CN110721333A - Antiallergic dressing used after anesthesia and preparation method thereof - Google Patents

Abstract

The invention discloses an antiallergic dressing used after anesthesia and a preparation method thereof, belonging to the technical field of medical dressings in anesthesia departments. The dressing has an antiallergic effect, can relieve allergic symptoms of patients, and has the effects of relieving pain and sterilizing.

Description

Antiallergic dressing used after anesthesia and preparation method thereof

Technical Field

The invention relates to the technical field of medical dressings in anesthesia departments, in particular to an anti-allergy dressing used after anesthesia and a preparation method thereof.

Background

The first written record in the world about anesthesia technology is Ma-boil decoction which appears in the Han dynasty of China and invented by ancient famous surgical experts and Huatuo Chinese pharmacologist. The decoction of ephedra decoction is a traditional Chinese medicine decoction which is equivalent to the existing oral general anesthetic, and the skin sensation of a patient is lost after oral administration, so that the operation is convenient to implement. Later, various anesthetics were invented in Western medicine, such as lidocaine, bupivacaine, procaine, etc., which are now prevalent. Anesthesia is a reversible functional inhibition of the central and peripheral nervous system, produced by drugs or other means, characterized primarily by loss of sensation, particularly pain.

The anesthesia is not only applied to sensory shielding of large-scale operations, but also applied to pain relief of wounds, so that the wounds can be conveniently cleaned and sutured, dressing such as block anesthesia is often needed in the anesthesia process, local anesthetic is injected around nerve trunks or main branches to block afferent stimulation of nerve endings, the nerve distribution area is enabled to generate anesthesia effect, and puncture points are covered by the dressing after needle withdrawal. The dressing materials commonly used at present comprise gauze, oily gauze, calcium alginate dressing, hydrocolloid dressing and the like, wherein the skin covered by the dressing such as the gauze and the oily gauze is repeatedly contacted with disinfectant and covered by adhesive dressing, and in addition, sweat of the skin is stimulated in seasons with rising air temperature, so that the adhesive barrier effect of the transparent dressing is influenced by the skin around the puncture point of some patients due to the condition of sweating and the like. Some patients, especially the elderly, can generate irritant dermatitis caused by skin irritation caused by the incision of the edge of the dressing after long-term use. The patient presents with symptoms of redness, itching, pain, blisters, etc. on the edge of the dressing. The calcium alginate dressing has the advantages of no toxicity, no immunogenicity, biodegradability and the like, but the calcium alginate dressing has poor spinnability due to the characteristics of poor mechanical property and high strength irregularity of calcium alginate fibers, is usually prepared in a non-woven form, is easy to crack in a right-angle direction, has low strength and poor durability, and can tilt and fall off. Therefore, the anti-allergic calcium alginate fiber dressing which has high strength and is not easy to tear is urgently needed at present.

Disclosure of Invention

In view of the above, the present invention aims to provide an antiallergic dressing used after anesthesia for covering a puncture site after anesthesia, and the prepared dressing has an antiallergic effect, can alleviate allergic symptoms already occurring in a patient, and has the effects of relieving pain and sterilizing, and a preparation method thereof.

The invention solves the technical problems by the following technical means:

the utility model provides an antiallergic dressing for after anesthesia, antiallergic dressing includes the non-woven fabrics and bonds the medicine-carrying layer on the non-woven fabrics, the medicine-carrying layer is prepared for the calcium alginate composite fiber who has the antiallergic gel granule of load and forms, the antiallergic gel granule includes the calcium alginate shell and loads in the intraformational antiallergic liquid of calcium alginate shell.

Further, the calcium alginate composite fiber is mainly prepared from sodium alginate and short cotton fiber according to the mass ratio of (20-25): (4-8) compounding and preparing.

Further, the mass ratio of the calcium alginate composite fiber to the antiallergic gel particles is (24-33) - (3-8), and the particle size of the antiallergic gel particles is 0.2-0.5 mm.

Further, the antiallergic liquid comprises the following components: ethyl hydroxybenzoate, menthol extract, fructus Kochiae extract, pearl powder, herba Schizonepetae extract, radix Saposhnikoviae extract, flos Lonicerae extract, herba Solidaginis extract, and herba Lobeliae chinensis extract.

