CN110755541A - A micro-enema for preventing and treating cough, asthma and common cold in children, and its preparation method - Google Patents
A micro-enema for preventing and treating cough, asthma and common cold in children, and its preparation method Download PDFInfo
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Abstract
The invention provides a micro enema for preventing and treating cough, asthma and cold in children, which comprises rhizoma anemarrhenae, almond, dried orange peel, pomegranate rind, ephedra, scutellaria, salvia, cicada shell, radix ophiopogonis, notopterygium root, sodium chloride, sucrose sulfate aluminum and adhesive; the sucrose sulfate aluminum has the aluminum content of 9.5-16.8% and the sulfur content of 6.2-10.4%. The purity of the sodium chloride is 99.6 percent or more, and the bromide content is less than or equal to 0.01 percent. The invention also provides a preparation method, which comprises weighing, enzymolysis, extraction and adhesion; the micro enema for preventing and treating cough, asthma and cold in children disclosed by the invention adopts natural green medicinal materials, exerts the advantages of each component, utilizes the mutual cooperation of the components to achieve the purpose of dispelling cold symptoms together, treats both symptoms and root causes, is remarkable in curative effect, high in total effective rate, short in treatment course and capable of healing after 3 days or so, and the total effective rate can reach 90.1%.
Description
Technical Field
The invention belongs to the technical field of enemas, relates to an enema for treating infantile cold, and particularly relates to a micro-enema for preventing and treating infantile cough, asthma and cold and a preparation method thereof.
Background
The common cold is a common clinical exogenous disease, has main symptoms of aversion to cold, fever, fatigue, nasal obstruction, running nose, cough, headache and the like, has certain infectivity, and can cause other inflammations after long-term treatment, such as acute rhinitis, acute pharyngitis, acute tonsillitis and the like. The cold of the children is that parents care the children all over the body in a place where the parents are not asleep or forget to eat, so that the bodies hollowed by the work are more tired and still need to be supported. The children dislike taking the medicine after illness due to the small age, or mostly spit out after taking the medicine, which causes the cold medicine to have low effective absorption rate and slow effect.
Chinese patent publication No. CN106728734B discloses a cold drug for treating cold, which is prepared from chinese brake herb, dandelion, echinacea, scutellaria, schizonepeta, pueraria, angelica, paris polyphylla, mint, houttuynia cordata, bombyx batryticatus, platycodon grandiflorum, periostracum cicadae, saposhnikovia divaricata, bitter apricot seed, notoginseng flower, plantain herb, cassia twig and honey-fried licorice root, and is a novel preparation for treating cold, which is a beneficial and promoting supplement to the existing cold drugs.
Chinese patent with publication number CN106421257B discloses a Chinese and western medicine granule for treating cold and a preparation method thereof, belonging to the technical field of traditional Chinese medicine preparations, and the Chinese and western medicine granule is prepared from 5-12 parts of umbellate rock jasmine, 5-12 parts of ricepaperplant pith, 5-12 parts of wild beans, 3-7 parts of poria cocos, 5-8 parts of ligusticum wallichii, 5-8 parts of folium artemisiae argyi, 1-5 parts of agaric and 0.5-1.5 parts of acetaminophen, the adopted ingredient acetaminophen belongs to western medicines, and improper combination of the Chinese and western medicines can cause the medicines to have conflicting conditions, so that the medicine properties are pressed mutually and can not be brought into play. To a certain extent, the two drugs conflict with each other, so that the absorption effect of the drugs is not obvious, and the effect of treating diseases in human bodies cannot be achieved.
Chinese patent with application number CN201610015183.3 discloses an external traditional Chinese medicine composition with functions of preventing cold and refreshing, which is prepared from five traditional Chinese medicines of rhizoma atractylodis, folium artemisiae argyi, rhizoma kaempferiae, borneol and rhizoma acori graminei with the functions of eliminating dampness and avoiding dirt with aromatics, has the effects of avoiding dirt and preventing infection and inducing resuscitation and refreshing, can be used for preventing cold, refreshing and the like, and has the advantages of definite curative effect, no toxic or side effect, low cost and convenient application. However, the dosage is strictly controlled and is prone to allergic signs, and then the dosage is not used in the pregnancy period.
