CN105497965A - Sustained drug release type medicine dressing - Google Patents

Sustained drug release type medicine dressing Download PDF

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Publication number
CN105497965A
CN105497965A CN201511001932.9A CN201511001932A CN105497965A CN 105497965 A CN105497965 A CN 105497965A CN 201511001932 A CN201511001932 A CN 201511001932A CN 105497965 A CN105497965 A CN 105497965A
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CN
China
Prior art keywords
layer
alginate
sodium alginate
release type
medicine
Prior art date
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Pending
Application number
CN201511001932.9A
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Chinese (zh)
Inventor
李俊刚
宁方刚
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Taian Feihong Hemp Thread Products Technology Co Ltd
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Taian Feihong Hemp Thread Products Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority to CN201511001932.9A priority Critical patent/CN105497965A/en
Publication of CN105497965A publication Critical patent/CN105497965A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/624—Nanocapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses a sustained drug release type medicine dressing. Sodium alginate drug carrying capsules and a sodium alginate spinning solution are blended, spinning equipment and wet spinning are utilized for preparing alginate fibers carrying nano drug carrying capsules, a basic layer is composed of a protection layer and an absorption core layer, and a functional layer prepared from the alginate fibers carrying the nano drug carrying capsules and the basic layer are prepared into the sustained drug release type medicine dressing through spunlace processing. Hemostasis, bacterium resistance and adhesion prevention are achieved, the moisture preserving effect is good, the healing speed is high, and the sustained drug release type medicine dressing can be used for treating and protecting a variety of wounds.

