CN106943233A - A kind of sticking structure - Google Patents
A kind of sticking structure Download PDFInfo
- Publication number
- CN106943233A CN106943233A CN201610008340.8A CN201610008340A CN106943233A CN 106943233 A CN106943233 A CN 106943233A CN 201610008340 A CN201610008340 A CN 201610008340A CN 106943233 A CN106943233 A CN 106943233A
- Authority
- CN
- China
- Prior art keywords
- layer
- sticking structure
- woven cloth
- melt
- hydrogel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/023—Adhesive plasters or dressings wound covering film layers without a fluid handling layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/023—Adhesive plasters or dressings wound covering film layers without a fluid handling layer
- A61F13/0243—Adhesive plasters or dressings wound covering film layers without a fluid handling layer characterised by the properties of the skin contacting layer, e.g. air-vapor permeability
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0259—Adhesive plasters or dressings characterised by the release liner covering the skin adhering layer
- A61F13/0266—Adhesive plasters or dressings characterised by the release liner covering the skin adhering layer especially adapted for wound covering/occlusive dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00544—Plasters form or structure
- A61F2013/00582—Properties of backing
- A61F2013/006—Elastic modulus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00544—Plasters form or structure
- A61F2013/00621—Plasters form or structure cast
- A61F2013/00638—Gel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00727—Plasters means for wound humidity control
- A61F2013/00748—Plasters means for wound humidity control with hydrocolloids or superabsorbers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00855—Plasters pervious to air or vapours
Abstract
The present invention be on it is a kind of breathe freely that good, tensile ductility is strong, antibacterial it is good with the high sticking structure of water absorption rate, comprising：One melt-blown non-woven cloth layer, positioned at upside, has multidirectional elasticity tension；One netted interlaced polymeric nitride layer, positioned at the lower section of the melt-blown non-woven cloth layer；And a hydrogel layer, positioned at the lower section of the netted interlaced polymeric nitride layer, the wherein netted interlaced polymeric nitride layer is formed by some of the melt-blown non-woven cloth layer and a part of combined polymerization of the hydrogel layer；And the base weight of the melt-blown non-woven cloth layer is 20 40g/m in the sticking structure2。
Description
Technical field
The present invention be on a kind of sticking structure, especially with respect to one kind breathe freely good, tensile ductility it is strong, anti-
Bacterium is good with the high sticking structure of water absorption rate.
Background technology
Reported according to science in recent years and statistics, the demand in global wound market is increasing, it is particularly outer
Section's operation class wound, its total number of persons has broken through 100,000,000 person-times every year, and in the trend increased year by year.Cause
For the wound and lacerated wound caused by contingency, about 2,000 ten thousand person-times annual, and burn and scald quantity is about 1
Ten million person-time annual；Exedens wound caused by chronic disease, diabetes, the aging of population has then surpassed
3,000 ten thousand person-times are crossed every year.
Surgical operation has been greatly reduced because operation because the demand for the treatment of and being in fashion for ESS
Caused risk, but the thing followed is to be looked after for more preferable wound and scar after the operation prevents
Demand, has occurred carrying out the method that wound is looked after by various advanced sticking structures at present, has used shortening wound
Mouth healing time eliminates scar simultaneously.
Traditional sticking structure is made up of natural plant fibre or animal hairs material, such as gauze, cotton pad,
Wool, all kinds of oil gauzes etc., this kind of sticking structure is temporary covering material, is both needed to when certain
It is interior to be changed.However, these wound sticking structures easily occur mutually to be stained with glutinous with wound when changing
Situation, therefore be possible to tear the epithelial cell of new life in the lump while sticking structure is removed or be gradually cured
The wound of conjunction, causes user's pain hard to bear, and is quite unfavorable for the natural recovery of wound.
