CN100400019C - Emergency wound dressing and its preparation method - Google Patents
Emergency wound dressing and its preparation method Download PDFInfo
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- CN100400019C CN100400019C CNB2005100162793A CN200510016279A CN100400019C CN 100400019 C CN100400019 C CN 100400019C CN B2005100162793 A CNB2005100162793 A CN B2005100162793A CN 200510016279 A CN200510016279 A CN 200510016279A CN 100400019 C CN100400019 C CN 100400019C
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Abstract
The present invention discloses a first-aid wound dressing and a preparation method thereof. The first-aid wound dressing is a composite non-woven fabric which is composed of three-layer fiber materials: an internal layer 1 is composed of marine organism material chitosan and mixed fiber of alginates; a middle layer 2 adopts hygroscopic fiber, and high water absorption resin 4 is mixed in the hygroscopic fiber; an outer layer 3 is hydrophobic type antibacterial fiber. The preparation method of the first-aid wound dressing comprises: hygroscopic fiber non-woven fabric blanks with the high water absorption resin 4 are prepared; the antibiotic hydrophobic fiber, the chitosan and the mixed fiber of alginates are respectively pricked on both surfaces of the blanks; the composite type non-woven fabric is pricked and fixed, and shearing, sealing, sterilization, etc. are carried out. The first-aid wound dressing has the favorable action of hemostasis, antibiosis and wound healing promotion, and is especially suitable for first-aid dressing to various wound surfaces under emergency conditions.
Description
Technical field
The present invention relates to a kind of emergency wound dressing, also relate to the preparation method of this dressing.
Background technology
Along with material science and technological progress, the research of medical dressing has also obtained development at full speed.Traditional emergency wound dressing is based on cotton products, characteristics such as water absorption is strong although the dressing of cotton system has, good heat resistance, alkali resistance are good, absorb easily shrinkage behind the secretions but also exist, Yi Yin pollutes and causes wound infection, easily cause shortcomings such as two degree wounds, simultaneously owing to belong to inertia dressing, to the healing of wound surface also tangible promotion healing effect (Li Xiaoyang not with the wound surface adhesion, Zhu Peifang, Hu Jianian. the development of novel burn dressing and evaluation. biomedical engineering's magazine 1994; 11 (1): 5).People are trying to explore to study other natural material such as Corii Sus domestica, amniotic membrane, collagen (Purna SK, Mary B.Collagenbased dressings-a review.Burns 2000 for this reason; 26 (1): 54), chitosan (Ye Chunting, Liu Xilin, the development of .CG wound dressings such as Ma Fuguang. Chinese biological engineering in medicine journal 1996; 112), alginate (Javis P.M.Galvin D.A.Blair S.D.How does calcium alginate achievehemostasis in surgery.Thrombosis and Hemostasis 1,987 15 (2):; 80) 58 (1): biomaterial and synthetic material such as polyurethane, polyvinyl alcohol (K.R.Park, Y.C.Nho.Synthesis of PVA/PVPhydrogels having two-layer by radiation and their physical properties.RadiationPhysics and Chemistry 2003 such as; 67:361) the dressing procucts of medical macromolecular materials such as grade.Yet these single materials are difficult to satisfy many performance requirements of medical dressing, exist as intensity, elasticity undesirablely, and breathability, poisture-penetrability are relatively poor, the moisture absorption drainage effect is not good enough, with human body the rejection effect is arranged, shortcomings such as transportation, storage inconvenience are difficult to large-scale promotion and use.To have the different materials of different characteristics compound be the research direction of current emergency wound dressing and development trend (Tian Jianguang, Xia Zhaofan. the progress of wound dressing. PLA's medical journal 2003; 28 (5): 470).