Description

A kind of medicament slow release type medical dressing
Technical field
The invention belongs to field of medical technology, particularly relate to a kind of medicament slow release type medical dressing.
Background technology
Common dressing is not suitable for acute and healing that is chronic wounds because healing rate is slow.In order to shorten the healing time of wound as much as possible, bio-medical dressing or active dressing receive increasing concern.Medicine carrying dressing only requires the new chemical medicine comprising certain therapeutic value, also needs the shortcoming solving traditional topical pharmaceutical formulation simultaneously.The medicine added in medical dressing plays an important role in the process of wound healing, and it can clean wound directly or indirectly, removes slough; As antibacterial, prevention or treatment bacteriological infection; As growth stimulator, promote tissue regeneration; Agent as a supplement, acceleration is wound healing; In addition, can continue within a period of time for making medicine and stable be applied to wound surface, avoid frequently changing dressings, and reach the object of steady controllable release, the drug delivery system being transformed into controllable release just progressively developed by modern medical dressing.Drug delivery system is on the bases such as pharmacokinetics, preparation theory and feedback biopharmaceutics, obtain, compared with conventional formulation, more can play the characteristic of medicine, and it is high to have curative effect, the advantage that quality is good and targeting is good through system design.Common dressing is not suitable for acute and healing that is chronic wounds because healing rate is slow.
Summary of the invention
The object of the invention is: the medicament slow release type medical dressing that a kind of hemostatic and antibacterial, moisturizing, healing rate are fast is provided.
The technical solution adopted for the present invention to solve the technical problems is: a kind of medicament slow release type medical dressing, the functional layer that the alginate fibre comprising loaded with nano medicine-carrying capsule is made and basic unit; Its production method is as follows:
(1) by Na-alginate medicine-carrying capsule and sodium alginate spinning liquid blended, utilize spinning equipment, take calcium chloride solution as coagulating bath, wet spinning prepares the alginate fibre of loaded with nano medicine-carrying capsule;
(2) basic unit is by protective layer with absorbent core layer is two-layer forms, absorbent core layer is viscose rayon layer, protective layer is formed by china-hemp fibers and viscose fiber blending, china-hemp fibers/viscose fiber blending ratio is 60/40, protective layer and the two-layer individually carding of absorbent core layer, then make two-layer fibre web be compound to together by non-woven water thorn consolidation, form non-woven Shui Ci dressing basic unit;
(3) functional layer made of the alginate fibre of loaded with nano medicine-carrying capsule and basic unit are processed into medicament slow release type medical dressing through water thorn.
Further, sodium alginate is joined in deionized water and obtains sodium alginate soln, Ca (OH) 2 solution and NaHCO3 solution are dropwise dropped in sodium alginate soln respectively, the mass ratio of wherein sodium alginate: Ca (OH) 2:NaHCO3 is 125:3.7:6.3, after interpolation NaHCO3 solution & stir, add methylene blue solution, wherein sodium alginate: the mass ratio of methylene blue is 125:1, again by centrifugal water washing collection, lyophilization, obtains Na-alginate medicine-carrying capsule.
Owing to have employed above-mentioned technical scheme, the present invention compared with prior art, there is following advantage and good effect: (1) is by Nano capsule carrying medicament, and be mixed in spinning liquid, prepare drug-loading fibre, the drug wastage amount in spinning process can be reduced, and load factor and the effective rate of utilization of medicine can be improved.(2) after fiber absorbing wound exudate, swelling formation gel, is convenient to the drug release in capsule and is applied to wound surface, and then promotes the healing of wound.(3) china-hemp fibers has natural antibacterial performance, plays certain protective effect to wound; And viscose rayon is as absorbent core layer, a large amount of juice can be absorbed; Both combine and provide good physical and mechanical properties, ensure the structural stability of dressing.(4) microcellular structure that spunlace non-woven cloth cover is excellent increases the specific surface area of dressing, imparts absorbability and the moisture-absorbing moisture-keeping ability of dressing uniqueness, therefore has the merit such as anti, high moisturizing by the medical dressing of water acupuncture manipulation processing.The present invention has good biocompatibility, excellent mechanical property, natural antibacterial, prepare nano drug-carrying capsule and the slow controlled release realizing medicine such as to put at the feature; hemostatic and antibacterial, moisturizing, healing rate are fast; can be used for treatment and the protection of multiple wound, such as haemostatic wound plaster etc.
Accompanying drawing explanation
Fig. 1 is cross-sectional view of the present invention.
Detailed description of the invention
As can be seen from cross-sectional view of the present invention shown in Fig. 1, the functional layer 1 that the alginate fibre that the present invention includes loaded with nano medicine-carrying capsule is made and the basic unit that protective layer 3 is made with absorbent core layer 2.Its production method is as follows:
Step one, by Na-alginate medicine-carrying capsule and sodium alginate spinning liquid blended, utilize spinning equipment, take calcium chloride solution as coagulating bath, wet spinning prepares the alginate fibre of loaded with nano medicine-carrying capsule.Sodium alginate is joined in deionized water and obtains sodium alginate soln, Ca (OH) 2 solution and NaHCO3 solution are dropwise dropped in sodium alginate soln respectively, the mass ratio of wherein sodium alginate: Ca (OH) 2:NaHCO3 is 125:3.7:6.3, after interpolation NaHCO3 solution & stir, add methylene blue solution, wherein sodium alginate: the mass ratio of methylene blue is 125:1, then by centrifugal water washing collection, lyophilization, obtains Na-alginate medicine-carrying capsule.
Use fast-acting nemostatic medicine thrombin as medicine, prepare the alginate fibre of loaded with nano medicine-carrying capsule.By Nano capsule carrying medicament, and be mixed in spinning liquid, prepare drug-loading fibre, the drug wastage amount in spinning process can be reduced, and load factor and the effective rate of utilization of medicine can be improved.Na-alginate medicine-carrying capsule is dispersed in fiber surface and inside, and fiber can absorb the secretions of a large amount of wound, and after fiber absorbing wound exudate, swelling formation gel, is convenient to the drug release in capsule and is applied to wound surface, and then promotes the healing of wound.
When carrying out wet spinning at normal temperatures, by Na-alginate medicine-carrying capsule and sodium alginate spinning liquid blended, and at room temperature stirring and dissolving, filters, and be placed in batch can more than vacuum deaerator 6h, concentration of dope is set to 3.5%, coagulating bath calcium chloride solution concentration 2.5%, and coagulation bath temperature is 30 DEG C, during draw ratio 1.5, fiber has good pattern, and hot strength and elongation at break all reach maximum, is respectively 18.90 ± 0.90cN/tex and 8.83 ± 0.35%.
Step 2, basic unit is by protective layer 3 and absorbent core layer 2 is two-layer forms, and absorbent core layer 2 is viscose rayon layer, and design grammes per square metre is 120g/m 2; Protective layer 3 is formed by china-hemp fibers and viscose fiber blending, and china-hemp fibers/viscose fiber blending ratio is 60/40, and design grammes per square metre is l00g/m 2, two-layer individually carding, then makes two-layer fibre web be compound to together by non-woven water thorn consolidation, forms non-woven Shui Ci dressing basic unit.
China-hemp fibers has natural antibacterial performance, and viscose rayon has excellent moisture pick-up properties, and there are longitudinal groove and hole in china-hemp fibers surface, gives the ability of fiber hydroscopic fast-drying.Fiber in dressing basic unit needs through water coronule joint, the web layer of different layers to be consolidated after comb net and lapping technique.China-hemp fibers adopts little carding machine to carry out comb net, the large carding machine carding of viscose rayon Bian.
The basic unit of the functional layer 1 that the alginate fibre of step 3, loaded with nano medicine-carrying capsule is made and step 2 is processed into medicament slow release type medical dressing through water thorn.
Water thorn concrete technology parameter is: reinforcing mode is direct water thorn; Distance 1.2cm; Water thorn pressure: prewet 15bar, the anti-30bar of the positive 30bar of the anti-40bar of the positive 30bar of main thorn.
The medicament slow release type medical dressing made by aforementioned production method has good biocompatibility, excellent mechanical property, natural antibacterial, hemostatic and antibacterial anti, and moistening effect is good, and healing rate is fast, can be used for treatment and the protection of multiple wound.

