CN110772576B - A Chinese medicinal composition for treating osteomyelitis and bone nonunion - Google Patents
A Chinese medicinal composition for treating osteomyelitis and bone nonunion Download PDFInfo
- Publication number
- CN110772576B CN110772576B CN201911217355.5A CN201911217355A CN110772576B CN 110772576 B CN110772576 B CN 110772576B CN 201911217355 A CN201911217355 A CN 201911217355A CN 110772576 B CN110772576 B CN 110772576B
- Authority
- CN
- China
- Prior art keywords
- parts
- root
- rhynchophylla
- leaf
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 28
- 206010031252 Osteomyelitis Diseases 0.000 title claims abstract description 27
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 25
- 239000003814 drug Substances 0.000 claims abstract description 31
- 241000037488 Coccoloba pubescens Species 0.000 claims abstract description 17
- 244000061456 Solanum tuberosum Species 0.000 claims abstract description 17
- 235000002595 Solanum tuberosum Nutrition 0.000 claims abstract description 17
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 15
- 241001632409 Aralia elata Species 0.000 claims abstract description 7
- 235000015888 Aralia elata Nutrition 0.000 claims abstract description 7
- 241001092489 Potentilla Species 0.000 claims abstract description 7
- 241001530209 Swertia Species 0.000 claims abstract description 7
- 240000001638 Scurrula parasitica Species 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 235000019991 rice wine Nutrition 0.000 claims abstract description 5
- 235000013311 vegetables Nutrition 0.000 claims abstract description 5
- 239000000463 material Substances 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 239000008213 purified water Substances 0.000 claims description 12
- 235000012015 potatoes Nutrition 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 6
- 241001092376 Astilbe Species 0.000 claims description 5
- 241001453380 Burkholderia Species 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 244000309464 bull Species 0.000 claims description 3
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 3
- 244000042238 Eurycoma Species 0.000 claims 2
- 241000123982 Astilbe chinensis Species 0.000 abstract description 2
- 241001337998 Machilus Species 0.000 abstract 1
- 230000007903 penetration ability Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 6
- 230000007547 defect Effects 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 206010060891 General symptom Diseases 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 230000017074 necrotic cell death Effects 0.000 description 3
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 2
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 2
- 244000089795 Clausena lansium Species 0.000 description 2
- 235000008738 Clausena lansium Nutrition 0.000 description 2
- 241000488974 Loranthus Species 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 238000004820 blood count Methods 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 230000003071 parasitic effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000032912 Local swelling Diseases 0.000 description 1
- 208000029549 Muscle injury Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 208000006735 Periostitis Diseases 0.000 description 1
- 208000035977 Rare disease Diseases 0.000 description 1
- 206010039203 Road traffic accident Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 230000000816 effect on animals Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 238000011587 new zealand white rabbit Methods 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 210000003460 periosteum Anatomy 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicine composition for treating osteomyelitis and bone nonunion, which comprises the following raw materials in parts by weight: 15-30 parts of large-leaf potato, 3-15 parts of rhizoma polygoni orientalis, 30-120 parts of burdenia glabrata root, 3-15 parts of cortex acanthopanacis, 10-60 parts of aralia elata root, 3-15 parts of loranthus parasiticus, 3-20 parts of potentilla trifoliata, 3-15 parts of radix achyranthis bidentatae, 3-10 parts of swertia blanco, 3-30 parts of astilbe chinensis and 3-60 parts of pearl vegetable root; wherein rhizoma Solani Tuber osi and Machilus Giraldii Miq are treated with rice wine yeast to enhance drug penetration ability.
Description
Technical field
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating osteomyelitis and bone nonunion.
Two background art
Osteomyelitis (Traumatic Osteomyelitis) is an infectious disease on bones, the main clinical manifestation is bone defect and subsequent bone nonunion, and the bone defect and the subsequent bone nonunion are often accompanied by the conditions of fracture, soft tissue and muscle damage, and the bone defect is easily caused if the bone defect and the subsequent bone nonunion are not controlled for a long time. Osteomyelitis is caused by high-energy injuries such as traffic accidents, industrial injuries in manual labor and the like, and is more and more common in modern society.