At present, chitin fiber dressing mainly is divided into two classes: a class is that chitin fiber is directly made adhesive-bonded fabric dressing, and another kind of is with compound adhesive-bonded fabric dressings of making of material such as itself and moisture-absorbing fibres.Although the chitosan adhesive-bonded fabric dressing has effect antibiotic preferably and the promotion wound healing, but complex manufacturing, price expensive (paddy Qingyang, Gao Yabing, Chen Xiaohua etc. the chitosan adhesive-bonded fabric dressing is to the incision wound hemostasis and promote the research of healing effect. PLA's medical journal 1999; 124 (6): 429; Guan Jing, Gao Huaisheng, Li Ruixin etc. the storage stability of novel chitosan burn dressing and biological assessment. institute of Military Medical Science Institute periodical 2002; 26 (1): 48).The dressing of alginate fiber generally is that it is directly made the non-woven fabrics form, this dressing anthemorrhagic performance and absorption sepage effect are better, can form layer of gel in wound surface, thereby avoid adhesion problems (the Attwood A.I.Calcium alginate dressingaccelerates split skin graft donor healing.British Journal of Plastic Surgery 1989 with wound surface; 42 (4): 373).Studies show that in recent years, chitosan and alginate have cooperative effect, with proper proportion certain density chitosan solution is mixed with alginate solution, make sponge material with suitable aperture through lyophilization, not only improve the adhesive and the absorbent of sponge material and wound surface, and can improve antibiotic and anthemorrhagic performance (L.L.Hui, A.Asad, D.Q.M.Craig.The preparation andcharacterisation of drug-loaded alginate and chitosan sponges.InternationalJournal of Pharmaceutics 2003; 251:175).The fibrous material that chitosan and alginate are mixed and made into proper proportion with nucleocapsid structure, not only can bring into play the advantage of the two, have significantly antibiotic, hemostasis and promote the function of wound healing, and the intensity of fiber obviously improves (C.J.Knill, J.F.Kennedy, J.Mistry, et al.Alginate fibers modified with unhydrolysed andhydrolysed chitosans for wound dressings.Carbohydrate Polymers 2004; 55:65).So far, as the wound surface contact material, do not see bibliographical information as yet with chitosan and alginate composite fiber with the research of the compounded emergency wound dressing of other material aspect.
Summary of the invention
In order to solve exist in the present emergency wound dressing hemostatic not good enough, easily the adhesion wound surface to the wound fluid absorption difference, easily causes shortcomings such as superinfection, the invention discloses a kind of new emergency wound dressing.
Emergency wound dressing of the present invention is a kind of compound non-woven fabrics with three-decker: internal layer 1 is the wound surface contact layer, is made up of the composite fibre of marine organism material chitosan and alginate; Intermediate layer 2 is a moisture absorption layer, is made up of the moisture-absorbing fibre of inner admixture High hydrophilous resin 4; Outer 3 is water blocking layer, is made up of the hydrophobic type anti-bacterial fibre.
Wherein the chitosan of internal layer 1, alginate composite fibre consumption are at 25g/m
2-50g/m
2Between, the mixed proportion of chitin fiber and alginate fiber is between 2.5: 1 and 3.5: 1, and alginate can be the mixture of calcium alginate or calcium alginate and sodium alginate.Chitosan and alginate are maritime biomaterial, have good biocompatibility, and toxicity is low, biodegradable, antibiotic property is strong, and hemostasis is fast, promote characteristics such as wound healing, wiping laceration, contusion, the multiple wound surface such as wound, operative incision that lancinate are had curative effect preferably.These two kinds of materials are mixed by proper proportion, can obviously improve the functions such as haemostatic effect, anti-microbial property and promotion wound healing of dressing, nor easy adhesion wound has been avoided because dressing removes the wound surface that is caused and damages once again.Chitosan, alginate composite fibre consumption are can form layer of even chitosan and alginate mixed fiber layer and to cover whole nonwoven surface as foundation.According to existing processing technique, its amount should be controlled at 25g/m
2More than, to measure greatly more, cost is high more.The ratio of chitosan and alginate in the composite fibre is to filter out according to zooperal haemostatic effect with the adhesive effect of wound surface.
The fiber of good hygroscopicity is the mixture of viscose rayon, wood pulp cellulose, bamboo fibre or these several fibers in the intermediate layer 2, and consumption is at 100g/m
2-300g/m
2, the High hydrophilous resin 4 of the inside admixture is the crosslinked body of sodium polyacrylate, the amount of admixture is 15g/m
2-25g/m
2Total imbibition ability of moisture-absorbing fibre and High hydrophilous resin 4 should reach instructions for use (the Murji Z.Brisebois H.Method ofmaking highly absorbent and flexible cellulosic pulp fluff sheet.USP 5 of emergency wound dressing, 387,385Feb 7,1995).