The research of existing sticking structure allows people for the understanding science increasingly of sticking structure, and research shows：Compared with
Good sticking structure can keep the good cell growth healing environment of site of injury, can control and absorption is oozed out
Thing；Ventilative, moisture-inhibiting, can prevent bacterium from invading；Individual can be closely pasted on；It can carry and set, discharge medicine；
Should have good tissue and blood compatibility in addition, be not adhered and furfur when being torn off from individual；Also
Should have preferably mechanical performance and tensile strength, it is easy to use.
Compared to traditional sticking structure, hydrogel sticking structure can provide preferably ventilative, moisture-inhibiting, barrier
Bacterium invades and the characteristic such as control and absorption diffusate so that wound is in good cell growth healing environment.
In addition, hydrogel sticking structure can closely be covered on wound, and glutinous wound will not be stained with when changing sticking structure
Mouth causes secondary injury, therefore hydrogel sticking structure is widely used in raw doctor field.
Typically, the support layer of traditional sticking structure product is the material such as polyethylene by being difficult to uphold
(polyethylene, PE), polypropylene (Polypropylene, PP) or nylon (Nylon) are made, with hydrogel
When combining to form sticking structure product, sticking structure fracture is easily caused simultaneously because support layer can not effectively be stretched
So that this structure or product can not comply with user's body, the compliance that this is lacked to user's body is general
Hydrogel can be caused, which to paste infrastructure product, does not have the comfort that user wants and docile degree.In addition, shortage pair
The compliance of user's body, which generally results in hydrogel and pastes infrastructure product, can not carry out effective liquid suction
Receive, be distributed and maintain ability.It is another by hydrogel sticking structure lack be easy to stretch derivative problem be,
The material that hydrogel sticking structure may disintegrate as each isolated region or group, causes the discomfort to user, drop
The efficiency of low hydrogel sticking structure.
The long-term demand in this area is to be intended to produce a kind of to surmount commonly known hydrogel and paste the existing characteristic of structural table
Hydrogel sticking structure.More particularly, also wishing to produce one kind can stretch, and comply with user's body
Hydrogel sticking structure, and the hydrogel sticking structure can quickly absorb user's body institute in general use
The liquid of discharge, and the ability with constant absorption liquid.
The content of the invention
Therefore inventor adjusts the material and base of the support layer of hydrogel sticking structure via discovery after multi-party test
The problem of Beijing South Maxpower Technology Co. Ltd enough improves above-mentioned, if the base weight of support layer is too high, because hydrogel is hydrophobic with support layer
Influence is difficult to be combined and caused the situation for having degumming, and too high the formed patch of base weight of support layer with hydrogel
Structure is covered to be opaque, it is unfavorable to use；If support layer base weight it is too low, because support layer tensile strength with
And stretching ratio is not as expected, and hydrogel water suction retreats glutinous cause and waterproof covering material disengaging.Therefore this hair
A kind of good, tensile ductility of breathing freely of bright offer is strong, antibacterial is good and the high sticking structure of water absorption rate, comprising:One melts
Spray type non-woven cloth layer, positioned at upside, has multidirectional elasticity tension；One netted interlaced polymeric nitride layer, it is molten positioned at this
The lower section of spray type non-woven cloth layer；And a hydrogel layer, positioned at the lower section of the netted interlaced polymeric nitride layer, wherein
Some and a part of copolymerization of the hydrogel layer of the netted interlaced polymeric nitride layer by the melt-blown non-woven cloth layer
Close and formed；And the base weight of the melt-blown non-woven cloth layer is 20-40g/m in the sticking structure2.It is preferable in one
In embodiment, the base weight of the melt-blown non-woven cloth layer is 20-35g/m in the sticking structure2.In another preferable
In embodiment, the base weight of the melt-blown non-woven cloth layer is 20-30g/m in the sticking structure2, make described paste
Structure is transparent.
