CN110749740A - Sample analyzer and cleaning method thereof - Google Patents

Sample analyzer and cleaning method thereof Download PDF

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Publication number
CN110749740A
CN110749740A CN201810812445.8A CN201810812445A CN110749740A CN 110749740 A CN110749740 A CN 110749740A CN 201810812445 A CN201810812445 A CN 201810812445A CN 110749740 A CN110749740 A CN 110749740A
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China
Prior art keywords
sub
cleaning
sample
cleaning liquid
controller
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CN201810812445.8A
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Chinese (zh)
Inventor
习武佳
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Shenzhen Dymind Biotechnology Co Ltd
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Shenzhen Dymind Biotechnology Co Ltd
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Priority to CN201810812445.8A priority Critical patent/CN110749740A/en
Publication of CN110749740A publication Critical patent/CN110749740A/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04Cleaning involving contact with liquid
    • B08B3/08Cleaning involving contact with liquid the liquid having chemical or dissolving effect

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The application discloses sample analysis device and cleaning method thereof, the device includes: a controller, a sample providing sub-device, a detecting sub-device and a cleaning liquid storing sub-device; the controller is respectively connected with the sample providing sub-device and the detection sub-device, and the sample providing sub-device is respectively connected with the detection sub-device and the cleaning solution storage sub-device; the sample providing sub-device can provide the sample to be detected to the detecting sub-device under the control of the controller or provide the cleaning liquid in the cleaning liquid storing sub-device to the detecting sub-device for cleaning under the control of the controller. By means of the mode, the automatic cleaning can be achieved, the process is simple, structural components of the sample analysis device are reused, and the structure is compact.