Outer 3 hydrophobic fiber is polypropylene fibre or second third composite fibre (being the ES fiber) or its mixture, the power of blocking water of these two kinds of fibers is more or less the same, but the ES fiber is soft more, and the block-water performance of the emergency wound dressing that the main foundation of its consumption is used is on the market determined, is 50g/m
2-70g/m
2(Gilding D.K.Wound Dressing.USP 5998692, Dec 7,1999) in addition, in order to strengthen the anti-microbial property of hydrophobic fiber, can add antibiotic rate wherein greater than 90% antibacterial such as organic antibacterial.
The invention also discloses the preparation method of above emergency wound dressing, concrete grammar is as follows:
Emergency wound dressing of the present invention is by the compound realization of needle point method: in moisture-absorbing fibre non-woven fabrics forming process, with super absorbent resin 4 admixtures of some in moisture-absorbing fibre, prepare the non-woven fabrics blank, the hydrophobic fiber of antibacterial action and chitosan, alginate composite fibre are arranged in the acupuncture respectively on this non-woven fabrics blank two sides then, and acupuncture is fixed into compound non-woven fabrics more at last.The compound non-woven fabrics of this biologically active is sheared by certain area, is packed back sterilization, be emergency wound dressing (Wang Rui. flax fiber felt reinforced composite and performance evaluation thereof. Tianjin University of Technology's journal 2003; 22 (4): 5).
Emergency wound dressing of the present invention has not only been avoided the shortcoming of homogenous material, and ventilative, poisture-penetrability is good, has intensity preferably, elasticity, the haemostatic effect excellence, drainage effect is obvious, has the function of significant promotion wound healing, and because of non-woven fabrics quality softness, better with the attaching of wound surface, help the healing of wound surface, and can prevent that body fluid is exuded to the dressing surface, has prevented the generation of superinfection.The emergency wound dressing of this compound nonwoven cloth preparation with biologically active has a good application prospect for the first aid bandage of multiple wound surface under the various cases of emergency provides a kind of new material of excellent combination property.
Description of drawings
Fig. 1 is the structural representation of emergency wound dressing.Wherein 1 is internal layer (wound surface contact layer), and 2 is intermediate layer (moisture absorption layer), and 3 is outer (water blocking layer), and 4 is High hydrophilous resin.
The specific embodiment
The present invention will be further described by following examples, but do not mean that any limitation of the invention.
The preparation of embodiment one emergency wound dressing
1. material:
Viscose rayon: Tangshan three FCFCs of friendly group, fracture strength: 1.6～2.7cN/dtex, elongation at break: 16.0～25.0%, line density: 1.5～1.7dtex, length: 36.0～38.0mm.
High hydrophilous resin: the agent of sucking blood of the FAVOR SXM 100F macromolecule of Stockhausen Superabsorber company, main component is the crosslinked body of polypropylene sodium, artificial blood absorbtivity: 26.0～33.0g/g; Particle Distribution rate: 600 orders＜1.0%, 300 order 60.0-90.0%, 150 order 5.0-30.0%; Remaining unimolecule:＜500.0ppm; Bulk density: 0.6～0.7g/cm
3
Chitin fiber: Qingdao sea hydrobiont company, fracture strength: 1.6～2.0cN/dtex, elongation at break: 16.0～20.0%, line density: 1.6～1.9dtex, length: 55.0～65.0mm.
Calcium alginate fibre: China Textile Science Inst., fracture strength: 1.5～1.9cN/dtex, elongation at break: 4.0～6.0%, line density: 3.5～4.0dtex, length: 55.0～65.0mm.
Second third fiber: Shanghai Institute of Synthetic Fiber, fusing point (outer/inner): 130 ℃/165 ℃, fracture strength: 2.6～3.8cN/dtex, elongation at break: 4.0～12.0%, line density: 1.3～2.5dtex, length:＞38.0mm.
