CN111249515A - Biomedical dressing with antibacterial, anti-inflammatory and wound healing promoting functions and preparation method thereof - Google Patents
Biomedical dressing with antibacterial, anti-inflammatory and wound healing promoting functions and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/50—Lubricants; Anti-adhesive agents
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
Abstract
The invention discloses a biomedical dressing for resisting bacteria, diminishing inflammation and promoting wound healing and a preparation method thereof, belonging to the technical field of medical supplies. The curcumin-containing calcium alginate fiber non-woven fabric is used as a skin-friendly layer, so that an ideal antibacterial environment can be provided for wound healing, wound healing is promoted, and wound pain is relieved. The chitosan fiber non-woven fabric is used as the middle layer, and has the functions of diminishing inflammation, promoting blood coagulation and inhibiting scars while absorbing seepage. The polyurethane film is used as an isolation layer, so that the effects of dust prevention, water prevention, air leakage prevention and pollution prevention can be achieved. The biomedical dressing prepared by compounding the three components has complementary advantages and synergistic effect, and has the advantages of antibacterial and bacteriostatic activity, good anti-inflammatory effect, adhesion prevention, rapid wound healing promotion, good biocompatibility and the like. The medical hemostatic dressing has no side effect on a human body, no irritation on skin, safe use, greenness and no pollution, and has wide application prospect in the field of biomedical materials.
Description
Technical Field
The invention belongs to the technical field of medical supplies, and particularly relates to a biomedical dressing for resisting bacteria, diminishing inflammation and promoting wound healing and a preparation method thereof.
Background
Traditional medical dressings are made of natural plant fibers or animal hair materials, such as gauze, wool, cotton pads, oil gauze, and the like. Such dressings are easily adhered to wounds during replacement, and when the dressings are removed, the new granulation tissues are easily damaged, so that pain is caused to a user, and the healing of the wounds is not facilitated.
In order to obtain better antibacterial performance and use effect, different methods are adopted in the medical dressing. In patent 201310165016.3, lie et al add sodium alginate to the nano silver sol, mix with the prepared macromolecule cross-linking agent, and provide a preparation method of nano silver-containing sodium alginate-based antibacterial medical dressing. Patent CN105311668A discloses a bacterial cellulose composite cuprous oxide antibacterial dressing and a preparation method thereof. However, in the using process, metal ions are released continuously, and the metal ions can possibly generate pathological changes after being absorbed by human bodies, so that the metal ions have potential harm to human organs. Patent 201610036304.2 discloses a method for preparing a wound dressing containing a certain amount of ciprofloxacin, but long-term use of antibiotics may cause variation of pathogenic bacteria and cause drug resistance. Patent ZL200420103421.9 discloses an antibacterial and anti-infection medical multi-layer gauze which is composed of an acidic medicine layer, an isolation layer and an alkaline medicine layer, but has the risk of chemical burn in the using process. Patent CN105640705A discloses a composite functional medical dressing composed of two layers, namely a functional layer and a protective layer, wherein the functional layer is made of alginic acid fiber and viscose fiber in a composite mode, the protective layer is made of viscose fiber and polyester fiber, and although the moisture absorption is enhanced, exudate is still stored in the functional layer which is in contact with a wound. Patent CN102648880A describes a dressing made of a composite of a bottom layer, a middle layer and an outer layer. The dressing bottom layer is cotton gauze, the middle layer is sterilization hemostatic gauze, the outer layer is breathable moisture-conducting gauze, and the dressing has good breathable moisture-conducting efficacy, but the gauze is easy to diffuse from a wound after absorbing moisture and seeping liquid, is adhered to the wound, and is easy to cause secondary damage to the wound when the dressing is removed. Patents CN201109221Y and US2009/0081911a1 disclose a composite nonwoven fabric having antibacterial and waterproof properties. The composite non-woven fabric is formed by compounding three layers of materials, wherein the surface layer of the composite non-woven fabric is a water absorption layer made of the water absorption non-woven fabric, the middle layer of the composite non-woven fabric is a waterproof layer made of polyethylene, a polyurethane film or a waterproof breathable film, and the inner layer of the composite non-woven fabric is an antibacterial layer made of the antibacterial non-woven fabric.