Description

Sample analyzer and cleaning method thereof
Technical Field
The present application relates to the field of immunoassay technologies, and in particular, to a sample analyzer and a cleaning method thereof.
Background
A sample analyzer is a common analyzer in the field of in vitro diagnostic medical devices, and is generally used for detecting and analyzing samples such as blood samples or body fluids.
In general, the individual analytical sub-assemblies or detector components of the sample analysis device are subjected to routine cleaning and maintenance with cleaning liquids to ensure the accuracy of the test results and the service life of the individual components. In the prior art, the conventional maintenance of sample analysis device will open the bottleneck of cleaning fluid storage sub-device and place at the sampling position by the manual work generally, then click the button, and sample analysis device is executed and is washd each detector part or complete machine cleaning fluid by behind the cleaning fluid of sampling needle absorption cleaning fluid storage sub-device. Some factory sample analyzers manually place the cleaning solution storage sub-device in an autoinjection device, convey the cleaning solution storage sub-device to the inside of the device through the autoinjection device, and then suck and carry out the washing to the ware part by the sampling needle. Because the automatic sample feeding device for conveying the cleaning liquid storage sub-device is required to be added in the mode, the cost of the instrument is increased; and still require the user to place cleaning solution in the autosampler daily, increasing the user's operation.
The inventor of the present application finds, in a long-term research and development process, that the above-mentioned cleaning operation adds manual operation, and the flow is relatively complex, and on the other hand, the structure of the sample analysis apparatus becomes complex and the volume becomes huge by providing a special cleaning system.
Disclosure of Invention
The technical problem that this application mainly solved provides a sample analysis device and cleaning method thereof, can realize self-cleaning, and the flow is simple, has alleviateed manual operation, and the cost is lower, and reuses sample analysis device's structural component, and makes its compact structure, and has reduced the cleaning solution to the influence of parts such as other in the analysis appearance.
In order to solve the technical problem, the application adopts a technical scheme that: there is provided a sample analysis device, the device comprising a detection sub-device and further comprising: a controller, a sample providing sub-assembly and a cleaning fluid storage sub-assembly; the controller is respectively connected with the sample providing sub-device and the detection sub-device, and the sample providing sub-device is respectively connected with the detection sub-device and the cleaning solution storage sub-device; the sample providing sub-device can provide the sample to be detected to the detecting sub-device under the control of the controller or provide the cleaning liquid in the cleaning liquid storing sub-device to the detecting sub-device for cleaning under the control of the controller.
In order to solve the above technical problem, another technical solution adopted by the present application is: there is provided a method of cleaning a sample analysis device, the method being adapted for use with a sample analysis device as described above, the method comprising: receiving a cleaning instruction; in response to the washing instruction, the sample providing sub-device is controlled to provide the cleaning liquid in the cleaning liquid storage sub-device to the detecting sub-device for washing thereof.
The beneficial effect of this application is: unlike the prior art, the apparatus of the present application comprises: a controller, a sample providing sub-device, a detecting sub-device and a cleaning liquid storing sub-device; the controller is respectively connected with the sample providing sub-device and the detection sub-device, and the sample providing sub-device is respectively connected with the detection sub-device and the cleaning solution storage sub-device; the sample providing sub-device can provide the sample to be detected to the detecting sub-device under the control of the controller or provide the cleaning liquid in the cleaning liquid storing sub-device to the detecting sub-device for cleaning under the control of the controller. The sample provides the sub-device and can provide the sample that waits to detect to the detection sub-device, under the control of controller, can also be automatically with the cleaning solution among the cleaning solution storage sub-device provide the detection sub-device in order to supply it to wash, through this kind of mode, can realize self-cleaning on the one hand, the flow is simple, manual operation has been alleviateed, the cost is lower, on the other hand, sample to sample analysis device provides the sub-device to multiplex, thereby make its compact structure, occupation space is little, the influence of other parts in the cleaning solution to the analysis appearance has been reduced.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts. Wherein:
FIG. 1 is a schematic structural view of an embodiment of a sample analyzer according to the present application;
FIG. 2 is a schematic structural view of another embodiment of a sample analyzer according to the present application;
FIG. 3 is a schematic view of the structure of another embodiment of the sample analyzer of the present application;
FIG. 4 is a schematic structural view of a sample analyzer according to another embodiment of the present application;
