CN110709090A - 用于在体内递送治疗剂的b细胞及其剂量 - Google Patents
用于在体内递送治疗剂的b细胞及其剂量 Download PDFInfo
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- CN110709090A CN110709090A CN201880037089.5A CN201880037089A CN110709090A CN 110709090 A CN110709090 A CN 110709090A CN 201880037089 A CN201880037089 A CN 201880037089A CN 110709090 A CN110709090 A CN 110709090A
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- A—HUMAN NECESSITIES
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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- A61K40/00—Cellular immunotherapy
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- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/13—B-cells
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- A61K40/24—Antigen-presenting cells [APC]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- A—HUMAN NECESSITIES
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0083—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0635—B lymphocytes
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- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01043—Phosphatidylcholine-sterol O-acyltransferase (2.3.1.43), i.e. lecithin-cholesterol acyltransferase or LCAT
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- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
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- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01076—L-Iduronidase (3.2.1.76)
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- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/12—Animals modified by administration of exogenous cells
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/50—Cellular immunotherapy characterised by the use of allogeneic cells
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
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- C12N2501/70—Enzymes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2800/00—Nucleic acids vectors
- C12N2800/90—Vectors containing a transposable element
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- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
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- Hematology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762491151P | 2017-04-27 | 2017-04-27 | |
| US62/491,151 | 2017-04-27 | ||
| PCT/US2018/029993 WO2018201071A1 (en) | 2017-04-27 | 2018-04-27 | B cells for in vivo delivery of therapeutic agents and dosages thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110709090A true CN110709090A (zh) | 2020-01-17 |
Family
ID=63919297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880037089.5A Pending CN110709090A (zh) | 2017-04-27 | 2018-04-27 | 用于在体内递送治疗剂的b细胞及其剂量 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220193129A1 (enExample) |
| EP (1) | EP3615045A4 (enExample) |
| JP (3) | JP2020517692A (enExample) |
| CN (1) | CN110709090A (enExample) |
| AU (2) | AU2018256887B2 (enExample) |
| BR (1) | BR112019022473A2 (enExample) |
| CA (1) | CA3061048A1 (enExample) |
| WO (1) | WO2018201071A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12440513B2 (en) | 2019-03-22 | 2025-10-14 | Albany Medical College | Methods for improving cognitive function |
| CN110499336B (zh) * | 2019-08-23 | 2021-10-12 | 华南农业大学 | 一种利用小分子化合物提高基因组定点修饰效率的方法 |
| JP2023548118A (ja) * | 2020-10-30 | 2023-11-15 | イミュソフト コーポレーション | 治療剤のin vivo送達のために、遺伝子改変B細胞を投与する方法 |
| TW202309270A (zh) * | 2021-04-19 | 2023-03-01 | 美商步行魚醫療公司 | 用於細胞療法的b細胞擴增之方法 |
| WO2024044697A2 (en) * | 2022-08-24 | 2024-02-29 | Walking Fish Therapeutics, Inc. | Compositions and methods for treatment of fabry disease |
| WO2024220447A2 (en) * | 2023-04-17 | 2024-10-24 | Be Biopharma, Inc. | Engineered cell preparations for treatment of niemann pick b disease |