Further, the antiallergic gel particles comprise the following raw materials in parts by weight: 40-56 parts of carboxymethyl cellulose, 35-45 parts of sodium alginate, 10 parts of glycerol, 0.1 part of ethylparaben, 1-2 parts of menthol extract, 1-3 parts of fructus kochiae extract, 2-3 parts of pearl powder, 5-6 parts of herba schizonepetae extract, 3-5 parts of radix sileris extract, 0.5-1 part of honeysuckle extract, 0.05-0.1 part of goldenrod extract and 0.05-0.2 part of Chinese lobelia extract.

Furthermore, the area ratio of the non-woven fabric to the drug-loaded layer is 1 (0.8-0.9).

The invention further discloses a preparation method of the antiallergic dressing, which comprises the steps of adding short cotton fibers and antiallergic gel particles into a saturated sodium alginate solution, spraying the obtained mixed spinning solution into a coagulation bath at 45 ℃ through a spinneret orifice of a wet spinning machine, separating out, drawing and stretching the obtained fibers through a stretching roller to obtain calcium alginate composite fibers loaded with the antiallergic gel particles, and forming a drug-loaded layer by the dried calcium alginate composite fibers; steaming nonwoven fabric in water vapor for 20-30min, drying to water content of 30-40%, heating the medicine-carrying layer to 80-85 deg.C, sticking the medicine-carrying layer on the nonwoven fabric while it is hot to obtain antiallergic dressing, naturally air drying at room temperature, sealing, and aseptically storing.

Further, the preparation of the drug-loaded layer comprises the following steps:

preparing mixed spinning solution: slowly dissolving sodium alginate in deionized water, stirring at the speed of 400-;

preparing a coagulating bath: preparing an ethanol-calcium chloride mixed solution, and adjusting the pH value of the mixed solution to 6.5-7 to obtain a coagulating bath;

preparing calcium alginate composite fibers: under the conditions that the ambient temperature is 30 ℃ and the relative humidity is less than or equal to 65%, a mixed spinning solution is sprayed out from a spinneret orifice of a wet spinning machine and enters a solidification bath at the temperature of 45 ℃, the single-nozzle spinning speed is 10ml/h, the mixed spinning solution is separated out from the solidification bath to obtain fibers, the fibers are drawn by a fiber drawing roller to be drawn to 1 time and then are cleaned by distilled water, and the calcium alginate composite fibers loaded with antiallergic gel particles are obtained after drying, wherein the diameter of the calcium alginate composite fibers is 0.6-1 mm;

preparing a drug-loaded layer: the dried calcium alginate composite fiber is woven into a drug-loaded layer with the thickness of 0.5-0.8cm by adopting a warp-weft weaving method.

Further, the volume ratio of the coagulation bath to the mixed spinning solution was 3: 1.

Further, the concentration of ethanol in the ethanol-calcium chloride mixed solution is 45-55 wt%, and the concentration of calcium chloride is 4-5 wt%.

Further, the preparation steps of the antiallergic gel particles are as follows:

adding sodium carboxymethylcellulose into deionized water, dissolving completely, adding glycerol and ethylparaben, stirring, adding Mentholum extract, Kochiae fructus extract, Margarita powder, herba Schizonepetae extract, radix Saposhnikoviae extract, flos Lonicerae extract, herba Solidaginis extract, and herba Lobeliae chinensis extract, mixing to obtain paste, adding the paste into 3-5 wt% sodium alginate solution, dispersing with 25kHz ultrasonic wave to obtain suspension, dripping the suspension into saturated calcium lactate solution, and taking out to obtain antiallergic gel granule.

The invention provides an anti-allergic dressing used after anesthesia and a preparation method thereof, and the anti-allergic dressing has the following beneficial effects:

the anti-allergy dressing is used for fixing the venous catheter, the surface layer in the double-layer structure of the dressing is a drug-loaded layer, the drug-loaded layer is directly contacted with the skin, and the bottom layer is medical non-woven fabric; the medical non-woven fabrics hinder fungus effect and ventilation effect good to waterproof nature and elasticity are all better, and the area is greater than the medicine-carrying layer, so the bottom covers the top layer completely, can reduce the invasion of bacterium, liquid, and the medicine-carrying layer load on top layer has anti allergic liquid medicine, can avoid the patient to be allergic to the bottom in the viscose of medicine-carrying layer outside, if the anaphylactic symptom takes place, can alleviate allergic adverse reaction.