FIG. 5 is a schematic view of the structure of yet another embodiment of the sample analyzer of the present application;
FIG. 6 is a schematic flow chart illustrating one embodiment of a method for cleaning a sample analyzer according to the present disclosure;
FIG. 7 is a schematic flow chart illustrating another embodiment of a method for cleaning a sample analyzer according to the present invention.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Referring to fig. 1, fig. 1 is a schematic structural diagram of an embodiment of a sample analyzer according to the present application, the sample analyzer including: a controller 1, a sample providing sub-arrangement 2, a detection sub-arrangement 3 and a cleaning liquid storage sub-arrangement 4.
Wherein the controller 1 is connected with the sample providing sub-device 2 and the detecting sub-device 3, respectively, and the sample providing sub-device 2 is connected with the detecting sub-device 3 and the cleaning solution storing sub-device 4, respectively; the sample providing sub-assembly 2, under the control of the controller 1, can provide the sample to be tested to the testing sub-assembly 3 for testing thereof or provide the cleaning liquid in the cleaning liquid storage sub-assembly 4 to the testing sub-assembly 3 for cleaning thereof under the control of the controller 1.
The sample analysis device may be any device for analysing or detecting or manipulating a sample to be detected, for example: an immunoassay device, a blood cell analysis device, a biochemical analysis device, and the like.
In the present embodiment, the sample providing sub-device 2 is mainly used for providing the sample to be tested to the testing sub-device 3, the testing sub-device 3 is not only cleaned by a common conventional cleaning solution after testing, but also cleaned by a cleaning solution periodically, in order to avoid adding redundant structural components as much as possible, the sample providing sub-device 2 is further connected with the cleaning solution storage sub-device 4, and under the control of the controller 1, the sample providing sub-device 2 is further enabled to provide the cleaning solution in the cleaning solution storage sub-device 4 to the testing sub-device 3 for cleaning.
The device of the embodiment of the application comprises: a controller 1, a sample supply sub-device 2, a detection sub-device 3, and a cleaning liquid storage sub-device 4; the controller 1 is connected with the sample providing sub-device 2 and the detecting sub-device 3, respectively, and the sample providing sub-device 2 is connected with the detecting sub-device 3 and the cleaning solution storing sub-device 4, respectively; the sample providing sub-assembly 2, under the control of the controller 1, can provide the sample to be tested to the testing sub-assembly 3 for testing thereof or provide the cleaning liquid in the cleaning liquid storage sub-assembly 4 to the testing sub-assembly 3 for cleaning thereof under the control of the controller 1. The sample providing sub-device 2 can provide a sample to be detected for the detecting sub-device 3, and can automatically provide the cleaning liquid in the cleaning liquid storage sub-device 4 for the detecting sub-device 3 to be cleaned under the control of the controller 1, so that on one hand, automatic cleaning can be realized, manual operation is reduced, the flow is simple, and on the other hand, the sample providing sub-device 2 of the sample analyzing device is reused, so that the sample providing sub-device has a compact structure and occupies small space; in addition, because the sample providing sub-device is used for directly sucking the liquid in the cleaning liquid storage sub-device, an additional cleaning liquid supply pipeline is not needed, the cost is reduced, the corrosion and the interference of the cleaning liquid to components such as valves on the flowing pipeline are also reduced, and the service life of the sample analyzer component is prolonged.
Referring to fig. 2, in one embodiment, the sample providing sub-assembly 2 includes: sampling needle 21, drive assembly 22, valve 23 and pipeline 24, sampling needle 21 and pipeline 24 connect, and drive assembly 22 and valve 23 set up on pipeline 24. Wherein, the driving assembly 22 and the valve 23 are respectively connected with the controller 1.
Further, referring to fig. 3, the driving assembly 22 includes: the horizontal motor subassembly 221, the vertical motor subassembly 222 and the driving motor 223, wherein the horizontal motor subassembly 221 and the vertical motor subassembly 222 are respectively connected with the driving motor 223. The drive motor 223 is connected to the controller 1.
The horizontal motor subassembly 221 controls the sampling needle 21 to move in the horizontal direction, and the walking path of the horizontal motor subassembly 221 is a straight line, a curve or a circle; the vertical motor subassembly 222 controls the movement of the sampling needle 21 in the vertical direction.
The sampling needle 21 of the sample providing sub-device 2 sucks a sample to be detected from the outside under the control of the controller 1, and then operates under the control of the horizontal motor sub-assembly 221 and the vertical motor sub-assembly 222 respectively to provide the sample to be detected to the detecting sub-device 3.
