CN110770553A - 集成黑白目标的显微镜载片 - Google Patents
集成黑白目标的显微镜载片 Download PDFInfo
- Publication number
- CN110770553A CN110770553A CN201880039127.0A CN201880039127A CN110770553A CN 110770553 A CN110770553 A CN 110770553A CN 201880039127 A CN201880039127 A CN 201880039127A CN 110770553 A CN110770553 A CN 110770553A
- Authority
- CN
- China
- Prior art keywords
- microscope slide
- black
- white reference
- white
- slide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000003384 imaging method Methods 0.000 claims abstract description 14
- 238000005286 illumination Methods 0.000 claims abstract description 8
- 150000008064 anhydrides Chemical class 0.000 claims description 18
- 238000010186 staining Methods 0.000 claims description 14
- 239000004593 Epoxy Substances 0.000 claims description 10
- 239000012620 biological material Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical group O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 6
- 150000001412 amines Chemical class 0.000 claims description 6
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims description 6
- 239000003973 paint Substances 0.000 claims description 6
- 239000000427 antigen Substances 0.000 claims description 5
- 102000036639 antigens Human genes 0.000 claims description 5
- 108091007433 antigens Proteins 0.000 claims description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- -1 diphenyliodonium hexafluoroarsenate Chemical compound 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000000428 dust Substances 0.000 claims description 3
- 229920006334 epoxy coating Polymers 0.000 claims description 3
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims description 3
- MWSKJDNQKGCKPA-UHFFFAOYSA-N 6-methyl-3a,4,5,7a-tetrahydro-2-benzofuran-1,3-dione Chemical compound C1CC(C)=CC2C(=O)OC(=O)C12 MWSKJDNQKGCKPA-UHFFFAOYSA-N 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- 150000001408 amides Chemical class 0.000 claims description 2
- 150000001722 carbon compounds Chemical class 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 210000002700 urine Anatomy 0.000 claims description 2
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 claims 1
- 238000004049 embossing Methods 0.000 claims 1
- 238000007490 hematoxylin and eosin (H&E) staining Methods 0.000 claims 1
- 238000011532 immunohistochemical staining Methods 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
- 238000003491 array Methods 0.000 abstract description 3
- 238000004886 process control Methods 0.000 abstract description 3
- 239000000976 ink Substances 0.000 description 11
- 239000003054 catalyst Substances 0.000 description 6
- 239000000049 pigment Substances 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 229910044991 metal oxide Inorganic materials 0.000 description 5
- 150000004706 metal oxides Chemical class 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000012128 staining reagent Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000007639 printing Methods 0.000 description 4
- SEACYXSIPDVVMV-UHFFFAOYSA-L eosin Y Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 SEACYXSIPDVVMV-UHFFFAOYSA-L 0.000 description 3
- 239000003822 epoxy resin Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000003364 immunohistochemistry Methods 0.000 description 3
- 229920000647 polyepoxide Polymers 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000013643 reference control Substances 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- 239000012463 white pigment Substances 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical class [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000013580 sausages Nutrition 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- FZHAPNGMFPVSLP-UHFFFAOYSA-N silanamine Chemical compound [SiH3]N FZHAPNGMFPVSLP-UHFFFAOYSA-N 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/06—Means for illuminating specimens
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/364—Projection microscopes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N2001/2893—Preparing calibration standards
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Multimedia (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Microscoopes, Condenser (AREA)
Abstract
Description
Claims (13)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762520178P | 2017-06-15 | 2017-06-15 | |
US62/520,178 | 2017-06-15 | ||
PCT/CN2018/091685 WO2018228574A1 (en) | 2017-06-15 | 2018-06-15 | Microscope slide with integrated black and white target |
Publications (1)
Publication Number | Publication Date |
---|---|
CN110770553A true CN110770553A (zh) | 2020-02-07 |
Family
ID=64659981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201880039127.0A Pending CN110770553A (zh) | 2017-06-15 | 2018-06-15 | 集成黑白目标的显微镜载片 |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP3638995A4 (zh) |
JP (1) | JP7369120B2 (zh) |
KR (1) | KR20200040746A (zh) |
CN (1) | CN110770553A (zh) |
