CN110770256A - 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途 - Google Patents

靶向axl的抗体及抗体-药物偶联物及其制备方法和用途 Download PDF

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CN110770256A
CN110770256A CN201980002582.8A CN201980002582A CN110770256A CN 110770256 A CN110770256 A CN 110770256A CN 201980002582 A CN201980002582 A CN 201980002582A CN 110770256 A CN110770256 A CN 110770256A
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antibody
seq
axl
variable region
light chain
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CN110770256B (zh
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余科
沈竞康
孟韬
裴金鹏
马兰萍
王昕�
金锐
杜志彦
陈驎
于霆
张永良
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Fudan University
Shanghai Institute of Materia Medica of CAS
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Fudan University
Shanghai Institute of Materia Medica of CAS
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Abstract

本发明公开了一种全新的靶向AXL的单克隆抗体以及抗体‑药物偶联物。本发明还公开了制备所述抗体、抗体‑药物偶联物的方法。本发明的AXL抗体能够高效，高特异性地结合纯化的人AXL蛋白和多种肿瘤细胞表面的AXL，所述人源化抗体同样具有很高的亲和力及很低的免疫原性，所述AXL抗体‑药物偶联物对AXL高表达的肿瘤具有显著的抗肿瘤作用。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201980002582.8A 2018-05-15 2019-05-10 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途 Active CN110770256B (zh)

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CN201810464287.1A CN110483639A (zh) 2018-05-15 2018-05-15 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途
PCT/CN2019/086475 WO2019218944A2 (zh) 2018-05-15 2019-05-10 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113444180A (zh) * 2021-06-16 2021-09-28 上海鑫湾生物科技有限公司 靶向axl蛋白的抗体及其抗原结合片段、其制备方法和应用
CN114517226A (zh) * 2021-12-24 2022-05-20 南京鼓楼医院 Axl作为宫腔粘连诊断和治疗靶点的应用
CN116715774A (zh) * 2023-05-12 2023-09-08 武汉爱博泰克生物科技有限公司 针对人axl的兔单克隆抗体及其制备方法和应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210393793A1 (en) * 2018-09-26 2021-12-23 Genmab A/S Axl-specific antibodies for treatment of non-small cell lung cancer
CN113045664B (zh) * 2019-11-28 2023-05-12 尚健单抗（北京）生物技术有限公司 一种分离的结合抗原axl的蛋白及其用途
CN110982791A (zh) * 2019-12-26 2020-04-10 百泰生物药业有限公司 一种分泌axl抗体的杂交瘤细胞的制备筛选方法
CN115125272B (zh) * 2021-03-29 2024-04-19 复旦大学 一种car-t治疗载体及其构建方法和应用
CN116102658A (zh) * 2021-11-09 2023-05-12 四川大学华西医院 基于gas6构建的嵌合抗原受体免疫细胞制备及其应用
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