In one embodiment, the diameter of the mouth of the cleaning liquid storage sub-device 4 is smaller than or equal to a preset diameter; this predetermined diameter is required to be as unfavorable as possible for the evaporation of the cleaning liquid. In order to further reduce the volatilization of the cleaning solution, a sealing rubber material is arranged at the bottle mouth of the cleaning solution storage sub-device 4; the cleaning liquid storage sub-assembly 4 is disposed on the traveling path of the sampling needle 21. Because the sampling needle 21 of the sample providing sub-device 2 needs to suck the cleaning liquid from the cleaning liquid storage sub-device 4 under the control of the controller 1, the cleaning liquid storage sub-device 4 is arranged on the walking path of the sampling needle 21, on one hand, the suction of the sampling needle 21 is convenient, on the other hand, the structure of the sample analyzing device can be made as compact as possible, and the occupied space is as small as possible.
Wherein, the sampling needle 21 runs to the bottle mouth of the cleaning liquid storage sub-device 4 under the control of the controller 1 and punctures to suck the cleaning liquid, and delivers the cleaning liquid to the detection sub-device 3 to perform cleaning. The sampling needle 21 sucks the cleaning solution in a puncturing mode, so that volatilization of the cleaning solution can be further prevented and reduced.
In one embodiment, the detection sub-device 3 is used for detecting a blood routine item or an immune protein item of a sample to be detected; the number of detection sub-devices 3 is more than one, such as 2, 3 or 4, etc.; the detection sub-device 3 is disposed on the traveling path of the sampling needle 21. For example, referring to fig. 4, the number of detection sub-devices 3 includes 3.
Referring to fig. 5, in one embodiment, the apparatus further comprises a cleaning button 5, the cleaning button 5 is electrically connected to the controller 1, and when the cleaning button 5 is triggered to send out a trigger signal, the controller 1 responds to the trigger signal to control the sample providing sub-apparatus 2 to provide the cleaning liquid in the cleaning liquid storage sub-apparatus 4 to the detecting sub-apparatus 3 for cleaning.
By arranging the cleaning key 5, the operation of a user can be facilitated, and when the detection sub-device 3 needs to be cleaned, the detection sub-device can be triggered to generate a trigger signal only by pressing the cleaning key 5. The setting position of the cleaning key 5 is not limited, and the user can operate the cleaning key conveniently.
In another embodiment, the controller 1 is further configured to receive a washing instruction, control the sample providing sub-apparatus 2 to provide the cleaning liquid in the cleaning liquid storage sub-apparatus 4 to the designated detecting sub-apparatus 3 for washing thereof in response to the washing instruction, and control the designated detecting sub-apparatus 3 to be powered off after the washing is completed.
Referring to fig. 6, fig. 6 is a schematic flow chart of an embodiment of a method for cleaning a sample analyzer according to the present application, which is suitable for use in any one of the above sample analyzers, and the detailed description of the related contents refers to the above method section, which is not repeated herein. The method comprises the following steps:
step S101: a purge instruction is received.
Step S102: in response to the washing instruction, the sample supply sub-assembly is controlled to supply the cleaning liquid in the cleaning liquid storage sub-assembly to the detection sub-assembly for washing thereof.
In the embodiment of the application, the sample provides the sub-device and can provide the sample that waits to detect to the detection sub-device, under the control of controller, can also provide the cleaning solution among the cleaning solution storage sub-device automatically and detect the sub-device and wash in order to supply it, through this kind of mode, can realize self-cleaning on the one hand, the flow is simple, and on the other hand, sample to sample analytical equipment provides sub-device 2 and multiplexes to make its compact structure, occupation space is little.
Wherein the cleaning instruction comprises a designated detection sub-device needing cleaning; the cleaning instruction also comprises shutdown after cleaning. The cleaning instruction may be generated by setting a cleaning button, triggered by a user click, or may be generated by a user by inputting through another input sub-device.
Referring to fig. 7, in step S102, the controlling the sample providing sub-apparatus to provide the cleaning liquid in the cleaning liquid storage sub-apparatus to the detecting sub-apparatus for cleaning thereof may specifically include: substep S1021, substep S1022, and substep S1023.
Substep S1021: and controlling the sampling needle of the sample providing sub-device to move to the position of the cleaning liquid storage sub-device and suck the cleaning liquid.
Substep S1022: and controlling the sampling needle to move and delivering the cleaning liquid to the specified detection sub-device.
Substep S1023: and controlling and executing the cleaning of the device parts of the designated detection sub-device.
The cleaning method reduces the number of times of manually placing the cleaning solution storage sub-device at the sampling position, cleaning of all device parts can be executed only by clicking the cleaning key, user operation is simplified through the one-key operation flow, user experience is improved, and the cleaning effect is reliable.
The above description is only for the purpose of illustrating embodiments of the present application and is not intended to limit the scope of the present application, and all modifications of equivalent structures and equivalent processes, which are made by the contents of the specification and the drawings of the present application or are directly or indirectly applied to other related technical fields, are also included in the scope of the present application.