According to the sticking structure of the present invention, in a preferred embodiment, the combined polymerization is including but not limited to chemistry
Property polymerization, and this is chemically polymerize including but not limited to being formed using ultraviolet light, and this is netted staggeredly
Melt-blown adhesive-bonded fabric is hydrophobicity in polymer, and few fibers are exposed.In another embodiment, the hydrogel
The absorbable excessive moisture of layer or wound tissue's liquid, keep the appropriate humidity of skin.And the hydrogel layer is included：(a) it is single
Body；(b) plasticiser；(c) light initiator；(d) crosslinking agent；And (e) thickener.
In the preferred embodiment, the hydrogel layer raw material weight proportioning of soup processed is：
In the preferred embodiment, the monomer includes acryl system amide monomer and acryl system Sulfonates monomer,
The acryl system Sulfonates monomer assigns hydrogel layer fungistatic effect；The plasticiser and thickener are glycerine,
The glycerine assigns hydrogel pliability and increase hydrophily；The light initiator is under 1 to 50 second ultraviolet light
Produce living radical and complete polymerisation, do not have cytotoxicity after reaction；The crosslinking agent is unsaturated double for tool
The difunctionality base ester class of key.
According to the sticking structure of the present invention, it additionally comprises a bioactivity non-woven cloth layer, and it is to fit in the water
The lower section of gel layer.In a preferred embodiment, the bioactivity non-woven cloth layer is by collagen or chitin
Matter is constituted.In another embodiment, sticking structure of the invention additionally comprises a polyurethane film, and it is list
One direction permeable membrane and a pressure sensing adhesive layer, it is hydrophobic, is coated on the polyurethane film.This is pasted
Structure is sequentially from top to bottom：It is polyurethane film, pressure sensing adhesive layer, melt-blown non-woven cloth layer, netted staggeredly poly-
Compound layer and hydrogel layer.
According to the sticking structure of the present invention, in a preferred embodiment, its water absorption rate is 10-40g/g, Wen Zhongsuo
" water absorption rate " stated refer to one gram of sticking structure of the invention absorbent water weight (gram).And the melt-blown
Type non-woven cloth layer is made up of thermoplastic polyurethane (Thermoplastic Polyurethane, TPU).
Hydrogel layer in the sticking structure of the present invention, in a preferred embodiment, is used as contact traumatic wounds
Binding face, the hydrogel layer can make traumatic wounds be in healing acceleration appropriate moisture condition.It is moist to be cured
Cyclization border is conducive to wound healing, if wound dehydrates, and cell can not then survive, although the yarn of various moistenings
Cloth or bandage can also provide moist healing environment, but be due to the gauze or bandage class sticking structure need through
Often change and cause the cell newly formed to be easy to damage, cause wound secondary injury, and have the danger of dehydration.
Glutinous characteristic is moved back in hydrogel layer tool water suction in sticking structure of the present invention, in dressing compared with the gauze typically moistened
Or bandage such as petrolatum gauze, the destruction to wound is less, and its water absorbent rate more conforms to wound healing institute
The optimal moisture state of demand, absorbs excessive moisture, keeps the appropriate humidity of skin, and more carries the property of medicine.
Present invention can apply to sticking structure, electrode paste after various wound sticking structure, ring-type foreskin stereotomy
Cover structure, pastille medicine adhesive plaster, facial mask or makeups patch, other paste sexual life articles for use (such as mosquito repellent patch, heel
Patch etc.).The beneficial effects of the present invention are the sticking structure can prepare the multidirectional elasticity of tool and meet various wounds
There is provided preferable traumatic wounds healing environment, shortening healing time, antibacterial for the wound sticking structure that wound is used
And reduce infection chance.
Brief description of the drawings
Fig. 1 is sticking structure schematic diagram of the invention.
In figure, 100 be sticking structure, 101 be melt-blown non-woven cloth layer, 102 be netted interlaced polymeric nitride layer,
103 it is hydrogel layer, 104 is bioactivity non-woven cloth layer.
