CN102327161A - Preparation process of wound dressing - Google Patents
Preparation process of wound dressing Download PDFInfo
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- CN102327161A CN102327161A CN201110161594A CN201110161594A CN102327161A CN 102327161 A CN102327161 A CN 102327161A CN 201110161594 A CN201110161594 A CN 201110161594A CN 201110161594 A CN201110161594 A CN 201110161594A CN 102327161 A CN102327161 A CN 102327161A
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Abstract
The invention discloses a preparation process of a wound dressing, which is characterized by comprising the steps of: with a first polyurethane elastic film as a base cloth, coating hydrogel on the first polyurethane elastic film; and then adhering a second polyurethane elastic film on the coating end face of the hydrogel by using a coiling device to form a composite layer body. The preparation process of the wound dressing can be used for preparing the wound dressing meeting the use requirements of multiple wounds, can also be used for preparing the wound dressing with the functions of keeping a wound healing environment, shortening healing time, resisting bacteria and reducing infection chances, is rapid, and accords with the industrial production requirements.
Description
Technical field
The invention belongs to the preparing technical field of medical dressing; Concrete relate to a kind ofly can keep traumatic wounds healing environment, shorten healing time, antibiotic and reduce the preparation technology of the novel wound dressing of infection chance; It can make wound dressing effectively meet the tissue physiological condition, realizes the scientific management of wound.
Background technology
According in recent years science and statistics report, the demand in global wound market is increasing, surgical operation class wound particularly, and its total number of persons has been broken through 100,000,000 person-times of every year, and is the trend that increases year by year.Because wound that contingency caused and lacerated wound are about 2,000 ten thousand person-times of every year, burn and scald quantity is about 1,000 ten thousand person-times of every year; Because of ulcer property wound that chronic disease, diabetes, the aging of population caused has then surpassed 3,000 ten thousand person-times of every year.
Surgical operation is because of the demand of treatment and being in fashion of endoscopic surgery; Significantly reduced because the risk that operation is caused; But but being better wound, the thing followed looks after and the scar after the operation prevention; Occurred carrying out wound at present and looked after, eliminated cicatrix simultaneously so as to shortening wound healing time by various advanced dressing.
Traditional dressing is to be made up of natural plant fibre or animal hairs material, and like gauze, cotton pad, Pilus Caprae seu Ovis, all kinds of oil gauzes etc., this type dressing is temporary cladding material, all needs in the regular hour, to change.The research of existing wound adjuvant makes and lets people for the understanding of wound adjuvant science day by day, and research shows: preferable wound adjuvant can keep the good cell growth healing environment of site of injury, can control and absorb exudate; Ventilative, wet thoroughly, can stop the antibacterial intrusion; Can closely stick in wound face; Can carry and establish, discharge medicine; Should have favorable tissue and blood compatibility in addition, not stick together and desquamation taking off from wound face when getting; Also should have preferable mechanical performance and tensile strength, easy to use.For example on October 29th, 2008, disclosed one Chinese patent application 200810122438.1 provided the method for preparing of adjuvant on a kind of medical aquogel bed in the prior art; For example on January 12nd, 2005, disclosed publication number was called the patent application of " containing aquogel type wound dressing of aqueous emulsion of polyurethane and preparation method thereof " for the CN1562382A name again; It is the medical accessory of matrix that hydrogel all is provided; But the medicine carrying property of above-mentioned adjuvant is limited, and adhesive can't thoroughly be eliminated.
Summary of the invention
The invention provides a kind of preparation technology who meets the wound dressing of multiple traumatic wounds use, the swellability of this wound adjuvant is preferable, and surface tackiness changes according to the suction state, and can create the optimal healing environment.This preparation technology can be maintained traumatic wounds healing environment, shorten healing time, antibiotic and reduce the wound dressing of infection chance.Its manufacturing process is quick, meets the suitability for industrialized production requirement.