Secondly, the calcium alginate composite fiber is non-toxic and harmless, is a pure natural green material, can absorb the exudate placed at the wound of the venous catheter, remove the breeding place of bacteria, and can adsorb bacteria to achieve the aim of antibiosis. When the calcium alginate composite fiber is prepared, the anti-allergic gel particles with the particle size of 0.2-0.5mm are loaded on or wrapped in the calcium alginate composite fiber prepared by mixing the mixed spinning solution prepared from the sodium alginate and the short cotton fiber with the anti-allergic gel particles, the calcium alginate composite fiber not only has the antibacterial effect, but also has the advantage of anti-allergy, and the short cotton fiber increases the toughness of the calcium alginate composite fiber.

And thirdly, the antiallergic gel particles contain various traditional Chinese medicine extracts, have the effects of resisting allergy, diminishing inflammation, resisting bacteria, relieving pain and relieving itching, are mixed with sodium alginate to prepare a suspension, and then are dropwise added into a calcium lactate solution to form the antiallergic gel particles with the external part being calcium alginate gel and the internal part being antiallergic liquid, and the calcium alginate gel has a certain slow release effect, can prolong the drug effect of the antiallergic liquid and achieves the aim of continuous administration.

Detailed Description

The present invention will be described in detail below with reference to specific examples:

example 1: preparation of antiallergic dressing 1

The preparation method of the antiallergic dressing is to prepare the antiallergic gel particles and comprises the following steps:

adding 40g of sodium carboxymethylcellulose into 500ml of deionized water, stirring, adding 10g of glycerol and 0.1g of ethylparaben after completely dissolving, uniformly stirring, adding 1g of menthol extract, 2g of fructus kochiae extract, 3g of pearl powder, 5g of herba schizonepetae extract, 3g of radix sileris extract, 0.5g of honeysuckle extract, 0.1g of herba solidaginis extract and 0.2g of Chinese lobelia extract, mixing to obtain paste, adding the paste into 4 wt% sodium alginate solution prepared from 35g of sodium alginate, dispersing into suspension by adopting 25kHz ultrasonic waves, dripping the suspension into saturated calcium lactate solution, and filtering to obtain the antiallergic gel particles. The detection shows that the particle size of the prepared antiallergic gel particles is 0.2-0.5 mm.

After the preparation of the antiallergic gel particles, the drug-loaded layer is prepared, and the preparation method comprises the following steps:

preparing mixed spinning solution: slowly dissolving 200g of sodium alginate in 2000ml of deionized water, stirring at the speed of 400rpm for 2h to obtain a saturated sodium alginate solution, adding 40g of short cotton fiber with the length of 0.5-1mm and 2g of DSA-5 defoaming agent into the saturated sodium alginate solution, stirring at 1000rpm for 2h, adding 30g of prepared antiallergic gel particles, and stirring at the speed of 300rpm for 20min to obtain a mixed spinning solution;

preparing a coagulating bath: preparing an ethanol-calcium chloride mixed solution, wherein the ethanol concentration is 45 wt%, the calcium chloride concentration is 5 wt%, and adjusting the pH of the mixed solution to 6.5 to obtain a coagulation bath, wherein the volume ratio of the coagulation bath to the mixed spinning solution is 3: 1;

preparing calcium alginate composite fibers: under the conditions that the ambient temperature is 30 ℃ and the relative humidity is less than or equal to 65%, mixed spinning solution is sprayed out of a spinneret orifice of a wet spinning machine and enters a coagulation bath at the temperature of 45 ℃, the spinning speed of a single spray head is 10ml/h, the spinning voltage is controlled to be 15kv, the spinning solution is separated out of the coagulation bath to obtain fibers, the fibers are pulled and stretched to 1 time by a drawing roller and then are cleaned by distilled water, the fibers are dried at the temperature of 35 ℃ to obtain the calcium alginate composite fibers loaded with the antiallergic gel particles, and the diameter of the calcium alginate composite fibers is measured to be about 1 mm;

preparing a drug-loaded layer: the dried calcium alginate composite fiber is woven into a rectangular drug-loaded layer with the width of 5 multiplied by 5cm and the thickness of 0.8cm by adopting a warp-weft weaving method.