Claims (13)

1. A sample analysis device, the device comprising a detection sub-device, characterized in that the device further comprises: a controller, a sample providing sub-assembly and a cleaning fluid storage sub-assembly; the controller is respectively connected with the sample providing sub-device and the detection sub-device, and the sample providing sub-device is respectively connected with the detection sub-device and the cleaning solution storage sub-device; the sample providing sub-device can provide the sample to be detected to the detecting sub-device under the control of the controller or provide the cleaning liquid in the cleaning liquid storing sub-device to the detecting sub-device for cleaning under the control of the controller.
2. The apparatus of claim 1, wherein the sample providing sub-apparatus comprises: sampling needle, drive assembly, valve and pipeline, the sampling needle with the tube coupling, drive assembly with the valve setting is in on the pipeline.
3. The apparatus of claim 2, wherein the drive assembly comprises: the motor comprises a horizontal motor subassembly, a vertical motor subassembly and a driving motor, wherein the horizontal motor subassembly and the vertical motor subassembly are respectively connected with the driving motor.
4. The device of claim 3, wherein the horizontal motor subassembly controls the sampling needle to move in a horizontal direction, and the path traveled by the horizontal motor subassembly is a straight line, a curve or a circle; the vertical motor subassembly controls the sampling needle to move in the vertical direction.
5. The apparatus of claim 4, wherein the sampling needle of the sample providing sub-apparatus is controlled by the controller to take a sample to be tested from outside, and then operated under the control of the horizontal motor sub-assembly and the vertical motor sub-assembly to provide the sample to be tested to the testing sub-apparatus.
6. The device of claim 2, wherein the diameter of the mouth of the cleaning solution storage sub-device is less than or equal to a preset diameter; a bottle opening of the cleaning solution storage sub-device is provided with a sealing rubber material; the cleaning liquid storage sub-device is arranged on a walking path of the sampling needle.
7. The device of claim 6, wherein the sampling needle runs to the mouth of the cleaning liquid storage sub-device and punctures to suck the cleaning liquid and deliver the cleaning liquid to the detection sub-device to perform cleaning under the control of the controller.
8. The device according to claim 2, wherein the detection sub-device is used for detecting a blood routine item or an immune protein item of a sample to be detected; the number of the detection sub-devices is more than one; the detection sub-device is arranged on a walking path of the sampling needle.
9. The device of claim 1, further comprising a cleaning button electrically connected to the controller, wherein when the cleaning button is activated to generate a trigger signal, the controller controls the sample providing sub-device to provide the cleaning solution in the cleaning solution storage sub-device to the detecting sub-device for cleaning thereof in response to the trigger signal.
10. The apparatus of claim 1, wherein the controller is further configured to receive a wash command, control the sample providing sub-apparatus to provide the cleaning liquid in the cleaning liquid storage sub-apparatus to a designated detecting sub-apparatus for washing in response to the wash command, and control the designated detecting sub-apparatus to shut down after washing is completed.
11. A method of cleaning a sample analysis device, the method being adapted for use with a sample analysis device according to any one of claims 1 to 10, the method comprising:
receiving a cleaning instruction;
in response to the washing instruction, the sample providing sub-device is controlled to provide the cleaning liquid in the cleaning liquid storage sub-device to the detecting sub-device for washing thereof.
12. The method of claim 11, wherein the cleaning instructions include a designated detection sub-device requiring cleaning; the cleaning instruction further comprises shutdown after cleaning is finished.
13. The method of claim 12, wherein said controlling said sample providing sub-assembly to provide cleaning fluid in said cleaning fluid storage sub-assembly to said detection sub-assembly for cleaning thereof comprises:
controlling the sampling needle of the sample providing sub-device to move to the position of the cleaning liquid storage sub-device and suck the cleaning liquid;
controlling the sampling needle to move and conveying the cleaning liquid to a designated detection sub-device;
and controlling and executing the cleaning of the device parts of the designated detection sub-device.
CN201810812445.8A 2018-07-23 2018-07-23 Sample analyzer and cleaning method thereof Pending CN110749740A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2827048A1 (en) * 2001-07-06 2003-01-10 Biotrol Diagnostic Apparatus for the delivery of immunological doses to samples for analysis has groups of vessels in modules, moved step-by-step in a cyclic and synchronized action, with a scanner and a single cleaner for washing
WO2013044454A1 (en) * 2011-09-27 2013-04-04 深圳市亚辉龙生物科技有限公司 Full-automatic immunity analyzer and detection method thereof
WO2018041249A1 (en) * 2016-09-02 2018-03-08 北京华为应运科技发展有限公司 Body health testing system
CN208607240U (en) * 2018-07-23 2019-03-15 深圳市帝迈生物技术有限公司 Device for analyzing samples

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2827048A1 (en) * 2001-07-06 2003-01-10 Biotrol Diagnostic Apparatus for the delivery of immunological doses to samples for analysis has groups of vessels in modules, moved step-by-step in a cyclic and synchronized action, with a scanner and a single cleaner for washing
WO2013044454A1 (en) * 2011-09-27 2013-04-04 深圳市亚辉龙生物科技有限公司 Full-automatic immunity analyzer and detection method thereof
WO2018041249A1 (en) * 2016-09-02 2018-03-08 北京华为应运科技发展有限公司 Body health testing system
CN208607240U (en) * 2018-07-23 2019-03-15 深圳市帝迈生物技术有限公司 Device for analyzing samples

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