The technical scheme that the present invention adopted is following:
A kind of preparation technology of wound dressing is characterized in that said preparation technology comprises:
Adopt the first elastic polyurethane film as base cloth, hydrogel is coated on this first elastic polyurethane film, utilize crimping device that the second elastic polyurethane film is coated with attached to this hydrogel then and form complex layered body on end face.
In one embodiment, above-mentioned said preparation technology further comprises:
When hydrogel is coated on the first elastic polyurethane film, adopt the ultraviolet light cross-linking mode make the hydrogel polymerization and and the first elastic polyurethane film between fit and stick together; The said first elastic polyurethane film carried out surface modification treatment before the hydrogel coating.
In one specific embodiment, said preparation technology further comprises:
On the end face of the second elastic polyurethane film, adopt adhesive agent to bind a nonwoven layer, the hydrogel coating layer of on the other end of nonwoven layer, applying ointment or plaster then.
In one specific embodiment, said preparation technology further comprises: on the other end of hydrogel coating, attach a thermoplastic urethane layers, this thermoplastic urethane layers is a waterproof polyurethane film.
In another specific embodiment, said preparation technology further comprises:
On the other end of this hydrogel coating, attach a medicine applying layer, the outer applying of this medicine applying layer is provided with a thermoplastic urethane layers;
Perhaps, employing has the hydrogel formation hydrogel layer that medicine mixes body.
In the specific embodiment, said preparation technology further comprises again:
Complex layered body to behind the cans carries out slitting cutting, then the strip shape body behind the itemize is carried out hatching line and stamp processing, obtains this wound dressing.
The present invention also provides a kind of preparation technology of wound dressing, it is characterized in that said preparation technology comprises:
Adopt the hydrophobic first elastic polyurethane film as base cloth;
Be coated with and adopt the ultraviolet light cross-linking mode to make hydrogel coating raw material form hydrogel layer the hydrogel raw material;
Adhesive agent is carried out homogenizing stir, adopt the apparatus for coating that curls then, adhesive agent is coated between the non-woven fabrics of the second elastic polyurethane film and aqueous gel, form wound dressing.
Concretely, said preparation technology further comprises:
End face to the first elastic polyurethane film or non-woven fabrics carries out the modification processing, applies hydrogel layer and stack applying one waterproof polyurethane film at this first elastic polyurethane film then;
Hydrogel layer and the stack of this non-woven fabrics are fitted, with the curling outside that is fitted in this hydrogel layer of the second elastic polyurethane film of water proofing property, form wound dressing then.
In one specific embodiment, said preparation technology further comprises:
Hydrogel is carried out medicine carrying handle, carry out crosslinked polymer then, form sustained release type aqueogel, and then with hydrogel and the curling applying of the first elastic polyurethane film.
Said preparation technology further comprises:
Surface-coated at said hydrogel layer is provided with a hydrophilic layer, and this hydrophilic layer promotes the wound healing medicine layer for containing.
The present invention mainly adopts the mode of the coating of curling; Each interlayer that will have difference in functionality applying of curling; Obtain with hydrogel as the protective layer that attaches traumatic wounds; This hydrogel layer can make wound be under the moistening situation than drying regime, make traumatic wounds be in the state of this healing acceleration.The wet union environment helps wound healing; If the wound dehydration, cell can not move about and can not survive, and this normally provides this moist healing environment by wound incrustation covering; But the cost that will be used as forming a scab with the tissue of wound like this; Though various moistening gauzes or binder also can provide moist healing environment, cause the new cell that forms to be easy to damage owing to this gauze or the dressing of binder class need often to change, and wound have the danger of dehydration.