The purpose of treating osteomyelitis is to control infection, repair bone defects, and restore continuity of bones, thereby maximally restoring limb functions. Except for surgical operations, the treatment is generally assisted by medicines, but the inflammatory part of osteomyelitis is protected by muscles, soft tissues, hyperplasia parts and even bone fragments, and the obvious curative effect cannot be obtained by simple antibiotics (including slow-release antibiotics). Although the traditional Chinese medicine is good at the chronic bone diseases, the traditional accumulation in the field of traditional Chinese medicine is insufficient due to the rare diseases caused by the high-energy trauma in ancient times. Therefore, the traditional Chinese medicine composition suitable for treating osteomyelitis is found according to the traditional Chinese medicine thought, and is a thought with a great development prospect.
Disclosure of the invention
Aiming at the problems, the applicant provides a traditional Chinese medicine composition for treating osteomyelitis and nonunion through scientific compatibility and adjustment of processing modes on the basis of the traditional prescription for treating osteomyelitis, nonunion and femoral head necrosis, has definite curative effect, and can be used alone or in an auxiliary way for treating osteomyelitis diseases.
On one hand, the invention provides a traditional Chinese medicine composition for treating osteomyelitis and bone nonunion, which comprises the following raw materials in parts by weight: 15-30 parts of large-leaf potato, 3-15 parts of rhizoma polygoni orientalis, 30-120 parts of burdenia glabrata root, 3-15 parts of cortex acanthopanacis, 10-60 parts of aralia elata root, 3-15 parts of loranthus parasiticus, 3-20 parts of potentilla trifoliata, 3-15 parts of radix achyranthis bidentatae, 3-10 parts of swertia blanco, 3-30 parts of astilbe chinensis and 3-60 parts of pearl vegetable root.
Further, the traditional Chinese medicine composition for treating osteomyelitis and bone nonunion provided by the invention is prepared from the following raw material medicines in parts by weight: 20 parts of large-leaf potato, 5 parts of rhizoma polygoni orientalis, 50 parts of burdenia koenigii root, 8 parts of cortex acanthopanacis, 20 parts of aralia elata root, 10 parts of loranthus parasiticus, 10 parts of potentilla trifoliata, 8 parts of radix achyranthis bidentatae, 8 parts of swertia blanco, 8 parts of astilbes chinensis and 25 parts of pearl vegetable root.
Further, the large-leaf potato and the burkholderia root are fermented by using distiller's yeast.
Further, the distiller's yeast is rice wine distiller's yeast.
Further, the method for processing the large-leaf potatoes and the bull green rhynchophylla roots by using the distiller's yeast comprises the following steps: adding 50 parts of water and 3 parts of distiller's yeast into the large-leaf potato and the burkholderia root, fermenting for 10 days at 37 ℃, taking out the large-leaf potato and the burkholderia root, and airing to serve as raw materials.
Furthermore, the traditional Chinese medicine composition is in the form of decoction.
Further, the traditional Chinese medicine composition is prepared according to the following method: (1) weighing the required amount of medicinal materials; (2) adding purified water which is 3 times of the total weight of the medicinal materials to soak the medicinal materials for 12 hours; (3) decocting for 2 hours, filtering and pouring out the decoction, adding purified water which is 3 times of the total weight of the medicinal materials, and decocting according to the same steps to obtain the decoction; (4) mixing the two decoctions, and collecting the medicinal liquid.
On the other hand, the invention provides a method for preparing the traditional Chinese medicine composition, which comprises the following steps of (1) weighing the required amount of medicinal materials; (2) adding purified water which is 3 times of the total weight of the medicinal materials to soak the medicinal materials for 12 hours; (3) decocting for 2 hours, filtering and pouring out the decoction, adding purified water which is 3 times of the total weight of the medicinal materials, and decocting according to the same steps to obtain the decoction; (4) mixing the two collected decoctions
On the other hand, the invention provides the application of the large-leaf potatoes and the bull chingium root which are subjected to the fermentation treatment of the distiller's yeast in the preparation of the medicines for treating osteomyelitis and nonunion.