Therefore, there is a need to develop a multifunctional biomedical dressing with antibacterial, anti-inflammatory and wound healing promoting functions.
Disclosure of Invention
In order to solve the problems, the invention aims to provide the biomedical dressing for resisting bacteria, diminishing inflammation and promoting wound healing and the preparation method thereof, wherein the source of the antibacterial raw materials is wide, the preparation method is simple, and the dressing is green and environment-friendly and has no pollution to the environment; the prepared biomedical dressing has good biocompatibility and good anti-inflammation effect, and can promote the wound surface to heal quickly.
The invention is realized by the following technical scheme:
the invention discloses a preparation method of a biomedical dressing for resisting bacteria and diminishing inflammation and promoting wound healing, which comprises the following steps:
step 1: adding curcumin into a sodium alginate solution, fully stirring uniformly, standing for defoaming, performing wet spinning in a calcium chloride coagulation bath, stretching, washing and heat treating the obtained nascent fiber, and sequentially opening, carding to form a web, needling, drying and winding the obtained drug-containing calcium alginate fiber to obtain the drug-containing calcium alginate fiber non-woven fabric;
step 2: dispersing chitosan powder in a formic acid aqueous solution, fully and uniformly stirring, standing for defoaming, carrying out wet spinning on the obtained chitosan spinning solution in a sodium hydroxide coagulation bath, stretching to obtain chitosan fibril, removing redundant formic acid, washing with water, drying in the air, and sequentially opening, carding to form a web, drafting, spunlacing, drying and winding the obtained chitosan fiber to obtain the chitosan fiber non-woven fabric;
and step 3: compounding the medicine-containing calcium alginate fiber non-woven fabric prepared in the step (1) and the chitosan fiber non-woven fabric prepared in the step (2) by adopting a needle punching method, laminating and compounding the medicine-containing calcium alginate fiber non-woven fabric and the polyurethane film, and drying to obtain the biomedical dressing which is antibacterial, anti-inflammatory and capable of promoting wound healing, wherein the skin-friendly layer is the medicine-containing calcium alginate fiber non-woven fabric, the middle layer is the chitosan fiber non-woven fabric, and the isolation layer is the polyurethane film.
Preferably, in the step 1, the sodium alginate solution is prepared by dissolving sodium alginate with molecular weight of 2000-200000 in deionized water, the mass percent of the sodium alginate in the sodium alginate solution is 1.5-5.0%, and the mass percent of the curcumin is 1-5% of the mass of the sodium alginate; the mass fraction of calcium chloride in the coagulating bath of calcium chloride is 1-5%.
Preferably, in the step 1, the temperature of wet spinning is 20-55 ℃, the stretching multiple of the nascent fiber is 1-2 times, the temperature of water washing is 20-55 ℃, and the temperature of heat treatment is 40-80 ℃; the opening time is 3-5 min, the rotating speed of a main cylinder of the carding machine is 600-800 r/min, and the feeding speed is 1-3 m/min.
Preferably, in the step 1, needling is divided into two procedures of pre-needling and main needling, wherein the needling depth of the pre-needling is 8-10 mm, the frequency is 800-1200 times/min, the needling depth of the main needling is 6-8 mm, and the frequency is 1000-1500 times/min.
Preferably, in step 2, the chitosan powder has a deacetylation degree of more than 80% and a molecular weight of 8 × 104～5×105(ii) a The mass concentration of the formic acid aqueous solution is 80-100%, and the mass concentration of chitosan in the chitosan spinning solution is 5-15%; the mass ratio of the sodium hydroxide in the sodium hydroxide coagulation bath is 0.1-5%.
Preferably, in the step 2, the stirring temperature is 20-40 ℃, and the stirring time is 1-2 h; the temperature of wet spinning is 20-60 ℃; the stretching ratio is 1 to 2.
Preferably, in the step 2, the opening time is 3-5 min, the rotating speed of a main cylinder of the carding machine is 600-800 r/min, and the feeding speed is 1-3 m/min; the drying temperature is 90-120 ℃, and the drying time is 2 min.
Preferably, in the step 2, the water jet is six continuous water jet, the first water jet is a pre-wet water jet head, the pressure is 5-10 bar, the pressure of the second water jet is 40-60 bar, the pressure of the third water jet is 40-60 bar, the pressure of the fourth water jet is 60-80 bar, the pressure of the fifth water jet is 60-80 bar, and the pressure of the sixth water jet is 50-70 bar.