The preparation technology of this wound dressing can adopt the mode of the pressing of curling will be as the intermembranous curling pressing of the first elastic polyurethane film, hydrogel and second elastic polyurethane of base cloth.After more can the attaching of the second elastic polyurethane film being gone up adhesive agent and pasted a fixing non-woven fabrics, again with hydrogel and the intermembranous curling pressing of first elastic polyurethane.This elastomeric nonwoven layer of cloth can be used as the support of hydrogel, and the opposing type becomes, and the protection wound does not receive external environment influence.The hydrogel layer of the wound dressing that this preparation technology makes destruction to wound when changing dressings is superior to kpetrolatum gauze, and hydrogel layer has more medicine carrying property, and the viscosity of self also meets the required best moisture state of wound healing.The first elastic polyurethane film is as base cloth, but thermoplasticity deformation elasticity and Zhang Du can be provided, and meets the coating demand of various wounds.This second elastic polyurethane film can adopt hydrophobicity elastic polyurethane film simultaneously, plays the outside waterproof effect of wound.
Beneficial effect of the present invention is; The preparation technology of this wound dressing can prepare and meet the wound dressing that multiple traumatic wounds is used, this preparation technology can be maintained traumatic wounds healing environment, shorten healing time, antibiotic and reduce the wound dressing of infection chance.Its manufacturing process is quick, meets the suitability for industrialized production requirement.
Below in conjunction with the accompanying drawing and the specific embodiment the present invention is done further elaboration.
Description of drawings
Fig. 1 is the step block diagram of the embodiment of the invention;
Fig. 2 is that the structure of the prepared wound dressing of Fig. 1 is formed sketch map;
Fig. 3 is the step block diagram of another specific embodiment of the present invention;
Fig. 4 is that the structure of the prepared wound dressing of Fig. 3 is formed sketch map.
The specific embodiment
As shown in Figure 1, the preparation technology of this wound dressing is specially, and at first like step S110, adopts the first elastic polyurethane film as base cloth, and this first elastic polyurethane film is carried out surface modification treatment, obtains the hydrophobic first elastic polyurethane film; Step S120 adopts adhesive agent to curl on the end face of the second elastic polyurethane film and is coated with for another example; Follow like step S130, the hydrogel coating layer of on an end face of nonwoven layer, applying ointment or plaster then, and adopt the ultraviolet light cross-linking mode to make the hydrogel polymerization, and fit with non-woven fabrics.Step S140 for another example: utilize crimping device with forming complex layered body on the other end of the second elastic polyurethane film attached to this hydrogel coating; Like step S150, the complex layered body behind the cans is carried out slitting cutting at last, then the strip shape body behind the itemize is carried out hatching line and stamp processing, obtain this wound dressing.
As shown in Figure 2; This wound dressing has the first elastic polyurethane film 21; This first elastic polyurethane film is a hydrophobicity elastic polyurethane film, has the thermoplastic elastic bulk properties, and an end face of this elastic polyurethane film is through the fixing nonwoven layer 23 of adhesive layer 22 bondings; This nonwoven layer bonding is provided with a hydrogel layer 24, and this hydrogel layer is that acryl is monomer-grafted copolymer hydrogel.The other end of hydrogel layer sticks 25 and is set to apply one deck promotes the formation of wound healing medicine with solubility hydrophilic layer.
As shown in Figure 3, in another embodiment, the preparation technology of this wound dressing is specially, and at first like step S310, adopts the hydrophobic first elastic polyurethane film as base cloth, the end face of the first elastic polyurethane film is carried out modification handle; Carry out step S320 again, hydrogel is carried out medicine carrying handle, carry out crosslinked polymer then, form sustained release type aqueogel; Step S330 is coated with and adopts the ultraviolet light cross-linking mode to make the hydrogel coating form hydrogel layer hydrogel for another example; Last like step S340, adhesive agent is carried out homogenizing stir, adopt the apparatus for coating that curls then, adhesive agent is coated between the first elastic polyurethane film and the hydrogel, form wound dressing.
As shown in Figure 4; This wound dressing has the first elastic polyurethane film 41; 43 of the hydrogel layers of this first elastic polyurethane film and medicine carrying are provided with an adhesive layer 42, and this adhesive layer is with the fixing wound dressing that forms of the hydrogel layer bonding of the first elastic polyurethane film and medicine carrying.
Claims (10)
1. the preparation technology of a wound dressing is characterized in that said preparation technology comprises:
Adopt the first elastic polyurethane film as base cloth, hydrogel is coated on this first elastic polyurethane film, utilize crimping device that the second elastic polyurethane film is coated with attached to this hydrogel then and form complex layered body on end face.
