素D滴剂。
CN201911180795.8A 2019-11-27 2019-11-27 一种预防佝偻病、促进钙磷吸收的滴剂饮料 Pending CN110786436A (zh)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105311037A (zh) * 2014-07-31 2016-02-10 山东达因海洋生物制药股份有限公司 一种维生素d胶囊型滴剂及其制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105311037A (zh) * 2014-07-31 2016-02-10 山东达因海洋生物制药股份有限公司 一种维生素d胶囊型滴剂及其制备方法

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Title
梅奥营养（广西）卢绍欣: "梅奥MAYO营养滴剂系列简介", 《美篇HTTPS://WWW.MEIPIAN.CN/2EQIT8FF》 *

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