Claims (2)

1. a medicament slow release type medical dressing, is characterized in that: the functional layer (1) that the alginate fibre comprising loaded with nano medicine-carrying capsule is made and basic unit; Its production method is as follows:
(1) by Na-alginate medicine-carrying capsule and sodium alginate spinning liquid blended, utilize spinning equipment, take calcium chloride solution as coagulating bath, wet spinning prepares the alginate fibre of loaded with nano medicine-carrying capsule;
(2) basic unit is by protective layer (3) with absorbent core layer (2) is two-layer forms, absorbent core layer (2) is viscose rayon layer, protective layer (3) is formed by china-hemp fibers and viscose fiber blending, china-hemp fibers/viscose fiber blending ratio is 60/40, protective layer (3) and the two-layer individually carding of absorbent core layer (2), then make two-layer fibre web be compound to together by non-woven water thorn consolidation, form non-woven Shui Ci dressing basic unit;
(3) functional layer (1) made of the alginate fibre of loaded with nano medicine-carrying capsule and basic unit are processed into medicament slow release type medical dressing through water thorn.
2. medicament slow release type medical dressing according to claim 1, it is characterized in that: sodium alginate is joined in deionized water and obtains sodium alginate soln, Ca (OH) 2 solution and NaHCO3 solution are dropwise dropped in sodium alginate soln respectively, the mass ratio of wherein sodium alginate: Ca (OH) 2:NaHCO3 is 125:3.7:6.3, after interpolation NaHCO3 solution & stir, add methylene blue solution, wherein sodium alginate: the mass ratio of methylene blue is 125:1, again by centrifugal water washing collection, lyophilization, obtains Na-alginate medicine-carrying capsule.
CN201511001932.9A 2015-12-29 2015-12-29 Sustained drug release type medicine dressing Pending CN105497965A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
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Application Number Priority Date Filing Date Title
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109276370A (en) * 2018-10-08 2019-01-29 武汉纺织大学 A kind of magnetism moisture absorption type intelligence humicap sensing dressing and application method
CN109432491A (en) * 2018-11-12 2019-03-08 广州润虹医药科技股份有限公司 A kind of slow release hemostatic gauze

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN202078568U (en) * 2011-01-30 2011-12-21 稳健实业(深圳)有限公司 Alginic acid dressing and applicator
WO2012170334A2 (en) * 2011-06-06 2012-12-13 Tyco Healthcare Group Lp Dressings and related methods therefor
CN103239755A (en) * 2013-05-15 2013-08-14 东华大学 Method for preparing multi-layer composite functional surgical dressing
CN103436992A (en) * 2013-08-29 2013-12-11 浙江理工大学 Method for preparing nano drug-carrying capsule-loaded alginate fibers
CN103861144A (en) * 2014-04-04 2014-06-18 杭州天诚药业有限公司 Medical dressing for promoting wound healing and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN202078568U (en) * 2011-01-30 2011-12-21 稳健实业(深圳)有限公司 Alginic acid dressing and applicator
WO2012170334A2 (en) * 2011-06-06 2012-12-13 Tyco Healthcare Group Lp Dressings and related methods therefor
CN103239755A (en) * 2013-05-15 2013-08-14 东华大学 Method for preparing multi-layer composite functional surgical dressing
CN103436992A (en) * 2013-08-29 2013-12-11 浙江理工大学 Method for preparing nano drug-carrying capsule-loaded alginate fibers
CN103861144A (en) * 2014-04-04 2014-06-18 杭州天诚药业有限公司 Medical dressing for promoting wound healing and preparation method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109276370A (en) * 2018-10-08 2019-01-29 武汉纺织大学 A kind of magnetism moisture absorption type intelligence humicap sensing dressing and application method
CN109432491A (en) * 2018-11-12 2019-03-08 广州润虹医药科技股份有限公司 A kind of slow release hemostatic gauze
CN109432491B (en) * 2018-11-12 2021-06-25 广州润虹医药科技股份有限公司 Slow-release hemostatic gauze

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