WO (1) | WO2018228574A1 (zh) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050142654A1 (en) * | 2002-10-18 | 2005-06-30 | Kazuji Matsumoto | Slide glass, cover glass and pathologic diagnosis system |
CN101529247A (zh) * | 2006-08-25 | 2009-09-09 | 利·H·安格罗斯 | 具有可标记部分的分析片和使用方法 |
US20140022631A1 (en) * | 2012-07-21 | 2014-01-23 | General Data Company, Inc. | Microscope slide for specimen tracking and verification, and method of making same |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4190314A (en) * | 1973-07-13 | 1980-02-26 | Stephen Goldsmith | Microscope and microscope slide for cytological analysis |
CN1138144C (zh) * | 1999-09-09 | 2004-02-11 | 申洪 | 免疫组织化学显微比色器及其制作方法 |
US8603804B2 (en) * | 2010-01-15 | 2013-12-10 | Qbc Diagnostics, Inc. | Fluorescent marked microscope slide |
US8976239B2 (en) * | 2012-08-24 | 2015-03-10 | Datacolor Holding Ag | System and apparatus for color correction in transmission-microscope slides |
-
2018
- 2018-06-15 CN CN201880039127.0A patent/CN110770553A/zh active Pending
- 2018-06-15 WO PCT/CN2018/091685 patent/WO2018228574A1/en unknown
- 2018-06-15 KR KR1020207001292A patent/KR20200040746A/ko not_active Application Discontinuation
- 2018-06-15 JP JP2020519172A patent/JP7369120B2/ja active Active
- 2018-06-15 EP EP18817809.9A patent/EP3638995A4/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050142654A1 (en) * | 2002-10-18 | 2005-06-30 | Kazuji Matsumoto | Slide glass, cover glass and pathologic diagnosis system |
CN101529247A (zh) * | 2006-08-25 | 2009-09-09 | 利·H·安格罗斯 | 具有可标记部分的分析片和使用方法 |
US20140022631A1 (en) * | 2012-07-21 | 2014-01-23 | General Data Company, Inc. | Microscope slide for specimen tracking and verification, and method of making same |
Also Published As
Publication number | Publication date |
---|---|
WO2018228574A1 (en) | 2018-12-20 |
JP7369120B2 (ja) | 2023-10-25 |
KR20200040746A (ko) | 2020-04-20 |
JP2020523646A (ja) | 2020-08-06 |
EP3638995A1 (en) | 2020-04-22 |
EP3638995A4 (en) | 2021-03-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7011945B2 (en) | Random array of micro-spheres for the analysis of nucleic acids | |
TWI249033B (en) | Encoding of microcarriers | |
Meier et al. | Combinatorial methods, automated synthesis and high‐throughput screening in polymer research: The evolution continues | |
KR100365915B1 (ko) | 페인트제품용착색제조성물 | |
WO2018228576A1 (en) | Process record slide for special staining | |
EP1217045B1 (en) | Halogen-free green pigment composition | |
CN1301285A (zh) | 颜料的分散体 | |
RU2742666C2 (ru) | Усовершенствования, относящиеся к подложкам для прикрепления молекул | |
KR101860660B1 (ko) | A-b 블록 코폴리머, a-b 블록 코폴리머의 제조방법, 수지 처리 안료 조성물, 수지 처리 안료 조성물의 제조방법, 안료 분산체 및 안료 분산액 | |
CN110770553A (zh) | 集成黑白目标的显微镜载片 | |
Ranefall et al. | Automatic quantification of immunohistochemically stained cell nuclei using unsupervised image analysis | |
KR20170100531A (ko) | 분산제 | |
Schmatloch et al. | Techniques and Instrumentation for Combinatorial and High‐Throughput Polymer Research: Recent Developments | |
JP4217071B2 (ja) | エポキシドおよびアミンから生成されるオキシアルキル化生成物、ならびに、顔料調製物におけるそれらの使用 | |
EP3639079A1 (en) | Process record slide for immunohistochemical staining | |
Feraru et al. | Comparative forensic analysis of ballpoint pen inks | |
RU2287805C2 (ru) | Способ экспрессного определения дисперсного состава аэрозоля | |
US20180229204A1 (en) | Ultra high-density oligomer arrays and method of production thereof | |
CN110161028A (zh) | 利用dllme和扫描仪数字图像分析测定食品中的高氯酸根的方法 | |
Abdrabou et al. | EXPERIMENTAL STUDY ON THE EFFICACY OF CLEANING SYSTEMS FOR THE REMOVAL OF PREVIOUS CONSERVATION TREATMENTS FROM TUTANKHAMUNS'GILDED WOODEN BED. | |
JP2022526120A (ja) | 塗料、ワニス、印刷インキ、研削用樹脂、色素濃縮物、または他のコーティング剤の組成物の生成方法 | |
CN111435192B (zh) | 利用荧光显微镜生成荧光照片的方法 | |
Reich | Instrumental thin-layer chromatography (planar chromatography) | |
JP2000060594A (ja) | 活性汚泥診断を目的とした細菌類の短時間染色法 | |
Rose | Spectroscopic studies of substrates used for solid-phase synthesis and combinatorial chemistry: fundamentals and applications |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20210422 Address after: 703, 2-13 / F, 7 / F, 48 Xinyu Road, Xinqiao community, Xinqiao street, Bao'an District, Shenzhen City, Guangdong Province Applicant after: Shenzhen Nuogao Experimental Equipment Co.,Ltd. Address before: Unit D, 3 / F, Feida Industrial and commercial centre, 3 Muchang street, To Kwa Wan, Kowloon, Hong Kong, China Applicant before: Sun Stone Technology Co.,Ltd. |
|
TA01 | Transfer of patent application right | ||
CB03 | Change of inventor or designer information |
Inventor after: Frederick Knut harsher Inventor after: Cen Zixiang Inventor after: Chen Jun Inventor after: Qian Feng Inventor after: Chen Qian Inventor before: Frederick Knut harsher Inventor before: Cen Zixiang |
|
CB03 | Change of inventor or designer information | ||
CI02 | Correction of invention patent application |
Correction item: Inventor Correct: Frederick Knut Hasher|Cen Zixiang False: Frederick Knut Hasher|Cen Zixiang|Jun Chen|Qian Feng|Chen Qian Number: 19-02 Volume: 38 |
|
CI02 | Correction of invention patent application |