2. method:
Line taking density is the viscose rayon of 1.6dtex, and acupuncture becomes 140.0g/m on needing machine
2The non-woven fabrics blank, on half cloth width of cloth of this blank, press 20.0g/m
2Amount spray High hydrophilous resin 4, with second half blank doubling, be tiled on the one side of High hydrophilous resin 4, acupuncture is compound in the lump; On the one side of this blank, have antibiotic in the acupuncture and second third fiber hydrophobic interaction, compound quantity is 60.0g/m
2The composite fibre of chitosan and calcium alginate (weight ratio of chitin fiber and calcium alginate fibre is 2.5: 1) on another side acupuncture is compound again, compound quantity is 28.0g/m
2Again compound nonwoven cloth acupuncture is fixed at last, thermal finalization (less than 110 ℃).Above-mentioned composite is cut into 10cm * 10cm, 18cm * 18cm, three kinds of specifications of 35cm * 30cm place the polyethylene composite film packaging bag, are emergency wound dressing through vacuum-packed, ethylene oxide sterilizing.
Embodiment two zooperies detect the wound surface adhesion effect and the haemostatic effect of emergency wound dressing
1 wound surface adhesion effect test
1.1 materials and methods:
1.1.1 material
A1 group: chitin fiber
The A2 group: the mixed proportion of chitin fiber, alginic acid fibre is 3: 1
The A3 group: the mixed proportion of chitin fiber, alginic acid fibre is 1: 1
1.1.2 animal
Healthy rabbits, male and female all have, body weight 2.0Kg～2.5Kg.
1.1.3 sample preparation
Materials A 1, A2, A3 are cut into 4cm * 4cm size, standby after 20 minutes through 121 ℃ of autoclavings.
1.1.4 wound surface adhesion test
Get 12 of rabbit and be divided into 3 groups at random, promptly A1, A2, A3 organize, every group of 4 rabbit, and two wound surface of every rabbit, eight wound surface are one group.With tame rabbit back left and right sides difference cropping 6 * 10cm, with the new 0.4ml/Kg intraperitoneal injection of anesthesia of speed dormancy.Operating-table is fixed in the rabbit ventricumbent position, iodine tincture, alcohol disinfecting, excise the holostrome skin of 2 * 2cm respectively in the left and right sides, back, be covered in sample on the wound surface respectively, observed material to wound surface adhesion situation in 1 day, 3 days and 7 days in postoperative, write down the percentage ratio of the complete adhesion and the wound surface gross area, the results are shown in Table 1:
The wound surface adhesion rate of the different proportioning chitosans of table 1, the dressing of alginate fiber
1.2 result and discussion
Learn that by last table the adhesion rate of different samples is A1＞A3＞A2, the result shows that the adhesion rate is low to be the A2 group, and next is the A3 group, and relatively poor is the A1 group.Show that its resistance to blocking is better when the mixed proportion of chitin fiber and alginic acid fibre is 3: 1.
The test of 2 haemostatic effects
2.1 materials and methods:
2.1.1 material
A1 group: chitin fiber
The A2 group: the mixed proportion of chitin fiber, alginic acid fibre is 3: 1
The A3 group: the mixed proportion of chitin fiber, alginic acid fibre is 1: 1
A4 group: absorbent cotton (matched group)
2.1.2 animal
Healthy rabbits, male and female all have, body weight 2.0Kg～2.5Kg.
2.1.3 sample preparation
The aseptic cotton A4 that materials A 1, A2, A3 and 2mm～3mm is thick is cut into 3cm * 1cm size, and is standby after 20 minutes through 121 ℃ of autoclavings.
2.1.4 rabbit ear wound surface hemostasis experiment
Get 16 of rabbit, rabbit is divided into two groups (8 every group) at random, 1 group of rabbit left side ear A1 wherein, auris dextra A4, another organizes the left ear A2 of rabbit, auris dextra A3.With rabbit left and right sides ear alignment, in ear edge (end) 1/3 place, with the wound of sterilization back shears crosscut one about 1cm length, wound is from ear edge crosscut rabbit ear, about be subjected to cutting equally wound.Respective sample spreads on wound in 5 seconds, pushed 1 minute with hands, at this moment between in do not observe, push always, the hemorrhage situation of later on observing damage location at any time in 1 minute is a bleeding stopping period with oozing of blood no longer, when hemorrhage, carries out statistical procedures, the results are shown in Table 2.