Further, the distiller's yeast is rice wine distiller's yeast.
The traditional Chinese medicinal materials in the invention can use qualified products of various production places, and are not limited to indexes such as production places, years and the like.
The osteomyelitis and nonunion in the invention comprise the osteomyelitis caused by external force injury, low immunity and special microbial infection and the osteomyelitis caused by osteomyelitis, femoral head necrosis, fracture and the like.
Attached drawings of four specifications
FIG. 1 is a typical CT image of a group of Chinese medicinal compositions;
fig. 2 typical CT images of a pure water set.
Detailed description of the preferred embodiments
EXAMPLE 1 preparation of the Chinese medicinal composition of the present invention
Chinese medicinal composition 1
(1) Weighing the required amount of medicinal materials, 20 parts of large-leaf potatoes, 5 parts of Chinese wampee roots, 50 parts of bull-gambir roots, 8 parts of cortex acanthopanacis, 20 parts of aralia elata roots, 10 parts of parasitic loranthus, 10 parts of potentilla trifoliata, 8 parts of radix achyranthis bidentatae, 8 parts of swertia blanco, 8 parts of astilbes chinensis and 25 parts of pearl roots; adding 50 parts of water and 3 parts of distiller's yeast (Angel brand sweet wine/rice distiller's yeast, powder) into rhizoma Solani Tuber osi and radix Gouling Gingae, fermenting at 37 deg.C for 10 days, taking out rhizoma Solani Tuber osi and radix Gouling Gingae, and air drying;
(3) adding purified water which is 3 times of the total weight of the medicinal materials to soak the medicinal materials for 12 hours;
(4) decocting for 2 hours, filtering and pouring out the decoction, adding purified water which is 3 times of the total weight of the medicinal materials, and decocting according to the same steps to obtain the decoction; (5) mixing the two decoctions, and collecting the medicinal liquid.
Chinese medicinal composition 2
(1) Weighing the required amount of medicinal materials, 20 parts of large-leaf potatoes, 5 parts of Chinese wampee roots, 50 parts of bull-gambir roots, 8 parts of cortex acanthopanacis, 20 parts of aralia elata roots, 10 parts of parasitic loranthus, 10 parts of potentilla trifoliata, 8 parts of radix achyranthis bidentatae, 8 parts of swertia blanco, 8 parts of astilbes chinensis and 25 parts of pearl roots;
(3) adding purified water which is 3 times of the total weight of the medicinal materials to soak the medicinal materials for 12 hours;
(4) decocting for 2 hours, filtering and pouring out the decoction, adding purified water which is 3 times of the total weight of the medicinal materials, and decocting according to the same steps to obtain the decoction; (5) mixing the two decoctions, and collecting the medicinal liquid.
Example 2 Effect on animal models of fracture
15 male New Zealand white rabbits (about 2 kg) are selected and divided into 3 groups, and after anesthesia, the left lower limb is shaved and disinfected. Cutting skin at the anterior and medial border of the cavity bone, removing periosteum to expose the upper and medial side of the cavity bone, drilling into medullary cavity with bone station, extracting part of medulla, injecting 50 μ l of 3% steel cod liver oleate and 5 μ l of 2X10 into the medullary cavity6cfu/ml Staphylococcus aureus, hole sealing backstitchAnd mixing the skin.
After the molding is finished, the three groups are respectively gavaged with 20ml of the traditional Chinese medicine composition 1 in the embodiment 1, the traditional Chinese medicine composition 2 in the embodiment 1 and purified water every day, and the administration is continuously carried out for 3 weeks.
On the day of molding, after 3 weeks of treatment after molding, ear edge blood was sampled to detect alkaline phosphatase and white blood cell count. And (5) carrying out CT scanning on the model making position image after 3 weeks of model making treatment.
