CN110720127A - 新抗原的鉴别、制造及使用 - Google Patents

新抗原的鉴别、制造及使用 Download PDF

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Publication number
CN110720127A
CN110720127A CN201880037822.3A CN201880037822A CN110720127A CN 110720127 A CN110720127 A CN 110720127A CN 201880037822 A CN201880037822 A CN 201880037822A CN 110720127 A CN110720127 A CN 110720127A
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presentation
peptide
neoantigen
neoantigens
patient
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CN201880037822.3A
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Chinese (zh)
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B·布里克-沙利文
R·耶冷斯凯
J·巴斯比
A·德里蒂
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Seattle Project Co
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Millstone Cancer Biotech Corp
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
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    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
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    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
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CN201880037822.3A 2017-06-09 2018-06-08 新抗原的鉴别、制造及使用 Pending CN110720127A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762517786P 2017-06-09 2017-06-09
US62/517,786 2017-06-09
PCT/US2018/036571 WO2018227030A1 (en) 2017-06-09 2018-06-08 Neoantigen identification, manufacture, and use

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CN110720127A true CN110720127A (zh) 2020-01-21

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US (1) US20200105377A1 (https=)
EP (2) EP3635594B1 (https=)
JP (3) JP7795291B2 (https=)
KR (2) KR20240165471A (https=)
CN (1) CN110720127A (https=)
AU (1) AU2018279627B2 (https=)
CA (1) CA3066635A1 (https=)
IL (1) IL271038A (https=)
SG (1) SG11201911620PA (https=)
WO (1) WO2018227030A1 (https=)

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CN111303268A (zh) * 2020-03-10 2020-06-19 江苏兰恩生物治疗技术研究院有限公司 子宫肌瘤新抗原、其应用和子宫肌瘤疫苗
CN112309502A (zh) * 2020-10-14 2021-02-02 深圳市新合生物医疗科技有限公司 一种计算肿瘤新抗原负荷的方法及系统
CN115836350A (zh) * 2020-07-14 2023-03-21 米尼奥公司 用于确定新抗原的呈递可能性的方法、系统和计算机程序产品
CN117321690A (zh) * 2021-03-15 2023-12-29 亚马逊科技公司 用于优化肿瘤疫苗抗原对异质性恶性肿瘤的覆盖的方法
CN118262793A (zh) * 2024-03-05 2024-06-28 复旦大学附属肿瘤医院 一种选择多价肿瘤新抗原组合系统和方法
CN118351934A (zh) * 2024-04-26 2024-07-16 广州润生细胞医药科技有限责任公司 一种基于二代测序数据的肿瘤新抗原识别方法及系统

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CN112368386A (zh) * 2018-05-23 2021-02-12 磨石肿瘤生物技术公司 共有抗原
US11599774B2 (en) * 2019-03-29 2023-03-07 International Business Machines Corporation Training machine learning model
MX2021014525A (es) 2019-05-30 2022-03-17 Gritstone Bio Inc Adenovirus modificados.
CN114761041A (zh) 2019-07-16 2022-07-15 吉利德科学公司 Hiv疫苗及其制备和使用方法
KR102159921B1 (ko) * 2020-03-24 2020-09-25 주식회사 테라젠바이오 펩타이드 서열 및 hla 대립유전자 서열을 이용하여 신생항원을 예측하는 방법 및 컴퓨터 프로그램
KR20230046313A (ko) 2020-08-06 2023-04-05 그릿스톤 바이오, 인코포레이티드 다중에피토프 백신 카세트
CN112210596B (zh) * 2020-09-08 2022-04-26 中生康元生物科技(北京)有限公司 基于基因融合事件的肿瘤新生抗原预测方法及其应用
CN114333998B (zh) * 2020-10-10 2024-10-15 格源致善(上海)生物科技有限公司 一种基于深度学习模型的肿瘤新抗原预测方法及新生抗原预测系统
EP4213158A1 (en) 2020-11-13 2023-07-19 Ahead Biocomputing, Co. Ltd Information processing device, information processing method, recording medium recording information processing program, and information processing system
EP4277652A1 (en) 2021-01-14 2023-11-22 Gilead Sciences, Inc. Hiv vaccines and methods of using
JP7057003B1 (ja) 2021-02-26 2022-04-19 国立大学法人東京工業大学 予測装置、学習済みモデルの生成装置、予測方法、学習済みモデルの生成方法、予測プログラム、及び学習済みモデルの生成プログラム
JP7057004B1 (ja) 2021-03-05 2022-04-19 国立大学法人東京工業大学 予測装置、学習済みモデルの生成装置、予測方法、学習済みモデルの生成方法、予測プログラム、及び学習済みモデルの生成プログラム
CA3216276A1 (en) 2021-04-29 2022-11-03 Yardena Samuels T cell receptors directed against ras-derived recurrent neoantigens and methods of identifying same
EP4148146A1 (en) * 2021-09-13 2023-03-15 OncoDNA Method to generate personalized neoantigens of a tumor of a patient
JP2024533501A (ja) * 2021-09-13 2024-09-12 オンコディーエヌエー 患者の腫瘍の個別化された新生抗原を生成する方法
CN117690495A (zh) * 2023-12-15 2024-03-12 南京鼓楼医院 一种肿瘤新抗原预测方法、系统、电子设备及存储介质
CN117711487B (zh) * 2024-02-05 2024-05-17 广州嘉检医学检测有限公司 胚系SNV、InDel变异的鉴定方法、系统以及可读存储介质
WO2025207836A1 (en) * 2024-03-26 2025-10-02 Wenyi Wang Methods for selecting cancer patients for immunotherapy using subclonal mutation analysis

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111303268A (zh) * 2020-03-10 2020-06-19 江苏兰恩生物治疗技术研究院有限公司 子宫肌瘤新抗原、其应用和子宫肌瘤疫苗
CN115836350A (zh) * 2020-07-14 2023-03-21 米尼奥公司 用于确定新抗原的呈递可能性的方法、系统和计算机程序产品
CN112309502A (zh) * 2020-10-14 2021-02-02 深圳市新合生物医疗科技有限公司 一种计算肿瘤新抗原负荷的方法及系统
CN117321690A (zh) * 2021-03-15 2023-12-29 亚马逊科技公司 用于优化肿瘤疫苗抗原对异质性恶性肿瘤的覆盖的方法
CN118262793A (zh) * 2024-03-05 2024-06-28 复旦大学附属肿瘤医院 一种选择多价肿瘤新抗原组合系统和方法
CN118351934A (zh) * 2024-04-26 2024-07-16 广州润生细胞医药科技有限责任公司 一种基于二代测序数据的肿瘤新抗原识别方法及系统

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AU2018279627A1 (en) 2020-01-16
JP2020523010A (ja) 2020-08-06
KR20240165471A (ko) 2024-11-22
SG11201911620PA (en) 2020-01-30
EP4512817A2 (en) 2025-02-26
NZ759958A (en) 2024-03-22
JP7651623B2 (ja) 2025-03-26
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US20200105377A1 (en) 2020-04-02
KR20200016265A (ko) 2020-02-14
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