WO2019218944A3 - 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途 - Google Patents

靶向axl的抗体及抗体-药物偶联物及其制备方法和用途 Download PDF

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Publication number
WO2019218944A3
WO2019218944A3 PCT/CN2019/086475 CN2019086475W WO2019218944A3 WO 2019218944 A3 WO2019218944 A3 WO 2019218944A3 CN 2019086475 W CN2019086475 W CN 2019086475W WO 2019218944 A3 WO2019218944 A3 WO 2019218944A3
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WIPO (PCT)
Prior art keywords
antibody
drug conjugate
axl
preparation
method therefor
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PCT/CN2019/086475
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English (en)
French (fr)
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WO2019218944A2 (zh
Inventor
余科
沈竞康
孟韬
裴金鹏
马兰萍
王昕�
金锐
杜志彦
陈驎
于霆
张永良
Original Assignee
复旦大学
中国科学院上海药物研究所
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Application filed by 复旦大学, 中国科学院上海药物研究所 filed Critical 复旦大学
Priority to CA3100260A priority Critical patent/CA3100260A1/en
Priority to JP2020564443A priority patent/JP2021530436A/ja
Priority to EP19803867.1A priority patent/EP3808773A4/en
Priority to CN201980002582.8A priority patent/CN110770256B/zh
Priority to US17/055,499 priority patent/US11939386B2/en
Publication of WO2019218944A2 publication Critical patent/WO2019218944A2/zh
Publication of WO2019218944A3 publication Critical patent/WO2019218944A3/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6875—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
    • A61K47/6877—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the antibody being an immunoglobulin containing regions, domains or residues from different species
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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Abstract

本发明公开了一种靶向AXL的单克隆抗体以及抗体-药物偶联物，以及制备所述抗体、抗体-药物偶联物的方法。
PCT/CN2019/086475 2018-05-15 2019-05-10 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途 WO2019218944A2 (zh)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA3100260A CA3100260A1 (en) 2018-05-15 2019-05-10 Axl-targeting antibody, antibody-drug conjugate, preparation method therefor, and use thereof
JP2020564443A JP2021530436A (ja) 2018-05-15 2019-05-10 Ａｘｌを標的とする抗体および抗体−薬物複合体ならびにその製造方法と使用
EP19803867.1A EP3808773A4 (en) 2018-05-15 2019-05-10 AXL-TARGETING ANTIBODY, ANTIBODY-DRUG CONJUGATE, METHOD FOR PREPARING IT, AND USE THEREOF
CN201980002582.8A CN110770256B (zh) 2018-05-15 2019-05-10 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途
US17/055,499 US11939386B2 (en) 2018-05-15 2019-05-10 AXL-targeting antibody, antibody-drug conjugate, preparation method therefor, and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201810464287.1A CN110483639A (zh) 2018-05-15 2018-05-15 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途
CN201810464287.1 2018-05-15

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WO2019218944A2 WO2019218944A2 (zh) 2019-11-21
WO2019218944A3 true WO2019218944A3 (zh) 2020-01-02

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US (1) US11939386B2 (zh)
EP (1) EP3808773A4 (zh)
JP (1) JP2021530436A (zh)
CN (2) CN110483639A (zh)
CA (1) CA3100260A1 (zh)
WO (1) WO2019218944A2 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210393793A1 (en) * 2018-09-26 2021-12-23 Genmab A/S Axl-specific antibodies for treatment of non-small cell lung cancer
CN113045664B (zh) * 2019-11-28 2023-05-12 尚健单抗（北京）生物技术有限公司 一种分离的结合抗原axl的蛋白及其用途
CN110982791A (zh) * 2019-12-26 2020-04-10 百泰生物药业有限公司 一种分泌axl抗体的杂交瘤细胞的制备筛选方法
CN115125272B (zh) * 2021-03-29 2024-04-19 复旦大学 一种car-t治疗载体及其构建方法和应用
CN113444180B (zh) * 2021-06-16 2023-03-31 上海鑫湾生物科技有限公司 靶向axl蛋白的抗体及其抗原结合片段、其制备方法和应用
CN116102658A (zh) * 2021-11-09 2023-05-12 四川大学华西医院 基于gas6构建的嵌合抗原受体免疫细胞制备及其应用
CN114517226B (zh) * 2021-12-24 2023-10-10 南京鼓楼医院 Axl作为宫腔粘连诊断和治疗靶点的应用
WO2024040114A2 (en) * 2022-08-18 2024-02-22 BioLegend, Inc. Anti-axl antibodies, antigen-binding fragments thereof and methods for making and using the same
WO2024065297A1 (zh) * 2022-09-28 2024-04-04 复旦大学 嵌合抗原受体及其衍生物和应用
CN116715774B (zh) * 2023-05-12 2023-11-24 武汉爱博泰克生物科技有限公司 针对人axl的兔单克隆抗体及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107074948A (zh) * 2014-07-11 2017-08-18 根马布股份公司 结合axl的抗体

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
CN102459344A (zh) * 2009-05-15 2012-05-16 中外制药株式会社 抗axl抗体
TWI609887B (zh) * 2012-11-05 2018-01-01 皮爾法伯製藥公司 新穎的抗原結合蛋白及其作爲治療癌症之定址產物的用途
HUE057977T2 (hu) 2012-12-13 2022-06-28 Immunomedics Inc Ellenanyagok és SN-38 immunkonjugátumainak dózisai javított hatásossággal és csökkentett toxicitással
US20160106861A1 (en) 2013-04-26 2016-04-21 Spirogen Sarl Axl antibody-drug conjugate and its use for the treatment of cancer
WO2014197871A2 (en) 2013-06-06 2014-12-11 Igenica Biotherapeutics, Inc. Antibody-drug conjugates, compositions and methods of use
EP3229836B1 (en) 2014-12-09 2019-11-13 Institut National de la Sante et de la Recherche Medicale (INSERM) Human monoclonal antibodies against axl
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
JP6857138B2 (ja) 2015-05-18 2021-04-14 アジェンシス，インコーポレイテッド Ａｘｌタンパク質に結合する抗体
PL3319993T3 (pl) * 2015-07-10 2020-07-27 Genmab A/S Specyficzne wobec AXL koniugaty przeciwciało-lek do leczenia raka
WO2017028823A1 (zh) * 2015-08-20 2017-02-23 复旦大学 靶向于组织因子的抗体、其制备方法和用途
KR102459684B1 (ko) 2016-04-15 2022-10-26 바이오아트라, 인코퍼레이티드 항 Axl항체 및 이의 면역접합체와 이것들의 용도
GB201610902D0 (en) 2016-06-22 2016-08-03 Bergen Teknologioverforing As And Bergenbio As Anti-Axl Antagonistic Antibodies
CN106938051B (zh) * 2016-08-22 2019-10-11 复旦大学 靶向于组织因子的抗体-药物偶联物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107074948A (zh) * 2014-07-11 2017-08-18 根马布股份公司 结合axl的抗体

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LI ET AL: "Repertoire diversification in mice with an IgH-locus-targeted tran- sgene for the rearranged VH domain of a physiologically selected anti-ssDNA antibody", MOLECULAR IMMUNOLOGY, vol. 42, no. 12, 1 August 2005 (2005-08-01), pages 1475 - 1484, XP027634953, DOI: 10.1016/j.molimm.2005.01.010 *
ROARK J. H ET AL: "Breakdown of B cell tolerance in a mouse model of systemic lu- pus erythematosus", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 181, no. 3, 1 March 1995 (1995-03-01), pages 1157 - 1167, XP008161570, ISSN: 0022-1007, DOI: 10.1084/jem.181.3.1157 *

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