The alkaline phosphatase levels and white blood cell counts were as follows:
the result shows that the anti-inflammatory effect of the traditional Chinese medicine composition 1 in the osteomyelitis is obviously better than that of the traditional Chinese medicine composition 2 in the traditional formula, the CT detection result shows that the two traditional Chinese medicine compositions have similar effects of promoting the bone recovery of the osteomyelitis part in a short term and are both better than that of a purified water group (in the typical situation, see figures 1 and 2), and the traditional Chinese medicine composition 1 is expected to obtain a better bone recovery result due to the good anti-inflammatory effect in a long term.
EXAMPLE 3 clinical effects of the Chinese medicinal composition of the present invention on treating osteomyelitis
And (3) observation of curative effect:
when the clinic treats osteomyelitis, a formula (300 mL each time twice a day) similar to the traditional Chinese medicine composition 2 in example 1 is generally used, and according to the traditional Chinese medicine syndrome diagnosis curative effect standard issued by the State administration of traditional Chinese medicine (curing: general symptoms and local swelling and pain disappear, wound heals after ulceration, no dead bone exists in X-ray radiograph, general symptoms are improved, swelling and pain are relieved, a sore is not healed, dead cavities and dead bones exist in the X-ray radiograph, ineffectiveness, the general symptoms and local symptoms cannot be controlled, focus is not relieved or continues to develop in the X-ray radiograph), the effective rate is about 80% after a three-month treatment period, and the cure rate is about 40%.
After the formula of the traditional Chinese medicine composition 2 in the example 1 is changed, the effective rate is still about 80% after three-month treatment period, but the cure rate reaches more than 65%, and the effect on the osteomyelitis caused by infection is obviously better than that of the traditional formula (part of the osteomyelitis and the femoral head necrosis are related to autoimmunity and endocrine, and the traditional Chinese medicine and the western medicine are difficult to cure).
Claims (3)
1. A traditional Chinese medicine composition for treating osteomyelitis and bone nonunion is characterized by being prepared from the following raw material medicines in parts by weight: 20 parts of large-leaf potato, 5 parts of rhizoma polygoni orientalis, 50 parts of bull-green rhynchophylla root, 8 parts of cortex acanthopanacis, 20 parts of aralia elata root, 10 parts of loranthus parasiticus, 10 parts of potentilla trifoliata, 8 parts of radix achyranthis bidentatae, 8 parts of swertia blanco, 8 parts of astilbes chinensis and 25 parts of pearl vegetable root; wherein rhizoma Solani Tuber osi and radix Goulingii are fermented with rice wine yeast; the method for fermenting large-leaf potatoes and bull green rhynchophylla roots by using rice wine distiller's yeast comprises the following steps: adding 50 parts by weight of water and 3 parts by weight of distiller's yeast into the large-leaf potato and the burkholderia rhynchophylla root, fermenting for 10 days at 37 ℃, taking out the large-leaf potato and the burkholderia rhynchophylla root, and airing.