Preferably, in the step 3, needling is divided into two procedures of pre-needling and main needling, wherein the needling depth of the pre-needling is 10-13 mm, the frequency is 1000-1800 times/min, the needling depth of the main needling is 8-10 mm, and the frequency is 800-1500 times/min; the drying temperature is 120 ℃ and the drying time is 30 s.
The invention discloses a biomedical dressing prepared by adopting the preparation method and used for resisting bacteria, diminishing inflammation and promoting wound healing, which is characterized in that the mass per unit area of the drug-containing calcium alginate fiber non-woven fabric is 55-85 g/m2The thickness is 0.5-1.5 mm; the mass per unit area of the chitosan fiber non-woven fabric is 80-120 g/m2The thickness of the non-woven fabric is 1 to 1.5 times of that of the non-woven fabric containing the medicine calcium alginate fibers; the thickness of the polyurethane film is 10-30 μm.
Compared with the prior art, the invention has the following beneficial technical effects:
the invention discloses a preparation method of a biomedical dressing for resisting bacteria, diminishing inflammation and promoting wound healing, which adopts non-woven fabric containing calcium alginate fibers and prepared by a curcumin-containing calcium alginate fibers through a needling process as a skin-friendly layer, and can form soft and transparent hydrogel when contacting exudate of a wound, thereby providing an ideal antibacterial environment. The gel is soft and hydrophilic, can keep the surface environment of the wound moist, absorb a large amount of exudates, prevent the diffusion of wound exudates and the impregnation of healthy tissues, block bacteria, reduce the infection possibility of the wound surface, and allow oxygen to pass through, thereby promoting the growth of new tissues. When the dressing is uncovered, the dressing can be easily uncovered by spraying normal saline, the newly-grown granulation tissue can not be damaged, secondary wound is avoided, and the integrity of the surface of the dressing is also ensured. The antibacterial calcium alginate fiber combines high hygroscopicity, gel forming property and antibacterial property, provides a better healing environment for the wound, and is beneficial to promoting the wound healing. The chitosan fiber non-woven fabric with good mechanical property is used as the middle layer, so that epidermal cells can grow in conveniently while seepage is further absorbed, no adhesion is generated after healing, the effects of stopping bleeding and relieving pain are achieved, the reproduction of microorganisms can be inhibited, and the healing of wounds can be better promoted. And has effects of promoting blood coagulation and inhibiting scar. Adopt the polyurethane membrane as the isolation layer, can play dustproof, waterproof, leak protection gas, anti-pollution effect, can effective separation bacterium and virus pierce through. The biomedical dressing prepared by compounding the three components has complementary advantages and synergistic effect, so that the prepared biomedical dressing has the advantages of antibacterial and bacteriostatic properties, good anti-inflammatory effect, adhesion prevention, promotion of rapid wound healing and good biocompatibility. Meanwhile, the operation is convenient, and the treatment time of medical staff is effectively shortened. Has no side effect on human body, no irritation to skin, safe use, no pollution and wide application prospect in the field of biomedical materials.
Further, if the molecular weight of sodium alginate is too high, the viscosity of the spinning solution is too high, and the spinning solution is not easily extruded from the spinneret into the coagulation bath, which hinders the normal spinning. If the molecular weight of sodium alginate is too low, the viscosity of the spinning solution becomes too low, and when the spinning solution is extruded from a spinneret into a coagulation bath, molding may be difficult, which may adversely affect the crystallization of the fiber.
Furthermore, the chitosan under the parameter has a large amount of active-NH 2-OH, so that the chitosan fiber obtained by wet spinning has positive charges and has good antibacterial property, biocompatibility and adsorbability. The high-concentration formic acid is used as a solvent to dissolve the chitosan, so that the crystallization degree of the chitosan is reduced while the reaction with amino groups on the chitosan is carried out, and the mechanical property of the fiber is enhanced. The sodium hydroxide coagulation bath with the content can reduce the reaction speed and improve the fiber quality. In the preparation process, an alcohol coagulant is not used, so that the potential safety hazard is reduced, and the raw material cost is reduced.