Embodiment
Presently preferred embodiments of the present invention will be explained in it is as follows, wherein the figure number and schema of cited embodiment
Shown in number it is identical, please also refer to schema and detailed description.The non-purpose of the following example is to limit this
Invention, and only as the representative of several aspects and feature of the invention.
Fig. 1 is sticking structure schematic diagram of the invention, and sticking structure 100 of the invention is included：One melt-blown
Non-woven cloth layer 101, positioned at upside, has multidirectional elasticity tension；One netted interlaced polymeric nitride layer 102, positioned at this
The lower section of melt-blown non-woven cloth layer 101；And a hydrogel layer 103, positioned at the netted interlaced polymeric nitride layer 102
Lower section, wherein the netted interlaced polymeric nitride layer 102 by the melt-blown non-woven cloth layer 101 some and should
The a part of combined polymerization of hydrogel layer 103 and formed；And the melt-blown adhesive-bonded fabric in the sticking structure 100
The base weight of layer 101 is 20-40g/m2。
According to the sticking structure 100 of the present invention, it additionally comprises a bioactivity non-woven cloth layer 104, and it is laminating
In the lower section of the hydrogel layer 103.In the present embodiment, the melt-blown non-woven cloth layer is by thermoplasticity polyamine
Carbamate (Thermoplastic Polyurethane, TPU) is constituted, and the bioactivity non-woven cloth layer 104
It is made up of collagen or chitin.
Hydrogel layer is formulated
(a) mixture is provided, comprising：
(I) light initiator and the amide monomer stirring of acryl system are mixed to dissolving；
(II) glycerine is further added to mix to dissolving；
(III) acryl system Sulfonates monomer is further added to mix to dissolving；
(IV) glycerine stirring mixing is further added.
(b) mixture is further provided for, comprising：
(I) the difunctionality base esters monomer of light initiator and unsaturated double-bond is stirred and mixed.
(c) stirring blend step (a) and the mixture of step (b).
(d) mixture of step (c) is coated on (such as thermoplastic polyurethane on a melt-blown non-woven cloth layer
Ester), it is anti-with ultra violet lamp progress cross-linked polymeric after the mixture of step (c) penetrates into melt-blown non-woven cloth layer
Should, to obtain the sticking structure 100 of the present invention.
Above-mentioned raw materials weight proportion is：
Each item data of the melt-blown non-woven cloth layer of the present invention is as shown in the table：
According to the sticking structure of the present invention, its water absorption rate is 10-40g/g, and " water absorption rate " described in text refers to one
Gram sticking structure of the invention absorbent water weight (gram).Being determined as follows for water absorption rate, will be prepared
The drying of sticking structure sample, cut sample, be weighed and placed in deionized water, wait sticking structure to reach that water suction is flat
After weighing apparatus, take out after standing, remove surface moisture using filter paper, weigh weight.The water absorption rate (g/g) of sticking structure
Calculate according to the following formula：Water absorption rate=(w2-w1)/w1.In formula, w1 is weight (unit when sticking structure is dried：
g)；W2 reaches the weight (unit after water suction balance for sticking structure：g).
Although the present invention is disclosed above with foregoing embodiment, so it is not limited to the present invention, any ripe
This those skilled in the art is practised, without departing from the spirit and scope of the present invention, when a little change and retouching can be made, therefore
The scope of patent protection of the present invention must be defined depending on the claim person of defining appended by this specification.
Claims (6)
1. a kind of sticking structure, comprising:
One melt-blown non-woven cloth layer, positioned at upside, has multidirectional elasticity tension；
One netted interlaced polymeric nitride layer, positioned at the lower section of the melt-blown non-woven cloth layer；And
One hydrogel layer, positioned at the lower section of the netted interlaced polymeric nitride layer,
Wherein the netted interlaced polymeric nitride layer by the melt-blown non-woven cloth layer some and the hydrogel layer one
Part combined polymerization and formed；
And the base weight of the melt-blown non-woven cloth layer is 20-40g/m in the sticking structure2。
2. sticking structure as claimed in claim 1, it additionally comprises a bioactivity non-woven cloth layer, and it is fitted
In the lower section of the hydrogel layer.