| AU2024257819A1 (en) * | 2023-04-17 | 2025-10-23 | Be Biopharma, Inc. | Engineered cell preparations for treatment of hemophilia |
| US20250152714A1 (en) | 2023-11-15 | 2025-05-15 | Immusoft Corporation | Migratory modified differentiated b cells for cancer therapy |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016202625A1 (en) * | 2007-07-27 | 2016-05-19 | Armagen Technologies, Inc. | Methods and compositions for increasing alpha-iduronidase activity in the CNS |
| WO2016100932A1 (en) * | 2014-12-19 | 2016-06-23 | Immusoft Corporation | B cells for in vivo delivery of therapeutic agents |
| WO2016161446A1 (en) * | 2015-04-03 | 2016-10-06 | Dana-Farber Cancer Institute, Inc. | Composition and methods of genome editing of b-cells |
| CN106103489A (zh) * | 2014-01-27 | 2016-11-09 | 分子模板公司 | Mhc i类表位递送多肽 |
| WO2016187017A1 (en) * | 2015-05-15 | 2016-11-24 | Mcivor R Scott | Adeno-associated for therapeutic delivery to central nervous system |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2029165B1 (en) * | 2006-04-27 | 2014-12-03 | Cellid Co., Ltd | B cell-based vaccine loaded with the ligand of natural killer t cell and antigen |
| WO2011085247A2 (en) * | 2010-01-08 | 2011-07-14 | Immusoft Corporation | Vectors and methods for transducing b cells |
| EP2971039B1 (en) * | 2013-03-14 | 2020-01-01 | Immusoft Corporation | Methods for in vitro memory b cell differentiation and transduction with vsv-g pseudotyped viral vectors |
| JP2021515576A (ja) * | 2018-03-16 | 2021-06-24 | イミュソフト コーポレーション | フォリスタチンを分泌するように遺伝子操作されたb細胞ならびにフォリスタチン関連疾患、状態、障害を処置するために、ならびに筋肉の成長および強度を増強するためにこれを使用する方法 |
-
2018
- 2018-04-27 CN CN201880037089.5A patent/CN110709090A/zh active Pending
- 2018-04-27 US US16/607,962 patent/US20220193129A1/en active Pending
- 2018-04-27 BR BR112019022473-4A patent/BR112019022473A2/pt unknown
- 2018-04-27 EP EP18790427.1A patent/EP3615045A4/en active Pending
- 2018-04-27 CA CA3061048A patent/CA3061048A1/en active Pending
- 2018-04-27 WO PCT/US2018/029993 patent/WO2018201071A1/en not_active Ceased
- 2018-04-27 JP JP2019557872A patent/JP2020517692A/ja not_active Withdrawn
- 2018-04-27 AU AU2018256887A patent/AU2018256887B2/en active Active
-
2023
- 2023-04-26 JP JP2023072284A patent/JP7526312B2/ja active Active
-
2024
- 2024-07-19 JP JP2024115656A patent/JP2024153703A/ja active Pending
-
2025
- 2025-04-09 AU AU2025202508A patent/AU2025202508A1/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016202625A1 (en) * | 2007-07-27 | 2016-05-19 | Armagen Technologies, Inc. | Methods and compositions for increasing alpha-iduronidase activity in the CNS |
| CN106103489A (zh) * | 2014-01-27 | 2016-11-09 | 分子模板公司 | Mhc i类表位递送多肽 |
| WO2016100932A1 (en) * | 2014-12-19 | 2016-06-23 | Immusoft Corporation | B cells for in vivo delivery of therapeutic agents |
| WO2016161446A1 (en) * | 2015-04-03 | 2016-10-06 | Dana-Farber Cancer Institute, Inc. | Composition and methods of genome editing of b-cells |
| WO2016187017A1 (en) * | 2015-05-15 | 2016-11-24 | Mcivor R Scott | Adeno-associated for therapeutic delivery to central nervous system |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2020517692A (ja) | 2020-06-18 |
| WO2018201071A1 (en) | 2018-11-01 |
| US20220193129A1 (en) | 2022-06-23 |
| JP7526312B2 (ja) | 2024-07-31 |
| EP3615045A1 (en) | 2020-03-04 |
| RU2019136194A3 (enExample) | 2021-08-02 |
| AU2025202508A1 (en) | 2025-06-05 |
| AU2018256887B2 (en) | 2025-01-09 |
| CA3061048A1 (en) | 2018-11-01 |
| JP2023093703A (ja) | 2023-07-04 |
| AU2018256887A1 (en) | 2019-11-07 |
| JP2024153703A (ja) | 2024-10-29 |
| RU2019136194A (ru) | 2021-05-27 |
| BR112019022473A2 (pt) | 2020-10-20 |
| EP3615045A4 (en) | 2021-01-13 |
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