Furthermore, because the chitosan fiber has less curl, smaller cohesive force, larger rigidity and larger static electricity, the phenomenon of web breaking often occurs in the carding process, and the fiber is difficult to form a fiber web in the first carding process, the chitosan fiber web needs to be carded for the second time, the humidity of the environment is properly improved, and the web forming is convenient.
Furthermore, in order to ensure effective entanglement of the carded fiber web, a plurality of spunlace processes are adopted, so that the front side and the back side of the fiber web are both subjected to spunlace reinforcement. The water jet pressure is set according to the form of low-high-low, the front water jet heads mainly entangle the fibers, and the last water jet head improves the appearance quality and uniformity of the cloth cover. Meanwhile, the front and back surfaces of the chitosan fiber web are reinforced, so that the fiber web is penetrated by water columns in different directions in the whole spunlace process, and the irregular entanglement reinforcement in all directions is formed.
The invention also discloses the biomedical dressing prepared by the preparation method, the dressing layers with different thicknesses are adopted for preparation, the skin-friendly layer is the lightest and is light, the comfort feeling when the dressing layer is in contact with the skin is improved, the thickness of the middle layer is 1-1.5 times of that of the skin-friendly layer, the air layer is enlarged, the oppression feeling to the wound is weakened, and the polyurethane film on the outermost layer is light and durable. The prepared dressing has reasonable thickness, moderate strength and simple use method, increases the use safety, can relieve the pain and the uncomfortable feeling of a patient, and improves the healing speed.
Drawings
Fig. 1 is a schematic structural diagram of the biomedical dressing for antisepsis and anti-inflammation and promoting wound healing prepared by the invention.
In the figure: 1 is an isolation layer, 2 is an intermediate layer, and 3 is a skin-friendly layer.
Detailed Description
The theoretical basis of the invention is as follows:
alginic acid is a kind of polysaccharide extracted from brown algae, and is a random block copolymer of β -D-mannuronic acid (M unit) and α -L-guluronic acid (G unit). The sodium alginate powder is odorless, tasteless, light yellow powder, and is a multi-polar, polyhydroxy high molecular compound+Can be reacted with Ca2+，Ba2+And (3) carrying out ion exchange on divalent cations to form hydrogel. The alginate dressing is a natural plant wound repair material, has high hygroscopicity, easy removability, good biocompatibility and biodegradability, can form wet gel on the surface of a wound, and has the effects of stopping bleeding and accelerating wound healing. And is widely used in the fields of drug delivery systems and tissue engineering due to its relatively low price.
The chitosan is obtained by deacetylation of chitin widely existing in nature, and has a chemical name of polyglucosamine (1-4) -2-amino-B-D glucose. As a natural polymer material, chitosan has good biocompatibility, biodegradability and high hydrophilicity human body affinity, and excellent performances of broad-spectrum antibiosis, hemostasis, wound healing promotion, infection resistance, mildew resistance, static electricity prevention, deodorization and the like. Can be absorbed by human body, inhibit bacterial reproduction, promote blood coagulation and skin regeneration, relieve pain, accelerate wound healing, inhibit scar formation, and enhance immunity. Its excellent performance is widely concerned by various industries, and its application range relates to many fields of medicine, food, chemical industry, cosmetics, water treatment, metal extraction and recovery, biochemistry and biomedical engineering, etc.
Curcumin is a yellow polyphenol extract containing diphenylene and diketone structural units extracted from rhizome of Curcuma aromatica Salisb of Zingiberaceae, Acorus calamus of Araceae, etc. Modern medical research shows that curcumin has some unique pharmacological actions, has various pharmacological actions of resisting inflammation, relieving pain, resisting oxidation, reducing blood fat, inducing apoptosis, resisting angiogenesis, resisting tumor, resisting atherosclerosis and the like, and has good clinical application potential. Curcumin has prevention and protection effects on various chronic diseases, such as cancer, cardiovascular diseases, inflammation, diabetes, obesity, nervous system diseases and the like, and a large number of clinical tests evaluate the safety and effectiveness of curcumin on human bodies. In addition, curcumin is a natural plant extract, and has been widely used in functional foods, food coloring, food preservation, medical fields and the like because of its safety and nontoxicity.