3. sticking structure as claimed in claim 1, its water absorption rate is 10-40g/g.
4. sticking structure as claimed in claim 1, wherein the melt-blown non-woven cloth layer are by thermoplasticity polyamine
Carbamate is constituted.
5. sticking structure as claimed in claim 2, wherein the bioactivity non-woven cloth layer is by collagen
Or chitin is constituted.
6. sticking structure as claimed in claim 1, wherein the copolymerization, which is combined into, chemically polymerize.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610008340.8A CN106943233A (en) | 2016-01-06 | 2016-01-06 | A kind of sticking structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610008340.8A CN106943233A (en) | 2016-01-06 | 2016-01-06 | A kind of sticking structure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106943233A true CN106943233A (en) | 2017-07-14 |
Family
ID=59465600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610008340.8A Pending CN106943233A (en) | 2016-01-06 | 2016-01-06 | A kind of sticking structure |
Country Status (1)
| Country | Link |
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| CN (1) | CN106943233A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1545401A (en) * | 2001-08-21 | 2004-11-10 | 3M | Stretch removable adhesive articles and methods |
| CN1830409A (en) * | 2005-03-09 | 2006-09-13 | 中国人民解放军军事医学科学院卫生装备研究所 | Emergency wound dressing and its preparation method |
| CN201337582Y (en) * | 2009-02-02 | 2009-11-04 | 沂南县天成生物制品有限公司 | Chitosan bactericidal dressing |
| CN102327639A (en) * | 2011-06-16 | 2012-01-25 | 安美得生医股份有限公司 | Preparation technique of wound dressing |
| CN102885672A (en) * | 2011-07-21 | 2013-01-23 | 日东电工株式会社 | Production method for medical pressure-sensitive adhesive tape or sheet |
| CN102895070A (en) * | 2012-10-31 | 2013-01-30 | 常州美杰医疗用品有限公司 | Manufacturing method for hydrogel moist dressing band-aid |
| CN103431947A (en) * | 2011-09-15 | 2013-12-11 | 英属维尔京群岛商科裕有限公司 | Dressing |
| CN205832004U (en) * | 2016-01-06 | 2016-12-28 | 沃康生技股份有限公司 | A kind of sticking structure |
-
2016
- 2016-01-06 CN CN201610008340.8A patent/CN106943233A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1545401A (en) * | 2001-08-21 | 2004-11-10 | 3M | Stretch removable adhesive articles and methods |
| CN1830409A (en) * | 2005-03-09 | 2006-09-13 | 中国人民解放军军事医学科学院卫生装备研究所 | Emergency wound dressing and its preparation method |
| CN201337582Y (en) * | 2009-02-02 | 2009-11-04 | 沂南县天成生物制品有限公司 | Chitosan bactericidal dressing |
| CN102327639A (en) * | 2011-06-16 | 2012-01-25 | 安美得生医股份有限公司 | Preparation technique of wound dressing |
| CN102885672A (en) * | 2011-07-21 | 2013-01-23 | 日东电工株式会社 | Production method for medical pressure-sensitive adhesive tape or sheet |
| CN103431947A (en) * | 2011-09-15 | 2013-12-11 | 英属维尔京群岛商科裕有限公司 | Dressing |
| CN102895070A (en) * | 2012-10-31 | 2013-01-30 | 常州美杰医疗用品有限公司 | Manufacturing method for hydrogel moist dressing band-aid |
| CN205832004U (en) * | 2016-01-06 | 2016-12-28 | 沃康生技股份有限公司 | A kind of sticking structure |
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| PB01 | Publication | ||
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Application publication date: 20170714 |