The different proportioning chitosans of table 2, the dressing of alginate fiber are observed rabbit ear wound surface haemostatic effect
*There is significant difference P＜0.05
2.2 result and discussion
The result shows that A1, A2, A3 and control group A 4 all have anastalsis in various degree, and wherein the A2 group compares P＜0.05 with control group A 4, and significant difference is arranged.Show that its anthemorrhagic performance is better when the mixed proportion of chitin fiber and alginic acid fibre is 3: 1.
The clinical result of use of embodiment three emergency wound dressings
General clinical data: use emergency wound dressing in all kinds of trauma patient 20 examples, wherein male 17 examples, women 3 examples, 15～46 years old age, average 28 years old.Upper limb wound 8 examples, lower limb wound 6 examples, women's head-ornaments portion 4 examples, trunk 2 examples.Be fresh wound surface, the conventional oil gauze contrasts 20 examples from body.
Materials and methods: after the wound surface debridement, directly wrap up in wound surface, rubberized fabric adhere is fixed, and changes dressings every day 1 time.Observe the tissue adhesion situation, absorb transudate effect, infection effect, soak the conventional oil gauze of chloromycetin with internal layer and do the consubstantiality contrast, the results are shown in Table 3.
Table 3. emergency wound dressing result of use is observed table
P＞0.05 no difference of science of statistics
The therapeutic evaluation standard:
The tissue adhesion effect: dressing comes off easily when changing dressings, and wound surface is not hemorrhage to be that effect is remarkable; Difficult drop-off, wound surface are hemorrhage slightly to be respond well; Difficult drop-off, it is hemorrhage that to be evident as effect general; Wound surface do not come off or hemorrhage be evident as invalid.The imbibition effect: the wrapping wound surface, after 24 hours dressing do not soak into for effect remarkable; Small part is soaked into for respond well; Major part soak into for effect general; All soak into for invalid.Antiphlogistic effects: wound surface does not have redness, and no secretor is that effect is remarkable; Slight red and swollen, it is respond well that a little secretor is arranged; Redness is more obvious, and the more person of secretions is that effect is general; Obviously red and swollen, the many persons of secretions are invalid.
Compare with the conventional oil gauze, this emergency wound dressing has following characteristics:
1. there is not adhesion with wound surface.Common dressing is often changed dressings and wound surface adhesion, hemorrhage, brings misery to patient.Do not have adhesion and emergency wound dressing is many with wound surface, be difficult for hemorrhagely when changing dressings, patient is gently painful.
2. has good absorption sepage effect.Wound surface oozes out manyly after the wound, and oily yarn in the past, gauze, cotton pad wrapping are often soaked into dressing, influence the bandaging method for treating effect, and emergency wound dressing absorption sepage performance obviously are better than the traditional dressing of same thickness, can reduce dressing change frequency.
3. has good anti-infectious function.Emergency wound dressing wrapping wound surface, it is light to create all inflammatory reactions, and red and swollen not obvious, secretions is few.
4. easy to use.Can select the dressing of different size for use according to wound site and size, open sterilization packaging and directly apply lid or wrap up and get final product in wound surface.
The anthemorrhagic performance of emergency wound dressing of the present invention with use at present that haemostatic effect such as collagen sponge, regenerated cellulose is suitable preferably.
The anthemorrhagic performance experiment of the rabbit ear portion wound surface that is undertaken by the same animals test model shows, chitosan and alginate composite fibre are suitable to the haemostatic effect of the haemostatic effect of rabbit ear portion wound surface and collagen sponge, regenerated cellulose, experimental result sees Table 4 (Wu Jimin, Miao Mingshan, wait quietly the pass. and collagen sponge is cured the hemorrhage animal experimental observation of body surface. biomedical engineering and clinical .2002:6 (1): 11).
The anthemorrhagic performance of the similar hemostatic material of table 4 (animal experiment)
*There is significant difference P＜0.05
The haemostatic effect of collagen sponge, regenerated cellulose obviously is better than the absorbent cotton matched group.Comparison sheet 2 and table 4 as can be known, chitosan and alginate composite fibre are suitable to the haemostatic effect of the haemostatic effect of rabbit ear portion wound surface and collagen sponge, regenerated cellulose.