The polyurethane is a macromolecular compound containing repeated urethane groups on the main chain, soft segments and hard segments with dissimilar chemical properties are contained in the polyurethane elastomer, and due to the incompatibility of the soft segments and the hard segments, the polyurethane has obvious microphase separation and is very similar to a biological membrane. The polyurethane has good elasticity, flexibility, wear resistance, tear resistance, compliance, physical properties, biocompatibility and blood compatibility, and is widely applied to the field of medical health, such as wound dressing, surgical gowns, medical gloves, medical mattresses, ice bags, bandages, plasma bags, artificial organs and the like.
The present invention is described in further detail below with reference to examples:
example 1
Weighing 10g of sodium alginate with molecular weight of 80000, adding the sodium alginate into 400mL of deionized water, and fully stirring and dissolving to obtain a sodium alginate solution with mass concentration of 2.5%; adding 0.3g curcumin extract into sodium alginate solution, stirring, and standing for defoaming. Adding the prepared spinning solution into a coagulating bath and a drafting bath of calcium chloride with the mass percentage of 2% and 5% respectively, then carrying out conventional wet spinning at the temperature of 20 ℃, carrying out post-drafting on the obtained nascent fiber by 1.5 times, then washing with water at the temperature of 20 ℃, and carrying out heat treatment at the temperature of 40 ℃ to obtain the drug-containing antibacterial anti-inflammatory calcium alginate fiber. And (3) sending the prepared fibers into an opener, wherein the opening time is 3min, feeding the fibers into a carding machine through a cotton feeding system to be carded into fiber webs, the rotating speed of a main cylinder of the carding machine is controlled at 600r/min, and the feeding speed is 1 m/min. The fiber net formed by lapping is subjected to two working procedures of pre-needling and main needling, wherein the depth of a needle of the pre-needling is 8mm, the frequency is 800 times/min, the depth of a needle of the main needling is 6mm, and the frequency is 1000 times/min; the unit area mass of the non-woven fabric containing the medicine calcium alginate fibers obtained by hot rolling the fiber net after needling reinforcement is 55g/m2And the thickness is 0.5mm, wherein the hot rolling temperature is 190 ℃, and the hot rolling is carried out for 5 s.
8g of molecular weight 8X 104Dispersing chitosan powder with the deacetylation degree of 80% in 92g of 80% formic acid aqueous solution, stirring and reacting for 2h at the temperature of 20 ℃, standing and defoaming to obtain 8 wt% of chitosan spinning solution; adding the spinning solution into a coagulating bath of 0.1% w/w sodium hydroxide, performing wet spinning at 20 ℃, stretching by 1.5 times to obtain chitosan fibrils, placing the chitosan fibrils in 0.1M sodium hydroxide solution for 20min, removing unreacted formic acid, washing with water twice, and drying to obtain the chitosan fibers. And (3) sending the prepared chitosan fiber into an opener, and opening for 3 min. The fiber net is carded by a feeding carding machine, the rotating speed of a main cylinder is 600r/min, and the feeding speed is 1 m/min. When the chitosan fiber enters a spunlace device for spunlace reinforcement, the pressure of the first pre-wetting spunlace is 5bar, the pressure of the second spunlace is 40bar, the pressure of the third spunlace is 40bar, the pressure of the fourth spunlace is 60bar,the pressure of the fifth water jet is 60bar, the pressure of the sixth water jet is 50bar, the drying temperature is 90 ℃, the drying time is 1min, and the mass per unit area of the obtained chitosan fiber non-woven fabric is 80g/m2The thickness is 1 mm.
Compounding the prepared medicine-containing calcium alginate fiber non-woven fabric and chitosan fiber non-woven fabric layer by using a needling reinforcement technology, wherein needling is divided into two procedures of pre-needling and main needling, the depth of a needle for pre-needling is 10mm, the frequency is 1000 times/min, the depth of a needle for main needling is 8mm, the frequency is 800 times/min, and the pre-needling and the main needling are laminated and compounded together with a polyurethane film with the thickness of 10 mu m, and then the mixture is placed in a drying oven at 120 ℃ for drying for 30s to obtain the biomedical dressing for resisting bacteria and diminishing inflammation and promoting wound healing.