2. The Chinese medicinal composition of claim 1, in the form of a decoction.
3. The traditional Chinese medicine composition according to claim 1 or 2, which is prepared according to the following method: (1) weighing the required amount of medicinal materials: 20 parts of large-leaf potato, 5 parts of rhizoma polygoni orientalis, 50 parts of bull-green rhynchophylla root, 8 parts of cortex acanthopanacis, 20 parts of aralia elata root, 10 parts of loranthus parasiticus, 10 parts of potentilla trifoliata, 8 parts of radix achyranthis bidentatae, 8 parts of swertia blanco, 8 parts of astilbes chinensis and 25 parts of pearl vegetable root; (2) adding 50 parts by weight of water and 3 parts by weight of distiller's yeast into the large-leaf potatoes and the eurycoma rhynchophylla roots, fermenting for 10 days at 37 ℃, taking out the large-leaf potatoes and the eurycoma rhynchophylla roots, and airing; (3) adding purified water which is 3 times of the total weight of the medicinal materials to soak the medicinal materials for 12 hours; (4) decocting for 2 hours, filtering and pouring out the decoction, adding purified water which is 3 times of the total weight of the medicinal materials, and decocting according to the same steps to obtain the decoction; (5) mixing the two collected decoctions to obtain the Chinese medicinal composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911217355.5A CN110772576B (en) | 2019-12-03 | 2019-12-03 | A Chinese medicinal composition for treating osteomyelitis and bone nonunion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911217355.5A CN110772576B (en) | 2019-12-03 | 2019-12-03 | A Chinese medicinal composition for treating osteomyelitis and bone nonunion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110772576A CN110772576A (en) | 2020-02-11 |
| CN110772576B true CN110772576B (en) | 2021-09-24 |
Family
ID=69393575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911217355.5A Expired - Fee Related CN110772576B (en) | 2019-12-03 | 2019-12-03 | A Chinese medicinal composition for treating osteomyelitis and bone nonunion |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110772576B (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494866A (en) * | 2012-03-29 | 2014-01-08 | 海丝克（河南）生物科技有限公司 | Formulation method of formula for treating waist-leg ache |
| CN103141650A (en) * | 2013-02-24 | 2013-06-12 | 沈根林 | Traditional Chinese medicine preserved fruit sausage for nourishing liver and kidney and expelling wind-damp |
| CN104857368A (en) * | 2015-05-26 | 2015-08-26 | 陈欣 | Traditional Chinese medicine composition for treating psoatic strain and preparation method |
| CN105012641A (en) * | 2015-06-19 | 2015-11-04 | 淄博职业学院 | Preparation for treating osteomyelitis and preparation method thereof |
-
2019
- 2019-12-03 CN CN201911217355.5A patent/CN110772576B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN110772576A (en) | 2020-02-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105535867A (en) | Antibacterial gel special for gynecology and preparation method thereof | |
| CN110772576B (en) | A Chinese medicinal composition for treating osteomyelitis and bone nonunion | |
| CN104825528A (en) | Composition capable of increasing bone mineral density, and preparation method and application thereof | |
| CN105434962A (en) | Chinese herbal preparation for treating thoracolumbar vertebral fracture and preparation method of Chinese herbal preparation | |
| CN102283917B (en) | Deer bone medicated liquor for treating fracture | |
| CN1215595A (en) | External use medicine for treating soft tissue injury and its producing method | |
| CN103585457B (en) | A kind of medicament for the treatment of fracture | |
| CN102949712A (en) | Chinese and western composite medicine for treating neoplastic diseases | |
| CN1089602C (en) | Medicinal composition for treating bone fracture and its preparing process | |
| CN106619809A (en) | Uygur medicine calculus removing powder and preparation method thereof | |
| CN105169262A (en) | Traditional Chinese medicine formula for bone-fracture postoperative recovery nursing | |
| CN116370553A (en) | Preparation method of compound preparation for osteomyelitis | |
| US9155771B2 (en) | Vegetable extract and method of use as an active principle in the production of a pharmacologically active product for the treatment of tissue lesions, and method for obtaining the extract | |
| CN106491923A (en) | A kind of method for treating pregnancy ewes scabies | |
| CN104248650A (en) | Topical drug combination for promotion of fracture healing and application | |
| CN104013780B (en) | The application of Chinese medicine composition, preparation technique of traditional Chinese medicine and the Chinese medicine in field of veterinary | |
| CN1223369C (en) | Osteoproliferation medicine and preparing method thereof | |
| CN110711215A (en) | A Chinese medicinal plaster for treating fracture, and its preparation method | |
| CN112138060A (en) | External liniment for treating femoral head necrosis and preparation method thereof | |
| CN102698020B (en) | Medicine composition for accelerating healing fractured bone of tibia | |
| CN112353910A (en) | Pure traditional Chinese medicine transdermal liniment for treating diabetes and preparation method thereof | |
| CN118178561A (en) | Traditional Chinese medicine composition with lung protecting and cough relieving effects, and preparation method and application thereof | |
| CN1270749C (en) | Bone impediment convalescence capsule | |
| CN109394960A (en) | A kind of Chinese medicine composition and preparation method thereof for treating hypertension | |
| CN107029033A (en) | A kind of medicine for treating the downright bad bed sore at ulcerative stage of bed patient |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20210924 |