The existing enema medicament for preventing and treating the cold of children has the following main defects: (1) each component acts independently, the curative effect is not obvious, the temporary solution is not the permanent solution, and the problem of promoting capillary microcirculation is not solved; (2) the use of a large amount of hormone is easy to generate drug resistance and has higher cost.
Disclosure of Invention
The invention aims at the defects, and the technical problem to be solved by the invention is to provide a micro enema for preventing and treating cough, asthma and cold in children and a preparation method thereof. The invention can realize the following purposes:
(1) the micro enema for preventing and treating cough, asthma and cold in children provided by the invention has the advantages that all components are mutually cooperated, the cold symptom is removed, both the symptoms and root causes are treated, and the effect of quick cure is achieved.
(2) The mini-enema for preventing and treating cough, asthma and cold in children has high total effective rate and does not generate drug resistance.
In order to solve the technical problems, the following technical scheme is adopted:
a micro-enema for preventing and treating cough, asthma and cold in children is characterized by comprising the following components in parts by weight: rhizoma anemarrhenae, semen Armeniacae amarum, pericarpium Citri Tangerinae, pericarpium Granati, herba Ephedrae, Scutellariae radix, Saviae Miltiorrhizae radix, periostracum Cicadae, radix Ophiopogonis, Notopterygii rhizoma, sodium chloride, sucrose sulfate aluminum and adhesive.
The following is a preferred technical scheme of the invention:
the micro enema for preventing and treating cough, asthma and cold in children comprises, by weight, 3-5 parts of rhizoma anemarrhenae, 2-6 parts of almond, 1-2 parts of dried orange peel, 1-2 parts of pomegranate rind, 3-8 parts of ephedra, 0.5-2 parts of scutellaria baicalensis, 1-3 parts of salvia miltiorrhiza, 0.8-2 parts of cicada shell, 1-4 parts of radix ophiopogonis, 1-3 parts of notopterygium root, 0.01-0.05 part of sodium chloride, 0.10-0.25 part of sucrose sulfate aluminum and an adhesive.
The micro enema for preventing and treating cough, asthma and cold in children comprises, by weight, 3-5g of rhizoma anemarrhenae, 2-6g of almond, 1-2g of dried orange peel, 1-2g of pomegranate rind, 3-8g of ephedra, 0.5-2g of scutellaria baicalensis, 1-3g of salvia miltiorrhiza, 0.8-2g of cicada shell, 1-4g of radix ophiopogonis, 1-3g of notopterygium root, 0.01-0.05g of sodium chloride, 0.10-0.25g of sucrose sulfate aluminum and an adhesive.
The sucrose sulfate aluminum has the aluminum content of 9.5-16.8% and the sulfur content of 6.2-10.4%.
The purity of the sodium chloride is 99.6 percent or more, and the bromide content is less than or equal to 0.01 percent.
The adhesive comprises water, gellan gum, hydroxypropyl starch and maltodextrin, wherein the gellan gum accounts for 2.5-10% of the total weight, the maltodextrin and the hydroxypropyl starch account for 45-60% of the total weight, the mass ratio of the hydroxypropyl starch to the maltodextrin is 1:2, and the balance is water.
The rhizoma anemarrhenae is as follows: purging fire and moistening dryness; the almond is characterized in that: relieving cough and asthma; the dried orange peel: reducing pathogenic fire and promoting blood circulation; the pomegranate rind: clearing heat and relieving dryness; the Chinese ephedra: relieving exterior syndrome and ventilating the lung; the scutellaria baicalensis: clearing away toxic materials and eliminating dampness; the red sage root: promoting blood circulation to remove blood stasis; the cicada-shell comprises the following components: relieving asthma and recovering from disease; the radix ophiopogonis: tonifying lung; the notopterygium root: relieving exterior syndrome and dispelling cold.