2. the preparation technology of wound dressing according to claim 1 is characterized in that said preparation technology further comprises:
When hydrogel is coated on the first elastic polyurethane film, adopt the ultraviolet light cross-linking mode make the hydrogel polymerization and and the first elastic polyurethane film between fit and stick together.
3. the preparation technology of wound dressing according to claim 1 is characterized in that said preparation technology further comprises:
On the end face of the first elastic polyurethane film, adopt adhesive agent to curl and be coated with a nonwoven layer, the hydrogel coating layer of on the other end of nonwoven layer, applying ointment or plaster then.
4. the preparation technology of wound dressing according to claim 3 is characterized in that said preparation technology further comprises: on the other end of hydrogel coating, attach a thermoplastic urethane layers, this thermoplastic urethane layers is a waterproof polyurethane film.
5. the preparation technology of wound dressing according to claim 3 is characterized in that said preparation technology further comprises:
On the other end of this hydrogel coating, attach a medicine applying layer, the outer applying of this medicine applying layer is provided with a thermoplastic urethane layers;
Perhaps, employing has the hydrogel formation hydrogel layer that medicine mixes body.
6. the preparation technology of wound dressing according to claim 1 is characterized in that said preparation technology further comprises:
Complex layered body to behind the cans carries out slitting cutting, then the strip shape body behind the itemize is carried out hatching line and stamp processing, obtains this wound dressing.
7. the preparation technology of a wound dressing is characterized in that said preparation technology comprises:
Adopt the hydrophobic first elastic polyurethane film as base cloth;
Be coated with and adopt the ultraviolet light cross-linking mode to make the hydrogel coating form hydrogel layer the hydrogel raw material;
Adhesive agent is carried out homogenizing stir, adopt the apparatus for coating that curls then, adhesive agent is coated between the first elastic polyurethane film and the hydrogel, form wound dressing.
8. the preparation technology of wound dressing according to claim 7 is characterized in that said preparation technology further comprises:
End face to the first elastic polyurethane film carries out the modification processing, applies a hydrogel layer and stack applying one non-woven fabrics at this first elastic polyurethane film then;
Hydrogel layer and the stack of this non-woven fabrics are fitted, with the curling outside that is fitted in this hydrogel layer of the second elastic polyurethane film of water proofing property, form wound dressing then.
9. the preparation technology of wound dressing according to claim 7 is characterized in that said preparation technology further comprises:
Hydrogel is carried out medicine carrying handle, carry out crosslinked polymer then, form sustained release type aqueogel, and then with hydrogel and the curling applying of the first elastic polyurethane film.
10. the preparation technology of wound dressing according to claim 7 is characterized in that said preparation technology further comprises:
Surface-coated at said hydrogel layer is provided with a hydrophilic layer, and this hydrophilic layer is the material layer that water solublity promotes wound healing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110161594A CN102327161A (en) | 2011-06-16 | 2011-06-16 | Preparation process of wound dressing |
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|---|---|---|---|
| CN201110161594A CN102327161A (en) | 2011-06-16 | 2011-06-16 | Preparation process of wound dressing |
