CN110771634A - Preparation method of clothing disinfection spray - Google Patents
Preparation method of clothing disinfection spray Download PDFInfo
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- CN110771634A CN110771634A CN201910994122.XA CN201910994122A CN110771634A CN 110771634 A CN110771634 A CN 110771634A CN 201910994122 A CN201910994122 A CN 201910994122A CN 110771634 A CN110771634 A CN 110771634A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
- A01N25/06—Aerosols
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/26—Meliaceae [Chinaberry or Mahogany family], e.g. mahogany, langsat or neem
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
- C08G81/02—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
- C08G81/024—Block or graft polymers containing sequences of polymers of C08C or C08F and of polymers of C08G
- C08G81/025—Block or graft polymers containing sequences of polymers of C08C or C08F and of polymers of C08G containing polyether sequences
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical & Material Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Dispersion Chemistry (AREA)
- Pest Control & Pesticides (AREA)
- Toxicology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a preparation method of a clothing disinfection spray, relating to the technical field of disinfectants and comprising the following steps: (1) utilization of honeysuckle; (2) utilization of the melia azedarach flower; (3) utilization of lavender; (4) and (4) preparing a disinfection spray. The honeysuckle flower, the chinaberry flower and the lavender are used as preparation raw materials of bactericidal and bacteriostatic active ingredients, the active ingredients contained in the three traditional Chinese medicines are extracted, and a surfactant is cooperated to prepare the disinfection spray applicable to clothes; the prepared disinfection spray has fragrant taste, is convenient to use, has obvious sterilization and bacteriostasis effects, does not generate any stimulation to skin after the clothing is disinfected, and has high use safety.
Description
The technical field is as follows:
the invention relates to the technical field of disinfectant processing, in particular to a preparation method of a clothing disinfection spray.
Background art:
clothes, a general term for articles for decorating human bodies, including clothes, shoes, hats, socks, gloves, scarves, ties, accessories, bags, umbrellas and the like. In daily life, clothes used by people can be contacted with various bacteria, and if some bacteria are not killed in time, the bacteria can cause harm to human health. The existing partial washing products have a sterilization effect, but have a limited sterilization effect and short action time, and cannot meet the sterilization requirements of people at all. In addition, although the washing products added with the chemical sterilization components have strong sterilization effect, the washing products have pungent taste and potential safety hazards in use.
Aiming at the problem, the invention provides a preparation method of a clothing disinfection spray, which utilizes plant components to exert sterilization and bacteriostasis effects, and has high use safety and remarkable sterilization and bacteriostasis effects.
The invention content is as follows:
the technical problem to be solved by the invention is to provide a preparation method of the clothing disinfection spray, the prepared disinfection spray has faint scent and obvious sterilization and bacteriostasis effects, and the disinfected clothing does not generate any stimulation to the skin.
The technical problem to be solved by the invention is realized by adopting the following technical scheme:
a preparation method of a clothes sterilizing spray comprises the following steps:
(1) utilization of honeysuckle flower: adding water into honeysuckle, making into slurry by a slurry mill, adding citric acid into the slurry, heating to 70-80 ℃, keeping the temperature, stirring, filtering, and freeze-drying the obtained filtrate to obtain powder, namely honeysuckle extract;
(2) utilization of the melia azedarach flowers: adding flos Meliae into anhydrous ethanol, heating to reflux state, stirring, filtering when the temperature is reduced to below 50 deg.C, adding water into the filtrate, stirring, and collecting upper oil layer to obtain flos Meliae extract;
(3) utilization of lavender: adding Lavender into anhydrous alcohol, heating to reflux state, stirring, filtering when the temperature is reduced to below 50 deg.C, adding water into the filtrate, stirring, and collecting upper oil layer to obtain Lavender extract;
(4) preparing a disinfection spray: adding flos Lonicerae extract, flos Meliae extract, Lavender extract and surfactant into water, and mixing.
The surfactant is selected from one or more of sodium dodecyl sulfate, α -olefin sodium sulfonate and dodecyl glucoside.
The mass ratio of the honeysuckle extract to the chinaberry flower extract to the lavender extract to the auxiliary materials is 0.5-5:0.5-5:0.5-5: 1-15.
In order to improve the storage stability of the melia azedarach extract and the lavender extract and ensure the sterilization and bacteriostasis effects of the melia azedarach extract and the lavender extract, the invention also adds a stabilizer into the hand sanitizer, namely replacing the content in the step (4) with: adding honeysuckle extract, chinaberry flower extract, lavender extract, surfactant and stabilizer into water, and mixing uniformly.
The stabilizer is modified carbomer and is prepared by chemically modifying carbomer, and the preparation method comprises the following steps: adding carbomer 941 and polyetheramine D-230 into water, heating to 60-70 deg.C, stirring under constant temperature, adding condensing agent, heating to reflux state, stirring under constant temperature, naturally cooling to room temperature, standing at 0-5 deg.C, filtering, washing with water, oven drying, and making into powder.
The condensing agent is EDCI and HOBt.
The mass ratio of the surfactant to the stabilizer is 5: 0.5-5.