Example 2
Weighing 10g of sodium alginate with the molecular weight of 100000, adding the sodium alginate into 323mL of deionized water, and fully stirring and dissolving to obtain a sodium alginate solution with the mass concentration of 3%; adding 0.4g curcumin extract into sodium alginate solution, stirring, and standing for defoaming. Adding the prepared spinning solution into a coagulating bath and a drafting bath of calcium chloride with the mass percentage of 2% and 5% respectively, then carrying out conventional wet spinning at the temperature of 40 ℃, carrying out post-drafting on the obtained nascent fiber by 1.7 times, then washing with water at the temperature of 40 ℃, and carrying out heat treatment at the temperature of 60 ℃ to obtain the drug-containing antibacterial anti-inflammatory calcium alginate fiber. And (3) sending the prepared fibers into an opener, wherein the opening time is 4min, feeding the fibers into a carding machine through a cotton feeding system to be carded into fiber webs, the rotating speed of a main cylinder of the carding machine is controlled at 70r/min, and the feeding speed is 2 m/min. The fiber net formed by lapping is subjected to two working procedures of pre-needling and main needling, wherein the depth of a needle of the pre-needling is 9mm, the frequency is 1000 times/min, the depth of a needle of the main needling is 7mm, and the frequency is 1200 times/min; the unit area mass of the non-woven fabric containing the medicine calcium alginate fiber obtained by hot rolling the fiber net after needling reinforcement is 70g/m2And the thickness is 1mm, wherein the hot rolling temperature is 190 ℃, and the hot rolling is carried out for 5 s.
10g of molecular weight 12X 104Dispersing chitosan powder with deacetylation degree of 85% in 90g 90% formic acid water solution, stirring at 30 deg.C for 1.5h, standing for defoaming to obtain 10 wt% chitosan textileSilk liquid; adding the spinning solution into 2% w/w sodium hydroxide coagulation bath, performing wet spinning at 40 ℃, stretching by 1.7 times to obtain chitosan fibril, placing the chitosan fibril in 0.1M sodium hydroxide solution for 20min, removing unreacted formic acid, washing with water twice and drying to obtain the chitosan fiber. And (3) sending the prepared chitosan fiber into an opener, and opening for 4 min. The fiber net is carded by a feeding carding machine, the rotating speed of a main cylinder is 700r/min, and the feeding speed is 2 m/min. When chitosan fiber enters a spunlace device for spunlace reinforcement, the pressure of a first pre-wet spunlace is 8bar, the pressure of a second spunlace is 50bar, the pressure of a third spunlace is 50bar, the pressure of a fourth spunlace is 70bar, the pressure of a fifth spunlace is 70bar, the pressure of a sixth spunlace is 60bar, the drying temperature is 90 ℃, the drying time is 1min, and the mass per unit area of the obtained chitosan fiber non-woven fabric is 100g/m2The thickness is 1.5 mm.
Compounding the prepared medicine-containing calcium alginate fiber non-woven fabric and chitosan fiber non-woven fabric by using a needling reinforcement technology, wherein needling is divided into two procedures of pre-needling and main needling, the depth of a pre-needled needle is 11mm, the frequency is 1500 times/min, the depth of a main needled needle is 9mm, the frequency is 1000 times/min, and the pre-needled needle and the main needling needle are laminated and compounded together with a polyurethane film with the thickness of 20 mu m, and then the mixture is placed in a drying oven at 120 ℃ for drying for 30s, so that the biomedical dressing with the functions of resisting bacteria, diminishing inflammation and promoting wound healing is obtained.
Example 3
Weighing 10g of sodium alginate with the molecular weight of 120000, adding the sodium alginate into 286mL of deionized water, and fully stirring and dissolving to obtain a sodium alginate solution with the mass concentration of 3.5%; adding 0.5g curcumin extract into sodium alginate solution, stirring, and standing for defoaming. Adding the prepared spinning solution into a coagulating bath and a drawing bath of calcium chloride with the mass percentage of 2% and 5% respectively, then carrying out conventional wet spinning at the temperature of 55 ℃, carrying out 2 times of back drawing on the obtained nascent fiber, then washing with water at the temperature of 55 ℃, and carrying out heat treatment at the temperature of 80 ℃ to obtain the drug-containing antibacterial anti-inflammatory calcium alginate fiber. Feeding the prepared fiber into an opener for 5min, feeding into a carding machine via a cotton feeding system, carding into fiber web, and cardingThe rotating speed of the main cylinder is controlled at 800r/min, and the feeding speed is 3 m/min. The fiber net formed by lapping is subjected to two working procedures of pre-needling and main needling, wherein the depth of a needle of the pre-needling is 10mm, the frequency is 1200 times/min, the depth of a needle of the main needling is 8mm, and the frequency is 1500 times/min; the unit area mass of the non-woven fabric containing the medicine calcium alginate fiber obtained by hot rolling the fiber net after needling reinforcement is 85g/m2And the thickness is 1.5mm, wherein the hot rolling temperature is 190 ℃, and the hot rolling is carried out for 5 s.
