CN110772627A - 一种藏药消痹膏及其制备方法和应用 - Google Patents
一种藏药消痹膏及其制备方法和应用 Download PDFInfo
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Abstract
本发明提供了一种藏药消痹膏及其制备方法和应用，属于中药技术领域，由以下重量份的原料组成：宽筋藤400～600份、独活400～600份、粗茎秦艽400～600份、乳香50～100份、决明子50～100份、黄葵子50～100份、儿茶50～100份、生姜150～225份、花椒粉50～75份、羊油300～450份、蜂蜜100～150份；本发明不仅能有效控制关节骨质增生的病情发展，还可以根治初期风湿、类风湿性关节病，并且能够彻底消除关节疼痛和晨僵，关节红肿等病症，特别对骨性关节疾病引起的晨僵、疼痛等的疗效更加显著；同时该藏药是膏剂外用，使用方便，疗效稳定，治疗彻底，无毒副作用。
Description
技术领域
本发明属于中药技术领域，具体涉及一种藏药消痹膏及其制备方法和应用。
背景技术
因为生活习性和地理环境等因素，关节疾病在青藏高原属常见疾病，在藏医治疗中主要采用藏医药浴法给予治疗，在治疗中常存在治疗不便和药物浪费等缺陷。藏医药对关节病的治疗中有详细的步骤及方法，其临床疗效也显著，但是因治疗方法都属古法，很难被当下的社会认知所认可，间接导致难以被患者接受推广应用。另外藏医外治法中主要延用藏医药浴法治疗关节疾病，但是因没有系统的研究，所以在施治中很难控制药物的给药量及其被皮肤吸收的有效量，从而导致药物的过度浪费和出现药量不足而治疗效果欠佳等弊端。
发明内容
为解决上述问题，本发明的目的在于提供一种藏药消痹膏。
本发明的第一个目的是提供一种藏药消痹膏，由以下重量份的原料制成：
宽筋藤400～600份、独活400～600份、粗茎秦艽400～600份、乳香50～100份、决明子50～100份、黄葵子50～100份、儿茶50～100份、生姜150～225份、花椒粉50～75份、羊油300～450份、蜂蜜100～150份；
优选的，所述藏药消痹膏由以下重量份原料制成：宽筋藤500份、独活500份、粗茎秦艽500份、乳香75份、决明子75份、黄葵子75份、儿茶100份、生姜175份、花椒粉50份、羊油300份、蜂蜜150份。
本发明的第二个目的是提供一种藏药消痹膏的制备方法，包括以下步骤：
S1：称取以下重量份数原料：宽筋藤400～600份、独活400～600份、粗茎秦艽400～600份、乳香50～100份、决明子50～100份、黄葵子50～100份、儿茶50～100份、生姜150～225份、花椒粉50～75份、羊油300～450份、蜂蜜100～150份；
S2：将S1宽筋藤、独活、粗茎秦艽、乳香、决明子、黄葵子、儿茶、生姜、花椒粉洗净后混合，研磨成药粉，然后加水溶解并浸泡22-26h；
S3：把S2浸泡后的药粉煎煮4～5.5h过滤，重复煎煮三次后合并三次滤液；
S4：将S3滤液煎熬并浓缩至滴在纸上不散开时，制得清膏；
S5：将S1羊油和蜂蜜倒入S4清膏中熬炼至能扯拉成旗或将膏汁滴入清水中凝结成珠而不散，即得药膏，冷却后密封存放。
本发明的第三个目的是提供一种上述藏药消痹膏在制备治疗关节疾病药物方面的应用。
本发明藏药配伍机理：
藏医理论中的“真布病”与中医痹病略同，都是因为外邪导致关节病变的一类疾病，与现代医学的骨性关节炎、风湿性关节炎、类风险关节炎等基本相同。藏医认为此类疾病是有身体“黄水”引起，所以本发明中有三味主要的“黄水”药物，既乳香、决明子、黄葵子，并加有儿茶一味“黄水”与关节病的常用药，此四味在本配伍中以臣用药。另外关节病常有关节痛痛的病症，所以在此配伍中加入三味消痛药物，既宽筋藤、独活、粗茎秦艽，此三味药物在本配伍中以君使用。另外关节疾病，尤其骨性关节炎常有晨僵现象，而藏医认为晨僵是因“隆”的失衡引起，所以在本配伍中加入一味调节“隆”的药物，既生姜，此药物在本配伍中以佐入药。为了提高药物的药效利用，能提高药物的渗透步入病灶以治疗疾病，所以在本配伍中加入两位引子药，既胡椒粉和羊油，次药在本配伍只能够以使入药。综上本发明主要用于消除各类关节疾病引起的疼痛和晨僵，以及缓解、治疗各类“黄水”型关节疾病。
本发明的有益效果是：