Claims (7)
1. emergency wound dressing, it is characterized in that this emergency wound dressing is a kind of compound non-woven fabrics with three-decker: internal layer (1) is the wound surface contact layer, is made up of the composite fibre of marine organism material chitosan and alginate; Intermediate layer (2) is a moisture absorption layer, is made up of inner admixture High hydrophilous resin (4) moisture-absorbing fibre; Outer (3) are water blocking layer, are made up of the hydrophobic type anti-bacterial fibre.
2. emergency wound dressing according to claim 1, wherein the consumption of the chitin fiber of internal layer (1) and alginate fibre blend is 25g/m
2-50g/m
2, the mixed proportion of chitin fiber and alginate fiber is 2.5: 1-3.5: 1.
3. emergency wound dressing according to claim 1 and 2, alginate fiber wherein is a calcium alginate fibre.
4. emergency wound dressing according to claim 1, wherein the moisture-absorbing fibre of intermediate layer (2) is viscose rayon, wood pulp cellulose, degreasing cotton fiber or bamboo fibre, its consumption is at 100g/m
2-300g/m
2, the High hydrophilous resin of inner admixture (4) is the crosslinked body of sodium polyacrylate, its consumption can be at 15g/m
2-25g/m
2
5. emergency wound dressing according to claim 1, the hydrophobic fiber of its ectomesoderm (3) are polypropylene fibre or second third composite fibre that antibacterial action is arranged, and consumption is 50g/m
2-70g/m
2
6. the preparation method of the described emergency wound dressing of arbitrary claim among the claim 1-5 comprises the steps:
(1) in moisture-absorbing fibre non-woven fabrics forming process, super absorbent resin (4) admixture of some in moisture-absorbing fibre, is prepared the non-woven fabrics blank;
(2) hydrophobic fiber of antibacterial action and chitosan, alginate composite fibre are arranged respectively in the acupuncture on this non-woven fabrics blank two sides, acupuncture is fixed into compound non-woven fabrics more at last, this compound non-woven fabrics biologically active;
(3) the compound non-woven fabrics of this biologically active is sheared by certain area, packed the back sterilization, be emergency wound dressing.
7. preparation method according to claim 6, wherein the step that super absorbent resin (4) is spiked in the moisture-absorbing fibre is that moisture-absorbing fibre acupuncture is become the non-woven fabrics blank, on this blank, spray High hydrophilous resin, another compact material is tiled on the one side of High hydrophilous resin (4), and acupuncture is composited in the lump.
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| JPH08322874A (en) * | 1995-06-02 | 1996-12-10 | Lintec Corp | Biocompatible tacky adhesive pad |
| US5914125A (en) * | 1991-02-07 | 1999-06-22 | Ultra Laboratories Limited | Wound dressing |
| CN2400080Y (en) * | 1999-12-09 | 2000-10-11 | 海南欣龙无纺股份有限公司 | Medical natural absorbable biological dressing |
| CN1403163A (en) * | 2002-10-23 | 2003-03-19 | 东南大学 | Absorbable fiber reinforced multilayer film material and its prepn |
| US6680113B1 (en) * | 1989-12-29 | 2004-01-20 | 3M Innovative Properties Company | Multi-layered dressing |
| CN1167471C (en) * | 2002-04-29 | 2004-09-22 | 苗九昌 | Composite biological non-woven cloth dressing of chitosan, collagen and calcium alginate |
-
2005
- 2005-03-09 CN CNB2005100162793A patent/CN100400019C/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6680113B1 (en) * | 1989-12-29 | 2004-01-20 | 3M Innovative Properties Company | Multi-layered dressing |
| US5914125A (en) * | 1991-02-07 | 1999-06-22 | Ultra Laboratories Limited | Wound dressing |
| JPH08322874A (en) * | 1995-06-02 | 1996-12-10 | Lintec Corp | Biocompatible tacky adhesive pad |
| CN2400080Y (en) * | 1999-12-09 | 2000-10-11 | 海南欣龙无纺股份有限公司 | Medical natural absorbable biological dressing |
| CN1167471C (en) * | 2002-04-29 | 2004-09-22 | 苗九昌 | Composite biological non-woven cloth dressing of chitosan, collagen and calcium alginate |
| CN1403163A (en) * | 2002-10-23 | 2003-03-19 | 东南大学 | Absorbable fiber reinforced multilayer film material and its prepn |
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| Publication number | Publication date |
|---|---|
| CN1830409A (en) | 2006-09-13 |
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