10g of molecular weight 5X 105Dispersing chitosan powder with deacetylation degree of 90% in 85g of 100% formic acid aqueous solution, stirring and reacting at 40 ℃ for 1h, standing and defoaming to obtain 15 wt% of chitosan spinning solution; adding the spinning solution into 2% w/w sodium hydroxide coagulation bath, performing wet spinning at 60 ℃, stretching by 2 times to obtain chitosan fibril, placing the chitosan fibril in 0.1M sodium hydroxide solution for 20min, removing unreacted formic acid, washing with water twice, and air drying to obtain the chitosan fiber. And (3) sending the prepared chitosan fiber into an opener, and opening for 5 min. The fiber net is carded by a feeding carding machine, the rotating speed of a main cylinder is 800r/min, and the feeding speed is 3 m/min. When chitosan fiber enters a spunlace device for spunlace reinforcement, the pressure of a first pre-wet spunlace is 10bar, the pressure of a second spunlace is 60bar, the pressure of a third spunlace is 60bar, the pressure of a fourth spunlace is 80bar, the pressure of a fifth spunlace is 80bar, the pressure of a sixth spunlace is 70bar, the drying temperature is 90 ℃, the drying time is 1min, and the mass per unit area of the obtained chitosan fiber non-woven fabric is 120g/m2And the thickness is 2.25 mm.
Compounding the prepared medicine-containing calcium alginate fiber non-woven fabric and chitosan fiber non-woven fabric by using a needling reinforcement technology, wherein needling is divided into two procedures of pre-needling and main needling, the depth of a pre-needled needle is 13mm, the frequency is 1800 times/min, the depth of a main needled needle is 10mm, the frequency is 1500 times/min, the pre-needled needle and the main needling needle are laminated and compounded together with a polyurethane film with the thickness of 30 mu m, and then the mixture is placed in a drying oven at 120 ℃ for drying for 30s, so that the biomedical dressing with the functions of resisting bacteria, diminishing inflammation and promoting wound healing is obtained.
As shown in figure 1, the prepared skin-friendly layer 3 is a non-woven fabric containing calcium alginate fibers, the middle layer 2 is a non-woven fabric containing chitosan fibers, and the isolation layer 1 is a polyurethane film, so that the biomedical dressing has the effects of resisting bacteria, diminishing inflammation and promoting wound healing.
Claims (10)
1. A preparation method of a biomedical dressing for resisting bacteria and diminishing inflammation and promoting wound healing is characterized by comprising the following steps:
step 1: adding curcumin into a sodium alginate solution, fully stirring uniformly, standing for defoaming, performing wet spinning in a calcium chloride coagulation bath, stretching, washing and heat treating the obtained nascent fiber, and sequentially opening, carding to form a web, needling, drying and winding the obtained drug-containing calcium alginate fiber to obtain the drug-containing calcium alginate fiber non-woven fabric;
step 2: dispersing chitosan powder in a formic acid aqueous solution, fully and uniformly stirring, standing for defoaming, carrying out wet spinning on the obtained chitosan spinning solution in a sodium hydroxide coagulation bath, stretching to obtain chitosan fibril, removing redundant formic acid, washing with water, drying in the air, and sequentially opening, carding to form a web, drafting, spunlacing, drying and winding the obtained chitosan fiber to obtain the chitosan fiber non-woven fabric;
and step 3: compounding the medicine-containing calcium alginate fiber non-woven fabric prepared in the step (1) and the chitosan fiber non-woven fabric prepared in the step (2) by adopting a needle punching method, laminating and compounding the medicine-containing calcium alginate fiber non-woven fabric and a polyurethane film, and drying to obtain the biomedical dressing which is antibacterial, anti-inflammatory and capable of promoting wound healing, wherein the skin-friendly layer (3) is the medicine-containing calcium alginate fiber non-woven fabric, the middle layer (2) is the chitosan fiber non-woven fabric, and the isolation layer (1) is the polyurethane film.