本发明不仅能有效控制关节骨质增生的病情发展，还可以根治初期风湿、类风湿性关节病，并且能够彻底消除关节疼痛和晨僵，关节红肿等病症，特别对骨性关节疾病引起的晨僵、疼痛等的疗效更加显著；同时该藏药是膏剂外用，使用方便，能够合理控制药物使用量，避免药物的过度浪费和出现药量不足的问题，疗效稳定，治疗彻底，无毒副作用。
具体实施方式
为了使本领域技术人员更好地理解本发明的技术方案能予以实施，下面结合具体实施例和数据对本发明作进一步说明，但所举实施例不作为对本发明的限定。
实施例1
一种藏药消痹膏，由以下原料制成：九宽筋藤400g、独活400g、粗茎秦艽400g、乳香50g、决明子50g、黄葵子50g、儿茶50g、生姜150g、花椒粉50g、羊油300、蜂蜜100g。
上述藏药消痹膏是具体由以下步骤制得：
称量：称取以下重量原料：九宽筋藤400g、独活400g、粗茎秦艽400g、乳香50g、决明子50g、黄葵子50g、儿茶50g、生姜150g、花椒粉50g、羊油300、蜂蜜100g；
浸泡：按照重量份数将宽筋藤、独活、粗茎秦艽、乳香、决明子、黄葵子、儿茶、生姜、花椒粉洗净后混合，用粉碎机研磨成药粉，然后把药粉放入砂锅内，加适量的水浸润药粉，充分溶解吸收后再加水没过药粉并浸泡22h；
煎煮：把浸泡后的药粉煎煮4h过滤，重复煎煮三次后合并三次过滤得药汁；
浓缩：将煎煮后的药汁煎熬，煎熬过程中不断搅拌，煎熬到药汁滴在纸上不散开时暂停煎熬，得清膏。
收膏：按重量份数将羊油和蜂蜜倒入上述清膏中熬炼至能扯拉成旗或将膏汁滴入清水中凝结成珠而不散，即得药膏，冷却后密封存放。
实施例2
一种藏药消痹膏，由以下原料制成：宽筋藤500g、独活500g、粗茎秦艽500g、乳香75g、决明子75g、黄葵子75g、儿茶100g、生姜175g、花椒粉50g、羊油300g、蜂蜜150g。
上述藏药消痹膏是具体由以下步骤制得：
称量：称取以下重量原料：宽筋藤500g、独活500g、粗茎秦艽500g、乳香75g、决明子75g、黄葵子75g、儿茶100g、生姜175g、花椒粉50g、羊油300g、蜂蜜150g；
浸泡：按照重量份数将宽筋藤、独活、粗茎秦艽、乳香、决明子、黄葵子、儿茶、生姜、花椒粉洗净后混合，用粉碎机研磨成药粉，然后把药粉放入砂锅内，加适量的水浸润药粉，充分溶解吸收后再加水没过药粉并浸泡24h；
煎煮：把浸泡后的药粉煎煮5h过滤，重复煎煮三次后合并三次过滤得药汁；
浓缩：将煎煮后的药汁煎熬，煎熬过程中不断搅拌，煎熬到药汁滴在纸上不散开时暂停煎熬，得清膏。
收膏：按重量份数将羊油和蜂蜜倒入上述清膏中熬炼至能扯拉成旗或将膏汁滴入清水中凝结成珠而不散，即得药膏，冷却后密封存放
实施例3
一种藏药消痹膏，由以下原料制成：宽筋藤600g、独活600g、粗茎秦艽600g、乳香100g、决明子100g、黄葵子100g、儿茶100g、生姜225g、花椒粉75g、羊油450g、蜂蜜150g。
上述藏药消痹膏是具体由以下步骤制得：
称量：称取以下重量原料：宽筋藤600g、独活600g、粗茎秦艽600g、乳香100g、决明子100g、黄葵子100g、儿茶100g、生姜225g、花椒粉75g、羊油450g、蜂蜜150g；
浸泡：按照重量份数将宽筋藤、独活、粗茎秦艽、乳香、决明子、黄葵子、儿茶、生姜、花椒粉洗净后混合，用粉碎机研磨成药粉，然后把药粉放入砂锅内，加适量的水浸润药粉，充分溶解吸收后再加水没过药粉并浸泡26h；
煎煮：把浸泡后的药粉煎煮5.5h过滤，重复煎煮三次后合并三次过滤得药汁；
浓缩：将煎煮后的药汁煎熬，煎熬过程中不断搅拌，煎熬到药汁滴在纸上不散开时暂停煎熬，得清膏。
收膏：按重量份数将羊油和蜂蜜倒入上述清膏中熬炼至能扯拉成旗或将膏汁滴入清水中凝结成珠而不散，即得药膏，冷却后密封存放。
上述实施例1～3所制备的中药组合物药效相似，下面以实施例2制备的藏药消痹膏为例，通过采用下述试验来进一步对本发明的效果进行说明。
1、一般资料
此次研究我们将重点放置于用藏药消痹膏治疗双膝骨性关节炎的疗效平均中，观察患者关节疼痛和晨僵，以及关节红肿等的变化。
2、诊断标准
疗效标准参照《藏医常见病临床诊疗指南》。临床治愈：主要症状与体征消失，无任何不适感；显效：关节疼痛明显好转，接近正常，晨僵时间减半至原先的三分之一，关节刺痛感消失，关节红肿完全消退；有效：主要症状与体征概述，关节疼痛及晨僵较治疗前有改善，但是未达到正常标准；无效：主要症状、体征无变化，甚至加重。