The invention also provides a preparation method of the micro-enema for preventing and treating cough, asthma and cold in children, which is characterized in that the preparation method of the micro-enema for preventing and treating cough, asthma and cold in children comprises the following steps: weighing, enzymolysis, extraction and adhesion.
The preparation method of the micro-enema for preventing and treating cough, asthma and cold in children comprises the following steps:
(1) weighing: weighing all the raw materials according to the proportion, respectively crushing rhizoma anemarrhenae, almond, dried orange peel, pomegranate rind, ephedra, scutellaria baicalensis, salvia miltiorrhiza, periostracum cicadae, radix ophiopogonis and notopterygium root into fragments, grinding into coarse powder, and mixing according to the proportion;
(2) enzymolysis: dissolving sodium chloride into deionized water to obtain a sodium chloride-water solution, adding the sodium chloride-water solution into the mixture according to the material-liquid ratio of 1:20-50, adding 0.05-0.08% of nicotinamide, uniformly stirring, then adding 4-7% (w/w) of cellulase for enzymolysis, removing enzyme after the enzymolysis is finished, and drying until the water content is 15-20%.
Wherein the enzymolysis time is 15-35min, and the enzymolysis temperature is 28-44 ℃.
(3) Extraction: extracting enzymolysis product with 10-18 times of 60-80% V ethanol as extractive solution under reflux for 55-85min for 2-3 times, mixing extractive solutions, removing ethanol, vacuum concentrating under reduced pressure, filtering, and drying to obtain paste with viscosity of 220pa.S/25 deg.C.
(4) Bonding: adding sucrose aluminum sulfate into the paste, uniformly stirring at the speed of 40-50rad/min, then adding a binder, and preparing the paste to obtain the micro enema. In addition, the invention can also be prepared into dripping pills, granules, oral liquid, microspheres, capsules, tablets and the like, is convenient for different people to select and meets the psychological needs of users.
By adopting the technical scheme, compared with the prior art, the invention has the following advantages:
(1) the micro enema for preventing and treating cough, asthma and cold in children adopts natural green medicinal materials, exerts the advantages of each component, utilizes the mutual cooperation of the components to jointly achieve the aim of dispelling cold symptoms, treats both principal and secondary aspect of disease and has obvious curative effect;
(2) the mini-enema for preventing and treating cough, asthma and cold in children has high total effective rate which can reach 90.1 percent, short treatment course, recovery in about 3 days and better safety.
Detailed Description
EXAMPLE 1A mini-enema for preventing and treating cough, asthma and cold in children and its preparation method
The invention relates to a micro enema for preventing and treating cough, asthma and cold in children, which comprises the following raw materials of 3g of rhizoma anemarrhenae, 2g of almond, 1g of dried orange peel, 1g of pomegranate rind, 3g of ephedra, 1g of scutellaria baicalensis, 2g of salvia miltiorrhiza, 1g of cicada shell, 2g of radix ophiopogonis, 1g of notopterygium root, 0.01g of sodium chloride, 0.1g of sucrose sulfate aluminum and an adhesive.
The sucrose sulfate aluminum has the aluminum content of 9.5-16.8% and the sulfur content of 6.2-10.4%.
The purity of the sodium chloride is 99.6 percent or more, and the bromide content is less than or equal to 0.01 percent.
The adhesive comprises water, gellan gum, hydroxypropyl starch and maltodextrin, wherein the gellan gum accounts for 2.5 percent of the total weight, the maltodextrin and the hydroxypropyl starch account for 50 percent of the total weight, the mass ratio of the hydroxypropyl starch to the maltodextrin is 1:2, and the balance is water.