2. The biomedical dressing for resisting bacteria and diminishing inflammation and promoting wound healing as claimed in claim 1, wherein in the step 1, the sodium alginate solution is prepared by dissolving sodium alginate with molecular weight of 2000-200000 in deionized water, the mass percent of the sodium alginate in the sodium alginate solution is 1.5% -5.0%, and the mass percent of the curcumin is 1% -5% of the mass of the sodium alginate; the mass fraction of calcium chloride in the coagulating bath of calcium chloride is 1-5%.
3. The biomedical dressing for resisting bacteria and diminishing inflammation and promoting wound healing according to claim 1, wherein in the step 1, the temperature of wet spinning is 20-55 ℃, the stretching multiple of the nascent fiber is 1-2 times, the temperature of water washing is 20-55 ℃, and the temperature of heat treatment is 40-80 ℃; the opening time is 3-5 min, the rotating speed of a main cylinder of the carding machine is 600-800 r/min, and the feeding speed is 1-3 m/min.
4. The biomedical dressing for resisting bacteria and diminishing inflammation and promoting wound healing according to claim 1, wherein in the step 1, needling is divided into two procedures of pre-needling and main needling, the needling depth of the pre-needling is 8-10 mm, the frequency is 800-1200 times/min, the needling depth of the main needling is 6-8 mm, and the frequency is 1000-1500 times/min.
5. The biomedical dressing for resisting bacteria, diminishing inflammation and promoting wound healing according to claim 1, wherein in the step 2, the deacetylation degree of the chitosan powder is more than 80%, and the molecular weight is 8 x 104～5×105(ii) a The mass concentration of the formic acid aqueous solution is 80-100%, and the mass concentration of chitosan in the chitosan spinning solution is 5-15%; the mass ratio of the sodium hydroxide in the sodium hydroxide coagulation bath is 0.1-5%.
6. The biomedical dressing for resisting bacteria, diminishing inflammation and promoting wound healing according to claim 1, wherein in the step 2, the stirring temperature is 20-40 ℃, and the stirring time is 1-2 hours; the temperature of wet spinning is 20-60 ℃; the stretching ratio is 1 to 2.
7. The biomedical dressing for resisting bacteria, diminishing inflammation and promoting wound healing according to claim 1, wherein in the step 2, the opening time is 3-5 min, the main cylinder rotating speed of a carding machine is 600-800 r/min, and the feeding speed is 1-3 m/min; the drying temperature is 90-120 ℃, and the drying time is 2 min.
8. The biomedical dressing for resisting bacteria and diminishing inflammation and promoting wound healing according to claim 1, wherein in the step 2, the water jet is performed by six continuous water jet, the first water jet is a pre-wet water jet head, the pressure is 5-10 bar, the pressure of the second water jet is 40-60 bar, the pressure of the third water jet is 40-60 bar, the pressure of the fourth water jet is 60-80 bar, the pressure of the fifth water jet is 60-80 bar, and the pressure of the sixth water jet is 50-70 bar.
9. The biomedical dressing for resisting bacteria and diminishing inflammation and promoting wound healing according to claim 1, wherein in the step 3, needling is divided into two procedures of pre-needling and main needling, the needling depth of the pre-needling is 10-13 mm, the frequency is 1000-1800 times/min, the needling depth of the main needling is 8-10 mm, and the frequency is 800-1500 times/min; the drying temperature is 120 ℃ and the drying time is 30 s.
10. The biomedical dressing for resisting bacteria, diminishing inflammation and promoting wound healing prepared by the preparation method of any one of claims 1 to 9, wherein the mass per unit area of the drug-containing calcium alginate fiber non-woven fabric is 55 to 85g/m2The thickness is 0.5-1.5 mm; the mass per unit area of the chitosan fiber non-woven fabric is 80-120 g/m2The thickness of the non-woven fabric is 1 to 1.5 times of that of the non-woven fabric containing the medicine calcium alginate fibers; the thickness of the polyurethane film is 10-30 μm.
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