3、治疗方法
(1)治疗组操作方法：在治疗中先用酒精或者碘伏清洗患处，使患处充分消毒洁净，再用干棉签擦拭患处，后将准备好的藏药消痹膏均匀的涂抹患处，即刻用TDP灯照射20-30分钟，每天2次，7天为一个疗程。
(2)对照组操作方法：在治疗中先用酒精或者碘伏清洗患处，使患处充分消毒洁净，再用干棉签擦拭患处，后将准备好的奇正消痛贴膏均匀的涂抹患处，即刻用TDP灯照射20-30分钟，每天2次，7天为一个疗程。
4、治疗效果
此次实验纳入观察的病例均未采取合并用药，通过第657例病例的观察对比，其中治疗组治愈有172例，显效有141例，有效有21例，无效有8例，总有效率占有97.66％。对照组治愈有101例，显效有142例，有效有44例，无效有28例，总有效率占有91％。其疗效观察数据总结见表1。
表1治疗效果
5、典型病例
(1)李某，男性，54岁，青海省尖扎县人，左膝关节肿胀，压痛，左膝关节在活动时有摩擦感，伴晨僵，使用本发明藏药2个疗程后，左膝关节肿胀，压痛，左膝关节在活动时有摩擦感，伴晨僵等基本消失，随之为加固，再使用一个疗程，患者上述症状完全消失，随之停药，三个月后回访未发病。
(2)才某，女，49岁，青海省尖扎县人，双膝关节疼痛，肿胀，伴晨僵，活动时膝关节有摩擦感，经诊断为双膝退行性病变，按照正规治疗方案使用2个疗程后，关节酸痛，肿胀，消失，晨僵有所缓解，再续2个疗程后，患者双膝关节酸痛，肿胀，晨僵，双膝关节摩擦感等完全消失，随之停药，3个月后回访未发病。
(3)多某，女，56岁，青海省同仁县人，右膝关节酸痛，活动时有摩擦感，并有“咔嗒”声，伴晨僵和肿胀，经过X平片照射，确诊为右膝关节退行性病变，伴有少量积液，按照治疗方案使用本发明3个疗程后关节酸痛，摩擦感，肿胀完全消失，晨僵有明显好转，继续使用本发明1个疗程后上述症状完全消失，5个月后回访未复发。
综上可得，本发明在治疗风湿及类风湿性关节炎，以及骨性关节炎中有显著疗效，尤其对骨性关节炎的关节疼痛和肿胀，晨僵上有明显的治愈率。通过宽筋藤、独活、粗茎秦艽、乳香、决明子、黄葵子、儿茶、生姜、花椒粉、羊油、蜂蜜的不同组成成分及加工筛选方式，极大的缩短了治疗周期，复发率，提高了治疗效果，避免了患者手术造成的经济和生活的压力。
尽管已描述了本发明的优选实施例，但本领域内的技术人员一旦得知了基本创造性概念，则可对这些实施例作出另外的变更和修改。所以，所附权利要求意欲解释为包括优选实施例以及落入本发明范围的所有变更和修改。
Claims (4)
1.一种藏药消痹膏，其特征在于，由以下重量份数的原料制成：宽筋藤400～600份、独活400～600份、粗茎秦艽400～600份、乳香50～100份、决明子50～100份、黄葵子50～100份、儿茶50～100份、生姜150～225份、花椒粉50～75份、羊油300～450份、蜂蜜100～150份。
2.根据权利要求1所述的藏药消痹膏，其特征在于，由以下重量份数的原料制成：宽筋藤500份、独活500份、粗茎秦艽500份、乳香75份、决明子75份、黄葵子75份、儿茶100份、生姜175份、花椒粉50份、羊油300份、蜂蜜150份。
3.根据权利要求1所述的藏药消痹膏的制备方法，其特征在于，包括以下步骤：
S1：称取以下重量份数原料：宽筋藤400～600份、独活400～600份、粗茎秦艽400～600份、乳香50～100份、决明子50～100份、黄葵子50～100份、儿茶50～100份、生姜150～225份、花椒粉50～75份、羊油300～450份、蜂蜜100～150份；
S2：将S1宽筋藤、独活、粗茎秦艽、乳香、决明子、黄葵子、儿茶、生姜、花椒粉洗净后混合，研磨成药粉，然后加水溶解并浸泡22-26h；
S3：把S2浸泡后的药粉煎煮4～5.5h过滤，重复煎煮三次后合并三次滤液；
S4：将S3滤液煎熬并浓缩至滴在纸上不散开时，制得清膏；
S5：将S1羊油和蜂蜜倒入S4清膏中熬炼至能扯拉成旗或将膏汁滴入清水中凝结成珠而不散，即得药膏，冷却后密封存放。
4.根据权利要求1所述的藏药消痹膏在制备治疗关节疾病药物方面的应用。
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