The rhizoma anemarrhenae is as follows: purging fire and moistening dryness;
the almond is characterized in that: relieving cough and asthma;
the dried orange peel: reducing pathogenic fire and promoting blood circulation;
the pomegranate rind: clearing heat and relieving dryness;
the Chinese ephedra: relieving exterior syndrome and ventilating the lung;
the scutellaria baicalensis: clearing away toxic materials and eliminating dampness;
the red sage root: promoting blood circulation to remove blood stasis;
the cicada-shell comprises the following components: relieving asthma and recovering from disease;
the radix ophiopogonis: tonifying lung;
the notopterygium root: relieving exterior syndrome and dispelling cold.
The invention also provides a preparation method of the micro enema for preventing and treating cough, asthma and cold in children, which comprises the following steps:
(1) weighing all the raw materials according to the proportion, respectively crushing rhizoma anemarrhenae, almond, dried orange peel, pomegranate rind, ephedra, scutellaria baicalensis, salvia miltiorrhiza, periostracum cicadae, radix ophiopogonis and notopterygium root into fragments, grinding into coarse powder, and mixing according to the proportion;
(2) dissolving sodium chloride into deionized water to obtain a sodium chloride-water solution, adding the sodium chloride-water solution into the mixture according to the feed-liquid ratio of 1:32, adding 0.07% of nicotinamide, uniformly stirring, then adding 5.5% (w/w) of cellulase for enzymolysis, removing enzyme after the enzymolysis is finished, and drying until the water content is 18%.
Wherein the enzymolysis time is 25min, and the enzymolysis temperature is 30 ℃.
(3) Extracting enzymolysis product with 15 times of 75% V ethanol as extractive solution under reflux for 3 times (65 min each time), mixing extractive solutions, removing ethanol, vacuum concentrating under reduced pressure, filtering, and drying to obtain paste with viscosity of 232pa.S/25 deg.C.
(4) Adding sucrose aluminum sulfate into the paste, uniformly stirring at the speed of 50rad/min, then adding a binder, and preparing the paste to obtain the micro enema. In addition, the invention can also be prepared into dripping pills, granules, oral liquid, microspheres, capsules, tablets and the like, is convenient for different people to select and meets the psychological needs of users.
EXAMPLE 2A mini-enema for preventing and treating cough, asthma and cold in children
5g of rhizoma anemarrhenae, 2g of almond, 2g of dried orange peel, 1g of pomegranate peel, 8g of ephedra, 0.5g of scutellaria baicalensis, 3g of salvia miltiorrhiza, 0.8g of cicada shell, 4g of radix ophiopogonis, 1g of notopterygium root, 0.05g of sodium chloride, 0.10g of sucrose sulfate aluminum and an adhesive.
The sucrose sulfate aluminum has the aluminum content of 9.5-16.8% and the sulfur content of 6.2-10.4%.
The purity of the sodium chloride is 99.6 percent or more, and the bromide content is less than or equal to 0.01 percent.
The adhesive comprises water, gellan gum, hydroxypropyl starch and maltodextrin, wherein the gellan gum accounts for 4.5 percent of the total weight, the maltodextrin and the hydroxypropyl starch account for 52 percent of the total weight, the mass ratio of the hydroxypropyl starch to the maltodextrin is 1:2, and the balance is water.
The rhizoma anemarrhenae is as follows: purging fire and moistening dryness; the almond is characterized in that: relieving cough and asthma; the dried orange peel: reducing pathogenic fire and promoting blood circulation; the pomegranate rind: clearing heat and relieving dryness; the Chinese ephedra: relieving exterior syndrome and ventilating the lung; the scutellaria baicalensis: clearing away toxic materials and eliminating dampness; the red sage root: promoting blood circulation to remove blood stasis; the cicada-shell comprises the following components: relieving asthma and recovering from disease; the radix ophiopogonis: tonifying lung; the notopterygium root: relieving exterior syndrome and dispelling cold.