Preparing an anti-allergic dressing:

steaming 6.2 × 6.2cm medical non-woven fabric under water vapor for 20min, taking out, drying until the water content is 30%, heating the medicine-carrying layer in water bath to 80 deg.C, sticking the medicine-carrying layer on the non-woven fabric when it is hot, pressing for 30s, naturally air drying at normal temperature, sealing, and aseptically storing.

Example 2: preparation of antiallergic dressing

The preparation method of the antiallergic dressing is to prepare the antiallergic gel particles and comprises the following steps:

adding 50g of sodium carboxymethylcellulose into 500ml of deionized water, stirring, adding 10g of glycerol and 0.1g of ethylparaben after completely dissolving, uniformly stirring, adding 2g of menthol extract, 3g of fructus kochiae extract, 2g of pearl powder, 6g of herba schizonepetae extract, 4g of radix sileris extract, 0.5g of honeysuckle extract, 0.05g of goldenrod extract and 0.05g of Chinese lobelia extract into paste, adding the paste into 3 wt% sodium alginate solution prepared from 40g of sodium alginate, dispersing into suspension by adopting 25kHz ultrasonic waves, dripping the suspension into saturated calcium lactate solution, and filtering to obtain the antiallergic gel particles. The detection shows that the particle size of the prepared antiallergic gel particles is 0.2-0.5 mm.

After the preparation of the antiallergic gel particles, the drug-loaded layer is prepared, and the preparation method comprises the following steps:

preparing mixed spinning solution: slowly dissolving 250g of sodium alginate in 2500ml of deionized water, stirring at the speed of 500rpm for 1.5h to obtain a saturated sodium alginate solution, adding 80g of short cotton fiber with the length of 0.5-1mm and 2g of DSA-5 defoaming agent into the saturated sodium alginate solution, stirring at 1200rpm for 1h, adding 70g of prepared antiallergic gel particles, and stirring at the speed of 300rpm for 25min to obtain a mixed spinning solution;

preparing a coagulating bath: preparing an ethanol-calcium chloride mixed solution, wherein the ethanol concentration is 50 wt%, the calcium chloride concentration is 4 wt%, the ethanol concentration is 4 wt%, the calcium chloride concentration is 4 wt%, the pH value of the mixed solution is 7, a coagulating bath is obtained, and the volume ratio of the coagulating bath to the mixed spinning solution is 3: 1;

preparing calcium alginate composite fibers: under the conditions that the ambient temperature is 30 ℃ and the relative humidity is less than or equal to 65%, mixed spinning solution is sprayed out of a spinneret orifice of a wet spinning machine and enters a coagulation bath at the temperature of 45 ℃, the spinning speed of a single spray head is 10ml/h, the spinning voltage is controlled to be 15kv, the spinning solution is separated out of the coagulation bath to obtain fibers, the fibers are pulled and stretched to 1 time by a drawing roller and then are cleaned by distilled water, the calcium alginate composite fibers loaded with antiallergic gel particles are obtained after drying at the temperature of 30 ℃, and the diameter of the calcium alginate composite fibers is measured to be about 0.9 mm;

preparing a drug-loaded layer: the dried calcium alginate composite fiber is woven into a rectangular drug-loaded layer with the width of 5 multiplied by 5cm and the thickness of 0.5cm by adopting a warp-weft weaving method.

Preparing an anti-allergic dressing:

steaming 5.6 × 5.6cm medical non-woven fabric under water vapor for 30min, taking out, drying until the water content is 35%, heating the medicine-carrying layer in water bath to 82 deg.C, sticking the medicine-carrying layer on the non-woven fabric when it is hot, pressing for 30s, naturally air drying at normal temperature, sealing, and aseptically storing.