And (3) taking polyether amine as a modifier, and carrying out condensation reaction on amino groups contained in the polyether amine and carboxyl groups contained in carbomer to generate amide bonds. Carbomer does not have stability to the storage of the melia azedarach extract and the lavender extract, modified carbomer obtained after modification by polyether amine can play a stabilizing role in the extracts, and the volatile oil in the extracts is prevented from volatilizing by utilizing the clathration effect.
The invention has the beneficial effects that:
(1) the invention takes honeysuckle, chinaberry flower and lavender as preparation raw materials of bactericidal and bacteriostatic active ingredients, extracts the active ingredients contained in the three traditional Chinese medicines and prepares the disinfection spray suitable for clothes by cooperating with a surfactant.
(2) The traditional Chinese medicine formula comprises honeysuckle, chinaberry flower and lavender, is simple, cheap and easy to obtain, and is obviously different from the traditional Chinese medicine disinfectant spray which needs to be added with a plurality of traditional Chinese medicines to obtain the sterilizing and bacteriostatic effect meeting the use requirement and the problem that the chemical disinfectant spray has potential safety hazard to human bodies although the sterilizing and bacteriostatic effect is good.
(3) The prepared disinfection spray has fragrant taste, is convenient to use, has obvious sterilization and bacteriostasis effects, does not generate any stimulation to skin after the clothing is disinfected, and has high use safety.
The specific implementation mode is as follows:
in order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
The following examples and comparative examples were prepared with honeysuckle, melia azedarach and lavender, respectively, from the same manufacturer.
Example 1
(1) Utilization of honeysuckle flower: adding 500mL of water into 30g of honeysuckle, preparing the mixture into slurry by a pulping machine, adding 1g of citric acid into the slurry, heating the mixture to 70-80 ℃, keeping the temperature, stirring the mixture for 8 hours, filtering the mixture, and freeze-drying the obtained filtrate to prepare powder to obtain a honeysuckle extract;
(2) utilization of the melia azedarach flowers: adding 30g of Melia azedarach flower into 500mL of anhydrous ethanol, heating to reflux state, stirring for 5h while maintaining the temperature, filtering when the temperature is reduced to below 50 ℃, adding 500mL of water into the obtained filtrate, stirring for 5min, and collecting the upper oil layer to obtain Melia azedarach flower extract;
(3) utilization of lavender: adding 30g Lavender into 500mL anhydrous ethanol, heating to reflux state, stirring for 5 hr, filtering when the temperature is reduced to below 50 deg.C, adding 500mL water into the filtrate, stirring for 5min, and collecting the upper oil layer to obtain Lavender extract;
(4) preparing a disinfection spray: adding 3g of honeysuckle extract, 3g of chinaberry flower extract, 1g of lavender extract and 5g of dodecyl glucoside into 200mL of water, and uniformly mixing.
Example 2
(1) Utilization of honeysuckle flower: adding 500mL of water into 30g of honeysuckle, preparing the mixture into slurry by a pulping machine, adding 1g of citric acid into the slurry, heating the mixture to 70-80 ℃, keeping the temperature, stirring the mixture for 8 hours, filtering the mixture, and freeze-drying the obtained filtrate to prepare powder to obtain a honeysuckle extract;
(2) utilization of the melia azedarach flowers: adding 30g of Melia azedarach flower into 500mL of anhydrous ethanol, heating to reflux state, stirring for 5h while maintaining the temperature, filtering when the temperature is reduced to below 50 ℃, adding 500mL of water into the obtained filtrate, stirring for 5min, and collecting the upper oil layer to obtain Melia azedarach flower extract;
(3) utilization of lavender: adding 30g Lavender into 500mL anhydrous ethanol, heating to reflux state, stirring for 5 hr, filtering when the temperature is reduced to below 50 deg.C, adding 500mL water into the filtrate, stirring for 5min, and collecting the upper oil layer to obtain Lavender extract;
(4) preparing a disinfection spray: adding 3g of honeysuckle extract, 3g of chinaberry flower extract, 2g of lavender extract and 5g of dodecyl glucoside into 200mL of water, and uniformly mixing.
Example 3
The procedure of example 1 was otherwise the same as that of example 3, in which a stabilizer was added to the liquid soap, using example 1 as a control.
(1) Utilization of honeysuckle flower: adding 500mL of water into 30g of honeysuckle, preparing the mixture into slurry by a pulping machine, adding 1g of citric acid into the slurry, heating the mixture to 70-80 ℃, keeping the temperature, stirring the mixture for 8 hours, filtering the mixture, and freeze-drying the obtained filtrate to prepare powder to obtain a honeysuckle extract;
(2) utilization of the melia azedarach flowers: adding 30g of Melia azedarach flower into 500mL of anhydrous ethanol, heating to reflux state, stirring for 5h while maintaining the temperature, filtering when the temperature is reduced to below 50 ℃, adding 500mL of water into the obtained filtrate, stirring for 5min, and collecting the upper oil layer to obtain Melia azedarach flower extract;
(3) utilization of lavender: adding 30g Lavender into 500mL anhydrous ethanol, heating to reflux state, stirring for 5 hr, filtering when the temperature is reduced to below 50 deg.C, adding 500mL water into the filtrate, stirring for 5min, and collecting the upper oil layer to obtain Lavender extract;
(4) preparing a disinfection spray: adding 3g of honeysuckle extract, 3g of chinaberry flower extract, 1g of lavender extract, 5g of dodecyl glucoside and 3g of stabilizer into 200mL of water, and uniformly mixing.