The invention also provides a preparation method of the micro enema for preventing and treating cough, asthma and cold in children, which comprises the following steps:
(1) weighing all the raw materials according to the proportion, respectively crushing rhizoma anemarrhenae, almond, dried orange peel, pomegranate rind, ephedra, scutellaria baicalensis, salvia miltiorrhiza, periostracum cicadae, radix ophiopogonis and notopterygium root into fragments, grinding into coarse powder, and mixing according to the proportion;
(2) dissolving sodium chloride into deionized water to obtain a sodium chloride-water solution, adding the sodium chloride-water solution into the mixture according to the feed-liquid ratio of 1:30, adding 0.07% of nicotinamide, uniformly stirring, then adding 5.2% (w/w) of cellulase for enzymolysis, removing enzyme after the enzymolysis is finished, and drying until the water content is 18%.
Wherein the enzymolysis time is 32min, and the enzymolysis temperature is 35 ℃.
(3) Extracting enzymolysis product with 75% V ethanol 12 times of enzymolysis product as extractive solution under reflux for 3 times, each time for 67min, mixing extractive solutions, removing ethanol, vacuum concentrating under reduced pressure, filtering, and drying to obtain paste with viscosity of 224pa.S/25 deg.C.
(4) Adding sucrose aluminum sulfate into the paste, uniformly stirring at the speed of 45rad/min, then adding a binder, and preparing the paste to obtain the micro enema. In addition, the invention can also be prepared into dripping pills, granules, oral liquid, microspheres, capsules, tablets and the like, is convenient for different people to select and meets the psychological needs of users.
EXAMPLE 3A mini-enema for preventing and treating cough, asthma and cold in children
The invention relates to a micro enema for preventing and treating cough, asthma and cold in children, which comprises the following raw materials of 3g of rhizoma anemarrhenae, 6g of almond, 1g of dried orange peel, 2g of pomegranate rind, 3g of ephedra, 2g of scutellaria baicalensis, 1g of salvia miltiorrhiza, 2g of cicada shell, 1g of radix ophiopogonis, 3g of notopterygium root, 0.01g of sodium chloride, 0.25g of sucrose sulfate aluminum and an adhesive.
The sucrose sulfate aluminum has the aluminum content of 9.5-16.8% and the sulfur content of 6.2-10.4%.
The purity of the sodium chloride is 99.6 percent or more, and the bromide content is less than or equal to 0.01 percent.
The adhesive comprises water, gellan gum, hydroxypropyl starch and maltodextrin, wherein the gellan gum accounts for 4.5 percent of the total weight, the maltodextrin and the hydroxypropyl starch account for 52 percent of the total weight, the mass ratio of the hydroxypropyl starch to the maltodextrin is 1:2, and the balance is water.
The rhizoma anemarrhenae is as follows: purging fire and moistening dryness; the almond is characterized in that: relieving cough and asthma; the dried orange peel: reducing pathogenic fire and promoting blood circulation; the pomegranate rind: clearing heat and relieving dryness; the Chinese ephedra: relieving exterior syndrome and ventilating the lung; the scutellaria baicalensis: clearing away toxic materials and eliminating dampness; the red sage root: promoting blood circulation to remove blood stasis; the cicada-shell comprises the following components: relieving asthma and recovering from disease; the radix ophiopogonis: tonifying lung; the notopterygium root: relieving exterior syndrome and dispelling cold.
The invention also provides a preparation method of the micro enema for preventing and treating cough, asthma and cold in children, which comprises the following steps:
(1) weighing all the raw materials according to the proportion, respectively crushing rhizoma anemarrhenae, almond, dried orange peel, pomegranate rind, ephedra, scutellaria baicalensis, salvia miltiorrhiza, periostracum cicadae, radix ophiopogonis and notopterygium root into fragments, grinding into coarse powder, and mixing according to the proportion;
(2) dissolving sodium chloride into deionized water to obtain a sodium chloride-water solution, adding the sodium chloride-water solution into the mixture according to the feed-liquid ratio of 1:30, adding 0.07% of nicotinamide, uniformly stirring, then adding 5.2% (w/w) of cellulase for enzymolysis, removing enzyme after the enzymolysis is finished, and drying until the water content is 18%.