Example 3: preparation of antiallergic dressing

The preparation method of the antiallergic dressing is to prepare the antiallergic gel particles and comprises the following steps:

adding 60g of sodium carboxymethylcellulose into 500ml of deionized water, stirring, adding 10g of glycerol and 0.1g of ethylparaben after completely dissolving, uniformly stirring, adding 2g of menthol extract, 1g of fructus kochiae extract, 2g of pearl powder, 6g of herba schizonepetae extract, 5g of radix sileris extract, 1g of honeysuckle extract, 0.1g of herba solidaginis extract and 0.1g of Chinese lobelia extract to mix into paste, adding the paste into a sodium alginate solution with the concentration of 3 wtwt% prepared from 45g of sodium alginate, dispersing into suspension by adopting 25kHz ultrasonic waves, dripping the suspension into a saturated calcium lactate solution, and filtering to obtain the antiallergic gel particles. The detection shows that the particle size of the prepared antiallergic gel particles is 0.2-0.5 mm.

After the preparation of the antiallergic gel particles, the drug-loaded layer is prepared, and the preparation method comprises the following steps:

preparing mixed spinning solution: slowly dissolving 200g of sodium alginate in 2000ml of deionized water, stirring at the speed of 600rpm for 2h to obtain a saturated sodium alginate solution, adding 60g of short cotton fiber with the length of 0.5-1mm and 2g of DSA-5 defoaming agent into the saturated sodium alginate solution, stirring at 1500rpm for 1h, adding 80g of prepared antiallergic gel particles, and stirring at the speed of 300rpm for 30min to obtain a mixed spinning solution;

preparing a coagulating bath: preparing an ethanol-calcium chloride mixed solution, wherein the ethanol concentration is 55 wt%, the calcium chloride concentration is 4 wt%, and adjusting the pH value of the mixed solution to 7 to obtain a coagulation bath, wherein the volume ratio of the coagulation bath to the mixed spinning solution is 3: 1;

preparing calcium alginate composite fibers: under the conditions that the ambient temperature is 30 ℃ and the relative humidity is less than or equal to 65%, mixed spinning solution is sprayed out of a spinneret orifice of a wet spinning machine and enters a coagulation bath at the temperature of 45 ℃, the spinning speed of a single spray nozzle is 10ml/h, the spinning voltage is controlled to be 15kv, the spinning solution is separated out in the coagulation bath to obtain fibers, the fibers are drawn and stretched to 1 time by a drawing roller and then are cleaned by distilled water, the calcium alginate composite fibers loaded with antiallergic gel particles are obtained after drying at the temperature of 30 ℃, and the diameter of the calcium alginate composite fibers is measured to be about 0.7 mm;

preparing a drug-loaded layer: the dried calcium alginate composite fiber is woven into a rectangular drug-loaded layer with the width of 5 multiplied by 5cm and the thickness of 0.7cm by adopting a warp-weft weaving method.

Preparing an anti-allergic dressing:

steaming 6 × 6cm medical non-woven fabric with water vapor for 25min, taking out, drying to water content of 40%, heating the medicine-carrying layer in water bath to 85 deg.C, sticking the medicine-carrying layer on the non-woven fabric while it is hot, pressing for 30s, naturally air drying at room temperature, sealing, and storing under aseptic condition.

The anti-allergic dressings prepared in examples 1-3 have breaking strength of 3.0-3.5 cN/dtex when measured, and breaking strength of 2.0-2.9 cN/dtex when measured, which indicates that the prepared anti-allergic dressings have high enough strength and are durable.

Although the present invention has been described in detail with reference to the preferred embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the spirit and scope of the invention as defined in the appended claims. The techniques, shapes, and configurations not described in detail in the present invention are all known techniques.

Claims (9)

1. The utility model provides an antiallergic dressing for after anesthesia, its characterized in that, antiallergic dressing includes the non-woven fabrics and bonds the medicine-carrying layer on the non-woven fabrics, the medicine-carrying layer is prepared for the calcium alginate composite fiber who loads the antiallergic gel granule, the antiallergic gel granule includes calcium alginate shell and fills the antiallergic liquid in calcium alginate shell.

2. The anti-allergic dressing used after anesthesia is characterized in that the calcium alginate composite fiber is mainly prepared from sodium alginate and short cotton fiber according to the mass ratio of (20-25): (4-8) compounding and preparing.

3. The anti-allergic dressing used after anesthesia is characterized in that the mass ratio of the calcium alginate composite fiber to the anti-allergic gel particles is (24-33) - (3-8), and the particle size of the anti-allergic gel particles is 0.2-0.5 mm.