Preparation of the stabilizer: adding 8.2g of carbomer 941 and 15.3g of polyetheramine D-230 into water, heating to 70 ℃, keeping the temperature and stirring, adding 10g of condensing agent (the molar ratio of EDCI to HOBt is 1:1), continuously heating to a reflux state, keeping the temperature and stirring for 3 hours, naturally cooling to room temperature, standing for 8 hours in a 3 ℃ environment, filtering, washing the obtained solid with water twice, using 100mL of water each time, and drying at 70 ℃ to prepare 80-mesh powder. The infrared characterization of the product shows that amido bond is generated.
Comparative example 1
Using example 3 as a control, comparative example 1 without lavender extract was set, and the rest of the procedure was the same as example 3.
Comparative example 2
The procedure of example 3 was repeated except that comparative example 2, in which no neem flower extract was added, was used as a control in example 3.
Sterile sprays were prepared using examples 1-3 and comparative examples 1-2, respectively.
Skin irritation test:
50 mice weighing 250-300g were randomly and equally divided into 5 groups, and the abdominal hairs of the mice were shaved off, and then the disinfectant spray prepared in examples 1-3 and comparative examples 1-2 were applied to the abdominal parts, respectively, and the abdominal skin condition and mental condition of the mice were observed 72 hours after application.
After 72h observation, the abdominal skin of the white mouse is found to have no adverse reaction, and the mental state of the white mouse is not obviously changed.
And (3) bacteriostatic test:
the prepared disinfection spray (the prepared disinfection spray is stored for 8 hours at the temperature of 35 ℃ and then filled) is tested for bacteriostasis effect according to QB/T2850-2007, the action concentration is 1 wt%, the action time is 15min, and the test results are shown in Table 1.
Table 1 shows the results of the test of the bacteriostatic effect of the disinfectant sprays
As can be seen from table 1, in example 3, the addition of the stabilizer can achieve the technical effect of enhancing the bacteriostatic effect, and the addition of the lavender extract and the melia azedarach extract can enhance the bacteriostatic effect of the disinfectant spray to different degrees.
The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (3)
1. A preparation method of a clothes disinfection spray is characterized by comprising the following steps: the method comprises the following steps:
(1) utilization of honeysuckle flower: adding water into honeysuckle, making into slurry by a slurry mill, adding citric acid into the slurry, heating to 70-80 ℃, keeping the temperature, stirring, filtering, and freeze-drying the obtained filtrate to obtain powder, namely honeysuckle extract;
(2) utilization of the melia azedarach flowers: adding flos Meliae into anhydrous ethanol, heating to reflux state, stirring, filtering when the temperature is reduced to below 50 deg.C, adding water into the filtrate, stirring, and collecting upper oil layer to obtain flos Meliae extract;
(3) utilization of lavender: adding Lavender into anhydrous alcohol, heating to reflux state, stirring, filtering when the temperature is reduced to below 50 deg.C, adding water into the filtrate, stirring, and collecting upper oil layer to obtain Lavender extract;
(4) preparing a disinfection spray: adding flos Lonicerae extract, flos Meliae extract, Lavender extract and surfactant into water, and mixing.
2. The preparation method according to claim 1, wherein the surfactant is selected from one or more of sodium dodecyl sulfate, α -olefin sulfonate, and dodecyl glucoside.
3. The method of claim 1, wherein: the mass ratio of the honeysuckle extract to the chinaberry flower extract to the lavender extract to the auxiliary materials is 0.5-5:0.5-5:0.5-5: 1-15.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019108153690 | 2019-08-30 | ||
| CN201910815369 | 2019-08-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110771634A true CN110771634A (en) | 2020-02-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201910994122.XA Pending CN110771634A (en) | 2019-08-30 | 2019-10-18 | Preparation method of clothing disinfection spray |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107496598A (en) * | 2017-10-11 | 2017-12-22 | 付金龙 | Skin antibacterial liquid and preparation method thereof |
| CN108633922A (en) * | 2018-05-01 | 2018-10-12 | 张诗敏 | Disinfectant |
-
2019
- 2019-10-18 CN CN201910994122.XA patent/CN110771634A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107496598A (en) * | 2017-10-11 | 2017-12-22 | 付金龙 | Skin antibacterial liquid and preparation method thereof |
| CN108633922A (en) * | 2018-05-01 | 2018-10-12 | 张诗敏 | Disinfectant |
Non-Patent Citations (1)
| Title |
|---|
| 刘韶，: ""苦楝花挥发油的气质-化学计量学分析及抑菌作用研究"", 《中国药学杂志》 * |
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Application publication date: 20200211 |
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