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| CN102327161A true CN102327161A (en) | 2012-01-25 |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600019A (en) * | 2012-03-09 | 2012-07-25 | 烟台万利医用品有限公司 | Medical hydrogel dressing and preparation method thereof |
| CN103230619A (en) * | 2013-05-15 | 2013-08-07 | 南京斯瑞奇医疗用品有限公司 | Composite hydrogel dressing and preparation method thereof |
| CN103637877A (en) * | 2013-12-25 | 2014-03-19 | 浙江隆泰医疗科技股份有限公司 | Novel foam composite wound dressing |
| CN103933019A (en) * | 2013-01-17 | 2014-07-23 | 舒朝锋 | Persistent hydrogel patch |
| WO2015096231A1 (en) * | 2013-12-25 | 2015-07-02 | 浙江隆泰医疗科技股份有限公司 | Medical closing adhesive tape |
| CN105232228A (en) * | 2015-09-29 | 2016-01-13 | 绍兴振德医用敷料有限公司 | Intelligent adjustable medical dressing and preparation method thereof |
| CN105999361A (en) * | 2016-06-14 | 2016-10-12 | 武汉纺织大学 | Medical dressing with capacity of intelligently releasing antibacterial agent and preparation method of medical dressing |
| CN111575904A (en) * | 2020-05-21 | 2020-08-25 | 东华大学 | Super-elastic waterproof breathable skin dressing with folded structure and preparation method thereof |
| WO2020211763A1 (en) * | 2019-04-15 | 2020-10-22 | 湖州依诺唯新药物制剂有限公司 | Covering film, system comprising same, and usage method and application therefor |
| CN111821100A (en) * | 2019-04-15 | 2020-10-27 | 湖州依诺唯新药物制剂有限公司 | Medical covering film, system containing same, use method and application of medical covering film |
| CN113573697A (en) * | 2019-04-15 | 2021-10-29 | 湖州依诺唯新药物制剂有限公司 | Pharmaceutical preparation, system containing same, preparation method and application thereof |
-
2011
- 2011-06-16 CN CN201110161594A patent/CN102327161A/en active Pending
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600019A (en) * | 2012-03-09 | 2012-07-25 | 烟台万利医用品有限公司 | Medical hydrogel dressing and preparation method thereof |
| CN102600019B (en) * | 2012-03-09 | 2014-04-09 | 烟台万利医用品有限公司 | Medical hydrogel dressing and preparation method thereof |
| CN103933019A (en) * | 2013-01-17 | 2014-07-23 | 舒朝锋 | Persistent hydrogel patch |
| CN103230619B (en) * | 2013-05-15 | 2014-11-26 | 南京斯瑞奇医疗用品有限公司 | Composite hydrogel dressing and preparation method thereof |
| CN103230619A (en) * | 2013-05-15 | 2013-08-07 | 南京斯瑞奇医疗用品有限公司 | Composite hydrogel dressing and preparation method thereof |
| WO2015096231A1 (en) * | 2013-12-25 | 2015-07-02 | 浙江隆泰医疗科技股份有限公司 | Medical closing adhesive tape |
| CN103637877A (en) * | 2013-12-25 | 2014-03-19 | 浙江隆泰医疗科技股份有限公司 | Novel foam composite wound dressing |
| CN103637877B (en) * | 2013-12-25 | 2016-08-17 | 浙江隆泰医疗科技股份有限公司 | A kind of foam composite wound dressing |
| CN105232228A (en) * | 2015-09-29 | 2016-01-13 | 绍兴振德医用敷料有限公司 | Intelligent adjustable medical dressing and preparation method thereof |
| CN105999361A (en) * | 2016-06-14 | 2016-10-12 | 武汉纺织大学 | Medical dressing with capacity of intelligently releasing antibacterial agent and preparation method of medical dressing |
| WO2020211763A1 (en) * | 2019-04-15 | 2020-10-22 | 湖州依诺唯新药物制剂有限公司 | Covering film, system comprising same, and usage method and application therefor |
| CN111821100A (en) * | 2019-04-15 | 2020-10-27 | 湖州依诺唯新药物制剂有限公司 | Medical covering film, system containing same, use method and application of medical covering film |
| CN113573697A (en) * | 2019-04-15 | 2021-10-29 | 湖州依诺唯新药物制剂有限公司 | Pharmaceutical preparation, system containing same, preparation method and application thereof |
| CN111575904A (en) * | 2020-05-21 | 2020-08-25 | 东华大学 | Super-elastic waterproof breathable skin dressing with folded structure and preparation method thereof |
| CN111575904B (en) * | 2020-05-21 | 2021-06-04 | 东华大学 | Super-elastic waterproof breathable skin dressing with folded structure and preparation method thereof |
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Application publication date: 20120125 |