4. The anti-allergic dressing used after anesthesia of claim 3, wherein the anti-allergic liquid comprises the following components: ethyl hydroxybenzoate, menthol extract, fructus Kochiae extract, pearl powder, herba Schizonepetae extract, radix Saposhnikoviae extract, flos Lonicerae extract, herba Solidaginis extract, and herba Lobeliae chinensis extract.

5. The antiallergic dressing used after anesthesia as claimed in claim 4, wherein the antiallergic gel particles comprise the following raw materials in parts by weight: 40-56 parts of carboxymethyl cellulose, 35-45 parts of sodium alginate, 10 parts of glycerol, 0.1 part of ethylparaben, 1-2 parts of menthol extract, 1-3 parts of fructus kochiae extract, 2-3 parts of pearl powder, 5-6 parts of herba schizonepetae extract, 3-5 parts of radix sileris extract, 0.5-1 part of honeysuckle extract, 0.05-0.1 part of goldenrod extract and 0.05-0.2 part of Chinese lobelia extract.

6. The method for preparing an antiallergic dressing used after anesthesia as set forth in claim 5, characterized in that the method comprises the following steps:

adding short cotton fibers and antiallergic gel particles into a saturated sodium alginate solution, spraying the obtained mixed spinning solution into a coagulating bath at 45 ℃ through a spinneret orifice of a wet spinning machine, separating out, drawing and stretching the obtained fibers through a drawing roller to obtain calcium alginate composite fibers loaded with the antiallergic gel particles, and forming a drug-loaded layer on the dried calcium alginate composite fibers; steaming nonwoven fabric in water vapor for 20-30min, drying to water content of 30-40%, heating the medicine-carrying layer to 80-85 deg.C, sticking the medicine-carrying layer on the nonwoven fabric while it is hot to obtain antiallergic dressing, naturally air drying at room temperature, sealing, and aseptically storing.

7. The preparation method of the antiallergic dressing used after anesthesia as claimed in claim 6, characterized in that the preparation method of the drug-loaded layer comprises the following steps:

preparing mixed spinning solution: slowly dissolving sodium alginate in deionized water, stirring at the speed of 400-;

preparing a coagulating bath: preparing an ethanol-calcium chloride mixed solution, and adjusting the pH value of the mixed solution to 6.5-7 to obtain a coagulating bath;

preparing calcium alginate composite fibers: under the conditions that the ambient temperature is 30 ℃ and the relative humidity is less than or equal to 65%, a spinneret orifice of a wet spinning machine sprays mixed spinning solution into a coagulation bath at the temperature of 45 ℃, the single-nozzle spinning speed is 10ml/h, the mixed spinning solution is separated out from the coagulation bath to obtain fibers, a fiber drawing roller is drawn and stretched to 1 time, then the fibers are cleaned by distilled water, and the calcium alginate composite fibers loaded with antiallergic gel particles are obtained after drying, wherein the diameter of the calcium alginate composite fibers is 0.6-1 mm;

preparing a drug-loaded layer: the dried calcium alginate composite fiber is woven into a drug-loaded layer with the thickness of 0.5-0.8cm by adopting a warp-weft weaving method.

8. The method for preparing an antiallergic dressing used after anesthesia as claimed in claim 7, wherein the ethanol concentration in the ethanol-calcium chloride mixed solution is 45-55 wt%, and the calcium chloride concentration is 4-5 wt%.

9. The method for preparing an antiallergic dressing used after anesthesia as claimed in claim 8, wherein the antiallergic gel particles are prepared by the following steps:

adding sodium carboxymethylcellulose into deionized water, dissolving completely, adding glycerol and ethylparaben, stirring, adding Mentholum extract, Kochiae fructus extract, Margarita powder, herba Schizonepetae extract, radix Saposhnikoviae extract, flos Lonicerae extract, herba Solidaginis extract, and herba Lobeliae chinensis extract, mixing to obtain paste, adding the paste into 3-5 wt% sodium alginate solution, dispersing with 25kHz ultrasonic wave to obtain suspension, dripping the suspension into saturated calcium lactate solution, and taking out to obtain antiallergic gel granule.