Wherein the enzymolysis time is 32min, and the enzymolysis temperature is 35 ℃.
(3) Extracting enzymolysis product with 75% V ethanol 12 times of enzymolysis product as extractive solution under reflux for 3 times, each time for 67min, mixing extractive solutions, removing ethanol, vacuum concentrating under reduced pressure, filtering, and drying to obtain paste with viscosity of 220pa.S/25 deg.C.
(4) Adding sucrose aluminum sulfate into the paste, uniformly stirring at the speed of 45rad/min, then adding a binder, and preparing the paste to obtain the micro enema. In addition, the invention can also be prepared into dripping pills, granules, oral liquid, microspheres, capsules, tablets and the like, is convenient for different people to select and meets the psychological needs of users.
Setup of comparative examples 1-6:
comparative example 1: the formulation was performed as in example 1, except that the almonds were replaced with ephedra.
Comparative example 2: the formulation was performed as in example 1, except that the dried orange peel was replaced with ephedra.
Comparative example 3: the formulation was performed as in example 1, except that the pomegranate rind was replaced with ephedra.
Comparative example 4: a formulation was prepared as in example 1, except that ephedra was substituted for salvia miltiorrhiza.
Comparative example 5: the formulation was performed as in example 1, except that the cicada shell was replaced with ephedra.
Comparative example 6: the formulation was performed as in example 1, except that ophiopogon root was replaced with ephedra.
The invention has the beneficial effects that:
the curative effect test of the mini-enema for preventing and treating cough, asthma and cold in children of the invention
1) Subject and method
Age: 0.5-2 years old; sex: male; quantity: 9000 names; the physical sign state: no other diseases except common cold; and others: other features that are statistically significant.
2) Clinically, a curative effect judgment standard is formulated:
the effect is shown: the symptoms of the common cold do not count for signs, or individual mild symptoms appear.
The method has the following advantages: individual symptoms or signs occurred, but were mild.
And (4) invalidation: the symptoms of the common cold, which are typical, are marked by physical signs.
3) The treatment method comprises the following steps: anus is plugged into enema for use, and dosage is as follows: 1.5-2 g/time, 2 times daily.
4) The treatment effect is as follows: in clinical experiments, statistics were conducted using the treatment effects of examples 1 to 3 of the present invention and comparative examples 1 to 6, and the evaluation results of the treatment effects are shown in the table:
total effective rate = (effective + effective)/total number × 100%.
As can be seen from the above table, 9000 cold patients of the present invention were recorded, and the treatment effect evaluation was performed using the treatment effect evaluation criteria: 595 and 817 cases of effective, 84-260 cases of effective, 99-193 cases of ineffective, the total effective rate is above 80%.
Therefore, the micro-enema for preventing and treating cough, asthma and cold in children in embodiments 1-3 of the invention adopts rhizoma anemarrhenae, almond, dried orange peel, pomegranate rind, ephedra, scutellaria, salvia, cicada shell, radix ophiopogonis, notopterygium root, sodium chloride and the like, and all the components generate synergistic action. Meanwhile, research and development personnel of the invention find that, during preparation, nicotinamide is added for enzymolysis of cellulose, a high-activity small molecule is detected in an enzymolysis product, the high-activity small molecule has high activity, can promote intestinal villus peristalsis and accelerate intestinal canal wall capillary microcirculation, the absorption rate of effective components of the medicine is greatly improved, the total effective rate of cure is high, the total effective rate can reach 90.1%, the treatment course is short, the cure can be realized in about 3 days, no toxin exists, and the effect of rapid cure is achieved.
In addition, the micro enema for preventing and treating cough, asthma and cold in children adopts natural green medicinal materials, utilizes the synergistic effect of various medicines, exerts the advantages of each component and achieves the aim of symptomatic treatment.
The preparation method of the micro-enema for preventing and treating cough, asthma and cold in children is simple and easy to operate, the product quality is convenient to control, and the safety is good.
The percentages used in the present invention are percentages by weight and the proportions described in the present invention are proportions by mass, unless otherwise indicated.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A micro-enema for preventing and treating cough, asthma and cold in children is characterized in that,
the micro enema for preventing and treating cough, asthma and cold in children comprises: rhizoma anemarrhenae, semen Armeniacae amarum, pericarpium Citri Tangerinae, pericarpium Granati, herba Ephedrae, Scutellariae radix, Saviae Miltiorrhizae radix, periostracum Cicadae, radix Ophiopogonis, Notopterygii rhizoma, sodium chloride, sucrose sulfate aluminum and adhesive.
2. The micro-enema for preventing and treating cough, asthma and cold in children as claimed in claim 1,
the micro enema for preventing and treating cough, asthma and cold in children comprises, by weight, 3-5 parts of rhizoma anemarrhenae, 2-6 parts of almond, 1-2 parts of dried orange peel, 1-2 parts of pomegranate rind, 3-8 parts of ephedra, 0.5-2 parts of scutellaria baicalensis, 1-3 parts of salvia miltiorrhiza, 0.8-2 parts of cicada shell, 1-4 parts of radix ophiopogonis, 1-3 parts of notopterygium root, 0.01-0.05 part of sodium chloride, 0.10-0.25 part of sucrose sulfate aluminum and an adhesive.
3. The micro-enema for preventing and treating cough, asthma and cold in children as claimed in claim 1, wherein the sucrose sulfate ester aluminum has an aluminum content of 9.5-16.8% and a sulfur content of 6.2-10.4%.
4. The micro-enema for preventing and treating cough, asthma and cold in children as claimed in claim 1,
the purity of the sodium chloride is 99.6 percent or more, and the bromide content is less than or equal to 0.01 percent.
5. The micro-enema for preventing and treating cough, asthma and cold in children as claimed in claim 1,
the adhesive is water, gellan gum, hydroxypropyl starch and maltodextrin;
the gellan gum accounts for 2.5-10% of the total weight;
the maltodextrin and the hydroxypropyl starch account for 45-60 percent of the total weight, and the mass ratio of the hydroxypropyl starch to the maltodextrin is 1: 2.
6. A preparation method of a micro-enema for preventing and treating cough, asthma and cold in children is characterized in that the preparation method of the micro-enema for preventing and treating cough, asthma and cold in children comprises the following steps: weighing, enzymolysis, extraction and adhesion.
7. The preparation method of the micro-enema for preventing and treating cough, asthma and cold in children as claimed in claim 6,
the enzymolysis: adding sodium chloride-water solution into the mixture according to the feed-liquid ratio of 1:20-50, adding 0.05-0.08% nicotinamide, stirring uniformly, adding 4-7% cellulase for enzymolysis, removing enzyme, and drying until the water content is 15-20%.
8. The preparation method of the micro-enema for preventing and treating cough, asthma and cold in children as claimed in claim 6, wherein the enzymolysis time is 15-35min, and the enzymolysis temperature is 28-44 ℃.
9. The preparation method of the micro-enema for preventing and treating cough, asthma and cold in children as claimed in claim 6,
the extraction: extracting enzymolysis product with 10-18 times of 60-80% V ethanol as extractive solution under reflux for 55-85min for 2-3 times, mixing extractive solutions, removing ethanol, vacuum concentrating, filtering, and drying.
10. The method as claimed in claim 9, wherein the viscosity of the paste is 200 and 300pa.s/25 ℃.
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